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This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码多巴胺受体的D2亚型。偶联受体该G蛋白抑制腺苷酸环化酶活性。在这个基因的错义突变导致肌阵挛性肌张力障碍;其他突变已与精神分裂症有关。两个转录本基因导致选择性剪接变异体编码不同亚型。第三种变体进行了说明,但它尚未确定这种形式是正常还是由于异常剪接。 [由RefSeq的,2008年7月提供]
DRD2基因(以及对应的蛋白质)的细胞分布位置:
DRD2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Schizophrenia | 0.291131658 | 162 | 12 | BeFree_CTD_human_GAD_LHGDN |
Myoclonic dystonia | 0.241628651 | 6 | 0 | BeFree_CTD_human_ORPHANET |
Parkinson Disease | 0.238958279 | 22 | 0 | BeFree_CTD_human_GAD_RGD |
Cocaine-Related Disorders | 0.204734064 | 13 | 0 | CTD_human_GAD_RGD |
Alcoholic Intoxication, Chronic | 0.203722004 | 163 | 7 | BeFree_GAD_LHGDN_RGD |
Dyskinesia, Drug-Induced | 0.202367032 | 5 | 0 | CTD_human_GAD_RGD |
Tachycardia | 0.2 | 3 | 0 | CTD_human_RGD |
Parkinsonian Disorders | 0.2 | 4 | 0 | CTD_human_RGD |
Attention deficit hyperactivity disorder | 0.155461872 | 34 | 5 | BeFree_CTD_human_GAD |
Tobacco Use Disorder | 0.148404384 | 13 | 1 | CTD_human_GAD |
Substance-Related Disorders | 0.138936256 | 9 | 0 | CTD_human_GAD |
Substance Withdrawal Syndrome | 0.134473634 | 7 | 1 | BeFree_CTD_human_GAD |
Dyskinetic syndrome | 0.131711727 | 8 | 0 | BeFree_CTD_human_LHGDN |
Pituitary Neoplasms | 0.131354408 | 8 | 0 | BeFree_CTD_human_GAD_LHGDN |
Weight Gain | 0.129468128 | 4 | 0 | CTD_human_GAD |
Heroin Dependence | 0.128729747 | 8 | 0 | BeFree_CTD_human_GAD |
Hyperprolactinemia | 0.128186863 | 6 | 0 | BeFree_CTD_human_GAD |
Anxiety Disorders | 0.125895776 | 14 | 1 | BeFree_CTD_human_GAD |
Basal Ganglia Diseases | 0.124734064 | 7 | 0 | CTD_human_GAD |
Memory Disorders | 0.124734064 | 3 | 0 | CTD_human_GAD |
Pain | 0.122638474 | 3 | 0 | BeFree_CTD_human_GAD |
Cognition Disorders | 0.122367032 | 2 | 0 | CTD_human_GAD |
Disruptive, Impulse Control, and Conduct Disorders | 0.122367032 | 4 | 0 | CTD_human_GAD |
Amphetamine-Related Disorders | 0.122367032 | 3 | 0 | CTD_human_GAD |
Hypertensive disease | 0.121628651 | 7 | 3 | BeFree_CTD_human |
Movement Disorders | 0.120814326 | 4 | 0 | BeFree_CTD_human |
Language Disorders | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Seizures | 0.120271442 | 4 | 0 | BeFree_CTD_human |
Catalepsy | 0.12 | 4 | 0 | CTD_human |
Developmental Disabilities | 0.12 | 1 | 0 | CTD_human |
Hypotension | 0.12 | 4 | 0 | CTD_human |
Hyperactive behavior | 0.12 | 2 | 0 | CTD_human |
Bradycardia | 0.12 | 2 | 0 | CTD_human |
Obesity | 0.105722303 | 30 | 3 | BeFree_GAD_RGD |
Gilles de la Tourette syndrome | 0.097359805 | 13 | 0 | BeFree_GAD_LHGDN_RGD |
Depressive disorder | 0.082442977 | 10 | 2 | BeFree_RGD |
Neuralgia | 0.080271442 | 3 | 0 | BeFree_RGD |
Brain Ischemia | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Morphine Dependence | 0.08 | 1 | 0 | RGD |
Neurotoxicity Syndromes | 0.08 | 1 | 0 | RGD |
Dementia | 0.08 | 1 | 0 | RGD |
Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
Bipolar Disorder | 0.023083829 | 27 | 1 | BeFree_GAD |
Lingual-Facial-Buccal Dyskinesia | 0.018545262 | 19 | 5 | BeFree_GAD |
Malignant neoplasm of lung | 0.016840666 | 7 | 1 | BeFree_GAD |
Tardive Dyskinesia | 0.01617823 | 18 | 5 | BeFree_GAD |
Alcohol abuse | 0.015830843 | 12 | 0 | BeFree_GAD |
Migraine Disorders | 0.015092462 | 14 | 4 | BeFree_GAD |
Neuroleptic Malignant Syndrome | 0.01444989 | 7 | 1 | BeFree_GAD_LHGDN |
Mood Disorders | 0.010358398 | 15 | 2 | BeFree_GAD |
Mental Depression | 0.009544073 | 10 | 2 | BeFree_GAD |
As If Personality | 0.009468128 | 4 | 0 | GAD |
