TRIB2(tribbles pseudokinase 2)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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2p25.1
基因染色体位置图

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

[中文简述(自动翻译):]  该基因编码中Tribbles家庭的三名成员之一。该中Tribbles成员共享一个Trb的结构域,其是同源的蛋白质丝氨酸 - 苏氨酸激酶,但缺乏活性位点的赖氨酸和可能缺乏催化功能。该中Tribbles蛋白相互作用并调节在许多生理和病理过程的信号转导途径的活性。这个中Tribbles构件诱导主要造血起源的细胞的细胞凋亡。它已被确定为蛋白质由在髓炎性刺激(THP-1)细胞上调,也可作为该失活转录因子C / EBPalpha(CCAAT /增强子结合蛋白α),并导致急性骨髓性白血病的癌基因。另外剪接转录变体也发现了这种基因。 [由RefSeq的,2009年03月提供]

TRIB2基因的碱基序列:[NCBI]
TRIB2基因的碱基突变:           显示全部snp
rs1544856       rs1863175       rs5829384       rs6719048       rs6748005       rs7564991       rs7604252       rs11687168       rs13016655       rs13016883       rs35330522       rs35813065       rs58608717       rs61554852       rs75978038       rs78536235       rs79053861       rs111625663       rs115536953       rs115940590       rs116582407       rs138481982       rs139740128       rs140656024       rs141012793       rs141695950       rs142801356       rs143466462       rs144550061       rs146855992       rs147161615       rs147855180       rs147980137       rs149629726       rs150218671       rs151026226       rs180788683      
rs183081182       rs183202020       rs183913619       rs185192244       rs185245501       rs186150741       rs186554055       rs187825989       rs188588110       rs189388460       rs189830871       rs191419375       rs191458293       rs192795462       rs528053064       rs530054008       rs530253025       rs532723856       rs533617474       rs533929887       rs535089061       rs542714475       rs543565752       rs543825159       rs548235601       rs548458899       rs550197244       rs552652767       rs554032711       rs554696744       rs555774704       rs556908874       rs558366826       rs558643313       rs560966828       rs562021020       rs562029267       rs562319029       rs564762466       rs566644626       rs566663312       rs566783209       rs569216731       rs571500805       rs571796170       rs572747650       rs573024961       rs574110378       rs576578835       rs576788961       rs750074016       rs764768093       rs779843840       rs1176       rs16350       rs509761       rs890069       rs1035677       rs1057001       rs1064258       rs1803387       rs2042566       rs2042567       rs2278117       rs2288191       rs2288192       rs2380450       rs3835944       rs4668781       rs6432324       rs6719434       rs6746071       rs6753723       rs7422473       rs7556820       rs7566554       rs7569039       rs7590994       rs7593863       rs7609362       rs10171579       rs10179713       rs10185404       rs10189072       rs10203137       rs10929829       rs11902337       rs11904706       rs11904711       rs13005077       rs13019538       rs13023023       rs13406133       rs13408093       rs13412894       rs16859293       rs16859312       rs17465002       rs17465023       rs17511374       rs28969622       rs34392899       rs34694635       rs35002856       rs35056165       rs35143408       rs55813198       rs56105169       rs59216273       rs60629366       rs62126063       rs62126064       rs62126066       rs62126067       rs62126068       rs62126069       rs62126070       rs62126071       rs66540381       rs67289685       rs71396737       rs71396739       rs73199189       rs73199195       rs73914130       rs74429569       rs74438852       rs74871467       rs75012946       rs75439400       rs75843285       rs76036599       rs76440188       rs76534707       rs76558681       rs76855379       rs76979063       rs76990333       rs77272773       rs77337896       rs77465069       rs77560390       rs77625451       rs77773048       rs77937402       rs78135674       rs78325263       rs78527330       rs78986177       rs79110076       rs79474056       rs79600925       rs79632638       rs79788894       rs79947828       rs80257530       rs111282515       rs111347524       rs111388054       rs111580826       rs111652127       rs111840543       rs111976201       rs112071850       rs112090260       rs112238170       rs112323864       rs112416614       rs112560547       rs112566251       rs112785680       rs112840729       rs112875762       rs113109330       rs113188919       rs113192828       rs113284736       rs113305500       rs113431291       rs113545418       rs113802678       rs113881146       rs114126710       rs114128315       