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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  蛋白激酶C(PKC)是可以通过钙和第二信使甘油二酯被激活丝氨酸和苏氨酸特异性蛋白激酶家族。 PKC家族成员磷酸化多种蛋白靶和已知参与不同的细胞信号传导途径。 PKC家族成员还作为主要受体佛波醇酯,一类促癌物。蛋白激酶C家族的每个成员都有特定的表达谱,并且被认为发挥细胞不同的作用。由该基因编码的蛋白质是蛋白激酶C家族成员之一。这种激酶已经报道在许多不同的细胞过程,例如细胞粘附,细胞转化,细胞周期关卡和细胞体积控制来发挥作用。在小鼠中敲除的研究表明,该激酶可能是心脏收缩和Ca(2+)在肌细胞的处理的基本调节。 [由RefSeq的,2008年7月提供]
PRKCA基因(以及对应的蛋白质)的细胞分布位置:
PRKCA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Cardiomegaly | 0.2 | 2 | 0 | CTD_human_RGD |
Diabetes Mellitus, Experimental | 0.12 | 1 | 0 | CTD_human |
Intestinal Neoplasms | 0.12 | 1 | 0 | CTD_human |
Polyuria | 0.12 | 1 | 0 | CTD_human |
Nephrogenic Diabetes Insipidus | 0.12 | 1 | 0 | CTD_human |
Ischemia | 0.080542884 | 3 | 0 | BeFree_RGD |
Heart failure | 0.080271442 | 2 | 0 | BeFree_RGD |
Brain Ischemia | 0.08 | 1 | 0 | RGD |
Hypertensive disease | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Left Ventricular Hypertrophy | 0.08 | 1 | 0 | RGD |
Right Ventricular Hypertrophy | 0.08 | 1 | 0 | RGD |
Mammary Neoplasms | 0.017431869 | 10 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.00643866 | 15 | 3 | BeFree_GAD |
Multiple Sclerosis | 0.00554839 | 3 | 0 | BeFree_GAD |
Prostatic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
ovarian neoplasm | 0.0054487 | 2 | 0 | LHGDN |
Schizophrenia | 0.005276948 | 3 | 1 | BeFree_GAD |
Asthma | 0.004734064 | 2 | 0 | GAD |
melanoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Breast Carcinoma | 0.004071628 | 15 | 3 | BeFree |
Glioblastoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Leukemia, Myelocytic, Acute | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Congenital Abnormality | 0.00272435 | 1 | 0 | LHGDN |
Basal cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Membranous glomerulonephritis | 0.00272435 | 1 | 0 | LHGDN |
Huntington Disease | 0.00272435 | 1 | 0 | LHGDN |
Myopathy | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Spina Bifida | 0.00272435 | 1 | 0 | LHGDN |
Small cell carcinoma of lung | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Obesity | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Bacterial Vaginosis | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
Cushing Syndrome | 0.002171535 | 8 | 0 | BeFree |
Neoplasm Metastasis | 0.001628651 | 6 | 0 | BeFree |
Liver carcinoma | 0.001628651 | 6 | 0 | BeFree |
Adrenal Cortical Adenoma | 0.001357209 | 5 | 0 | BeFree |
Pancreatic carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of lung | 0.001357209 | 5 | 0 | BeFree |
Carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
Adenoma | 0.001085767 | 4 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Glioma | 0.001085767 | 4 | 0 | BeFree |
Neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Adrenal Gland Hyperfunction | 0.000814326 | 3 | 0 | BeFree |
Adrenal Gland Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Hyperglycemia | 0.000814326 | 3 | 0 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
Congenital adrenal hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of skin | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetic Nephropathy | 0.000542884 | 2 | 0 | BeFree |
Pituitary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Post-Traumatic Stress Disorder | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Metastatic malignant neoplasm to brain | 0.000542884 | 2 | 0 | BeFree |
Adrenal hypertrophy or hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adrenal hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Infection by Cryptococcus neoformans | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Pemphigus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Retinitis | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Histiocytoma, Benign Fibrous | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 1 | BeFree |
Extrapyramidal sign | 0.000271442 | 1 | 0 | BeFree |
Neoplasm, Residual | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Vascular Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Fibrolamellar hepatocellular carcinoma | 0.000271442 | 1 | 0 | BeFree |
Superficial spreading malignant melanoma of skin | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of colon | 0.000271442 | 1 | 0 | BeFree |
Acral Lentiginous Malignant Melanoma | 0.000271442 | 1 | 0 | BeFree |
Carney Complex | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
Spot pigmented | 0.000271442 | 1 | 0 | BeFree |
Advanced cancer | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Oncocytic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Skin Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Tumor Promotion | 0.000271442 | 1 | 0 | BeFree |
MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Papillary glioneuronal tumor | 0.000271442 | 1 | 0 | BeFree |
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