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This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因产物属于核受体超家族,成员是其特征在于由配体结合结构域和DNA-结合结构域的转录因子。所编码的蛋白质是细胞色素P450基因CYP3A4的转录调节,与9-顺 - 视黄酸受体RXR异二聚体结合到CYP3A4启动子的响应元素。它是由一系列诱导CYP3A4,包括地塞米松和利福平化合物激活。编码不同同种型的几个可变剪接转录物,其中的一些使用非AUG(CUG)翻译起始密码子,已为此基因说明。额外转录变体存在,然而,它们还没有被完全表征。 [由RefSeq的,2008年7月提供]
NR1I2基因(以及对应的蛋白质)的细胞分布位置:
NR1I2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Osteosarcoma | 0.123267234 | 2 | 0 | BeFree_CTD_human_LHGDN |
Drug-Induced Liver Injury | 0.122367032 | 2 | 0 | CTD_human_GAD |
Adenocarcinoma | 0.121085767 | 5 | 0 | BeFree_CTD_human |
Diabetes Mellitus | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Obesity | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Esophageal Neoplasms | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Fatty Liver | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Neonatal Jaundice | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Metabolic Syndrome X | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Barrett Esophagus | 0.12 | 1 | 0 | CTD_human |
Hepatomegaly | 0.12 | 1 | 0 | CTD_human |
Female infertility | 0.12 | 1 | 0 | CTD_human |
Hypophosphatemia | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of breast | 0.013887143 | 26 | 0 | BeFree_GAD |
Ulcerative Colitis | 0.010258709 | 10 | 2 | BeFree_GAD_LHGDN |
Inflammatory Bowel Diseases | 0.008805692 | 15 | 0 | BeFree_GAD |
Crohn Disease | 0.006991475 | 8 | 14 | BeFree_GAD_LHGDN |
Breast Carcinoma | 0.006786047 | 25 | 0 | BeFree |
Mammary Neoplasms | 0.006448592 | 7 | 0 | BeFree_GAD_LHGDN |
Neoplasm Metastasis | 0.005157396 | 19 | 0 | BeFree |
Neutropenia | 0.005005506 | 2 | 0 | BeFree_GAD |
Colorectal Cancer | 0.004267125 | 7 | 0 | BeFree_GAD |
Liver carcinoma | 0.004071628 | 15 | 0 | BeFree |
Prostate carcinoma | 0.003800186 | 14 | 1 | BeFree |
Malignant neoplasm of prostate | 0.003528744 | 13 | 1 | BeFree |
HIV Infections | 0.003452799 | 5 | 3 | BeFree_GAD |
Malignant neoplasm of lung | 0.003452799 | 5 | 0 | BeFree_GAD |
Epilepsy | 0.003181358 | 3 | 1 | BeFree_GAD |
Intrahepatic Cholestasis | 0.00272435 | 1 | 0 | LHGDN |
Endometrial Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Adult Rickets | 0.00272435 | 1 | 0 | LHGDN |
Malignant tumor of colon | 0.002714419 | 10 | 0 | BeFree |
Leri-Weill dyschondrosteosis | 0.002714419 | 10 | 0 | BeFree |
Colon Carcinoma | 0.002714419 | 10 | 0 | BeFree |
Cholangitis, Sclerosing | 0.002638474 | 1 | 0 | BeFree_GAD |
Leukemia, Myelocytic, Acute | 0.002638474 | 2 | 0 | BeFree_GAD |
Leukopenia | 0.002638474 | 1 | 0 | BeFree_GAD |
Liver Cirrhosis | 0.002638474 | 2 | 0 | BeFree_GAD |
Myocardial Infarction | 0.002638474 | 2 | 0 | BeFree_GAD |
Rheumatoid Arthritis | 0.002442977 | 9 | 0 | BeFree |
Deafness | 0.002367032 | 1 | 0 | GAD |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hearing Loss, Partial | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Osteoporosis, Postmenopausal | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
hearing impairment | 0.002367032 | 1 | 0 | GAD |
WARFARIN SENSITIVITY (disorder) | 0.002367032 | 1 | 0 | GAD |
Hearing Loss | 0.002367032 | 1 | 0 | GAD |
Dwarfism | 0.002171535 | 8 | 0 | BeFree |
Carcinogenesis | 0.002171535 | 8 | 0 | BeFree |
Colorectal Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Arthritis | 0.001628651 | 6 | 0 | BeFree |
melanoma | 0.001628651 | 6 | 3 | BeFree |
Cholestasis | 0.001357209 | 5 | 0 | BeFree |
Degenerative polyarthritis | 0.001357209 | 5 | 0 | BeFree |
Colonic Neoplasms | 0.001085767 | 4 | 0 | BeFree |
Immune System Diseases | 0.001085767 | 4 | 0 | BeFree |
Liver neoplasms | 0.001085767 | 4 | 0 | BeFree |
Lung Neoplasms | 0.001085767 | 4 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.001085767 | 4 | 0 | BeFree |
Alzheimer's Disease | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Asthma | 0.000814326 | 3 | 0 | BeFree |
Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000814326 | 3 | 0 | BeFree |
Colitis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
Metabolic Diseases | 0.000814326 | 3 | 0 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Pneumonia | 0.000814326 | 3 | 0 | BeFree |
Prostatic Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Pulmonary Fibrosis | 0.000814326 | 3 | 0 | BeFree |
Turner Syndrome | 0.000814326 | 3 | 0 | BeFree |
Cholestasis of pregnancy | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma of colon | 0.000814326 | 3 | 0 | BeFree |
Adenoma of lung | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
Endometrial Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of kidney | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
Renal carcinoma | 0.000814326 | 3 | 0 | BeFree |
Uterine Corpus Cancer | 0.000814326 | 3 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
Primary biliary cirrhosis | 0.000542884 | 2 | 0 | BeFree |
