HOXD13(homeobox D13) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

2q31.1
基因染色体位置图

基因简述

基因简述

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因属于同源盒基因家族。的同源基因编码的，在形态在所有的多细胞生物体中发挥重要作用的转录因子的高度保守的家族。哺乳动物具有项同类同源基因簇，HOXA，HOXB，HOXC和HOXD，位于不同的染色体上，由串联配置的9至11个基因。这种基因是位于一个簇号染色体上的2几个同源HOXD个基因的一个缺失该删除整个HOXD基因簇或者这簇的5‘端已被严重肢体和生殖器异常。突变在这个特定的基因原因synpolydactyly。 [由RefSeq的，2008年7月提供]

OMIM数据库中对HOXD13基因的介绍     Wikipedia数据库中对HOXD13基因的介绍

基因序列

基因序列

HOXD13基因的碱基序列：[NCBI]

基因突变

基因突变

HOXD13基因的碱基突变：           显示全部snp
rs847202       rs6752623       rs11332366       rs11888176       rs12104464       rs12474905       rs35158526       rs61086530       rs72919095       rs72919097       rs72919100       rs72919101       rs74396931       rs76003791       rs76128413       rs78584540       rs79476627       rs113520369       rs115056165       rs138880282       rs140482701       rs142371260       rs146148996       rs147662703       rs150016406       rs151303899       rs182413892       rs183290578       rs184185487       rs186750795       rs189132120       rs191925543       rs191934303       rs193054294       rs372339108       rs376328733       rs397986770      
rs529978727       rs531280690       rs532395721       rs534182593       rs536550346       rs538301246       rs538948096       rs540692250       rs541655155       rs542685732       rs545260828       rs545419744       rs548912031       rs551743572       rs554923603       rs556092774       rs556293455       rs556943828       rs557413019       rs558969936       rs559522286       rs560054211       rs562674654       rs563295910       rs565041675       rs565078400       rs566473500       rs569474873       rs571465444       rs571990518       rs573273930       rs574526455       rs574657509       rs577436534       rs577936974       rs847192       rs847193       rs847194       rs847195       rs847196       rs847197       rs847198       rs847199       rs847200       rs847201       rs2518053       rs2593769       rs3754983       rs6732069       rs6760988       rs10930722       rs28928891       rs28928892       rs35290213       rs55691205       rs59637648       rs66508389       rs71004256       rs72923424       rs72923425       rs72923426       rs72923428       rs73029926       rs73029933       rs73029937       rs73974635       rs73974637       rs75658361       rs75955114       rs76802048       rs78368994       rs79645162       rs79835123       rs111593893       rs112259280       rs112690657       rs113143979       rs113236238       rs113439497       rs113826400       rs113848671       rs114386082       rs114713005       rs114813623       rs115632146       rs115691165       rs115870548       rs116679102       rs137896965       rs138026533       rs138525096       rs138557314       rs138630870       rs139357380       rs139995491       rs140031618       rs140163341       rs141649575       rs141671331       rs142600246       rs142866045       rs143487752       rs143533320       rs144577020       rs144773201       rs146173864       rs146183964       rs146564993       rs147705577       rs147720746       rs148040228       rs148568124       rs148979353       rs149097061       rs149857063       rs150319624       rs150383892       rs150545132       rs150914949       rs180709917       rs180917143       rs182081063       rs182165381       rs183354757       rs183799517       rs184218504       rs184749616       rs185086675       rs185454060       rs186609217       rs186680746       rs187698441       rs188176891       rs188371903       rs188378193       rs189204555       rs189407940       rs189973590       rs190775947       rs191059735       rs191190433       rs192660699       rs193176537       rs199549554       rs199832686       rs199982017       rs200067774       rs200274374       rs200514497       rs200745868       rs200750564       rs200799183       rs201504145       rs201600075       rs201821228       rs201904809       rs367650583       rs369216922       rs369717765       rs370288408       rs370721677       rs371429510       rs371820771       rs372153814       rs372331342       rs372343718       rs372534114       rs372613309       rs373216015       rs373546423       rs373737493       rs373988286       rs374086950       rs374920154       rs375054751       rs376366804       rs527391478       rs527826234       rs529313826       rs530359856       rs530421027       rs530658089       rs531009419       rs531648050       rs531769125       rs531835514       rs531887212       rs532048046       rs532239725       rs532408282       rs532776884       rs533261413       rs534182473       rs534597774       rs534884267       rs534921728       rs535266089       rs536639583       rs536676052       rs536915097       rs537148502       rs537275586       rs537956487       rs538071300       rs538627159       rs538701696       rs538966260       rs539248930       