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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
[中文简述(自动翻译):]  该基因编码的酶的细胞色素P450超家族的成员。细胞色素P450蛋白是能催化涉及药物代谢和胆固醇,类固醇和其他脂类的合成许多反应单加氧酶。此蛋白质定位于内质网和已知代谢的常见的处方药多达25%。其底物包括抗抑郁药,抗精神病药,止痛剂和镇咳药,β肾上腺素受体阻断剂,antiarrythmics和止吐剂。该基因是在人类群体高度多态性;某些等位基因导致代谢表型较差,其特点是代谢酶的底物能力下降。与代谢表型可怜有些人没有功能性蛋白,因为他们携带2无效等位基因,而在其他人的基因是不存在的。这个基因可以在拷贝数和个人用超速代谢表型变化可具有该基因的3个或更多活跃的副本。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的,2014年7月提供]
CYP2D6基因(以及对应的蛋白质)的细胞分布位置:
CYP2D6基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Parkinson Disease | 0.160044047 | 24 | 0 | BeFree_CTD_human_GAD |
| Mammary Neoplasms | 0.151843371 | 14 | 0 | CTD_human_GAD_LHGDN |
| Alzheimer's Disease | 0.135916719 | 11 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Basal Ganglia Diseases | 0.134202192 | 7 | 0 | CTD_human_GAD |
| Major Depressive Disorder | 0.126905599 | 11 | 2 | BeFree_GAD_GWASCAT |
| Amphetamine-Related Disorders | 0.124734064 | 2 | 0 | CTD_human_GAD |
| Tonic-Clonic Epilepsy | 0.122367032 | 1 | 0 | CTD_human_GAD |
| Substance-Related Disorders | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Bradycardia | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Manganese Poisoning | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Comatose | 0.12 | 1 | 0 | CTD_human |
| Dystonia | 0.12 | 1 | 0 | CTD_human |
| Muscle Rigidity | 0.12 | 1 | 0 | CTD_human |
| Nephritis, Interstitial | 0.12 | 1 | 0 | CTD_human |
| Occupational Diseases | 0.12 | 1 | 0 | CTD_human |
| Prenatal Exposure Delayed Effects | 0.12 | 1 | 0 | CTD_human |
| Psychosexual Disorders | 0.12 | 2 | 0 | CTD_human |
| Tremor | 0.12 | 1 | 0 | CTD_human |
| Adverse reaction to drug | 0.12 | 1 | 0 | CTD_human |
| Weight Gain | 0.12 | 1 | 0 | CTD_human |
| Drug Metabolism, Poor, CYP2D6-Related | 0.12 | 0 | 0 | CTD_human |
| Acute kidney injury | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of breast | 0.087796748 | 99 | 0 | BeFree_GAD |
| Cognition Disorders | 0.08 | 1 | 0 | CTD_rat |
| Schizophrenia | 0.051440724 | 40 | 2 | BeFree_GAD_LHGDN |
| Malignant neoplasm of lung | 0.02680807 | 36 | 1 | BeFree_GAD |
| Breast Carcinoma | 0.023886885 | 88 | 0 | BeFree |
| Hypertensive disease | 0.017383549 | 8 | 0 | BeFree_GAD |
| Dyskinesia, Drug-Induced | 0.016569224 | 7 | 0 | GAD |
| Colorectal Cancer | 0.016569224 | 7 | 0 | GAD |
| Malignant neoplasm of urinary bladder | 0.013735253 | 11 | 0 | BeFree_GAD |
| Mental Depression | 0.012996872 | 16 | 0 | BeFree_GAD |
| Hepatitis, Autoimmune | 0.012787563 | 18 | 0 | BeFree_LHGDN |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.012649486 | 7 | 0 | BeFree_GAD |
| Lingual-Facial-Buccal Dyskinesia | 0.012529933 | 20 | 4 | BeFree_GAD |
| Tardive Dyskinesia | 0.012529933 | 20 | 4 | BeFree_GAD |
| Animal Mammary Neoplasms | 0.01183516 | 5 | 0 | GAD |
| Cancer of Head and Neck | 0.010825337 | 8 | 0 | BeFree_GAD |
| Liver diseases | 0.010553895 | 7 | 0 | BeFree_GAD |
| Hepatitis C, Chronic | 0.010258709 | 10 | 0 | BeFree_GAD_LHGDN |
| Cardiovascular Diseases | 0.010011012 | 4 | 0 | BeFree_GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.010011012 | 6 | 0 | BeFree_GAD |
| HIV Infections | 0.00973957 | 5 | 0 | BeFree_GAD |
| Squamous cell carcinoma | 0.009272631 | 10 | 0 | BeFree_GAD |
| Lichen Planus, Oral | 0.008186863 | 4 | 0 | BeFree_GAD |
| Carcinoma of lung | 0.007871814 | 29 | 1 | BeFree |
