COASY(CoA synthase) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17q12-q21
基因染色体位置图

基因简述

基因简述

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]

[中文简述(自动翻译):]  辅酶A（辅酶A）的功能如细胞乙酰和酰基的载体，从而起到在所有生物体大量合成和降解的代谢途径中起重要作用。在真核生物中，辅酶A和其衍生物也参与膜运输和信号转导。该基因编码的双功能蛋白质辅酶A合成酶（CoAsy），其执行在辅酶A从泛酸（维生素B5）的生物合成中的最后两个步骤。而其脱磷酸-CoA激酶结构域完成通过磷酸dpCoA以形成辅酶A的最后步骤中，该双功能蛋白质的phosphopantetheine腺苷酰转移酶结构域催化4‘- phosphopantetheine转化成脱磷酸辅酶A（dpCoA）。在这种基因突变与脑铁累积的（NBIA）神经变性有关。选择性剪接的结果在多个同种型。 [由RefSeq的，2014年4月提供]

OMIM数据库中对COASY基因的介绍     Wikipedia数据库中对COASY基因的介绍

基因序列

基因序列

COASY基因的碱基序列：[NCBI]

基因突变

基因突变

COASY基因的碱基突变：           显示全部snp
rs598126       rs615942       rs621141       rs629861       rs666039       rs668799       rs2301132       rs2855484       rs3752386       rs7219522       rs9903960       rs12945575       rs16967862       rs34135057       rs57815547       rs62075858       rs71377286       rs74629432       rs74886553       rs76169050       rs77883531       rs111289205       rs111659616       rs111683625       rs112168204       rs112423989       rs113352767       rs113657484       rs113816549       rs113930535       rs114030171       rs114439049       rs115390312       rs115817227       rs115827449       rs117419466       rs117980685      
rs137943833       rs138037463       rs139263701       rs139742477       rs140423595       rs140709867       rs140982382       rs141320026       rs141350621       rs141500308       rs141668781       rs141831105       rs142297801       rs142799649       rs143127062       rs143827517       rs143964295       rs144328390       rs144615655       rs144898188       rs145108650       rs145141640       rs145251799       rs145315110       rs145349142       rs145519299       rs145552423       rs145723983       rs145954924       rs146190184       rs146857074       rs147052952       rs147852474       rs147880619       rs148132220       rs148652390       rs149098118       rs149475124       rs149996795       rs150045759       rs150098326       rs150148070       rs150292156       rs151074271       rs151238347       rs180969454       rs181270578       rs181738088       rs181852718       rs182761324       rs183263493       rs184601988       rs184629852       rs185194604       rs185235382       rs186047488       rs186481084       rs186631005       rs186871565       rs188130770       rs188473326       rs188790503       rs189242970       rs189750610       rs190585567       rs191068578       rs191362307       rs191530176       rs191831643       rs192571848       rs199623481       rs199787345       rs199822609       rs199842317       rs199952439       rs199953631       rs200009135       rs200084076       rs200491699       rs200561549       rs200710685       rs200715008       rs200849974       rs200879332       rs200908147       rs200916991       rs201244211       rs201301832       rs201346715       rs201430313       rs201479820       rs201571427       rs201600053       rs201779417       rs201819803       rs201949834       rs202081974       rs202162428       rs367865615       rs368104356       rs368119926       rs368413834       rs368532520       rs368716842       rs368766159       rs368875340       rs368976372       rs369027722       rs369371425       rs370095840       rs370287461       rs370378776       rs370580318       rs370751417       rs370765119       rs370902320       rs371155752       rs371212299       rs371437268       rs371486284       rs371637855       rs371871675       rs371994704       rs372050877       rs372184601       rs372241324       rs372394606       rs372563296       rs372738661       rs372825682       rs373087412       rs373422876       rs373822601       rs373894044       rs373975726       rs373985260       rs373992537       rs374017503       rs374081233       rs374206406       rs374429855       rs374448845       rs374709763       rs374725383       rs374924508       rs374954180       rs375069596       rs375318918       rs375422516       rs375555007       rs375703381       rs375799916       rs375845459       rs375859066       rs376040856       rs376318601       rs376373074       rs376607081       rs376677692       rs376690899       rs376935671       rs377161549       rs377301164       rs377332971       rs377630195       rs528235676       rs528361272       rs528587865       rs528627809       rs528640437       rs529363251       rs529809353       rs529809660       rs529996015       rs530335241       rs530895861       rs531459470       rs532233851       rs534242449       rs535796292       rs536494048       rs536495098       rs536569335       