rs114162965       rs114493863       rs114652709       rs114743196       rs114819401       rs114874345       rs114943916       rs115103561       rs115111076       rs115183369       rs115555850       rs115564303       rs115758025       rs115919286       rs115935201       rs116068311       rs116097592       rs116179055       rs116204891       rs116410612       rs116499032       rs116599983       rs116713677       rs117718684       rs137939965       rs138141141       rs138272133       rs138385154       rs138729119       rs138770066       rs139009776       rs139027449       rs139097419       rs139145997       rs139396743       rs139779476       rs139811174       rs139869781       rs140143213       rs140281730       rs140368546       rs140480058       rs140567321       rs140608739       rs140781296       rs140897683       rs140990189       rs141122325       rs141161870       rs141531665       rs141698374       rs141870939       rs141952131       rs142204277       rs142204673       rs142225286       rs142295729       rs142311912       rs142350606       rs142368999       rs142544661       rs142618853       rs142731205       rs142817604       rs142971674       rs143069391       rs143237005       rs143258586       rs143299305       rs143347546       rs143601351       rs143999847       rs144061272       rs144085251       rs144380528       rs144421263       rs144503903       rs144662339       rs144738962       rs144779580       rs144961119       rs145220611       rs145340351       rs145543992       rs145741051       rs145922987       rs145934300       rs145951347       rs146382327       rs146457912       rs146493595       rs146823313       rs147226548       rs147268616       rs147309844       rs147393056       rs147416073       rs147497665       rs147777662       rs147884983       rs147961352       rs148096117       rs148122913       rs148148614       rs148275615       rs148421975       rs148534688       rs148588734       rs148787439       rs148861785       rs148913448       rs149152932       rs149481060       rs149596088       rs149647007       rs149668038       rs149922146       rs149955393       rs150264888       rs150394328       rs150404135       rs150659305       rs150706307       rs150722548       rs150973712       rs151156228       rs151207925       rs180748058       rs180783037       rs181434914       rs181525165       rs181725227       rs181769150       rs181801956       rs182032682       rs182037183       rs182200052       rs182271615       rs182275947       rs182296905       rs182393844       rs182554486       rs182630801       rs182738327       rs182914653       rs183117354       rs183231229       rs183249684       rs183343135       rs183430076       rs183515245       rs183584625       rs183642256       rs183863370       rs184045079       rs184314618       rs184318696       rs184458522       rs184462424       rs184473587       rs184495829       rs184560785       rs185183312       rs185325233       rs185729683       rs186142524       rs186204534       rs186214430       rs186300581       rs186385065       rs186413267       rs186878710       rs186947815       rs187031687       rs187236382       rs187513289       rs187762607       rs187769467       rs187916442       rs187968640       rs188017859       rs188058040       rs188115270       rs188196433       rs188351149       rs188576907       rs188602575       rs188729291       rs188780828       rs188849807       rs189023171       rs189066300       rs189238605       rs189246940       rs189300353       rs189380107       rs189518756       rs189523531       rs189533836       rs190071196       rs190073735       rs190249876       rs190477192       rs190623285       rs190674031       rs190915348       rs190987387       rs190995392       rs191140337       rs191172246       rs191254247       rs191327196       rs191428770       rs191554786       rs191646430       rs191796052       rs191939439       rs191974862       rs192069404       rs192132798       rs192632999       rs192734469       rs192837096       rs193000701       rs193083229       rs193131311       rs199647863       rs199911383       rs199927235       rs200046201       rs200061820       rs200063071       rs200355355       rs200383586       rs200687298       rs200743113       rs200880275       rs201044612       rs201441619       rs201543065       rs201718135       rs202169970       rs202225424       rs367693345       