rs539281961       rs539314007       rs539442835       rs540457957       rs541301008       rs542428021       rs542462519       rs542476431       rs543043092       rs543065292       rs543104446       rs543435071       rs543897513       rs544065459       rs544449825       rs544809174       rs545124931       rs545444280       rs545467978       rs545655860       rs546134089       rs546445993       rs546802875       rs547163263       rs547199994       rs547372726       rs547535347       rs547766927       rs548479737       rs548947724       rs549053300       rs550052701       rs550322272       rs550531830       rs550875393       rs551429321       rs551570187       rs551762149       rs552555257       rs553290983       rs553526094       rs553562514       rs554637608       rs554977181       rs555036809       rs555136684       rs555140119       rs555371759       rs555536826       rs555551617       rs555900957       rs556455717       rs556662470       rs557241904       rs558335999       rs559289939       rs559449355       rs559682693       rs559843297       rs560633989       rs561028602       rs561074467       rs561366695       rs561626680       rs561764210       rs561896396       rs562405548       rs562638200       rs563665659       rs563707434       rs564021690       rs564236662       rs564279890       rs564797981       rs565039134       rs565209814       rs565494111       rs565829551       rs566140257       rs566987103       rs567591545       rs567865840       rs568205324       rs568881925       rs568921148       rs569957026       rs570077823       rs570818428       rs570839831       rs571216448       rs571866542       rs572724114       rs572755709       rs573118095       rs573355705       rs573511396       rs573694735       rs573756672       rs574011780       rs574408202       rs576003487       rs576037431       rs576462049       rs576609094       rs576685098       rs577016423       rs745735651       rs745798601       rs746179598       rs746269519       rs746687888       rs746854273       rs747071040       rs747533650       rs747707173       rs747794993       rs749474029       rs749785909       rs749930395       rs749975299       rs749985629       rs750176735       rs750412684       rs750927181       rs751010417       rs751241743       rs751492206       rs751640729       rs751801650       rs751993795       rs751994842       rs752471203       rs752667409       rs752962281       rs753049145       rs753157172       rs753431560       rs753639374       rs753726144       rs753809256       rs753870336       rs754689022       rs754874846       rs755071995       rs755087311       rs755283984       rs755758160       rs755848849       rs756191400       rs756210413       rs756710908       rs756844068       rs756869286       rs757175860       rs757447876       rs757780371       rs757927553       rs758363080       rs758638811       rs758726777       rs758766383       rs758944808       rs759038167       rs759051786       rs759071152       rs759224337       rs760041709       rs760168666       rs760465283       rs760687062       rs760983394       rs761102776       rs761192563       rs761366377       rs761394795       rs761520404       rs761679301       rs761846984       rs761949520       rs762514388       rs762822252       rs762909441       rs763149315       rs763867556       rs763998494       rs764371902       rs764838478       rs765137360       rs765227186       rs766189203       rs766755072       rs766764389       rs766957833       rs767313108       rs767444448       rs767527649       rs767675768       rs768084107       rs769084692       rs769412328       rs769890218       rs769954517       rs770226826       rs770519205       rs770945263       rs771082552       rs771123279       rs771357123       rs771851753       rs771939727       rs772276440       rs772479524       rs772837876       rs773282226       rs773346852       rs773372452       rs773877947       rs774136455       rs774237510       rs774314169       rs774419506       rs774807865       rs774883281       rs775175316       rs775201150       rs775647171       rs776131391       rs776313574       rs776997927       rs777264698       rs777926146       rs778122220       rs778129623       rs778213795       rs778217352       rs778978474       rs779259177       rs779276776       rs779349115       rs779629324       rs779846895       rs779934918       rs780305650       rs780480581       rs780860190       rs780959735       rs781344527       rs781428411       rs781708716       rs869138836      

基因表达

基因表达

HOXD13基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCCTACATCTCCATGGAGG
59
CTGATTTAGAGCCACATCCC
58
CCTACATCTCCATGGAGGG
59
CTGATTTAGAGCCACATCCC
58
CCTACATCTCCATGGAGGG
59
GCTGATTTAGAGCCACATCC
59
TTGGAAATCTTCCTTTCCAGG
58
TCCTCCCTCTTCGGTAGAC
60
TTTGGAAATCTTCCTTTCCAGG
59
TCCTCCCTCTTCGGTAGAC
60
GGAAATCTTCCTTTCCAGGG
58
TCCTCCCTCTTCGGTAGAC
60

