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Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
[中文简述(自动翻译):]  醛脱氢酶氧化各种醛为相应的酸。它们参与醇衍生乙醛的解毒和皮质类固醇,生物胺,神经递质,和脂质过氧化的代谢。由该基因编码的酶形成饱和细胞质同型二聚体,其优先氧化芳族和中链(6个碳原子或更多个)和不饱和醛底物。它被认为是促进紫外线和在角膜4-羟基-2-壬烯醛诱导的氧化损伤性。该基因位于史密斯马盖尼斯综合征区域内染色体上17多个可变剪接变体,编码相同的蛋白质,也已确定。 [由RefSeq的,2008年9月提供]
ALDH3A1基因(以及对应的蛋白质)的细胞分布位置:
ALDH3A1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Malignant neoplasm of breast | 0.005005506 | 3 | 0 | BeFree_GAD |
Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Schizophrenia | 0.002638474 | 1 | 0 | BeFree_GAD |
Autistic Disorder | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Germ Cell and Embryonal | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
childhood brain tumor | 0.002367032 | 1 | 0 | GAD |
ovarian neoplasm | 0.002367032 | 1 | 0 | GAD |
Mammary Neoplasms | 0.002367032 | 1 | 0 | GAD |
Liver carcinoma | 0.001357209 | 5 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Pterygium | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Hemorrhagic cystitis | 0.000271442 | 1 | 0 | BeFree |
Cataract | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Recurrent pterygium | 0.000271442 | 1 | 0 | BeFree |
Hepatocellular Adenoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Bilateral cataracts (disorder) | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
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