rs367792158       rs368336131       rs368445022       rs368512058       rs369137652       rs369189598       rs369596172       rs369895270       rs370433974       rs370540952       rs370946452       rs371172548       rs371275622       rs371345394       rs371662950       rs372273948       rs372856863       rs373317792       rs373415131       rs373482368       rs373497688       rs373672540       rs373979024       rs373997699       rs374295040       rs374686543       rs375446131       rs376093252       rs376273712       rs376927997       rs377086079       rs377427702       rs377445193       rs527253721       rs527299993       rs527615807       rs527900601       rs528054866       rs528156866       rs528238694       rs528290054       rs528394164       rs528861617       rs529016654       rs529159199       rs529232917       rs529264826       rs529457057       rs529600516       rs529668260       rs529672945       rs529706885       rs529912422       rs530516885       rs530635629       rs530881903       rs531065037       rs531296710       rs531303391       rs531391745       rs531395332       rs531742817       rs531744298       rs531800454       rs531920232       rs532086102       rs532097557       rs532163404       rs532285710       rs532412071       rs532533378       rs532585565       rs532587355       rs532997114       rs533043069       rs533109738       rs533323916       rs533326004       rs533451596       rs533513966       rs533535521       rs533966462       rs534003036       rs534092604       rs534108777       rs534205129       rs534284494       rs534364079       rs534584273       rs534912679       rs535092933       rs535207032       rs535210276       rs535241020       rs535364790       rs535501848       rs535594898       rs535599608       rs535658228       rs535798496       rs536243319       rs536258845       rs536277006       rs536632979       rs536642264       rs536780171       rs536785578       rs536999153       rs537460142       rs537508293       rs537639576       rs537841523       rs537979249       rs538000716       rs538066269       rs538170418       rs538466032       rs538726159       rs538877819       rs538954979       rs539035808       rs539038121       rs539052236       rs539065650       rs539085605       rs539173109       rs539198176       rs539367102       rs539635053       rs540057614       rs540298936       rs540807536       rs540891557       rs541076631       rs541218537       rs541264268       rs541420433       rs541431281       rs541471012       rs541623577       rs541682801       rs541837364       rs541840958       rs541877821       rs542453513       rs542470191       rs542549118       rs542627005       rs542627124       rs542628717       rs542807536       rs542940298       rs543175494       rs543265390       rs543287093       rs543677297       rs543795736       rs543874590       rs544005479       rs544204867       rs544271201       rs544423880       rs544455061       rs544869943       rs544870249       rs544913680       rs545102993       rs545606244       rs545611314       rs545623541       rs545771566       rs546051426       rs546055799       rs546566880       rs546637194       rs546825227       rs547311802       rs547329635       rs547747201       rs547834107       rs547836907       rs547919705       rs548205339       rs548297111       rs548458935       rs548479846       rs548601086       rs548688602       rs548747818       rs548982537       rs549173973       rs549410188       rs549422148       rs549610725       rs549656173       rs549657988       rs549692285       rs549719535       rs549968555       rs549980966       rs549992456       rs550590507       rs550604863       rs550684756       rs550727847       rs550854017       rs550915016       rs550942671       rs551033405       rs551075516       rs551138833       rs551141393       rs551203274       rs551729876       rs551867597       rs552077354       rs552140378       rs552203902       rs552333383       rs552392331       rs552975557       rs553235015       rs553346545       rs553420903       rs553468682       rs553537221       rs553719764       rs553722219       rs553784682       rs554001966       rs554176148       rs554208620       rs554359306       rs554652846       rs554660110       rs554665397       rs554779446       rs554799848       rs554920402       rs554927943       rs555160237       rs555177499       rs555247699       