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Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  细胞色素b(-245)是由色素bα(CYBA)和β(CYBB)链。已经提出作为吞噬细胞的杀微生物氧化酶系统的主要成分。 CYBB缺乏是慢性肉芽肿病(CGD)相关的5所描述的生化缺陷之一。在这种疾病,有吞噬细胞NADPH氧化酶的活性下降;嗜中性粒细胞能吞噬细菌,但在吞噬泡不能杀死他们。杀害缺陷的原因是没有能力以增加细胞的呼吸和随之而来的未交付活化氧气进入吞噬液泡。 [由RefSeq的,2008年7月提供]
CYBB基因(以及对应的蛋白质)的细胞分布位置:
CYBB基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Granulomatous Disease, Chronic, X-Linked | 0.44 | 15 | 61 | CLINVAR_CTD_human_MGD_UNIPROT |
Atypical Mycobacteriosis, Familial, X-Linked 2 | 0.36 | 1 | 2 | CLINVAR_ORPHANET_UNIPROT |
Chronic granulomatous disease | 0.287942979 | 112 | 0 | BeFree_CTD_human_GAD_LHGDN_ORPHANET |
Hypertensive disease | 0.200814326 | 6 | 0 | BeFree_CTD_human_RGD |
Diabetes Mellitus, Experimental | 0.2 | 3 | 0 | CTD_human_RGD |
Kidney Failure, Chronic | 0.2 | 2 | 0 | CTD_human_RGD |
Reperfusion Injury | 0.2 | 2 | 0 | CTD_human_RGD |
Diabetes Mellitus | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Heart failure | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Kidney Diseases | 0.120271442 | 2 | 0 | BeFree_CTD_human |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Myocardial Reperfusion Injury | 0.12 | 1 | 0 | CTD_human |
Proteinuria | 0.12 | 1 | 0 | CTD_human |
Brain Infarction | 0.12 | 1 | 0 | CTD_human |
Subarachnoid Hemorrhage | 0.080271442 | 2 | 0 | BeFree_RGD |
Hyperaldosteronism | 0.08 | 1 | 0 | RGD |
Myocardial Infarction | 0.08 | 1 | 0 | RGD |
HIV Infections | 0.002909916 | 3 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
Ectodermal Dysplasia | 0.00272435 | 1 | 0 | LHGDN |
Malaria, Falciparum | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
Primary immune deficiency disorder | 0.001900093 | 7 | 0 | BeFree |
Arthritis | 0.001085767 | 4 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000814326 | 3 | 0 | BeFree |
Atherosclerosis | 0.000814326 | 3 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia | 0.000814326 | 3 | 0 | BeFree |
Mycoses | 0.000814326 | 3 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000814326 | 3 | 0 | BeFree |
Endothelial dysfunction | 0.000814326 | 3 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Hyperglycemia | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Malaria | 0.000542884 | 2 | 0 | BeFree |
Mycobacterium Infections | 0.000542884 | 2 | 0 | BeFree |
Pneumonia | 0.000542884 | 2 | 0 | BeFree |
Tuberculosis | 0.000542884 | 2 | 0 | BeFree |
Human anaplasmosis due to Anaplasma phagocytophilum | 0.000542884 | 2 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | 0.000542884 | 2 | 0 | BeFree |
Agranulocytosis | 0.000271442 | 1 | 0 | BeFree |
Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
Bloom Syndrome | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Creutzfeldt-Jakob disease | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Meningitis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Opportunistic Infections | 0.000271442 | 1 | 0 | BeFree |
Retinal Diseases | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Septicemia | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Tachycardia | 0.000271442 | 1 | 0 | BeFree |
Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
Prion Diseases | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
invasive aspergillosis | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Pelvic Inflammatory Disease | 0.000271442 | 1 | 0 | BeFree |
Dyslipidemias | 0.000271442 | 1 | 0 | BeFree |
Sepsis | 0.000271442 | 1 | 0 | BeFree |
Chronic granulomatous disease, type II | 0.000271442 | 1 | 0 | BeFree |
Rhinovirus infection | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Hyper-IgM Immunodeficiency Syndrome, Type 1 | 0.000271442 | 1 | 0 | BeFree |
X-Linked Lymphoproliferative Disorder | 0.000271442 | 1 | 0 | BeFree |
Hyperhomocysteinemia | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Terminal illness | 0.000271442 | 1 | 0 | BeFree |
Thrombocytosis | 0.000271442 | 1 | 0 | BeFree |
Infectious disease of lung | 0.000271442 | 1 | 0 | BeFree |
Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
Transfusion related acute lung injury | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Experimental | 0.000271442 | 1 | 0 | BeFree |
Cardiac fibrosis | 0.000271442 | 1 | 0 | BeFree |
Ectodermal dysplasia, hypohidrotic, with immune deficiency | 0.000271442 | 1 | 0 | BeFree |
AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
ZAP70 deficiency | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Homocysteinemia | 0.000271442 | 1 | 0 | BeFree |
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