| Neuroleptic Malignant Syndrome | 0.007805801 | 10 | 0 | BeFree_GAD_LHGDN |
| Multiple Chemical Sensitivity | 0.00764398 | 3 | 0 | BeFree_GAD |
| Rhinitis | 0.007458414 | 2 | 0 | GAD_LHGDN |
| Hypercholesterolemia | 0.007372538 | 4 | 0 | BeFree_GAD |
| Pain | 0.007372538 | 4 | 0 | BeFree_GAD |
| Arthritis | 0.007101096 | 3 | 0 | GAD |
| Atrial Fibrillation | 0.007101096 | 3 | 0 | GAD |
| Degenerative polyarthritis | 0.007101096 | 3 | 0 | GAD |
| Premature Birth | 0.007101096 | 3 | 0 | GAD |
| Nausea | 0.005819831 | 4 | 0 | BeFree_GAD |
| Postoperative Nausea and Vomiting | 0.005819831 | 4 | 0 | BeFree_GAD |
| leukemia | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
| Anemia, Sickle Cell | 0.00554839 | 3 | 0 | BeFree_GAD |
| Heart failure | 0.00554839 | 5 | 0 | BeFree_GAD |
| Leukemia, Myelocytic, Acute | 0.00554839 | 4 | 0 | BeFree_GAD |
| Lupus Erythematosus, Systemic | 0.00554839 | 3 | 0 | BeFree_GAD |
| Pain, Postoperative | 0.00554839 | 5 | 0 | BeFree_GAD |
| Hot flushes | 0.005352893 | 11 | 0 | BeFree_GAD |
| Systemic Scleroderma | 0.005276948 | 3 | 0 | BeFree_GAD |
| Infection | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Myopathy | 0.005005506 | 3 | 0 | BeFree_GAD |
| Malignant neoplasm of liver | 0.005005506 | 3 | 0 | BeFree_GAD |
| Adenoma | 0.004734064 | 2 | 0 | GAD |
| Asthma | 0.004734064 | 2 | 0 | GAD |
| Blood Coagulation Disorders | 0.004734064 | 2 | 0 | GAD |
| Chromosome Aberrations | 0.004734064 | 2 | 0 | GAD |
| Inflammation | 0.004734064 | 2 | 0 | GAD |
| Myeloid Leukemia | 0.004734064 | 2 | 0 | GAD |
| Chronic Obstructive Airway Disease | 0.004734064 | 2 | 0 | GAD |
| Opioid-Related Disorders | 0.004734064 | 2 | 0 | GAD |
| Stomach Neoplasms | 0.004734064 | 2 | 0 | GAD |
| Helicobacter pylori infection | 0.004734064 | 2 | 0 | GAD |
| Parkinsonian Disorders | 0.004538567 | 8 | 0 | BeFree_GAD |
| Hepatitis C | 0.004353001 | 6 | 0 | BeFree_LHGDN |
| Dementia | 0.00408156 | 6 | 0 | BeFree_LHGDN |
| Depressive disorder | 0.003528744 | 13 | 0 | BeFree |
| Liver Cirrhosis | 0.003452799 | 4 | 0 | BeFree_GAD |
| Malignant neoplasm of prostate | 0.003452799 | 5 | 0 | BeFree_GAD |
| Attention deficit hyperactivity disorder | 0.003452799 | 5 | 0 | BeFree_GAD |
| Dyskinetic syndrome | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Torsades de Pointes | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Absence of pain sensation | 0.003257302 | 12 | 1 | BeFree |
| Ankylosing spondylitis | 0.003181358 | 4 | 0 | BeFree_GAD |
| Vomiting | 0.003181358 | 3 | 0 | BeFree_GAD |
| Cervix carcinoma | 0.003181358 | 3 | 0 | BeFree_GAD |
| Mental disorders | 0.002909916 | 3 | 0 | BeFree_GAD |
| Inflammatory Bowel Diseases | 0.002909916 | 2 | 0 | BeFree_GAD |
| Myeloid Leukemia, Chronic | 0.002909916 | 2 | 0 | BeFree_GAD |
| Multiple Sclerosis | 0.002909916 | 3 | 0 | BeFree_GAD |
| Pituitary Neoplasms | 0.002909916 | 2 | 0 | BeFree_GAD |
| Multiple System Atrophy | 0.002909916 | 3 | 0 | BeFree_GAD |
| Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
| Diabetes Mellitus, Insulin-Dependent | 0.00272435 | 1 | 0 | LHGDN |
| Hepatitis, Chronic | 0.00272435 | 1 | 0 | LHGDN |
| Autistic Disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
| Hyperlipidemia | 0.002638474 | 2 | 0 | BeFree_GAD |
| melanoma | 0.002638474 | 1 | 0 | BeFree_GAD |
| Multiple Myeloma | 0.002638474 | 1 | 0 | BeFree_GAD |
