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The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  B细胞的增殖和分化是依赖于B细胞抗原受体(BCR)的复合物。抗原在通过BCR复合酪氨酸磷酸化反应特异性B细胞受体的结果的结合,并导致多种信号转导途径。 [由RefSeq的,2008年7月提供]
IGBP1基因(以及对应的蛋白质)的细胞分布位置:
IGBP1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Corpus Callosum, Agenesis of, with Mental Retardation, Ocular Coloboma, and Micrognathia | 0.36 | 0 | 0 | CLINVAR_CTD_human_ORPHANET |
| Neoplastic Cell Transformation | 0.12 | 1 | 0 | CTD_human |
| Lung Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Liver carcinoma | 0.12 | 1 | 0 | CTD_human |
| alpha^+^ Thalassemia | 0.003257302 | 12 | 0 | BeFree |
| alpha-Thalassemia | 0.002442977 | 9 | 0 | BeFree |
| Thalassemia | 0.002442977 | 9 | 2 | BeFree |
| Autosomal Dominant Nocturnal Frontal Lobe Epilepsy | 0.001628651 | 6 | 0 | BeFree |
| Alport Syndrome | 0.001357209 | 5 | 0 | BeFree |
| Nicotine Dependence | 0.001085767 | 4 | 0 | BeFree |
| alpha^0^ Thalassemia | 0.000814326 | 3 | 0 | BeFree |
| Attention deficit hyperactivity disorder | 0.000814326 | 3 | 0 | BeFree |
| Alport Syndrome, Autosomal Recessive | 0.000814326 | 3 | 0 | BeFree |
| Hartnup Disease | 0.000542884 | 2 | 2 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Nephritis | 0.000542884 | 2 | 0 | BeFree |
| Alport Syndrome, X-Linked | 0.000542884 | 2 | 0 | BeFree |
| Opitz-G syndrome, type 2 | 0.000542884 | 2 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Developmental Disabilities | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Epilepsies, Partial | 0.000271442 | 1 | 0 | BeFree |
| Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Intestinal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Leukoencephalopathy, Progressive Multifocal | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
| Seizures | 0.000271442 | 1 | 0 | BeFree |
| Synovitis | 0.000271442 | 1 | 0 | BeFree |
| Seasonal Affective Disorder | 0.000271442 | 1 | 0 | BeFree |
| Polycystic Kidney, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
| Epilepsy, Frontal Lobe | 0.000271442 | 1 | 0 | BeFree |
| FG syndrome | 0.000271442 | 1 | 0 | BeFree |
| Lesion of brain | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Propionic acidemia | 0.000271442 | 1 | 0 | BeFree |
| beta^0^ Thalassemia | 0.000271442 | 1 | 0 | BeFree |
| delta-Thalassemia | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis, Relapsing-Remitting | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Alport Syndrome, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
| Channelopathies | 0.000271442 | 1 | 0 | BeFree |
| Rolandic Epilepsy, Mental Retardation, And Speech Dyspraxia, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
| Benign Rolandic Epilepsy | 0.000271442 | 1 | 0 | BeFree |
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