rs537375735       rs537541340       rs537900212       rs538122894       rs538291194       rs538352082       rs538766507       rs540738540       rs541071987       rs541507808       rs541920949       rs542862216       rs543482512       rs544190054       rs544357049       rs544472330       rs545238488       rs545304443       rs545720982       rs545863395       rs547215924       rs547423828       rs547608928       rs547644095       rs548467363       rs548663586       rs548699190       rs548997873       rs549792395       rs549852864       rs550992012       rs550996329       rs551629036       rs552156827       rs552448757       rs552709476       rs553028103       rs553664611       rs553812373       rs553970054       rs554730930       rs554919057       rs555133764       rs555169563       rs555759624       rs556130042       rs556712407       rs558207258       rs558701508       rs558884002       rs559380691       rs560703312       rs560957373       rs560987504       rs561196674       rs561315972       rs561534535       rs561601439       rs561931249       rs563192501       rs563516420       rs563924473       rs563959731       rs564620226       rs564917146       rs565751461       rs566267770       rs568769350       rs569226075       rs569578413       rs569894519       rs570094654       rs571030856       rs571068316       rs571280036       rs571442410       rs571625859       rs572433547       rs572515727       rs572640144       rs573242618       rs573275485       rs573884678       rs573922615       rs574491277       rs575280023       rs576943976       rs577650192       rs577714887       rs577860019       rs745310397       rs745340641       rs745397408       rs745576360       rs745605140       rs745689131       rs745865351       rs745893855       rs745907150       rs745969255       rs746142018       rs746152052       rs746159558       rs746252959       rs746412403       rs746456954       rs746849574       rs746962904       rs747033277       rs747242800       rs747329874       rs747362210       rs747378550       rs747489929       rs747577673       rs747579820       rs747643104       rs747782882       rs747872751       rs747905818       rs747923685       rs747994159       rs748072653       rs748123529       rs748194668       rs748263334       rs748463979       rs748492085       rs748736278       rs748740886       rs748862854       rs748907041       rs749009471       rs749028245       rs749098593       rs749174098       rs749205667       rs749242869       rs749293853       rs749348651       rs749449687       rs749588993       rs749835853       rs749842607       rs749914439       rs749946116       rs750083588       rs750189095       rs750412647       rs750537316       rs750696357       rs750805074       rs750848492       rs751039293       rs751069547       rs751101120       rs751333991       rs751353009       rs751580164       rs751663857       rs751668196       rs751688453       rs751753677       rs751893869       rs751957332       rs752004747       rs752152111       rs752163931       rs752236735       rs752294499       rs752442631       rs752454666       rs752707793       rs752792997       rs752819851       rs752833307       rs753140799       rs753302219       rs753365072       rs753374212       rs753558798       rs753779026       rs753921053       rs754010252       rs754159736       rs754225451       rs754255973       rs754433169       rs754589324       rs754591371       rs754778428       rs754871882       rs754912117       rs754940764       rs754950721       rs755132109       rs755151398       rs755259628       rs755354716       rs755438696       rs755445525       rs755520740       rs755619184       rs755790188       rs755884836       rs755891384       rs755926377       rs756088989       rs756141692       rs756298801       rs756436403       rs756476464       rs756566231       rs756650004       rs756847999       rs756864275       rs756922318       rs756932678       rs756940923       rs757167875       rs757217072       rs757257485       rs757277522       rs757436633       rs757515358       rs757650180       rs757747490       rs757765951       rs757786032       rs757811719       rs758124303       rs758261808       rs758262019       rs758280125       rs758518922       rs758542011       rs758562645       rs758786122       rs758932446       rs758938442       rs759055031       rs759078658       rs759106341       rs759365582       rs759493779       rs759494047       rs759581809       rs759611664       rs759781513       rs759826012       rs759827568       rs759913830       