PLP1基因详情-基因数据库-基因云馆

PLP1(proteolipid protein 1)

基因简称(symbol)

PLP1 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

GPM6C

基因家族代码(gene_family_id)

[HGNC] [GenScript]

omim代码

300401

entrez码

5354 [Vega]

vega基因码

OTTHUMG00000022111

ensembl基因码

ENSG00000123560 [Ensembl]

基因家族(gene family)

refseq数据库代号

NM_001128834

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

Xq22

同源基因名称(alias name)

Pelizaeus-Merzbacher disease

基因名称批准使用时间(date_approved_reserved)

2001-06-22T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

2008-07-28T00:00:00Z

更新时间(date_modified)

2014-11-19T00:00:00Z

ucsc码

uc033epo.1

ena

M27110

ccds数据码

CCDS14513|CCDS14514

uniprot数据码

P60201

pubmed代码

mgd码

MGI:97623

rgd码

RGD:3354

生命科学数据库(lsdb)

Mental Retardation database|http://grenada.lumc.nl/LOVD2/MR/home.php?select_db=PLP1

更新时间(date modified)

2014-11-19T00:00:00Z

cosmic

PLP1

mirbase

基因曾用简称(prev symbol)

SPG2|PLP

基因曾用名称(prev name)

spastic paraplegia 2, uncomplicated

homeodb

cosmic

PLP1

snornabase

bioparadigms slc

orphanet

117894

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

Xq22

This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]

[中文简述(自动翻译):] 这个基因编码的跨膜蛋白脂质蛋白是髓鞘的主要组分。所编码的蛋白质可能在压实，稳定化，和维护髓鞘少突胶质细胞在发展和轴突存活的作用，以及。突变该基因引起佩 - 梅病和痉挛性截瘫类型2中的多个转录物变体，包括DM20剪接变体可替代地剪接的结果。 [由RefSeq的，2015年2月提供]

OMIM数据库中对PLP1基因的介绍 Wikipedia数据库中对PLP1基因的介绍

PLP1基因的碱基序列：[NCBI]

PLP1基因的碱基突变：显示全部snp

rs781398260 rs781201175 rs781156947 rs781088398 rs780949487 rs780936979 rs780722962 rs780642451 rs780609276 rs780315091 rs780293374 rs780244695 rs780100343 rs779848213 rs779819142 rs779691407 rs779620495 rs779572907 rs779532463 rs779377752 rs779258535 rs779161409 rs778964512 rs778928513 rs778783545 rs778733164 rs778691626 rs778681722 rs778594601 rs778487661 rs778217267 rs778127363 rs777983768 rs777789140 rs777670118 rs777645250 rs777630802

