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This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码属于非组蛋白染色体高迁移率组(HMG)蛋白家族的蛋白。 HMG蛋白质充当建筑的因素和是enhancesome的重要组成部分。此蛋白含有结构DNA结合结构域和可作为转录调控因子起作用。的缺失,扩增,和与粘液样脂肪肉瘤相关该基因的重排的鉴定表明在脂肪生成和间质分化的作用。基因敲除小鼠对应的研究表明,该基因参与饮食引起的肥胖。备用转录剪接变体,编码不同同种型,已经表征。 [由RefSeq的,2008年7月提供]
HMGA2基因(以及对应的蛋白质)的细胞分布位置:
HMGA2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Lipomatosis, Multiple | 0.123528744 | 13 | 0 | BeFree_CTD_human |
| Liposarcoma, Dedifferentiated | 0.120814326 | 3 | 0 | BeFree_ORPHANET |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.120542884 | 3 | 1 | BeFree_GWASCAT |
| Liposarcoma, well differentiated | 0.120542884 | 2 | 0 | BeFree_ORPHANET |
| Birth Weight | 0.12 | 1 | 0 | CTD_human |
| Polycystic Ovary Syndrome | 0.12 | 1 | 1 | GWASCAT |
| Birth length | 0.12 | 1 | 1 | GWASCAT |
| Infant length | 0.12 | 1 | 1 | GWASCAT |
| Lipoma | 0.015472187 | 57 | 0 | BeFree |
| Fibroid Tumor | 0.014591848 | 36 | 0 | BeFree_GAD_LHGDN |
| Uterine Fibroids | 0.013300652 | 49 | 0 | BeFree |
| Mixed Salivary Gland Tumor | 0.008977445 | 14 | 0 | BeFree_LHGDN |
| Hamartoma | 0.008706003 | 13 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
| Carcinogenesis | 0.007871814 | 29 | 0 | BeFree |
| liposarcoma | 0.007620235 | 9 | 0 | BeFree_LHGDN |
| Pituitary Neoplasms | 0.006263026 | 5 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.006263026 | 4 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.005428837 | 20 | 0 | BeFree |
| Primary Myelofibrosis | 0.00408156 | 5 | 2 | BeFree_LHGDN |
| Congenital chromosomal disease | 0.004071628 | 15 | 0 | BeFree |
| Benign Neoplasm | 0.004071628 | 15 | 0 | BeFree |
| Smooth Muscle Tumor | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Adenocarcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Polycythemia Vera | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Chondroma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Myeloid Leukemia, Chronic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Lymphangioleiomyomatosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Glioma | 0.002909916 | 3 | 0 | BeFree_GAD |
| Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Ovarian Carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.002714419 | 10 | 0 | BeFree |
| Brain Neoplasms | 0.002638474 | 2 | 0 | BeFree_GAD |
| Brain Diseases | 0.002367032 | 1 | 1 | GAD |
| Cardiovascular Diseases | 0.002367032 | 1 | 0 | GAD |
| Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
| Tooth eruption | 0.002367032 | 1 | 1 | GAD |
| Uterine Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Ventricular Dysfunction, Left | 0.002367032 | 1 | 0 | GAD |
| Solid tumour | 0.002171535 | 8 | 0 | BeFree |
| Adenoma | 0.001900093 | 7 | 0 | BeFree |
| Pituitary Adenoma | 0.001900093 | 7 | 0 | BeFree |
| Stomach Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.001628651 | 6 | 0 | BeFree |
| Aggressive angiomyxoma | 0.001628651 | 6 | 0 | BeFree |
| Prolactinoma | 0.001357209 | 5 | 0 | BeFree |
| Uterine Polyp | 0.001357209 | 5 | 0 | BeFree |
| Sarcoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Dwarfism | 0.001085767 | 4 | 0 | BeFree |
| Glioblastoma | 0.001085767 | 4 | 0 | BeFree |
| Paroxysmal nocturnal hemoglobinuria | 0.001085767 | 4 | 0 | BeFree |
| Myelofibrosis | 0.001085767 | 4 | 0 | BeFree |
| Pituitary Diseases | 0.001085767 | 4 | 0 | BeFree |
| Thyroid Neoplasm | 0.001085767 | 4 | 0 | BeFree |
| Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
| Carcinoma ex pleomorphic adenoma | 0.001085767 | 4 | 0 | BeFree |
| Epithelial ovarian cancer | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
| Pygmy (disorder) | 0.001085767 | 4 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Carcinosarcoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| leukemia | 0.000814326 | 3 | 0 | BeFree |
| Myeloproliferative disease | 0.000814326 | 3 | 0 | BeFree |
| Myoma | 0.000814326 | 3 | 0 | BeFree |
| synovial sarcoma | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
| Tumor Initiation | 0.000814326 | 3 | 0 | BeFree |
| Chronic myeloproliferative disorder | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
| Endometriosis | 0.000542884 | 2 | 0 | BeFree |
