GDF15(growth differentiation factor 15)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19p13.11
基因染色体位置图

基因简述

基因简述

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]

[中文简述(自动翻译):]  骨形态发生蛋白（例如，BMP9; MIM 605120）是转化生长因子β的成员（见TGFB1; MIM 190180）超家族和规范组织分化和维护。它们被合成为被在二元切割位点，以释放出含有在成熟蛋白质的7保守半胱氨酸的特征基序的C-末端结构域进行处理的前体分子。[由OMIM，2009年10月供给]

OMIM数据库中对GDF15基因的介绍     Wikipedia数据库中对GDF15基因的介绍

基因序列

基因序列

GDF15基因的碱基序列：[NCBI]

基因突变

基因突变

GDF15基因的碱基突变：           显示全部snp
rs1054221       rs1054564       rs1055150       rs1058587       rs1059022       rs1059369       rs1059519       rs1227731       rs1227732       rs1227733       rs1804826       rs3746195       rs3787023       rs6413435       rs8101804       rs8182537       rs10405394       rs11275597       rs12459782       rs12979706       rs12984969       rs17526126       rs34937778       rs45535632       rs57573498       rs58807758       rs62122429       rs62122430       rs75347775       rs77109188       rs77305894       rs77541450       rs111589486       rs113103572       rs113323060       rs113971422       rs114127150      
rs114853515       rs114929417       rs115439266       rs115816988       rs115985081       rs115987783       rs116140384       rs117562959       rs138494600       rs138519614       rs140036220       rs141415836       rs141542836       rs141640567       rs141878712       rs141930920       rs142606058       rs143047052       rs143208531       rs143520034       rs143742934       rs144738434       rs145420064       rs145666559       rs146143437       rs146900068       rs146939890       rs147994992       rs148208958       rs149338544       rs149807809       rs150500439       rs151271136       rs182973350       rs184794718       rs184798014       rs186369683       rs187441754       rs188073999       rs189140116       rs189597130       rs189839804       rs192506148       rs199595024       rs199673307       rs199905616       rs199975964       rs200179968       rs200748406       rs200847341       rs200851545       rs200945193       rs201445214       rs201533332       rs201695537       rs201802816       rs201804244       rs202099116       rs367741987       rs368079673       rs368861357       rs370175575       rs370432678       rs371105072       rs371689796       rs372120002       rs372444493       rs372617009       rs372819877       rs373073926       rs374606889       rs376223063       rs376237203       rs376302581       rs529018037       rs529308097       rs531458257       rs531646893       rs531728821       rs532895243       rs533387302       rs534464462       rs535086108       rs535653724       rs535733199       rs535988272       rs536224215       rs537315987       rs538113521       rs539395730       rs539823551       rs539903510       rs540937999       rs543355766       rs545070690       rs545296324       rs547044924       rs547703417       rs548083837       rs549470539       rs549750462       rs550396790       rs551556155       rs552234112       rs553522199       rs553770280       rs555920966       rs556097307       rs556247365       rs556858157       rs558050145       rs558703689       rs558740746       rs559087452       rs559794219       rs560248639       rs562749331       rs562981553       rs565101064       rs565768917       rs565807551       rs567029569       rs567933846       rs568217418       rs569322447       rs569439012       rs569674537       rs569787718       