rs777530817 rs777448818 rs777439275 rs777157938 rs777104445 rs777033519 rs776918539 rs776708243 rs776423464 rs776333412 rs776315414 rs776243524 rs776231227 rs775878564 rs775671930 rs775659063 rs775558355 rs775500666 rs775484528 rs775195153 rs775096104 rs775007393 rs775001756 rs774992577 rs774977774 rs774801110 rs774511719 rs774443520 rs774181784 rs773941742 rs773842592 rs773621482 rs773577048 rs773452392 rs773418220 rs773350786 rs773303979 rs773033228 rs772900083 rs772751047 rs772502762 rs772313778 rs772312288 rs772222512 rs771968665 rs771884223 rs771842340 rs771833180 rs771794739 rs771695859 rs771605929 rs771591300 rs771517064 rs771189523 rs771185742 rs771156134 rs770845275 rs770807782 rs770645902 rs770636465 rs770569809 rs770461324 rs770399715 rs770378518 rs770044352 rs769978094 rs769850744 rs769471963 rs769381987 rs769235659 rs769034718 rs768984598 rs768948636 rs768814398 rs768813979 rs768728281 rs768565263 rs768512408 rs768511490 rs768300961 rs767956534 rs767893921 rs767855810 rs767644415 rs767421490 rs766899165 rs766855339 rs766835727 rs766812456 rs766768168 rs766272763 rs766185598 rs766096776 rs766033633 rs766024604 rs766013171 rs765784563 rs765770013 rs765716596 rs765696751 rs765421365 rs765324737 rs765207439 rs764723428 rs764648137 rs764512140 rs764358713 rs764159806 rs764138116 rs763892975 rs763727530 rs763449532 rs763376651 rs763205905 rs763083823 rs762944339 rs762939742 rs762823016 rs762736084 rs762649426 rs762579043 rs762337725 rs762333078 rs762156779 rs762055065 rs762042640 rs761919527 rs761733192 rs761680101 rs761666491 rs761505460 rs761426222 rs761372429 rs761081128 rs761012212 rs760994834 rs760936679 rs760769797 rs760717297 rs760645028 rs760605698 rs760513906 rs760487438 rs760386490 rs760339313 rs760227141 rs760127301 rs760115722 rs760039534 rs759782561 rs759745724 rs759656798 rs759384122 rs759342687 rs759338517 rs759296333 rs759194853 rs759106420 rs759188505 rs759074300 rs758929133 rs758841186 rs758780517 rs758471190 rs758445341 rs758372406 rs758148748 rs758126987 rs758058757 rs757904948 rs757780584 rs757700416 rs757696907 rs757690406 rs757682626 rs757642989 rs757600628 rs757526205 rs757089790 rs756994985 rs756986379 rs756976500 rs756954760 rs756534856 rs756426032 rs756334357 rs756188731 rs756004043 rs755964153 rs755960945 rs755645540 rs755624318 rs755574353 rs755529767 rs755194076 rs755154014 rs754929570 rs754862834 rs754488693 rs754455683 rs754378176 rs754348170 rs754326867 rs754320464 rs753992883 rs753956524 rs753741833 rs753706052 rs753571902 rs753479760 rs753378245 rs753285570 rs753140839 rs752946912 rs752753316 rs752563088 rs752418330 rs752393093 rs752244939 rs752029650 rs751911083 rs751774113 rs751734702 rs751719782 rs751578266 rs751530856 rs751435520 rs751404730 rs751201822 rs750987027 rs750917573 rs750791586 rs750635056 rs750560180 rs750532798 rs750400035 rs750336927 rs750272749 rs750265686 rs750184625 rs750073011 rs749816741 rs749939050 rs749774009 rs749727888 rs749647087 rs749532126 rs749278720 rs749251393 rs749243691 rs749163852 rs748894669 rs748595198 rs748242742 rs748205356 rs748061143 rs748024425 rs747978554 rs747936650 rs747822336 rs747690339 rs747619543 rs747410747 rs747254687 rs747175128 rs746949269 rs747120430 rs746921009 rs746599075 rs746727972 rs746559581 rs746504643 rs746502580 rs746397060 rs746270709 rs746111516 rs746081433 rs745999693 rs745702467 rs745708306 rs567332701 rs556915178 rs553153122 rs547192841 rs540831827 rs539157441 rs529807126 rs528629366 rs377277524 rs377170286 rs376388062 rs376342119 rs376327266 rs376305277 rs376226964 rs376033543 rs375460973 rs374956670 rs374325895 rs374324001 rs374312325 rs373973633 rs373844748 rs372434302 rs371857048 rs371828309 rs369401853 rs368688220 rs368423174 rs368005801 rs367845254 rs202202262 rs202117910 rs201156822 rs201103416 rs201006606 rs200231542 rs199926029 rs199854517 rs199794221 rs199758338 rs199732440 rs193025011 rs192952647 rs192378708 rs192304072 rs192141365 rs192084979 rs191826919 rs191744226 rs191506525 rs191203625 rs191185689 rs191117731 rs190720641 rs190431889 rs190366376 rs190126062 rs189884106 rs189561698 rs189295366 rs188734237 rs188707059 rs188465650 rs188179429 rs187952499 rs187933840 rs187691381 rs187444920 rs187417121 rs187098129 rs187023963 rs187015140 rs186765972 rs186429139 rs186270804 rs185953263 rs185856943 rs185713046 rs185646515 rs185421252 rs185301882 rs185063481 rs185146146 rs184673699 rs184878506 rs184546595 rs184166250 rs183866945 rs183708797 rs183500507 rs183259017 rs182623199 rs182606431 rs182508622 rs182435041 rs182402974 rs182240913 rs181738431 rs181449808 rs181312516 rs180837748 rs151116667 rs150525459 rs150504967 rs150364583 rs150231386 rs149817148 rs149766354 rs149501240 rs149447885 rs149109043 rs148415197 rs147937097 rs147929910 rs147893875 rs147695213 rs147684590 rs146673482 rs145727972 rs145567904 rs144929833 rs143752119 rs143345401 rs143246498 rs142512292 rs141695975 rs141638303 rs140707701 rs140319649 rs140047941 rs138092961 rs137966879 rs132630282 rs114798618 rs113897548 rs113649764 rs113345335 rs112937128 rs113056718 rs112667596 rs112576686 rs112471483 rs112198561 rs112162882 rs112019925 rs111521400 rs111407550 rs78329109 rs75548020 rs73633889 rs73524191 rs73258096 rs72616843 rs72616842 rs72616841 rs72616840 rs72568631 rs67533285 rs58036578 rs56980503 rs56855317 rs41306283 rs34596543 rs17003884 rs17003883 rs17003882 rs16984053 rs16984049 rs16984048 rs12353803 rs12353638 rs11543023 rs11796658 rs11543022 rs11543012 rs11371342 rs7880553 rs5987582 rs5903226 rs5011496 rs2858198 rs2858197 rs2858194 rs2858193 rs2858191 rs2858189 rs2858188 rs2858187 rs2858184 rs2858183 rs2857312 rs2857311 rs2857310 rs2655408 rs2294153 rs2294152 rs2233697 rs2233696 rs2233695 rs2233694 rs2233693 rs1599989 rs1126707 rs1042460 rs1042442 rs1042440 rs958928 rs532117 rs521895 rs509691 rs508804 rs475827 rs471416

