HBA1(hemoglobin, alpha 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

16p13.3
基因染色体位置图

基因简述

基因简述

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  位于16号染色体上的人α珠蛋白基因簇跨越大约30 kb和包括七个基因位点：5‘-泽塔 - pseudozeta - 亩 - pseudoalpha-1 - α-2 - α-1 - THETA - 3‘。 α-2（HBA2）和α-1（HBA1）编码序列是相同的。这些基因在5略有差异‘非翻译区和内含子，但它们在3显著不同‘非编码区。两个α链和两个β链构成的HBA，在正常成年人的生活包括血红蛋白总量的97％左右;阿尔法链与增量链结合以构成HBA-2，其与的HbF（胎儿血红蛋白）构成成人血红蛋白的其余3％。阿尔法地中海贫血从每个阿尔法基因以及既HBA2和HBA1缺失的缺失导致;也有报道一些nondeletion阿尔法地中海贫血有。 [由RefSeq的，2008年7月提供]

OMIM数据库中对HBA1基因的介绍     Wikipedia数据库中对HBA1基因的介绍

基因序列

基因序列

HBA1基因的碱基序列：[NCBI]

基因突变

基因突变

HBA1基因的碱基突变：           显示全部snp
rs1060339       rs2698755       rs2858942       rs3760046       rs11639532       rs17407508       rs28928881       rs33914470       rs33960522       rs33984024       rs34011123       rs34098449       rs34220980       rs34324664       rs34635364       rs34702814       rs34830032       rs34883113       rs34936612       rs35059618       rs35331909       rs35615982       rs35654345       rs35723200       rs35932809       rs41530750       rs62030351       rs63749882       rs63749927       rs63749948       rs63750090       rs63750566       rs63750613       rs63750751       rs63751008       rs71391119       rs72763684      
rs75354118       rs76462751       rs111306104       rs111624126       rs111634924       rs112128183       rs112460909       rs113703630       rs114920844       rs116703473       rs138407823       rs140053617       rs141514155       rs143710505       rs144198409       rs144829417       rs145613521       rs146478344       rs146547556       rs148228241       rs148595248       rs148915533       rs149264789       rs150149358       rs181138451       rs181734727       rs181996974       rs182740645       rs182901235       rs186139213       rs186701229       rs189895984       rs190457331       rs190857737       rs191167772       rs200097667       rs200499392       rs281864487       rs281864533       rs281864551       rs281864580       rs368241947       rs370305736       rs374054030       rs375518794       rs376827361       rs527265799       rs527796571       rs528742912       rs529500914       rs529568422       rs529592631       rs531798893       rs531847810       rs532393319       rs533065033       rs533430676       rs535741924       rs535893942       rs536512291       rs536757548       rs538035969       rs539517916       rs542309128       rs542596953       rs544132337       rs544228014       rs544436920       rs545018415       rs545195355       rs545248706       rs546857368       rs547544320       rs549251504       rs549337649       rs550905802       rs550973018       rs551340234       rs551376957       rs551457487       rs553770674       rs553807551       rs554412411       rs555255920       rs555558452       rs556086584       rs556340454       rs556381239       rs556544864       rs557532935       rs560320950       rs560649937       rs561310354       rs562116138       rs562707241       rs562871086       rs565367308       rs565866202       rs566499689       rs566657309       rs567746116       rs568656328       rs568771034       rs568864558       rs570479204       rs571422135       rs571582665       rs571903706       rs572129372       rs572660775       rs572684179       rs572997200       rs573563323       rs573829863       rs573893402       rs577938658       rs745607257       rs745658629       rs747020299       rs748369967       rs748874265       rs749104494       rs750023320       rs750079784       rs750352335       rs750737757       rs750867079       rs751745556       rs752155421       rs754145030       rs754313225       rs754558741       rs754685409       rs756053083       rs756774032       rs756810015       rs757072529       rs757531184       rs758093235       rs758099572       rs759750475       rs760822952       rs760980531       rs761086044       rs761296048       rs762508461       rs764512772       rs764798737       rs764831969       rs765563255       rs767911847       rs768017043       rs769031119       rs769740560       rs770226969       rs770601112       rs770988111       rs771294277       rs772025927       rs772408952       rs773103482       rs774082530       rs774497372       rs775764044       rs775810878       rs777134051       rs777155983       rs778614540       rs780047520       rs780511253       rs780843865       rs781198510       rs781242079      

基因表达

基因表达

HBA1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTCAACTTCAAGCTCCTAAGC
59
CAGGAACTTGTCCAGGGAG
59
CCTGGAGAGGATGTTCCTG
59
CTCACCTTGAAGTTGACCG
58
AACTTCAAGCTCCTAAGCCA
59
CAGGAACTTGTCCAGGGAG
59
CTGGAGAGGATGTTCCTGTC
59
GCTCACCTTGAAGTTGACC
58
CAACTTCAAGCTCCTAAGCC
59
CAGGAACTTGTCCAGGGAG
59
CTGGAGAGGATGTTCCTGTC
59
CTCACCTTGAAGTTGACCG
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

