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HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  HLA-DMA属于HLA II类α链旁系同源基??因。此Ⅱ类分子是选自由α(DMA)和一个β链(DMB)的异源二聚体,在膜中两个锚定的。它坐落在细胞内的囊泡。 DM通过帮助释放从肽结合位点的剪辑分子II分子起着MHC II类的肽装载中心作用。 (:B淋巴细胞,树突细胞,巨噬细胞,APC)II类分子在抗原呈递细胞中表达。的α链是约33-35 kDa和其基因含有5个外显子。外显子1编码前导肽,外显子2和3编码的两个细胞外结构域,外显子4编码的跨膜结构域和胞质尾区。 [由RefSeq的,2008年7月提供]
HLA-DMA基因(以及对应的蛋白质)的细胞分布位置:
HLA-DMA基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Contact Dermatitis | 0.122367032 | 1 | 0 | CTD_human_GAD |
| Dermatitis, Occupational | 0.12 | 1 | 0 | CTD_human |
| Lupus Erythematosus, Systemic | 0.010911214 | 5 | 0 | BeFree_GAD_LHGDN |
| Rheumatoid Arthritis | 0.004810009 | 9 | 0 | BeFree_GAD |
| Multiple Sclerosis | 0.004734064 | 2 | 0 | GAD |
| HIV Infections | 0.002638474 | 1 | 0 | BeFree_GAD |
| Acquired Immunodeficiency Syndrome | 0.002367032 | 1 | 0 | GAD |
| Condylomata Acuminata | 0.002367032 | 1 | 0 | GAD |
| IGA Glomerulonephritis | 0.002367032 | 1 | 0 | GAD |
| Psoriasis | 0.002367032 | 1 | 0 | GAD |
| Antiphospholipid Syndrome | 0.002367032 | 1 | 0 | GAD |
| Lupus Erythematosus | 0.002367032 | 1 | 0 | GAD |
| Sarcoidosis | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 2 | BeFree |
| Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Polyendocrinopathies, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
| Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
| Lupus anticoagulant disorder | 0.000271442 | 1 | 0 | BeFree |
| Superficial ulcer | 0.000271442 | 1 | 0 | BeFree |
| Primary antiphospholipid syndrome | 0.000271442 | 1 | 0 | BeFree |
| dmac | 0.000271442 | 1 | 0 | BeFree |
| Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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