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This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
[中文简述(自动翻译):]  这个基因编码属于白介素1受体家族细胞因子受体。所编码的蛋白质是白介素-1α,白细胞介素-1β,和白细胞介素-1受体拮抗剂的受体。它是参与许多细胞因子诱导的免疫和炎症反应的重要介质。该基因位于相关的细胞因子受体基因在染色体二季度集群。 [由RefSeq的,2013年12月提供]
IL1R1基因(以及对应的蛋白质)的细胞分布位置:
IL1R1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Endometriosis | 0.136445791 | 7 | 0 | BeFree_CTD_human_GAD_LHGDN |
Dermatologic disorders | 0.122367032 | 2 | 0 | CTD_human_GAD |
Hypersensitivity | 0.12 | 1 | 0 | CTD_human |
Pneumonia | 0.12 | 1 | 0 | CTD_human |
Fibrinogen Adverse Event | 0.12 | 1 | 1 | GWASCAT |
Diabetes Mellitus, Insulin-Dependent | 0.100022023 | 8 | 0 | BeFree_GAD_MGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Pulpitis | 0.08 | 1 | 0 | RGD |
Asthma | 0.015102394 | 8 | 0 | BeFree_GAD_LHGDN |
Premature Birth | 0.009468128 | 4 | 0 | GAD |
Rheumatoid Arthritis | 0.00764398 | 5 | 0 | BeFree_GAD |
Degenerative polyarthritis | 0.00764398 | 4 | 0 | BeFree_GAD |
Infection | 0.007458414 | 3 | 0 | GAD_LHGDN |
Periodontitis | 0.007372538 | 4 | 0 | BeFree_GAD |
Systemic Scleroderma | 0.007372538 | 4 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.007101096 | 3 | 0 | GAD |
Arthritis | 0.007101096 | 3 | 0 | GAD |
Juvenile arthritis | 0.007101096 | 3 | 0 | GAD |
Inflammatory Bowel Diseases | 0.005276948 | 4 | 0 | BeFree_GAD |
Obesity | 0.005276948 | 4 | 0 | BeFree_GAD |
Ulcerative Colitis | 0.005005506 | 3 | 0 | BeFree_GAD |
Graft-vs-Host Disease | 0.005005506 | 3 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.005005506 | 3 | 0 | BeFree_GAD |
Atherosclerosis | 0.004734064 | 2 | 0 | GAD |
Head and Neck Neoplasms | 0.004734064 | 2 | 0 | GAD |
Hepatitis B | 0.004734064 | 2 | 0 | GAD |
Inflammation | 0.004734064 | 2 | 0 | GAD |
Myeloid Leukemia, Chronic | 0.004734064 | 2 | 0 | GAD |
Multiple Sclerosis | 0.004734064 | 2 | 0 | GAD |
Pemphigus | 0.004734064 | 2 | 0 | GAD |
Pulmonary Fibrosis | 0.004734064 | 2 | 0 | GAD |
Tuberculosis | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of lung | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of ovary | 0.003724241 | 6 | 0 | BeFree_GAD |
Hepatitis B, Chronic | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Nephrotic Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Odontogenic Tumors | 0.00272435 | 1 | 0 | LHGDN |
Rheumatic Heart Disease | 0.00272435 | 1 | 0 | LHGDN |
Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002638474 | 1 | 0 | BeFree_GAD |
Cardiovascular Diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
Febrile Convulsions | 0.002638474 | 2 | 0 | BeFree_GAD |
Crohn Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Diabetic Nephropathy | 0.002638474 | 2 | 0 | BeFree_GAD |
HIV Infections | 0.002638474 | 2 | 1 | BeFree_GAD |
Lupus Erythematosus, Systemic | 0.002638474 | 2 | 0 | BeFree_GAD |
Malaria, Cerebral | 0.002638474 | 2 | 0 | BeFree_GAD |
Meningococcal Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Psoriasis | 0.002638474 | 2 | 0 | BeFree_GAD |
Schizophrenia | 0.002638474 | 2 | 2 | BeFree_GAD |
Ankylosing spondylitis | 0.002638474 | 2 | 0 | BeFree_GAD |
Helicobacter pylori infection | 0.002638474 | 1 | 0 | BeFree_GAD |
Acquired Immunodeficiency Syndrome | 0.002367032 | 1 | 0 | GAD |
Albuminuria | 0.002367032 | 1 | 0 | GAD |
Anemia | 0.002367032 | 1 | 0 | GAD |
Arthritis, Psoriatic | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Common Variable Immunodeficiency | 0.002367032 | 1 | 0 | GAD |
Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
Cystic Fibrosis | 0.002367032 | 1 | 0 | GAD |