HBA1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HBA1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005344
P69905(UniProtKB)
IEA
GO:0005506
P69905(UniProtKB)
IEA
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005515
P69905(UniProtKB)
IPI
GO:0005576
P69905(UniProtKB)
TAS
GO:0005576
P69905(UniProtKB)
TAS
GO:0005576
P69905(UniProtKB)
TAS
GO:0005576
P69905(UniProtKB)
TAS
GO:0005576
P69905(UniProtKB)
TAS
GO:0005829
P69905(UniProtKB)
TAS
GO:0005829
P69905(UniProtKB)
TAS
GO:0005833
P69905(UniProtKB)
IDA
GO:0005833
P69905(UniProtKB)
TAS
GO:0006898
P69905(UniProtKB)
TAS
GO:0010942
P69905(UniProtKB)
IDA
GO:0015671
P69905(UniProtKB)
TAS
GO:0015701
P69905(UniProtKB)
TAS
GO:0015701
P69905(UniProtKB)
TAS
GO:0016020
P69905(UniProtKB)
IDA
GO:0019825
P69905(UniProtKB)
IEA
GO:0020037
P69905(UniProtKB)
IEA
GO:0022627
P69905(UniProtKB)
IDA
GO:0031838
P69905(UniProtKB)
IDA
GO:0042542
P69905(UniProtKB)
IDA
GO:0042744
P69905(UniProtKB)
IDA
GO:0051291
P69905(UniProtKB)
IDA
GO:0070062
P69905(UniProtKB)
IDA
GO:0070062
P69905(UniProtKB)
IDA
GO:0070062
P69905(UniProtKB)
IDA
GO:0070062
P69905(UniProtKB)
IDA
GO:0071682
P69905(UniProtKB)
TAS
GO:0072562
P69905(UniProtKB)
IDA
GO:0098869
P69905(UniProtKB)
IEA
GO:0004601
P69905(UniProtKB)
IDA
GO:0031720
P69905(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HBA1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
alpha-Thalassemia 0.332899267 211 2 BeFree_CLINVAR_CTD_human_GAD
Heinz Body Anemias 0.24 0 0 CLINVAR_CTD_human
Hemoglobin H Disease 0.123257302 12 0 BeFree_ORPHANET
Diabetes Mellitus, Non-Insulin-Dependent 0.120814326 4 0 BeFree_CTD_human
Polycythemia 0.120542884 3 0 BeFree_CTD_human
Cerebral Infarction 0.12 1 0 CTD_human
Animal Mammary Neoplasms 0.12 1 0 CTD_human
Mammary Neoplasms, Experimental 0.12 1 0 CTD_human
Methemoglobinemia 0.12 1 0 CTD_human
Polycythemia Vera 0.12 1 0 CTD_human
Chloracne 0.12 1 0 CTD_human
Hydrops Fetalis, Non-Immune 0.12 0 0 ORPHANET
Alpha thalassemia-mental retardation syndrome 0.12 0 0 ORPHANET
Finding of Mean Corpuscular Hemoglobin 0.12 1 1 GWASCAT
alpha^+^ Thalassemia 0.054559816 201 2 BeFree
beta Thalassemia 0.049541836 148 1 BeFree_GAD_LHGDN
Thalassemia 0.038565947 79 0 BeFree_GAD_LHGDN
Anemia, Sickle Cell 0.014787345 29 0 BeFree_GAD_LHGDN
Anemia 0.010977227 25 0 BeFree_GAD
alpha^0^ Thalassemia 0.009500466 35 0 BeFree
Malaria, Falciparum 0.009468128 4 0 GAD
Beta thalassemia trait 0.00868614 32 0 BeFree
Hemoglobinopathies 0.007524428 20 0 BeFree_GAD
Hypochromic anemia 0.007372538 4 0 BeFree_GAD
Deficiency of glucose-6-phosphate dehydrogenase 0.007101096 3 0 GAD
Thalassemia Intermedia 0.005971721 22 2 BeFree
Sickle Cell Trait 0.005276948 4 0 BeFree_GAD
BETA THALASSEMIA, HETEROZYGOUS 0.005157396 19 0 BeFree
Hartnup Disease 0.004885954 18 0 BeFree
beta^0^ Thalassemia 0.004885954 18 0 BeFree
Malaria 0.004538567 9 0 BeFree_GAD
Hydrops Fetalis 0.004071628 15 0 BeFree
Beta thalassemia intermedia 0.003800186 14 0 BeFree
delta-Thalassemia 0.003528744 13 0 BeFree
Microcytic hypochromic anemia (disorder) 0.003452799 5 0 BeFree_GAD
Polycystic Kidney, Autosomal Dominant 0.003257302 12 0 BeFree
Cardiovascular Diseases 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Cerebrovascular accident 0.002638474 2 0 BeFree_GAD
Hereditary persistence of fetal hemoglobin thalassemia 0.002442977 9 0 BeFree
Albuminuria 0.002367032 1 0 GAD