rs570405410       rs570826633       rs571160599       rs571510025       rs572360547       rs572499815       rs573590688       rs574670019       rs576196780       rs577234123       rs745462168       rs745582302       rs745656135       rs745931308       rs746138936       rs746324703       rs746494128       rs746717245       rs747501744       rs747593548       rs747695479       rs747749674       rs748361296       rs748621260       rs748711062       rs749012224       rs749208957       rs749362675       rs749673730       rs749733219       rs749868105       rs749896240       rs750316256       rs750512037       rs750770077       rs750870829       rs751332608       rs751442752       rs751528542       rs751528957       rs751857872       rs751869658       rs752235375       rs752431818       rs752480227       rs752811038       rs753080403       rs753270463       rs753582192       rs753661154       rs753738649       rs753938594       rs754281891       rs754377947       rs754567391       rs754651673       rs754659172       rs754819829       rs755423018       rs755483029       rs755582196       rs755708694       rs756589279       rs756677303       rs756681583       rs756784767       rs757154769       rs757242849       rs757529602       rs757849452       rs758095463       rs758223513       rs758400077       rs758615517       rs758627025       rs758727175       rs758859571       rs759404452       rs759715270       rs759852873       rs760121803       rs760720564       rs760774572       rs760810398       rs760868748       rs761020016       rs761494251       rs761625643       rs761874696       rs761917229       rs761995859       rs762192147       rs762218742       rs762445958       rs762557942       rs762752208       rs762753931       rs762797167       rs763108346       rs763610802       rs763651039       rs764026337       rs764221522       rs764282108       rs764317780       rs764794071       rs764881876       rs765285195       rs765432235       rs765943532       rs765959535       rs766218944       rs766308906       rs766507873       rs766872918       rs767111447       rs767249391       rs767444807       rs767447445       rs767748520       rs767818932       rs767853331       rs768091168       rs768710344       rs768850435       rs769279586       rs769512659       rs769647608       rs769807576       rs769842898       rs769891685       rs769997784       rs770227598       rs770376692       rs770559920       rs770666764       rs770946968       rs771076187       rs771321013       rs771328712       rs771508425       rs771598240       rs771834657       rs771850653       rs771892633       rs772448360       rs772493789       rs772697815       rs772858793       rs773146712       rs773866051       rs773889399       rs773905547       rs774931007       rs774973928       rs775018710       rs775262219       rs775695357       rs775710896       rs776087601       rs776264741       rs776459489       rs776539622       rs776544586       rs776770993       rs776932462       rs777034751       rs777237692       rs777381130       rs777978926       rs778245434       rs778350753       rs778528624       rs778921237       rs779012793       rs779385896       rs779393592       rs779481097       rs779481233       rs779865510       rs779963911       rs780049947       rs780075693       rs780163227       rs780528900       rs780728583       rs780761584       rs781579662      

