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This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
[中文简述(自动翻译):]  该基因编码中Tribbles家庭的三名成员之一。该中Tribbles成员共享一个Trb的结构域,其是同源的蛋白质丝氨酸 - 苏氨酸激酶,但缺乏活性位点的赖氨酸和可能缺乏催化功能。该中Tribbles蛋白相互作用并调节在许多生理和病理过程的信号转导途径的活性。这个中Tribbles构件诱导主要造血起源的细胞的细胞凋亡。它已被确定为蛋白质由在髓炎性刺激(THP-1)细胞上调,也可作为该失活转录因子C / EBPalpha(CCAAT /增强子结合蛋白α),并导致急性骨髓性白血病的癌基因。另外剪接转录变体也发现了这种基因。 [由RefSeq的,2009年03月提供]
TRIB2基因(以及对应的蛋白质)的细胞分布位置:
TRIB2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Uveitis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Acute Erythroblastic Leukemia | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Creatinine finding | 0.002367032 | 1 | 1 | GAD |
Glomerular filtration rate finding | 0.002367032 | 1 | 1 | GAD |
Leukemia, Myelocytic, Acute | 0.001357209 | 5 | 0 | BeFree |
leukemia | 0.000814326 | 3 | 0 | BeFree |
Narcolepsy | 0.000814326 | 3 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of liver | 0.000814326 | 3 | 0 | BeFree |
melanoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Cataplexy | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Nevi and Melanomas | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
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