Weight Gain Adverse Event | 0.009468128 | 4 | 0 | GAD |
Heroin Abuse | 0.00764398 | 4 | 0 | BeFree_GAD |
Post-Traumatic Stress Disorder | 0.007177041 | 9 | 2 | BeFree_GAD |
Major Depressive Disorder | 0.006905599 | 9 | 4 | BeFree_GAD |
Dystonia | 0.00617715 | 6 | 0 | BeFree_GAD_LHGDN |
Marijuana Abuse | 0.006091273 | 7 | 10 | BeFree_GAD |
nervous system disorder | 0.006091273 | 6 | 0 | BeFree_GAD |
Prolactinoma | 0.005981653 | 12 | 0 | BeFree_LHGDN |
Anorexia Nervosa | 0.005905708 | 3 | 0 | BeFree_GAD_LHGDN |
Psychotic Disorders | 0.005895776 | 13 | 4 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005819831 | 5 | 1 | BeFree_GAD |
Postoperative Nausea and Vomiting | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
Autistic Disorder | 0.00554839 | 5 | 0 | BeFree_GAD |
Stuttering | 0.00554839 | 4 | 0 | BeFree_GAD |
Colorectal Cancer | 0.00554839 | 4 | 0 | BeFree_GAD |
Crohn Disease | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Adenoma | 0.005276948 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.005276948 | 3 | 3 | BeFree_GAD |
Delirium | 0.005276948 | 2 | 0 | BeFree_GAD |
Cocaine Dependence | 0.005081451 | 10 | 0 | BeFree_GAD |
Personality Disorders | 0.005005506 | 3 | 0 | BeFree_GAD |
Nicotine Dependence | 0.004885954 | 18 | 6 | BeFree |
Alzheimer's Disease | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.004734064 | 2 | 0 | GAD |
Psychoses, Substance-Induced | 0.004734064 | 2 | 0 | GAD |
Behavioral tic | 0.004734064 | 2 | 0 | GAD |
Mental disorders | 0.00434307 | 16 | 2 | BeFree |
Substance Dependence | 0.00434307 | 16 | 1 | BeFree |
Antisocial Personality Disorder | 0.003995683 | 7 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 2 | 0.003995683 | 6 | 0 | BeFree_GAD |
Drug abuse | 0.003800186 | 14 | 0 | BeFree |
Substance abuse problem | 0.003800186 | 14 | 1 | BeFree |
Alcohol or Other Drugs use | 0.003724241 | 5 | 0 | BeFree_GAD |
Obsessive-Compulsive Disorder | 0.003538676 | 3 | 0 | BeFree_LHGDN |
MAJOR AFFECTIVE DISORDER 1 | 0.003452799 | 4 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 4 | 0.003452799 | 4 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 5 | 0.003452799 | 4 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 6 | 0.003452799 | 4 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 7 | 0.003452799 | 4 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 8 | 0.003452799 | 4 | 0 | BeFree_GAD |
MAJOR AFFECTIVE DISORDER 9 | 0.003452799 | 4 | 0 | BeFree_GAD |
Substance Use Disorders | 0.003257302 | 12 | 0 | BeFree |
Cocaine Abuse | 0.003181358 | 4 | 0 | BeFree_GAD |
Impaired cognition | 0.003181358 | 4 | 0 | BeFree_GAD |
Nonorganic psychosis | 0.002985861 | 11 | 4 | BeFree |
Schizoaffective Disorder | 0.002909916 | 3 | 0 | BeFree_GAD |
Methamphetamine dependence | 0.002909916 | 3 | 0 | BeFree_GAD |
Alcohol Withdrawal Delirium | 0.002638474 | 1 | 0 | BeFree_GAD |
Ulcerative Colitis | 0.002638474 | 1 | 0 | BeFree_GAD |
Kidney Failure, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
Fibroid Tumor | 0.002638474 | 1 | 0 | BeFree_GAD |
Obesity, Morbid | 0.002638474 | 2 | 0 | BeFree_GAD |
Panic Disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
Migraine with Aura | 0.002638474 | 2 | 0 | BeFree_GAD |
Metabolic Syndrome X | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of ovary | 0.002638474 | 1 | 0 | BeFree_GAD |
Methamphetamine abuse | 0.002638474 | 2 | 0 | BeFree_GAD |
Drug Dependence | 0.002442977 | 9 | 1 | BeFree |
Acute Disease | 0.002367032 | 1 | 0 | GAD |