| Personality Disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
| Disorders of Porphyrin Metabolism | 0.002638474 | 1 | 0 | BeFree_GAD |
| Psychophysiologic Disorders | 0.002638474 | 1 | 0 | BeFree_GAD |
| Seizures | 0.002638474 | 2 | 0 | BeFree_GAD |
| Extrapyramidal sign | 0.002442977 | 9 | 0 | BeFree |
| Spontaneous abortion | 0.002367032 | 1 | 0 | GAD |
| Papillary adenocarcinoma | 0.002367032 | 1 | 0 | GAD |
| Agranulocytosis | 0.002367032 | 1 | 0 | GAD |
| Apnea | 0.002367032 | 1 | 0 | GAD |
| Cardiac Arrhythmia | 0.002367032 | 1 | 0 | GAD |
| As If Personality | 0.002367032 | 1 | 0 | GAD |
| Brain Diseases, Metabolic | 0.002367032 | 1 | 0 | GAD |
| Basal cell carcinoma | 0.002367032 | 1 | 0 | GAD |
| Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
| Drug Allergy | 0.002367032 | 1 | 0 | GAD |
| Patent ductus arteriosus | 0.002367032 | 1 | 1 | GAD |
| Dysmenorrhea | 0.002367032 | 1 | 0 | GAD |
| Fatigue | 0.002367032 | 1 | 0 | GAD |
| Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
| Fetal Growth Retardation | 0.002367032 | 1 | 0 | GAD |
| Gastrointestinal Diseases | 0.002367032 | 1 | 0 | GAD |
| Gastrointestinal Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Glaucoma | 0.002367032 | 1 | 0 | GAD |
| Glaucoma, Open-Angle | 0.002367032 | 1 | 0 | GAD |
| Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Heroin Dependence | 0.002367032 | 1 | 0 | GAD |
| Disorders of Excessive Somnolence | 0.002367032 | 1 | 0 | GAD |
| Hypoglycemia | 0.002367032 | 1 | 0 | GAD |
| Hyponatremia | 0.002367032 | 1 | 0 | GAD |
| Kidney Diseases | 0.002367032 | 1 | 0 | GAD |
| Laryngeal neoplasm | 0.002367032 | 1 | 0 | GAD |
| Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 0 | GAD |
| Low Back Pain | 0.002367032 | 1 | 0 | GAD |
| Mouth Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Ocular Hypertension | 0.002367032 | 1 | 0 | GAD |
| Polycystic Ovary Syndrome | 0.002367032 | 1 | 0 | GAD |
| Postoperative Complications | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Pregnancy Complications | 0.002367032 | 1 | 0 | GAD |
| Pregnancy Complications, Cardiovascular | 0.002367032 | 1 | 0 | GAD |
| Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
| Respiratory Tract Infections | 0.002367032 | 1 | 0 | GAD |
| Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
| Skin Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Gastric ulcer | 0.002367032 | 1 | 0 | GAD |
| Substance Withdrawal Syndrome | 0.002367032 | 1 | 0 | GAD |
| Tachycardia | 0.002367032 | 1 | 0 | GAD |
| Thyroid Neoplasm | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Tuberculosis, Pulmonary | 0.002367032 | 1 | 0 | GAD |
| Urticaria | 0.002367032 | 1 | 0 | GAD |
| Xerostomia | 0.002367032 | 1 | 0 | GAD |
| T-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| Agitation | 0.002367032 | 1 | 0 | GAD |
| Deep Vein Thrombosis | 0.002367032 | 1 | 0 | GAD |
| Premature ventricular contractions | 0.002367032 | 1 | 0 | GAD |
| Gastroparesis | 0.002367032 | 1 | 0 | GAD |
| Depression, Postpartum | 0.002367032 | 1 | 0 | GAD |
| Alcohol-Related Disorders | 0.002367032 | 1 | 0 | GAD |
| Age related macular degeneration | 0.002367032 | 1 | 0 | GAD |
| Scleroderma, Limited | 0.002367032 | 1 | 0 | GAD |
| Drug-Induced Liver Injury | 0.002367032 | 1 | 0 | GAD |
| Diffuse Scleroderma | 0.002367032 | 1 | 0 | GAD |
| Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
| Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
| Coronary Artery Disease | 0.002367032 | 1 | 0 | GAD |
| Tachycardia by ECG Finding | 0.002367032 | 1 | 0 | GAD |
| Psychomotor Agitation | 0.002367032 | 1 | 0 | GAD |
| Unipolar Depression | 0.002171535 | 8 | 0 | BeFree |
| Carcinoma of bladder | 0.001900093 | 7 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.001628651 | 6 | 3 | BeFree |
| Lewy Body Disease | 0.001628651 | 6 | 0 | BeFree |
| Anxiety Disorders | 0.001357209 | 5 | 0 | BeFree |
| Presenile dementia | 0.001357209 | 5 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
| Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
| Epilepsy | 0.001085767 | 4 | 0 | BeFree |
| Movement Disorders | 0.001085767 | 4 | 0 | BeFree |
| Acute leukemia | 0.001085767 | 4 | 0 | BeFree |
| Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Cirrhosis | 0.001085767 | 4 | 0 | BeFree |
| Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
| CNS disorder | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of cervix | 0.000814326 | 3 | 0 | BeFree |
| Drug abuse | 0.000814326 | 3 | 0 | BeFree |
| Congestive heart failure | 0.000814326 | 3 | 0 | BeFree |
| Kidney Failure, Chronic | 0.000814326 | 3 | 0 | BeFree |
| Psychotic Disorders | 0.000814326 | 3 | 0 | BeFree |
| Kidney Failure | 0.000814326 | 3 | 0 | BeFree |
| Essential Hypertension | 0.000814326 | 3 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Myocardial Ischemia | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000814326 | 3 | 0 | BeFree |
| Nonorganic psychosis | 0.000814326 | 3 | 0 | BeFree |
| Abnormal involuntary movement | 0.000814326 | 3 | 1 | BeFree |
| Sleep Apnea, Obstructive | 0.000814326 | 3 | 0 | BeFree |
| Invasive breast carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
| Cervical high grade squamous intraepithelial lesion | 0.000814326 | 3 | 0 | BeFree |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Early-Stage Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of larynx | 0.000542884 | 2 | 0 | BeFree |
| Bronchogenic Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Clubbed Fingers | 0.000542884 | 2 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
| Heart Diseases | 0.000542884 | 2 | 0 | BeFree |
| Malignant Carcinoid Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Myoclonus | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Schizoaffective Disorder | 0.000542884 | 2 | 0 | BeFree |
| Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
| Depressive Symptoms | 0.000542884 | 2 | 0 | BeFree |
| Clubbing | 0.000542884 | 2 | 0 | BeFree |
| Central nervous system depression (disorder) | 0.000542884 | 2 | 0 | BeFree |
| Glaucoma, Primary Open Angle | 0.000542884 | 2 | 1 | BeFree |
| Opiate Addiction | 0.000542884 | 2 | 0 | BeFree |
| Intraocular pressure disorder | 0.000542884 | 2 | 0 | BeFree |
| Chemical Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Psychotic symptom | 0.000542884 | 2 | 0 | BeFree |
| Enzyme inhibition disorder | 0.000542884 | 2 | 0 | BeFree |
| Cardiomyopathies | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Renal Insufficiency | 0.000542884 | 2 | 0 | BeFree |
| Chronic kidney disease stage 5 | 0.000542884 | 2 | 0 | BeFree |
| Acquired Immunodeficiency Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Aplastic Anemia | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Basal Cell Nevus Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Cholestasis | 0.000271442 | 1 | 0 | BeFree |