Rheumatoid Arthritis 0.002367032 1 0 GAD
Fetal Diseases 0.002367032 1 0 GAD
Hemolysis (disorder) 0.002367032 1 0 GAD
Hypertensive disease 0.002367032 1 0 GAD
Microcytosis 0.002367032 1 0 GAD
Dyslipidemias 0.002367032 1 0 GAD
Pregnancy loss 0.002367032 1 0 GAD
Haptoglobin Adverse Event 0.002367032 1 0 GAD
Cooley's anemia 0.002171535 8 0 BeFree
Alpha trait thalassemia 0.002171535 8 0 BeFree
Thalassemia trait 0.002171535 8 0 BeFree
Iron deficiency 0.001900093 7 0 BeFree
Delta-Beta Thalassemia 0.001900093 7 0 BeFree
Hemoglobin F Disease 0.001628651 6 0 BeFree
Severe alpha thalassemia 0.001628651 6 0 BeFree
Homozygous alpha thalassemia 0.001357209 5 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.001085767 4 0 BeFree
Acute Erythroblastic Leukemia 0.001085767 4 0 BeFree
Preleukemia 0.001085767 4 0 BeFree
Thalassemia Minor 0.001085767 4 0 BeFree
Sicca Syndrome 0.001085767 4 0 BeFree
Anemia, severe 0.001085767 4 0 BeFree
Hemoglobin Bart's hydrops syndrome 0.001085767 4 0 BeFree
Severe beta thalassemia 0.001085767 4 0 BeFree
Anemia, Hemolytic 0.000814326 3 0 BeFree
Diabetes Mellitus 0.000814326 3 0 BeFree
Polycystic Kidney Diseases 0.000814326 3 0 BeFree
Iron-Refractory Iron Deficiency Anemia 0.000814326 3 0 BeFree
Iron deficiency anemia 0.000814326 3 0 BeFree
Beta thalassemia minor 0.000814326 3 0 BeFree
Diabetes 0.000542884 2 0 BeFree
Cardiac Arrest 0.000542884 2 0 BeFree
Kidney Diseases 0.000542884 2 0 BeFree
leukemia 0.000542884 2 0 BeFree
Mental Retardation 0.000542884 2 0 BeFree
Familial Mediterranean Fever 0.000542884 2 0 BeFree
Sickle cell-beta-thalassemia 0.000542884 2 0 BeFree
Normocytic hypochromic anemia 0.000542884 2 0 BeFree
Dehydration 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Gastrointestinal Neoplasms 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Leg Ulcer 0.000271442 1 0 BeFree
Myeloproliferative disease 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pain 0.000271442 1 0 BeFree
Trisomy 0.000271442 1 0 BeFree
Rous Sarcoma 0.000271442 1 0 BeFree
Renal glomerular disease 0.000271442 1 0 BeFree
Spastic syndrome 0.000271442 1 0 BeFree
^A^gamma delta beta^0^ thalassemia 0.000271442 1 0 BeFree
delta^0^ Thalassemia 0.000271442 1 0 BeFree
alpha^+^ Thalassemia, deletion type 0.000271442 1 0 BeFree
Hemoglobin D trait 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Hemoglobin E/beta thalassemia disease 0.000271442 1 0 BeFree
Alpha-Thalassemia Myelodysplasia Syndrome 0.000271442 1 0 BeFree
Toxic nephropathy 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Acute Chest Syndrome 0.000271442 1 0 BeFree
Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Hemolytic disorder 0.000271442 1 0 BeFree
TUBEROUS SCLEROSIS 2 (disorder) 0.000271442 1 0 BeFree
Histiocytosis with joint contractures and sensorineural deafness 0.000271442 1 0 BeFree
Alcoholic Steatohepatitis 0.000271442 1 0 BeFree
S-Beta Thalassemia 0.000271442 1 0 BeFree
Hemoglobin H Constant Spring 0.000271442 1 0 BeFree
MYELODYSPLASTIC SYNDROME 0.000271442 1 0 BeFree
Bart's Hemoglobinopathy 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

没有相关文献

基因相关服务

基因相关服务

基因评论

基因评论

我要说两句
热门评论
还没有评论，赶快来抢沙发吧。

登陆

用户名:

密    码:

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

扫一扫右方二维码，关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2016.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2