rs760131437       rs760194932       rs760282616       rs760320519       rs760336973       rs760399173       rs760441921       rs760495701       rs760626646       rs760751009       rs760922962       rs760947875       rs761146097       rs761347168       rs761370789       rs761439725       rs761594654       rs761859267       rs762035640       rs762115836       rs762190694       rs762198022       rs762483163       rs762483890       rs762503189       rs762573411       rs762699414       rs762780076       rs762858854       rs762997091       rs763015133       rs763077348       rs763154184       rs763314347       rs763334155       rs763336054       rs763384454       rs763420863       rs763492648       rs763581665       rs763611726       rs763727451       rs763770736       rs763993868       rs764214751       rs764233489       rs764492939       rs764495695       rs764627382       rs764722100       rs764726258       rs764809468       rs764866507       rs764897395       rs765029731       rs765118088       rs765269018       rs765332663       rs765361096       rs765396519       rs765531925       rs765636733       rs765768374       rs766034518       rs766063561       rs766170889       rs766174617       rs766260913       rs766439658       rs766448525       rs766450381       rs766451940       rs766482965       rs766549127       rs766617792       rs766896511       rs766909925       rs766977029       rs767151837       rs767160210       rs767178238       rs767186759       rs767187311       rs767405706       rs767587064       rs767660167       rs767662264       rs767698305       rs767753702       rs767753813       rs768013364       rs768102908       rs768104219       rs768136304       rs768349924       rs768379291       rs768391053       rs768480206       rs768824427       rs768897320       rs768990950       rs769005486       rs769068183       rs769114710       rs769118653       rs769141286       rs769149059       rs769241823       rs769272758       rs769330035       rs769360620       rs769397082       rs769511957       rs769644844       rs769804661       rs769818125       rs770033307       rs770126185       rs770142620       rs770235902       rs770274030       rs770294084       rs770394938       rs770407833       rs770579099       rs770590463       rs770695550       rs770716821       rs770932751       rs770990218       rs771124897       rs771179370       rs771214991       rs771343272       rs771414302       rs771590313       rs771627280       rs771807432       rs771834837       rs771834923       rs771992634       rs772007071       rs772065240       rs772093704       rs772241005       rs772307596       rs772331281       rs772431211       rs772841300       rs772880365       rs773028683       rs773068932       rs773425303       rs773456001       rs773556974       rs773567120       rs773717759       rs773731771       rs773988511       rs774006531       rs774007203       rs774145309       rs774147266       rs774471218       rs774485077       rs774611804       rs774636354       rs774675557       rs774747274       rs774748328       rs774848837       rs775097561       rs775126015       rs775245472       rs775254407       rs775259112       rs775363623       rs775531979       rs775706381       rs775715779       rs775724445       rs775808304       rs775831311       rs775969544       rs776186874       rs776351815       rs776381740       rs776458551       rs776578070       rs776636915       rs776756268       rs776853967       rs776940502       rs776971972       rs776992474       rs777078367       rs777151965       rs777345692       rs777501191       rs777678251       rs777697945       rs777768099       rs777983479       rs778161660       rs778200719       rs778257471       rs778345551       rs778345611       rs778362075       rs778368610       rs778462315       rs778574486       rs778587218       rs778779430       rs778875945       rs779159494       rs779309874       rs779390522       rs779409128       rs779508470       rs779508936       rs779510974       rs779623012       rs779780364       rs779920645       rs779974186       rs779997818       rs780060015       rs780081141       rs780099544       rs780177247       rs780191999       rs780285484       rs780377091       rs780388244       rs780563335       rs780582354       rs780672020       rs780721537       rs780911195       rs781104723       rs781118243       rs781219437       rs781225303       rs781238220       rs781294581       rs781310247       rs781331668       rs781511200       rs781599851       rs781629360       rs781633012      