Anxiety | 0.002367032 | 1 | 0 | GAD |
Cardiovascular Diseases | 0.002367032 | 1 | 0 | GAD |
Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Esophageal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Hyperphagia | 0.002367032 | 1 | 0 | GAD |
Laryngeal neoplasm | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis, Alcoholic | 0.002367032 | 1 | 0 | GAD |
Low Back Pain | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
Narcolepsy | 0.002367032 | 1 | 0 | GAD |
Opioid-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Pharyngeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Prenatal Exposure Delayed Effects | 0.002367032 | 1 | 0 | GAD |
Sciatica | 0.002367032 | 1 | 0 | GAD |
Stress | 0.002367032 | 1 | 0 | GAD |
Tic disorder | 0.002367032 | 1 | 0 | GAD |
Uterine Neoplasms | 0.002367032 | 1 | 0 | GAD |
Gastroparesis | 0.002367032 | 1 | 0 | GAD |
Iron deficiency anemia | 0.002367032 | 1 | 0 | GAD |
Malnutrition | 0.002367032 | 1 | 0 | GAD |
Akathisia, Drug-Induced | 0.002367032 | 1 | 0 | GAD |
Personality Traits | 0.002367032 | 1 | 0 | GAD |
Binge eating disorder | 0.002367032 | 1 | 0 | GAD |
Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Chronic ulcerative colitis | 0.002367032 | 1 | 0 | GAD |
Opium abuse | 0.002367032 | 1 | 0 | GAD |
Unipolar Depression | 0.002171535 | 8 | 4 | BeFree |
Opiate Addiction | 0.001900093 | 7 | 0 | BeFree |
Pituitary Diseases | 0.001628651 | 6 | 0 | BeFree |
Extrapyramidal sign | 0.001628651 | 6 | 0 | BeFree |
alcohol use disorder | 0.001357209 | 5 | 0 | BeFree |
Depressive Symptoms | 0.001357209 | 5 | 0 | BeFree |
Eating Disorders | 0.001085767 | 4 | 2 | BeFree |
Pituitary Adenoma | 0.001085767 | 4 | 0 | BeFree |
Dystonia Disorders | 0.001085767 | 4 | 0 | BeFree |
Overweight | 0.001085767 | 4 | 0 | BeFree |
NEUROTICISM | 0.001085767 | 4 | 1 | BeFree |
Bulimia | 0.000814326 | 3 | 2 | BeFree |
Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Delusional disorder | 0.000814326 | 3 | 1 | BeFree |
Huntington Disease | 0.000814326 | 3 | 0 | BeFree |
melanoma | 0.000814326 | 3 | 0 | BeFree |
Gambling, Pathological | 0.000814326 | 3 | 0 | BeFree |
Tobacco Dependence | 0.000814326 | 3 | 0 | BeFree |
Memory impairment | 0.000814326 | 3 | 0 | BeFree |
Drug usage | 0.000814326 | 3 | 0 | BeFree |
Obsessive compulsive behavior | 0.000814326 | 3 | 0 | BeFree |
Alexithymia | 0.000542884 | 2 | 1 | BeFree |
Ataxia Telangiectasia | 0.000542884 | 2 | 0 | BeFree |
Borderline Personality Disorder | 0.000542884 | 2 | 0 | BeFree |
Delusions | 0.000542884 | 2 | 1 | BeFree |
Drug Use Disorders | 0.000542884 | 2 | 0 | BeFree |
Endometriosis | 0.000542884 | 2 | 0 | BeFree |
Headache | 0.000542884 | 2 | 4 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Osteochondritis Dissecans | 0.000542884 | 2 | 0 | BeFree |
Pheochromocytoma | 0.000542884 | 2 | 0 | BeFree |
Conduct Disorder | 0.000542884 | 2 | 0 | BeFree |
Antisocial behavior | 0.000542884 | 2 | 0 | BeFree |
Bradykinesia | 0.000542884 | 2 | 0 | BeFree |
Alcohol withdrawal syndrome | 0.000542884 | 2 | 0 | BeFree |
Bipolar II disorder | 0.000542884 | 2 | 0 | BeFree |
Generalized Anxiety Disorder | 0.000542884 | 2 | 3 | BeFree |
Sexual abuse | 0.000542884 | 2 | 0 | BeFree |
Common Migraine | 0.000542884 | 2 | 0 | BeFree |
Akathisia | 0.000542884 | 2 | 0 | BeFree |
Chronic Kidney Insufficiency | 0.000542884 | 2 | 0 | BeFree |
Delinquent behavior | 0.000542884 | 2 | 0 | BeFree |
Neurobehavioral Manifestations | 0.000542884 | 2 | 1 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 3 | BeFree |
