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Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  热休克转录因子(HSFS)激活的热量或其他应力条件下的热休克反应基因。 HSF4缺乏其所有脊椎动物HSFS中共享并已建议要参与DNA结合活性的负调节的羧基末端疏水性重复。两个编码不同同种型和具有不同的转录活性可变剪接转录物已有描述。 [由RefSeq的,2008年7月提供]
HSF4基因(以及对应的蛋白质)的细胞分布位置:
HSF4基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| CATARACT, MARNER TYPE | 0.240814326 | 3 | 1 | BeFree_CTD_human_ORPHANET |
| CATARACT 5, MULTIPLE TYPES | 0.2 | 2 | 1 | MGD_UNIPROT |
| Congenital lamellar cataract | 0.120814326 | 3 | 5 | BeFree_CLINVAR |
| Cataract | 0.012244679 | 15 | 0 | BeFree_LHGDN |
| HIV Infections | 0.002985861 | 11 | 0 | BeFree |
| Congenital cataract | 0.001900093 | 7 | 0 | BeFree |
| Bilateral cataracts (disorder) | 0.001900093 | 7 | 0 | BeFree |
| Age-related cataract | 0.001628651 | 6 | 1 | BeFree |
| AIDS related complex | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis C | 0.000542884 | 2 | 0 | BeFree |
| Mental Retardation | 0.000271442 | 1 | 0 | BeFree |
| Tetralogy of Fallot | 0.000271442 | 1 | 0 | BeFree |
| Congenital Transposition | 0.000271442 | 1 | 0 | BeFree |
| Viremia | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Posterior subcapsular cataract | 0.000271442 | 1 | 0 | BeFree |
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