基因表达

基因表达

GDF15基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCTGGGAAGATTCGAACAC
58
ACTTCTGGCGTGAGTATCC
59
TTAGACAAGGAGAGCCAGG
58
ATGAGGACACCATTCCAGC
59
TAGACAAGGAGAGCCAGGA
59
ATGAGGACACCATTCCAGC
59
GGGAAGATTCGAACACCGA
59
ACTTCTGGCGTGAGTATCC
59
CTGGGAAGATTCGAACACC
58
ACTTCTGGCGTGAGTATCC
59
TAGACAAGGAGAGCCAGGA
59
TATGAGGACACCATTCCAGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GDF15基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GDF15基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005125
Q99988(UniProtKB)
IEA
GO:0005160
Q99988(UniProtKB)
IBA
GO:0005576
Q99988(UniProtKB)
TAS
GO:0005615
Q99988(UniProtKB)
IBA
GO:0007165
Q99988(UniProtKB)
TAS
GO:0007179
Q99988(UniProtKB)
TAS
GO:0007267
Q99988(UniProtKB)
TAS
GO:0008083
Q99988(UniProtKB)
IEA
GO:0010862
Q99988(UniProtKB)
IBA
GO:0042981
Q99988(UniProtKB)
IBA
GO:0043408
Q99988(UniProtKB)
IBA
GO:0048468
Q99988(UniProtKB)
IBA
GO:0060395
Q99988(UniProtKB)
IBA
GO:0070062
Q99988(UniProtKB)
IDA
GO:0070062
Q99988(UniProtKB)
IDA
GO:1901741
Q99988(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GDF15基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Prostatic Neoplasms 0.136888985 9 0 BeFree_CTD_human_LHGDN
melanoma 0.12408156 6 0 BeFree_CTD_human_LHGDN
Left Ventricular Hypertrophy 0.122638474 1 0 BeFree_CTD_human_GAD
Neoplasm Metastasis 0.122171535 8 0 BeFree_CTD_human
Heart failure 0.120542884 3 0 BeFree_CTD_human
Coronary Artery Disease 0.120271442 2 0 BeFree_CTD_human
Liver carcinoma 0.120271442 2 0 BeFree_CTD_human
Sideroblastic anemia 0.12 1 0 CTD_human
Gastrointestinal Neoplasms 0.12 1 0 CTD_human
Mouth Diseases 0.12 1 0 CTD_human
Weight Gain 0.12 1 0 CTD_human
Myocardial Ischemia 0.12 1 0 CTD_human
Malignant neoplasm of prostate 0.007795869 21 0 BeFree_GAD
Glioblastoma 0.007348794 8 0 BeFree_LHGDN
Prostate carcinoma 0.005971721 22 0 BeFree
Carcinogenesis 0.00434307 16 0 BeFree
Colorectal Cancer 0.003995683 6 0 BeFree_GAD
Adenoma 0.003810118 4 0 BeFree_LHGDN
Thalassemia 0.003810118 4 0 BeFree_LHGDN
Rheumatoid Arthritis 0.003538676 3 0 BeFree_LHGDN
Myocardial Infarction 0.003267234 3 0 BeFree_LHGDN
Iron Overload 0.003267234 2 0 BeFree_LHGDN
Malignant neoplasm of urinary bladder 0.003181358 4 0 BeFree_GAD
Stomach Neoplasms 0.002995792 2 0 BeFree_LHGDN
Malignant neoplasm of lung 0.002909916 3 0 BeFree_GAD
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Hemochromatosis 0.00272435 1 0 LHGDN
Metaplasia 0.00272435 1 0 LHGDN
Pancreatic Neoplasm 0.00272435 1 0 LHGDN
Premature Birth 0.00272435 1 0 LHGDN
Cardiovascular Diseases 0.002714419 10 0 BeFree
Chronic Obstructive Airway Disease 0.002638474 2 0 BeFree_GAD
Tumor Progression 0.002442977 9 0 BeFree
Alzheimer's Disease 0.002367032 1 0 GAD
Hypertensive disease 0.002367032 1 0 GAD
Colon Carcinoma 0.002171535 8 0 BeFree
Malignant tumor of colon 0.001900093 7 0 BeFree
Colorectal Carcinoma 0.001900093 7 0 BeFree
Breast Carcinoma 0.001900093 7 0 BeFree
Malignant neoplasm of breast 0.001628651 6 0 BeFree
Malignant neoplasm of stomach 0.001628651 6 0 BeFree
Stomach Carcinoma 0.001628651 6 0 BeFree
Obesity 0.001085767 4 0 BeFree
Pancreatic carcinoma 0.001085767 4 0 BeFree
Malignant neoplasm of pancreas 0.001085767 4 0 BeFree
Carcinoma of lung 0.001085767 4 0 BeFree
Diabetes Mellitus 0.000814326 3 0 BeFree
Glioma 0.000814326 3 0 BeFree
Intestinal Neoplasms 0.000814326 3 0 BeFree
Ovarian Carcinoma 0.000814326 3 0 BeFree
Secondary malignant neoplasm of bone 0.000814326 3 0 BeFree
Carcinoma of bladder 0.000814326 3 0 BeFree
Malignant neoplasm of ovary 0.000814326 3 0 BeFree
Benign Prostatic Hyperplasia 0.000814326 3 0 BeFree
Anemia 0.000542884 2 0 BeFree