| Failure to Thrive | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| leiomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Myelodysplasia | 0.000542884 | 2 | 0 | BeFree |
| Myxoma | 0.000542884 | 2 | 0 | BeFree |
| Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
| Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
| Preleukemia | 0.000542884 | 2 | 0 | BeFree |
| Retinoblastoma | 0.000542884 | 2 | 0 | BeFree |
| Thyroid Nodule | 0.000542884 | 2 | 0 | BeFree |
| Trisomy | 0.000542884 | 2 | 0 | BeFree |
| Russell-Silver syndrome | 0.000542884 | 2 | 0 | BeFree |
| Follicular adenoma | 0.000542884 | 2 | 0 | BeFree |
| Fibroadenoma | 0.000542884 | 2 | 0 | BeFree |
| Mucoepidermoid Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000542884 | 2 | 0 | BeFree |
| Benign Mesenchymoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Growth failure | 0.000542884 | 2 | 0 | BeFree |
| Myolipoma | 0.000542884 | 2 | 0 | BeFree |
| Lipoblastoma | 0.000542884 | 2 | 0 | BeFree |
| Myofibroma (morphologic abnormality) | 0.000542884 | 2 | 0 | BeFree |
| Atypical teratoid/rhabdoid tumor | 0.000542884 | 2 | 0 | BeFree |
| Soft tissue chondroma | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Salivary Gland Pleomorphic Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| beta Thalassemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
| Blast Phase | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Papillary | 0.000271442 | 1 | 0 | BeFree |
| Phyllodes Tumor | 0.000271442 | 1 | 0 | BeFree |
| Diabetic Nephropathy | 0.000271442 | 1 | 1 | BeFree |
| Exanthema | 0.000271442 | 1 | 0 | BeFree |
| Gigantism | 0.000271442 | 1 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lipomatosis | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Meigs Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Myoepithelioma | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Soft Tissue Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Teratoma | 0.000271442 | 1 | 0 | BeFree |
| Testicular Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Tetanus | 0.000271442 | 1 | 0 | BeFree |
| Thrombocythemia, Essential | 0.000271442 | 1 | 0 | BeFree |
| Hamartoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of nasopharynx | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma, Oxyphilic | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Liposarcoma, Myxoid | 0.000271442 | 1 | 0 | BeFree |
| Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Rhabdoid Tumor | 0.000271442 | 1 | 0 | BeFree |
| Neuroendocrine Tumors | 0.000271442 | 1 | 0 | BeFree |
| childhood rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gallbladder Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
| PULMONARY LYMPHANGIOMYOMATOSIS | 0.000271442 | 1 | 0 | BeFree |
| Endometrioma | 0.000271442 | 1 | 0 | BeFree |
| Leiomyosarcoma of uterus | 0.000271442 | 1 | 0 | BeFree |
| Diffuse Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Papillary serous cystadenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Thyroid associated opthalmopathies | 0.000271442 | 1 | 0 | BeFree |
| Pleomorphic adenoma of lacrimal gland | 0.000271442 | 1 | 0 | BeFree |
| Pleomorphic adenoma of parotid gland | 0.000271442 | 1 | 0 | BeFree |
| Follicular neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Overweight | 0.000271442 | 1 | 0 | BeFree |
| Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
| Benign bone neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Malignant Peripheral Nerve Sheath Tumor | 0.000271442 | 1 | 0 | BeFree |
| Spots on skin | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung, stage IV | 0.000271442 | 1 | 0 | BeFree |
| Colon Lipoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Spindle cell rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Salivary duct carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Serous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Vaginal Leiomyoma | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Tumorigenesis | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Benign symmetrical lipomatosis | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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