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The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因的产物属于家庭的G蛋白偶联受体。该家族具有不同的药理学选择性,重叠在某些情况下,对各种腺苷和尿苷核苷酸几个受体亚型。该受体的功能为细胞外的ATP和ADP受体。在血小板结合的ADP通过磷脂酶C,在血小板形状的改变,并且可能对血小板聚集的活化导致动员细胞内钙离子。 [由RefSeq的,2008年7月提供]
P2RY1基因(以及对应的蛋白质)的细胞分布位置:
P2RY1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Thrombosis | 0.12 | 1 | 0 | CTD_human |
Erectile dysfunction | 0.08 | 1 | 0 | RGD |
Skin Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Atherosclerosis | 0.002367032 | 1 | 0 | GAD |
HIV Infections | 0.002367032 | 1 | 0 | GAD |
Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 2 | GAD |
ASPIRIN RESISTANCE | 0.002367032 | 1 | 0 | GAD |
Lupus Erythematosus, Systemic | 0.000814326 | 3 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Bipolar Disorder | 0.000542884 | 2 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Coronary heart disease | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Coronary Artery Disease | 0.000542884 | 2 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Blood Coagulation Disorders | 0.000271442 | 1 | 0 | BeFree |
Chlamydia Infections | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Fatigue | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Sudden infant death syndrome | 0.000271442 | 1 | 0 | BeFree |
Toxoplasmosis | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Retinal ischemia | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
Intraocular pressure disorder | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Thrombocytosis | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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