rs555389362       rs555743797       rs555807023       rs555889797       rs555943449       rs555950844       rs556108344       rs556162156       rs556245315       rs556332013       rs556457582       rs557056607       rs557087403       rs557176708       rs557226562       rs557314033       rs557315805       rs557377262       rs557402287       rs558640928       rs558798937       rs558836724       rs558908100       rs558987247       rs559022030       rs559146762       rs559214116       rs559343339       rs559397664       rs559877325       rs559887571       rs560008833       rs560124570       rs560414682       rs560458910       rs560474493       rs560673715       rs560711718       rs560830196       rs560832088       rs560863679       rs560972568       rs561151075       rs561162391       rs561448897       rs561512542       rs561631816       rs561641926       rs562034339       rs562166994       rs562216770       rs562394275       rs562420046       rs562502338       rs562530570       rs562536505       rs562623157       rs562709312       rs563028383       rs563187768       rs563204670       rs563245641       rs563248463       rs563392366       rs563458344       rs563734396       rs564006324       rs564458352       rs564475760       rs564914640       rs564931954       rs564992186       rs565133799       rs565310654       rs565432195       rs565449085       rs565572239       rs565581962       rs565646056       rs565771267       rs565997692       rs566393452       rs566501689       rs566603952       rs566609428       rs566704159       rs566783235       rs567159703       rs567221281       rs567284986       rs567360708       rs567381343       rs567561412       rs567843087       rs567882448       rs567936451       rs567997842       rs568038202       rs568203374       rs568330322       rs568344679       rs568350160       rs568531755       rs568600261       rs568897715       rs569028394       rs569113627       rs569125961       rs569314529       rs569398050       rs569549354       rs569560966       rs570188441       rs570232306       rs570294422       rs570346148       rs570482560       rs570525706       rs570759143       rs570769837       rs571081393       rs571214949       rs571291191       rs571297246       rs571563860       rs571697465       rs571754652       rs571786905       rs571815278       rs571965120       rs571977346       rs572101723       rs572109684       rs572437376       rs573162530       rs573442221       rs573523353       rs573646878       rs573726268       rs574065525       rs574207300       rs574238235       rs574299213       rs574316980       rs574454383       rs574564523       rs574593023       rs574652896       rs574739016       rs575191513       rs575437420       rs575502351       rs575524404       rs575567873       rs575591391       rs575625303       rs575690603       rs575692433       rs575731743       rs575734924       rs576182121       rs576304869       rs576367877       rs576439686       rs576515395       rs576935932       rs576990821       rs577077196       rs577266048       rs577280550       rs577501072       rs577562917       rs577722874       rs577725868       rs577784862       rs577789476       rs578091522       rs578199052       rs578204593       rs745893396       rs746256609       rs746410973       rs746603696       rs746954188       rs747065082       rs747242699       rs747668837       rs748091689       rs748317982       rs748546596       rs748937694       rs748964987       rs749206102       rs749601905       rs749654890       rs749899658       rs749904372       rs749950718       rs750293522       rs750302119       rs750481302       rs750627914       rs750705782       rs751126004       rs751185195       rs751289993       rs751324639       rs751664816       rs751935232       rs751988198       rs752492245       rs752498995       rs752550457       rs752731552       rs752833186       rs752915707       rs753024028       rs753213750       rs753298982       rs753648238       rs753974846       rs754028360       rs754995271       rs755066008       rs755624221       rs755829009       rs755884349       rs756009177       rs756047229       rs756204751       rs757196090       rs757541368       rs757929609       rs758384930       rs758430503       rs758793068       rs758995072       rs759295610       rs759509033       rs759964561       rs760295020       rs760389021       rs760444066       rs760569557       