Dermatitis, Atopic | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Eczema | 0.000542884 | 2 | 0 | BeFree |
Gastroesophageal reflux disease | 0.000542884 | 2 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Hyperalgesia | 0.000542884 | 2 | 0 | BeFree |
Influenza | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Liver diseases | 0.000542884 | 2 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000542884 | 2 | 0 | BeFree |
Mycoses | 0.000542884 | 2 | 0 | BeFree |
Myocarditis | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Pain | 0.000542884 | 2 | 0 | BeFree |
Prader-Willi Syndrome | 0.000542884 | 2 | 0 | BeFree |
Psoriasis | 0.000542884 | 2 | 0 | BeFree |
Pulmonary Edema | 0.000542884 | 2 | 0 | BeFree |
Dermatologic disorders | 0.000542884 | 2 | 0 | BeFree |
Arterial thrombosis | 0.000542884 | 2 | 0 | BeFree |
Madelung Deformity | 0.000542884 | 2 | 0 | BeFree |
Inflammatory pain | 0.000542884 | 2 | 0 | BeFree |
Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
Chronic Periodontitis | 0.000542884 | 2 | 0 | BeFree |
Metastatic melanoma | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
Osteomalacia secondary to drug | 0.000542884 | 2 | 0 | BeFree |
Langer Mesomelic Dysplasia Syndrome | 0.000542884 | 2 | 0 | BeFree |
Primary sclerosing cholangitis | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
Tumor Initiation | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Cholestatic liver disease | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Coronary Artery Disease | 0.000542884 | 2 | 0 | BeFree |
Allergic rhinitis (disorder) | 0.000542884 | 2 | 0 | BeFree |
Acne Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Bone Marrow Diseases | 0.000271442 | 1 | 0 | BeFree |
Candidiasis | 0.000271442 | 1 | 0 | BeFree |
Candidiasis, Chronic Mucocutaneous | 0.000271442 | 1 | 0 | BeFree |
Female Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
CNS disorder | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Craniosynostosis | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Diarrhea | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal Diseases | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hay fever | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
Hypothyroidism | 0.000271442 | 1 | 0 | BeFree |
Irritable Bowel Syndrome | 0.000271442 | 1 | 0 | BeFree |
Keloid | 0.000271442 | 1 | 0 | BeFree |
Leishmaniasis | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Lung diseases | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Peutz-Jeghers Syndrome | 0.000271442 | 1 | 0 | BeFree |
Pruritus | 0.000271442 | 1 | 0 | BeFree |
Psychotic Disorders | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Emphysema | 0.000271442 | 1 | 0 | BeFree |
Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Spinal Cord Diseases | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Antiphospholipid Syndrome | 0.000271442 | 1 | 0 | BeFree |
Polyendocrinopathies, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lip | 0.000271442 | 1 | 0 | BeFree |
Hepatic necrosis | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Joint swelling | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
Lipid Metabolism Disorders | 0.000271442 | 1 | 0 | BeFree |
Cicatrix, Hypertrophic | 0.000271442 | 1 | 0 | BeFree |
Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of female breast | 0.000271442 | 1 | 0 | BeFree |
Dyslipidemias | 0.000271442 | 1 | 0 | BeFree |
Proliferative vitreoretinopathy | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Carotid artery occlusion | 0.000271442 | 1 | 0 | BeFree |
Gray Platelet Syndrome | 0.000271442 | 1 | 0 | BeFree |
Disease due to Parvoviridae | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Vascular Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Ichthyosis Bullosa of Siemens | 0.000271442 | 1 | 0 | BeFree |
Dementia | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Acne | 0.000271442 | 1 | 0 | BeFree |
Poorly differentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hyperalgesia, Thermal | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
Diabetic Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
Rhinosinusitis | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Partial Trisomy | 0.000271442 | 1 | 0 | BeFree |
Liver regeneration disorder | 0.000271442 | 1 | 0 | BeFree |
Asthma, Aspirin-Induced | 0.000271442 | 1 | 0 | BeFree |
Chronic Cancer Pain | 0.000271442 | 1 | 0 | BeFree |
Stage I Hepatocellular Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Cardiac fibrosis | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Tumor Promotion | 0.000271442 | 1 | 0 | BeFree |
androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Mechanical Allodynia | 0.000271442 | 1 | 0 | BeFree |
Stage III Hepatocellular Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Idiopathic pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
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