PPBP(pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

4q12-q13
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

[中文简述(自动翻译):]  由该基因编码的蛋白是属于趋化因子家族，血小板衍生的生长因子。这种生长因子是一种强效化学引诱物和嗜中性粒细胞的活化剂。已经表明，以刺激各种细胞过程，包括DNA的合成，有丝分裂，糖酵解，细胞内cAMP积聚，前列腺素E2的分泌，和透明质酸和硫酸化糖胺聚糖的合成。它也刺激由滑膜细胞的形成和纤维蛋白溶酶原活化剂的分泌。该蛋白质也是抗微生物蛋白具有杀菌和抗真菌活性。 [由RefSeq的，2014年11月提供]

OMIM数据库中对PPBP基因的介绍     Wikipedia数据库中对PPBP基因的介绍

基因序列

基因序列

PPBP基因的碱基序列：[NCBI]

基因突变

基因突变

PPBP基因的碱基突变：           显示全部snp
rs183028       rs352009       rs352010       rs377579       rs552582       rs2435197       rs2435198       rs2458097       rs2458098       rs9291191       rs16850295       rs35033774       rs55765475       rs60720029       rs61290993       rs73824590       rs74663056       rs75099296       rs75481791       rs75893465       rs77522449       rs111910007       rs112280968       rs113170400       rs113810823       rs115994466       rs116220395       rs116538408       rs138080486       rs139810955       rs140669044       rs140909896       rs141400228       rs143535762       rs143538687       rs143910155       rs145613589      
rs146549266       rs147418011       rs147853456       rs148303332       rs148885848       rs149225987       rs149698073       rs150179122       rs150852563       rs182007352       rs182902460       rs184311190       rs184586452       rs184591149       rs186553901       rs187674690       rs188697455       rs188743042       rs189261898       rs189912105       rs190615189       rs192167879       rs192210153       rs200353259       rs200365607       rs200454336       rs201450284       rs201716206       rs201755460       rs201872789       rs202202826       rs202224981       rs267600255       rs367589614       rs367601214       rs367724966       rs368469253       rs368597269       rs370008047       rs371849071       rs372219154       rs372324884       rs372365443       rs373114326       rs373274764       rs373328329       rs374758220       rs375062598       rs376030139       rs376303862       rs376737679       rs376773889       rs377472942       rs527392274       rs529151291       rs529189535       rs530286401       rs531179806       rs531482264       rs532568748       rs532849092       rs533118308       rs533886989       rs536192416       rs536209485       rs537604616       rs538109768       rs538197603       rs538383623       rs538712375       rs541598508       rs542020048       rs544413739       rs545912473       rs547012644       rs547162282       rs548203131       rs550197811       rs550662588       rs551197857       rs553940943       rs554052126       rs554521346       rs556016697       rs556871216       rs558211014       rs558656228       rs560988932       rs561198430       rs561392145       rs563053663       rs563120088       rs563911240       rs564976290       rs565587834       rs566370306       rs566580373       rs567941892       rs568035398       rs568930158       rs568996030       rs570920354       rs571795460       rs572634888       rs573289378       rs575217084       rs575338624       rs575741195       rs577001611       rs577092070       rs745485068       rs745503298       rs745521300       rs746635979       rs746925866       rs746980365       rs747448934       rs747703873       rs748070389       rs748408619       rs748587767       rs748655123       rs749413673       rs749613904       rs750555220       rs750993219       rs751441359       rs752037837       rs752048344       rs752298201       rs752351624       rs752884048       rs753998004       rs754086026       rs754225791       rs754647950       rs754650925       rs754931402       rs755459068       rs755809397       rs756418685       rs756511867       rs756752155       rs757180957       rs757629637       rs757864218       rs758809256       rs759008769       rs759944510       rs761242980       rs761317488       rs761666297       rs762380605       rs762642176       rs763097903       rs763562819       rs763786130       rs763955336       rs764086855       rs765295005       rs765491686       rs766662863       rs766738989       rs767300244       rs767705628       rs768190493       rs768825217       rs769639655       rs769642041       rs770710194       rs770743796       rs771222493       rs771402468       rs772035654       rs772261845       rs772967769       rs773055695       rs773469633       rs773682993       rs773810967       rs773999304       rs774274246       rs774644890       rs775503733       rs775715280       rs777210623       rs777286878       rs777542569       rs778293904       rs778342233       rs778453233       rs778593503       rs779348146       rs779682048       rs781398672       rs781688514       rs781700993      