PLP1基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

CAGCTGAACAAAGTCAGCC

59

CTAACAAGCCCATGTCTTTGG

59

CTCATCAATGTGATCCATGCC

59

GTGGTGTAGAAGCCCTCAG

59

GTTCCAAATGACCTTCCACC

59

ATCATGAAGGTGAGCAGGG

59

TCCAAATGACCTTCCACCT

58

CAATCATGAAGGTGAGCAGG

59

CCAGCTGAACAAAGTCAGC

59

CTAACAAGCCCATGTCTTTGG

59

CTGGATTGTGTTTCTTTGGG

57

GCATGGATCACATTGATGAG

57

GTGCAAGATGTCTGGTAGG

57

GCATGGATCACATTGATGAG

57

AGCTGAACAAAGTCAGCCA

59

CTAACAAGCCCATGTCTTTGG

59

TACTTCAACACCTGGACCA

58

GGAGAACACCATACATTCTGG

58

ACTGGATTGTGTTTCTTTGGG

59

GGCATGGATCACATTGATGAG

59

尚未收录相关数据

PLP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

PLP1基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0016021

A0A0U1RVI3(UniProtKB)

IEA

GO:0016021

B1B1G1(UniProtKB)

IEA

GO:0016021

B1B1G2(UniProtKB)

IEA

GO:0016021

B1B1G3(UniProtKB)

IEA

GO:0016021

B1B1G4(UniProtKB)

IEA

GO:0016021

B1B1G6(UniProtKB)

IEA

GO:0005198

P60201(UniProtKB)

TAS

GO:0005515

P60201(UniProtKB)

IPI

GO:0005886

P60201(UniProtKB)

IDA

GO:0006954

P60201(UniProtKB)

IEA

GO:0007229

P60201(UniProtKB)

IEA

GO:0007268

P60201(UniProtKB)

TAS

GO:0008366

P60201(UniProtKB)

TAS

GO:0010628

P60201(UniProtKB)

IEA

GO:0014002

P60201(UniProtKB)

IEA

GO:0016021

P60201(UniProtKB)

IEA

GO:0019911

P60201(UniProtKB)

IEA

GO:0021762

P60201(UniProtKB)

IEP

GO:0022010

P60201(UniProtKB)

IEA

GO:0042759

P60201(UniProtKB)

IEA

GO:0043209

P60201(UniProtKB)

IEA

GO:0048469

P60201(UniProtKB)

IEA

GO:0061564

P60201(UniProtKB)