基因表达

基因表达

COASY基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCTGTTGAAGAGCAAGTTGC
59
TCCACCAGGAATTCACTCAG
60
TGTTGAAGAGCAAGTTGCTC
59
TGTCCACCAGGAATTCACTC
60
TCTGTTGAAGAGCAAGTTGC
59
TCCACCAGGAATTCACTCAG
60
GAGGTTTCACTTAGCAAGAGG
59
CTCTAAGCCTTGGTGTCCT
59
CATCAGAGGATCTGGGTGG
59
TCACAGATTCCCTTCTGGC
59
GAAGAGGACAAAGTCAGCT
57
CTCTGGCCTTTCATATGGAG
58
TAAGACGCATTGTGGAGAG
57
GATGAGTCTTGGGAATGCG
59
GCCTTGAGAATGACCTGGA
59
CCTCTTCATTCTCTGTATGTCTG
59
GCCTTGAGAATGACCTGGA
59
CCTCTTCATTCTCTGTATGTCTG
59
ATCAGAGGATCTGGGTGGT
60
TCACAGATTCCCTTCTGGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

COASY基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

COASY基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005654
K7EN91(UniProtKB)
IDA
GO:0005737
K7EN91(UniProtKB)
IDA
GO:0004140
K7EQ60(UniProtKB)
IEA
GO:0005524
K7EQ60(UniProtKB)
IEA
GO:0005654
K7EQ60(UniProtKB)
IDA
GO:0005737
K7EQ60(UniProtKB)
IDA
GO:0015937
K7EQ60(UniProtKB)
IEA
GO:0016310
K7EQ60(UniProtKB)
IEA
GO:0005654
K7ES73(UniProtKB)
IDA
GO:0005737
K7ES73(UniProtKB)
IDA
GO:0004140
Q13057(UniProtKB)
IDA
GO:0004140
Q13057(UniProtKB)
IDA
GO:0004140
Q13057(UniProtKB)
TAS
GO:0004595
Q13057(UniProtKB)
IDA
GO:0004595
Q13057(UniProtKB)
IDA
GO:0004595
Q13057(UniProtKB)
TAS
GO:0005515
Q13057(UniProtKB)
IPI
GO:0005515
Q13057(UniProtKB)
IPI
GO:0005515
Q13057(UniProtKB)
IPI
GO:0005524
Q13057(UniProtKB)
IEA
GO:0005654
Q13057(UniProtKB)
IDA
GO:0005737
Q13057(UniProtKB)
IDA
GO:0005741
Q13057(UniProtKB)
TAS
GO:0005741
Q13057(UniProtKB)
TAS
GO:0005759
Q13057(UniProtKB)
IDA
GO:0009108
Q13057(UniProtKB)
TAS
GO:0015937
Q13057(UniProtKB)
IEA
GO:0015937
Q13057(UniProtKB)
IDA
GO:0015937
Q13057(UniProtKB)
TAS
GO:0016310
Q13057(UniProtKB)
IEA
GO:0070062
Q13057(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控COASY基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 6 0.36 1 2 CLINVAR_ORPHANET_UNIPROT
Malignant neoplasm of breast 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Pseudohypoparathyroidism, Type Ia 0.001900093 7 0 BeFree
Pseudohypoparathyroidism 0.001357209 5 0 BeFree
Fibrous Dysplasia 0.001357209 5 0 BeFree
Neuroblastoma 0.000814326 3 0 BeFree
Pseudopseudohypoparathyroidism 0.000814326 3 0 BeFree
Central neuroblastoma 0.000814326 3 0 BeFree
Albright's hereditary osteodystrophy 0.000814326 3 0 BeFree
Uveal melanoma 0.000542884 2 0 BeFree
McCune-Albright Syndrome 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Neurodegeneration with brain iron accumulation (NBIA) 0.000542884 2 0 BeFree
Congenital adrenal hyperplasia 0.000271442 1 0 BeFree
Bone Diseases 0.000271442 1 0 BeFree
Malignant tumor of cervix 0.000271442 1 0 BeFree
Cystic Fibrosis 0.000271442 1 0 BeFree
Endocrine System Diseases 0.000271442 1 0 BeFree
Osteitis Fibrosa Disseminata 0.000271442 1 0 BeFree
Hypothyroidism 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Obesity 0.000271442 1 8 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pancreatic Cyst 0.000271442 1 0 BeFree
Pituitary Adenoma 0.000271442 1 0 BeFree
Precocious Puberty 0.000271442 1 0 BeFree
Vitamin D Deficiency 0.000271442 1 0 BeFree
Hyperphosphatemia (disorder) 0.000271442 1 0 BeFree
Thyroid Gland Follicular Adenoma 0.000271442 1 0 BeFree
Memory impairment 0.000271442 1 0 BeFree
Extrapyramidal sign 0.000271442 1 0 BeFree
Osteodystrophy 0.000271442 1 0 BeFree
Cancer of Head and Neck 0.000271442 1 0 BeFree
Cervix carcinoma 0.000271442 1 0 BeFree
Pseudohypoparathyroidism and pseudopseudohypoparathyroidism 0.000271442 1 0 BeFree
Adrenal hypertrophy or hyperplasia 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Pancreatic intraepithelial neoplasia 0.000271442 1 0 BeFree
Adrenal hyperplasia 0.000271442 1 0 BeFree

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