Polysubstance abuse | 0.000542884 | 2 | 0 | BeFree |
Bipolar I disorder | 0.000542884 | 2 | 0 | BeFree |
Sleeplessness | 0.000542884 | 2 | 0 | BeFree |
Autism Spectrum Disorders | 0.000542884 | 2 | 0 | BeFree |
INTELLIGENCE QUANTITATIVE TRAIT LOCUS 1 | 0.000542884 | 2 | 2 | BeFree |
Bulimia Nervosa | 0.000542884 | 2 | 0 | BeFree |
Pediatric Obesity | 0.000542884 | 2 | 1 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Anovulation | 0.000271442 | 1 | 0 | BeFree |
Behavior Disorders | 0.000271442 | 1 | 0 | BeFree |
Bronchopulmonary Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Cannabis Dependence | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
CNS disorder | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Cluster A personality disorder | 0.000271442 | 1 | 0 | BeFree |
Communication impairment | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 1 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 1 | BeFree |
Disruptive Behavior Disorder | 0.000271442 | 1 | 0 | BeFree |
Dyspepsia | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Microcephaly | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Muscle Rigidity | 0.000271442 | 1 | 0 | BeFree |
Nausea | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Nicotine withdrawal | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Phobia, Social | 0.000271442 | 1 | 2 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Schizoid Personality Disorder | 0.000271442 | 1 | 0 | BeFree |
organic sexual dysfunction | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Polydipsia | 0.000271442 | 1 | 0 | BeFree |
Emotional Stress | 0.000271442 | 1 | 0 | BeFree |
Withdrawal Symptoms | 0.000271442 | 1 | 0 | BeFree |
Teratocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Recurrent depression | 0.000271442 | 1 | 0 | BeFree |
Chronic schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Resting Tremor | 0.000271442 | 1 | 0 | BeFree |
Cerebral atrophy | 0.000271442 | 1 | 0 | BeFree |
opioid use | 0.000271442 | 1 | 0 | BeFree |
Erectile dysfunction | 0.000271442 | 1 | 0 | BeFree |
bilateral breast cancer | 0.000271442 | 1 | 0 | BeFree |
Mixed anxiety and depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Absence of pain sensation | 0.000271442 | 1 | 0 | BeFree |
Abnormal involuntary movement | 0.000271442 | 1 | 2 | BeFree |
Dystonia, Diurnal | 0.000271442 | 1 | 0 | BeFree |
Dyslexia | 0.000271442 | 1 | 0 | BeFree |
Alzheimer Disease, Late Onset | 0.000271442 | 1 | 0 | BeFree |
Sexual Dysfunction | 0.000271442 | 1 | 0 | BeFree |
Alcohol Withdrawal Seizures | 0.000271442 | 1 | 1 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
heavy drinking | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Punctate inner choroidopathy | 0.000271442 | 1 | 0 | BeFree |
psychosocial stressor | 0.000271442 | 1 | 0 | BeFree |
Opium addiction | 0.000271442 | 1 | 0 | BeFree |
Childhood aggression | 0.000271442 | 1 | 0 | BeFree |
Acute schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Developmental reading disorder | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
ACTH-Secreting Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Dopa-Responsive Dystonia | 0.000271442 | 1 | 0 | BeFree |
Executive dysfunction | 0.000271442 | 1 | 0 | BeFree |
Alcohol abuse or dependence | 0.000271442 | 1 | 0 | BeFree |
Intellectual Disability | 0.000271442 | 1 | 0 | BeFree |
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