Diabetic Retinopathy | 0.002367032 | 1 | 0 | GAD |
Equine Infectious Anemia | 0.002367032 | 1 | 0 | GAD |
Esophageal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
IGA Glomerulonephritis | 0.002367032 | 1 | 0 | GAD |
Gout | 0.002367032 | 1 | 0 | GAD |
Graves Disease | 0.002367032 | 1 | 0 | GAD |
Hematological Disease | 0.002367032 | 1 | 0 | GAD |
Hemorrhagic Fever with Renal Syndrome | 0.002367032 | 1 | 0 | GAD |
Hodgkin Disease | 0.002367032 | 1 | 0 | GAD |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Intervertebral Disk Displacement | 0.002367032 | 1 | 0 | GAD |
Irritable Bowel Syndrome | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Laryngeal neoplasm | 0.002367032 | 1 | 0 | GAD |
Leptospirosis | 0.002367032 | 1 | 0 | GAD |
Lymphoproliferative Disorders | 0.002367032 | 1 | 0 | GAD |
Malaria, Falciparum | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of stomach | 0.002367032 | 1 | 0 | GAD |
Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
Multiple Myeloma | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
Occupational Diseases | 0.002367032 | 1 | 0 | GAD |
Osteopenia | 0.002367032 | 1 | 0 | GAD |
Pemphigus Vulgaris | 0.002367032 | 1 | 0 | GAD |
Periodontal Diseases | 0.002367032 | 1 | 0 | GAD |
Pharyngeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Postoperative Complications | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Q Fever | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Sarcoidosis | 0.002367032 | 1 | 0 | GAD |
Sarcoidosis, Pulmonary | 0.002367032 | 1 | 0 | GAD |
Skin Ulcer | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Lung Diseases, Interstitial | 0.002367032 | 1 | 0 | GAD |
Lytic lesion | 0.002367032 | 1 | 0 | GAD |
Coronary Stenosis | 0.002367032 | 1 | 0 | GAD |
Parasitemia | 0.002367032 | 1 | 0 | GAD |
Sepsis | 0.002367032 | 1 | 0 | GAD |
Restenosis | 0.002367032 | 1 | 0 | GAD |
Thyroid associated opthalmopathies | 0.002367032 | 1 | 0 | GAD |
Osteoarthritis, Knee | 0.002367032 | 1 | 0 | GAD |
Lung Diseases, Obstructive | 0.002367032 | 1 | 0 | GAD |
Epithelial ovarian cancer | 0.002367032 | 1 | 0 | GAD |
Coronary Restenosis | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Chronic ulcerative colitis | 0.002367032 | 1 | 0 | GAD |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.001628651 | 6 | 0 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Myofibroblastic Tumor | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Adjuvant-Induced | 0.000271442 | 1 | 0 | BeFree |
Transient Ischemic Attack | 0.000271442 | 1 | 2 | BeFree |
Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Leprosy, Lepromatous | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Mastodynia | 0.000271442 | 1 | 1 | BeFree |
Mycobacterium Infections | 0.000271442 | 1 | 0 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Respiratory Distress Syndrome, Adult | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Cyclic neutropenia | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Juvenile Myelomonocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Dengue Shock Syndrome | 0.000271442 | 1 | 0 | BeFree |
Complex Regional Pain Syndromes | 0.000271442 | 1 | 0 | BeFree |
Overweight | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
BREAST PAIN FEMALE | 0.000271442 | 1 | 1 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
Acute Cerebrovascular Accidents | 0.000271442 | 1 | 2 | BeFree |
Lymphoma, Primary Cutaneous Anaplastic Large Cell | 0.000271442 | 1 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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