rs760868940       rs760976899       rs761590725       rs761863456       rs761976611       rs762116241       rs762250707       rs762323829       rs762373462       rs762464840       rs762477259       rs762743420       rs762835253       rs762977455       rs763182019       rs763434178       rs763495130       rs763551688       rs763843608       rs763968049       rs764029213       rs764153753       rs764485871       rs764512877       rs764612344       rs764941371       rs764993256       rs765176244       rs765210830       rs765225177       rs765253133       rs765283592       rs765380707       rs765730179       rs765789999       rs766174110       rs766340841       rs766840958       rs767077120       rs767148205       rs767201347       rs767201489       rs767627435       rs767986237       rs768041128       rs768253815       rs768429546       rs768494029       rs768775866       rs768883790       rs768938972       rs769288879       rs769503190       rs769913210       rs770116295       rs770116479       rs770239256       rs770292342       rs770337879       rs770724703       rs771099145       rs771225712       rs771451620       rs771677491       rs771800128       rs771949812       rs772378978       rs772434910       rs772672172       rs772938398       rs773201528       rs773280939       rs773634877       rs773666083       rs773691614       rs773691736       rs773779934       rs773967204       rs774247119       rs774688040       rs775130378       rs775198683       rs775385892       rs775750955       rs775854564       rs776251980       rs776974281       rs777039601       rs777882618       rs777884568       rs777998116       rs778051727       rs778566813       rs779026155       rs779131015       rs779495796       rs780227431       rs780322811       rs780794177       rs781017530       rs781024400       rs781077225       rs781121933       rs781377123       rs781771642      

TRIB2基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTCGGTGACATTGAATGGG
58
AGAACTGGATCTCGTCGTG
59
GTGTCGGTGACATTGAATGG
59
AGAACTGGATCTCGTCGTG
59
TTGTTGGAACCTCTGGAGG
59
ATCAAACACCTTGCACACC
59
TGTGCAAGGTGTTTGATATCAG
59
GGTTGATGTTACTATGAGCAGAC
59
CGGAAATTCATCTTTAAGGACG
57
GAATGTAGGCGTCTTCCAG
58
GTCGGTGACATTGAATGGG
58
AGAACTGGATCTCGTCGTG
59
ATTGTTGGAACCTCTGGAGG
59
ATCAAACACCTTGCACACC
59
CGGAAATTCATCTTTAAGGACG
57
AATGTAGGCGTCTTCCAGG
59
GCGGAAATTCATCTTTAAGGAC
58
AATGTAGGCGTCTTCCAGG
59
      尚未收录相关数据

TRIB2基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TRIB2基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0004672
B5MCX4(UniProtKB)
IEA
GO:0005524
B5MCX4(UniProtKB)
IEA
GO:0006468
B5MCX4(UniProtKB)
IEA
GO:0004672
F8WA18(UniProtKB)
IEA
GO:0005524
F8WA18(UniProtKB)
IEA
GO:0006468
F8WA18(UniProtKB)
IEA
GO:0004860
Q92519(UniProtKB)
IEA
GO:0005634
Q92519(UniProtKB)
IBA
GO:0005737
Q92519(UniProtKB)
ISS
GO:0005856
Q92519(UniProtKB)
IEA
GO:0006469
Q92519(UniProtKB)
NAS
GO:0008134
Q92519(UniProtKB)
ISS
GO:0031434
Q92519(UniProtKB)
IBA
GO:0031625
Q92519(UniProtKB)
ISS
GO:0032436
Q92519(UniProtKB)
IBA
GO:0032436
Q92519(UniProtKB)
ISS
GO:0043405
Q92519(UniProtKB)
ISS
GO:0043405
Q92519(UniProtKB)
IBA
GO:0045081
Q92519(UniProtKB)
IMP
GO:0045599
Q92519(UniProtKB)
ISS
GO:0055106
Q92519(UniProtKB)
ISS
GO:0000166
Q92519(UniProtKB)
ISS
GO:0004672
Q92519(UniProtKB)
ISS
GO:0006468
Q92519(UniProtKB)
ISS
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控TRIB2基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Uveitis 0.003267234 2 0 BeFree_LHGDN
Acute Erythroblastic Leukemia 0.00272435 1 0 LHGDN
Alcoholic Intoxication, Chronic 0.002367032 1 0 GAD
Creatinine finding 0.002367032 1 1 GAD
Glomerular filtration rate finding 0.002367032 1 1 GAD
Leukemia, Myelocytic, Acute 0.001357209 5 0 BeFree
leukemia 0.000814326 3 0 BeFree
Narcolepsy 0.000814326 3 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of liver 0.000814326 3 0 BeFree
melanoma 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of skin 0.000271442 1 0 BeFree
Cataplexy 0.000271442 1 0 BeFree
Inflammatory Bowel Diseases 0.000271442 1 0 BeFree
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Prostatic Neoplasms 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Nevi and Melanomas 0.000271442 1 0 BeFree
Metastatic melanoma 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Leukemogenesis 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
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