| Colonic Diseases | 0.000271442 | 1 | 0 | BeFree |
| Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Diarrhea | 0.000271442 | 1 | 0 | BeFree |
| Disruptive Behavior Disorder | 0.000271442 | 1 | 0 | BeFree |
| Eating Disorders | 0.000271442 | 1 | 0 | BeFree |
| Exanthema | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Single major depressive episode | 0.000271442 | 1 | 3 | BeFree |
| Primary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
| Obsessive-Compulsive Disorder | 0.000271442 | 1 | 0 | BeFree |
| Oligospermia | 0.000271442 | 1 | 0 | BeFree |
| Osteochondritis Dissecans | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Shy-Drager Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Violence | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilia-Myalgia Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Neurofibrillary degeneration (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
| Polydipsia | 0.000271442 | 1 | 0 | BeFree |
| Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
| Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
| Acute onset pain | 0.000271442 | 1 | 0 | BeFree |
| Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Chronic schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Small Cell | 0.000271442 | 1 | 0 | BeFree |
| Chronic heart failure | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer, Familial | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of vulva | 0.000271442 | 1 | 0 | BeFree |
| Amelogenesis Imperfecta, Type IB | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune liver disease | 0.000271442 | 1 | 0 | BeFree |
| Social fear | 0.000271442 | 1 | 0 | BeFree |
| Tonic - clonic seizures | 0.000271442 | 1 | 0 | BeFree |
| Chronic active hepatitis | 0.000271442 | 1 | 0 | BeFree |
| Vomiting, Postoperative | 0.000271442 | 1 | 0 | BeFree |
| Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| Pseudoparkinsonism | 0.000271442 | 1 | 0 | BeFree |
| Cancer pain | 0.000271442 | 1 | 0 | BeFree |
| Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
| CARCINOMA OF VULVA | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| psychiatric hospitalization | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia and related disorders | 0.000271442 | 1 | 1 | BeFree |
| Spots on skin | 0.000271442 | 1 | 0 | BeFree |
| Smoker's lung | 0.000271442 | 1 | 0 | BeFree |
| Advanced cancer | 0.000271442 | 1 | 0 | BeFree |
| Hypersomnia | 0.000271442 | 1 | 0 | BeFree |
| Hepatic impairment | 0.000271442 | 1 | 0 | BeFree |
| Heart Failure, Systolic | 0.000271442 | 1 | 0 | BeFree |
| Congenital long QT syndrome | 0.000271442 | 1 | 0 | BeFree |
| Abnormal breathing | 0.000271442 | 1 | 0 | BeFree |
| Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
| Low Grade Cervical Squamous Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Progesterone receptor positive tumor | 0.000271442 | 1 | 2 | BeFree |
| Hormone receptor positive tumor | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| Slow acetylator due to N-acetyltransferase enzyme variant | 0.000271442 | 1 | 0 | BeFree |
| Wilms Tumor 4 | 0.000271442 | 1 | 0 | BeFree |
| Mammographic Density | 0.000271442 | 1 | 0 | BeFree |
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