转录因子

转录因子

转录因子
影响类型
PubMed链接
FHL1
Unknown
18758158

基因本体信息

HOXD13基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HOXD13基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000978
P35453(UniProtKB)
IEA
GO:0001077
P35453(UniProtKB)
IEA
GO:0001501
P35453(UniProtKB)
IEA
GO:0003677
P35453(UniProtKB)
IDA
GO:0003682
P35453(UniProtKB)
IEA
GO:0005634
P35453(UniProtKB)
IDA
GO:0006355
P35453(UniProtKB)
TAS
GO:0006366
P35453(UniProtKB)
IEA
GO:0007275
P35453(UniProtKB)
TAS
GO:0009952
P35453(UniProtKB)
IEA
GO:0030539
P35453(UniProtKB)
IEA
GO:0042127
P35453(UniProtKB)
IEA
GO:0042733
P35453(UniProtKB)
IEA
GO:0045944
P35453(UniProtKB)
IEA
GO:0048619
P35453(UniProtKB)
IEA
GO:0060527
P35453(UniProtKB)
IEA
GO:0060571
P35453(UniProtKB)
IEA
GO:0060602
P35453(UniProtKB)
IEA
GO:0060687
P35453(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HOXD13基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Synpolydactyly 1 0.560542884 4 3 BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT
Syndactyly, type v 0.480271442 2 1 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
BRACHYDACTYLY-SYNDACTYLY SYNDROME 0.360271442 2 0 BeFree_CLINVAR_CTD_human_ORPHANET
BRACHYDACTYLY, TYPE D 0.36 2 2 CLINVAR_CTD_human_UNIPROT
BRACHYDACTYLY, TYPE E1 0.36 2 2 CLINVAR_CTD_human_UNIPROT
VATER Association 0.24 1 0 CTD_human_ORPHANET
Limb Deformities, Congenital 0.12434307 17 0 BeFree_CTD_human
Rheumatoid Arthritis 0.120271442 2 0 BeFree_CTD_human
VACTERL Association 0.120271442 1 0 BeFree_ORPHANET
Brachydactyly syndrome type E 0.12 0 0 ORPHANET
Synpolydactyly With Foot Anomalies 0.12 0 0 CLINVAR
Syndactyly, type 2 0.009771907 36 0 BeFree
Congenital clubfoot 0.005362824 2 0 BeFree_GAD_LHGDN
leukemia 0.003267234 3 0 BeFree_LHGDN
MYELODYSPLASTIC SYNDROME 0.003267234 3 0 BeFree_LHGDN
Hypospadias 0.002995792 1 0 BeFree_LHGDN
Alzheimer's Disease 0.002367032 1 0 GAD
Autistic Disorder 0.002367032 1 0 GAD
Leukemia, Myelocytic, Acute 0.001900093 7 0 BeFree
Syndactyly 0.001357209 5 0 BeFree
Hand foot uterus syndrome 0.001357209 5 0 BeFree
Brachydactyly 0.001085767 4 0 BeFree
Congenital Abnormality 0.000814326 3 0 BeFree
Platelet Storage Pool Deficiency 0.000814326 3 0 BeFree
Acute leukemia 0.000814326 3 0 BeFree
Leukemogenesis 0.000814326 3 0 BeFree
Blood Coagulation Disorders 0.000542884 2 0 BeFree
Congenital Foot Deformity 0.000542884 2 0 BeFree
Preleukemia 0.000542884 2 0 BeFree
Polydactyly 0.000542884 2 0 BeFree
Anxiety Disorders 0.000271442 1 0 BeFree
Astrocytoma 0.000271442 1 0 BeFree
Blood Platelet Disorders 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Congenital chromosomal disease 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Degenerative polyarthritis 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Triphalangeal thumb 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Miller Dieker syndrome 0.000271442 1 0 BeFree
MRSA - Methicillin resistant Staphylococcus aureus infection 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Anxiety and fear 0.000271442 1 0 BeFree
Simple syndactyly of toes, first web space 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Limb defects 0.000271442 1 0 BeFree
Synpolydactyly 3 0.000271442 1 0 BeFree
Brachymesophalangy 2 and 5 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

我要说两句
热门评论
还没有评论，赶快来抢沙发吧。

登陆

用户名:

密    码:

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

扫一扫右方二维码，关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2016.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2