IEA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控PLP1基因的相关microRNA：

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
SPASTIC PARAPLEGIA 2, X-LINKED (disorder)	0.56	10	5	CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT
Pelizaeus-Merzbacher Disease	0.497082245	147	14	BeFree_CLINVAR_CTD_human_LHGDN_MGD_UNIPROT
Pelizaeus-Merzbacher Disease, Atypical	0.12	0	1	CLINVAR
Classic Pelizaeus-Merzbacher Disease	0.12	0	0	ORPHANET
Pelizaeus-Merzbacher Disease, Transitional	0.12	0	0	ORPHANET
Seizures	0.080271442	3	0	BeFree_RGD
Hereditary X-Linked Recessive Spastic Paraplegia	0.005971721	22	0	BeFree
Leukodystrophy	0.005895776	13	0	BeFree_GAD
Paraplegia	0.0054487	2	0	LHGDN
Schizophrenia	0.00408156	5	0	BeFree_LHGDN
Cerebral Palsy	0.003267234	2	0	BeFree_LHGDN
Inflammation	0.00272435	1	0	LHGDN
Quadriplegia	0.00272435	1	0	LHGDN
Multiple Sclerosis, Chronic Progressive	0.00272435	1	0	LHGDN
Spastic Paraplegia	0.001900093	7	0	BeFree
Experimental Autoimmune Encephalomyelitis	0.001628651	6	0	BeFree
Nystagmus	0.001085767	4	0	BeFree
Multiple Sclerosis	0.000814326	3	0	BeFree
Muscle Spasticity	0.000814326	3	0	BeFree
nervous system disorder	0.000814326	3	0	BeFree
Spastic Paraplegia, Hereditary	0.000814326	3	0	BeFree
Neurodegenerative Disorders	0.000814326	3	0	BeFree
CNS disorder	0.000542884	2	0	BeFree
Muscle hypotonia	0.000542884	2	0	BeFree
Peripheral Neuropathy	0.000542884	2	0	BeFree
Paraparesis, Spastic	0.000542884	2	0	BeFree
Cerebral atrophy	0.000542884	2	0	BeFree
Developmental delay (disorder)	0.000542884	2	0	BeFree
Spastic	0.000542884	2	0	BeFree
Major Depressive Disorder	0.000542884	2	0	BeFree
Astrocytoma	0.000271442	1	0	BeFree
Autistic Disorder	0.000271442	1	0	BeFree
Cocaine Abuse	0.000271442	1	0	BeFree
Presenile dementia	0.000271442	1	0	BeFree
Demyelinating Diseases	0.000271442	1	0	BeFree
Hypophosphatasia	0.000271442	1	0	BeFree
Kidney Failure, Chronic	0.000271442	1	0	BeFree
Protein Deficiency	0.000271442	1	0	BeFree
Henoch-Schoenlein Purpura	0.000271442	1	0	BeFree
Shy-Drager Syndrome	0.000271442	1	0	BeFree
Unipolar Depression	0.000271442	1	0	BeFree
Lysosomal Storage Diseases	0.000271442	1	0	BeFree
X-linked agammaglobulinemia	0.000271442	1	0	BeFree
Primary hyperoxaluria, type I	0.000271442	1	0	BeFree
Axonal neuropathy	0.000271442	1	0	BeFree
Peripheral demyelinating neuropathy	0.000271442	1	1	BeFree
Pendular Nystagmus	0.000271442	1	0	BeFree
Multiple System Atrophy	0.000271442	1	0	BeFree
Neuropathy	0.000271442	1	0	BeFree
Dementia	0.000271442	1	0	BeFree
Hyperhomocysteinemia	0.000271442	1	0	BeFree
Multiple Sclerosis, Primary Progressive	0.000271442	1	0	BeFree
Multiple Sclerosis, Relapsing-Remitting	0.000271442	1	0	BeFree
Peripheral axonal neuropathy	0.000271442	1	0	BeFree
Urban Schosser Spohn syndrome	0.000271442	1	0	BeFree
Non-Neoplastic Disorder	0.000271442	1	0	BeFree
Lubs X-linked mental retardation syndrome	0.000271442	1	0	BeFree
Spastic Ataxia	0.000271442	1	0	BeFree
Chronic kidney disease stage 5	0.000271442	1	0	BeFree
Homocysteinemia	0.000271442	1	0	BeFree
Isodicentric Chromosome 15 Syndrome	0.000271442	1	0	BeFree