基因表达

基因表达

PPBP基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGGCAAAGAGGAAAGTCTAGAC
60
TTTGGGATGAATTCCAGAGGT
60
CTGTCATTGCTGCTGACTG
59
GACTTTCCTCTTTGCCTTTCG
60
CTTCTGTCATTGCTGCTGAC
60
GACTTTCCTCTTTGCCTTTCG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PPBP基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PPBP基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0002523
P02775(UniProtKB)
IEA
GO:0002576
P02775(UniProtKB)
TAS
GO:0002690
P02775(UniProtKB)
IBA
GO:0005355
P02775(UniProtKB)
TAS
GO:0005576
P02775(UniProtKB)
TAS
GO:0005576
P02775(UniProtKB)
TAS
GO:0005576
P02775(UniProtKB)
TAS
GO:0005576
P02775(UniProtKB)
TAS
GO:0005576
P02775(UniProtKB)
TAS
GO:0005615
P02775(UniProtKB)
IBA
GO:0006954
P02775(UniProtKB)
IBA
GO:0006955
P02775(UniProtKB)
IBA
GO:0007186
P02775(UniProtKB)
IBA
GO:0008009
P02775(UniProtKB)
IBA
GO:0008083
P02775(UniProtKB)
IEA
GO:0015758
P02775(UniProtKB)
TAS
GO:0030593
P02775(UniProtKB)
IEA
GO:0031093
P02775(UniProtKB)
TAS
GO:0032496
P02775(UniProtKB)
IBA
GO:0042127
P02775(UniProtKB)
IBA
GO:0042742
P02775(UniProtKB)
IEA
GO:0043312
P02775(UniProtKB)
IEA
GO:0045236
P02775(UniProtKB)
IBA
GO:0051781
P02775(UniProtKB)
IEA
GO:0070098
P02775(UniProtKB)
IBA
GO:1904659
P02775(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PPBP基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hypersensitivity 0.12 1 0 CTD_human
Hypertensive disease 0.12 2 0 CTD_human
Acute Coronary Syndrome 0.00272435 1 0 LHGDN
Coronary Artery Disease 0.00272435 1 0 LHGDN
Asthma 0.002367032 1 0 GAD
Bronchiolitis, Viral 0.002367032 1 0 GAD
Respiratory Syncytial Virus Infections 0.002367032 1 0 GAD
MRSA - Methicillin resistant Staphylococcus aureus infection 0.001357209 5 0 BeFree
Influenza 0.001085767 4 0 BeFree
Anemia, Sickle Cell 0.000542884 2 0 BeFree
Coronary heart disease 0.000542884 2 0 BeFree
Chagas Disease 0.000542884 2 0 BeFree
Vitamin B 12 Deficiency 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Aspergillosis 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Mycobacterium Infections 0.000271442 1 0 BeFree
Nephroblastoma 0.000271442 1 0 BeFree
Lobar Pneumonia 0.000271442 1 0 BeFree
Tuberculosis 0.000271442 1 0 BeFree
Streptococcal pneumonia 0.000271442 1 0 BeFree
Infections, Hospital 0.000271442 1 0 BeFree
Cervical Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Conventional (Clear Cell) Renal Cell Carcinoma 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Secondary malignant neoplasm of liver 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Colorectal cancer metastatic 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree

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