Anorexia 0.000542884 2 0 BeFree
Arteriosclerosis 0.000542884 2 0 BeFree
Atherosclerosis 0.000542884 2 0 BeFree
Cachexia 0.000542884 2 0 BeFree
Malignant neoplasm of thyroid 0.000542884 2 0 BeFree
Diabetes 0.000542884 2 0 BeFree
Congestive heart failure 0.000542884 2 0 BeFree
Schizophrenia 0.000542884 2 0 BeFree
Adenocarcinoma of lung (disorder) 0.000542884 2 0 BeFree
Thyroid carcinoma 0.000542884 2 0 BeFree
Acute Coronary Syndrome 0.000542884 2 0 BeFree
Squamous cell carcinoma of the head and neck 0.000542884 2 0 BeFree
Mammary Neoplasms 0.000542884 2 0 BeFree
Refractory anemias 0.000271442 1 0 BeFree
Anemia, Sickle Cell 0.000271442 1 0 BeFree
Barrett Esophagus 0.000271442 1 0 BeFree
beta Thalassemia 0.000271442 1 0 BeFree
Brain Neoplasms 0.000271442 1 0 BeFree
Adenocarcinoma of prostate 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
Presenile dementia 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Hepatitis C 0.000271442 1 0 BeFree
Intestinal Polyps 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Multiple Myeloma 0.000271442 1 0 BeFree
Muscular Atrophy 0.000271442 1 0 BeFree
Mycoses 0.000271442 1 0 BeFree
oligodendroglioma 0.000271442 1 0 BeFree
Pregnancy in Diabetics 0.000271442 1 0 BeFree
Prostatic Diseases 0.000271442 1 0 BeFree
Pulmonary Embolism 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree
Thyroid Neoplasm 0.000271442 1 0 BeFree
Viral hepatitis 0.000271442 1 0 BeFree
Essential Hypertension 0.000271442 1 0 BeFree
Deep Vein Thrombosis 0.000271442 1 1 BeFree
Deep thrombophlebitis 0.000271442 1 1 BeFree
Idiopathic pulmonary hypertension 0.000271442 1 0 BeFree
Acute myocardial infarction 0.000271442 1 0 BeFree
Anaplastic thyroid carcinoma 0.000271442 1 0 BeFree
Metastatic melanoma 0.000271442 1 0 BeFree
Cancer of Head and Neck 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree
Adenocarcinoma Of Esophagus 0.000271442 1 0 BeFree
Prostatic Intraepithelial Neoplasias 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Superficial ulcer 0.000271442 1 0 BeFree
Anaplastic Oligodendroglioma 0.000271442 1 0 BeFree
Impaired cognition 0.000271442 1 0 BeFree
Intestinal Cancer 0.000271442 1 0 BeFree
Dementia 0.000271442 1 0 BeFree
Prostatic Adenoma 0.000271442 1 0 BeFree
Recurrent tumor 0.000271442 1 0 BeFree
Pulmonary Thromboembolisms 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Central nervous system lesion 0.000271442 1 0 BeFree
early pregnancy 0.000271442 1 0 BeFree
Well Differentiated Oligodendroglioma 0.000271442 1 0 BeFree
Mitochondrial Diseases 0.000271442 1 0 BeFree
Endothelial dysfunction 0.000271442 1 0 BeFree
Stromal Neoplasm 0.000271442 1 0 BeFree
ovarian neoplasm 0.000271442 1 0 BeFree
Metastatic Prostate Carcinoma 0.000271442 1 0 BeFree
Mitochondrial Respiratory Chain Deficiencies 0.000271442 1 0 BeFree
High-Grade Prostatic Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Low Grade Prostatic Intraepithelial Neoplasia 0.000271442 1 0 BeFree
Mild cognitive disorder 0.000271442 1 0 BeFree
Hormone refractory prostate cancer 0.000271442 1 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000271442 1 0 BeFree
Cancer Cell Growth 0.000271442 1 0 BeFree
Neoplasms, Intracranial 0.000271442 1 0 BeFree
Non-Neoplastic Disorder 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree
Pulmonary arterial hypertension 0.000271442 1 0 BeFree
Refractory anemia, without ringed sideroblasts, without excess blasts 0.000271442 1 0 BeFree
Idiopathic pulmonary arterial hypertension 0.000271442 1 0 BeFree
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia 0.000271442 1 0 BeFree

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