CSTA(cystatin A (stefin A)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

3q21
基因染色体位置图

基因简述

基因简述

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  半胱氨酸蛋白酶抑制剂家族包括含有多种蛋白酶抑制剂类序列的蛋白质。一些成员是活性半胱氨酸蛋白酶抑制剂，而另一些人已经失去或也许从未获得这种抑制活性。有三个抑制家庭的家族，包括1型半胱氨酸蛋白酶抑制剂（stefins），2型半胱氨酸蛋白酶抑制剂和激肽原。该基因编码一个胱抑蛋白，其功能作为半胱氨酸蛋白酶抑制剂，形成用木瓜蛋白酶和组织蛋白酶B，H，和L蛋白是角质细胞包膜的角质形成细胞中的前体蛋白中的一个紧配合，并在表皮发展中起着一定的作用，并保养。 Stefins已被提议作为用于癌症预后和诊断工具。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CSTA基因的介绍     Wikipedia数据库中对CSTA基因的介绍

基因序列

基因序列

CSTA基因的碱基序列：[NCBI]

基因突变

基因突变

CSTA基因的碱基突变：           显示全部snp
rs17589       rs2332182       rs2332183       rs2877603       rs3792292       rs4380359       rs4443111       rs4678182       rs4678183       rs4678184       rs4678185       rs6438722       rs6762112       rs6801854       rs6807958       rs7373784       rs7628094       rs7631500       rs7648977       rs9289190       rs9289191       rs9784373       rs9811343       rs9811434       rs9814414       rs9817571       rs9823459       rs9823509       rs9825704       rs9831039       rs9832098       rs9839253       rs9842752       rs9847850       rs9864079       rs9880915       rs9881125      
rs10575257       rs11301827       rs11338611       rs11717203       rs12490040       rs12491981       rs12632654       rs12632735       rs12637428       rs13084032       rs17265703       rs17838788       rs34021626       rs34145621       rs34173813       rs34336119       rs34569363       rs34830005       rs35221036       rs35225251       rs35350263       rs35835531       rs35968958       rs55784797       rs55998334       rs56024300       rs56050926       rs56085624       rs56098325       rs56139997       rs58030037       rs58446448       rs59503001       rs59568582       rs60876354       rs62269138       rs62269140       rs62269141       rs71136564       rs71136565       rs71329268       rs71632695       rs72378481       rs72481286       rs72971295       rs72971298       rs72972703       rs72972705       rs73186057       rs73186059       rs73186060       rs73855749       rs73855767       rs74575004       rs74872011       rs75498128       rs75762356       rs75932939       rs76856102       rs77020227       rs77208758       rs77382134       rs78032804       rs78491174       rs79265784       rs79405450       rs79424361       rs79520351       rs80117785       rs80273009       rs111300953       rs111585996       rs111666574       rs111765901       rs111928357       rs112527366       rs112596751       rs112658592       rs112779893       rs112983192       rs112987743       rs112999617       rs113032079       rs113057153       rs113677853       rs113792930       rs113987863       rs114027054       rs114296463       rs114476290       rs115960425       rs116067387       rs116526194       rs116611810       rs116839596       rs116850235       rs138162860       rs138167942       rs138213343       rs138225569       rs138353846       rs138589007       rs138813522       rs138860031       rs139473443       rs139493213       rs139493434       rs139513131       rs139944862       rs140093539       rs140227379       rs140350012       rs140492651       rs140744162       rs141271358       rs141557618       rs141830517       rs141934329       rs142032585       rs142047389       rs142056307       rs142162591       rs142245519       rs142863324       rs142873112       rs143090482       rs143194624       rs143215147       rs143317355       rs143417981       rs143837513       rs144114610       rs144160837       rs144380828       rs144701843       rs144802947       rs145175477       rs145623937       rs145652763       rs145707272       rs146347519       rs146375625       rs146510719       rs146654971       rs146775614       rs146872511       rs146973047       rs147345422       rs147583442       rs147616144       rs147743547       rs147774049       rs147791928       rs148282344       rs148356877       rs148458958       rs148523573       rs148651219       rs148804607       rs148912972       rs149167485       rs149431851       rs149474339       rs149631317       rs149675464       rs149692729       rs150148756       rs150205927       rs150923706       rs180845476       rs180846490       rs181008707       rs181438044       rs181635674       rs181705095       rs181972409       rs182043186       rs182129003       rs182314362       rs182404895       rs182735423       rs183170987       rs183353951       rs183367958       rs183664060       rs183822760       rs184127583       rs184195805       rs184505365       rs184654787       rs184660147       rs184975759       rs185045499       rs185411936       rs185608158       rs186118272       rs186324959       rs186679870       rs186860698       rs186992319       rs187135491       rs187154953       rs187293765       rs187796734       rs187898815       rs187940701       rs188100853       rs188364812       rs188367275       rs188709353       rs188719591       rs189031638       rs189163759       rs189308724       rs189365164       rs189635632       rs190245631       rs190567948       rs190750582       rs190788005       rs190975412       rs191055978       rs191208286       rs191381325       rs191500425       rs191532026       rs191627016       rs191678963       rs191813106       rs191844615       rs192062598       rs192499649       rs192854813       rs193265592       rs200394711       rs200855788       rs201521132       rs201579531       rs367649200       rs367720700       rs367941220       rs368962976       rs369153947       rs370013210       rs370025416       rs370121674       rs370210949       rs370215343       rs370439004       rs370837839       rs370949692       rs370979915       rs372265005       rs372447631       rs372477875       rs374232225       rs374525010       rs375535991       rs376048701       rs376628255       rs397812462       rs397990964       rs398122804       rs527499692       rs527785360       rs527814561       rs528166567       rs528203320       rs528219879       rs528547895       rs528599734       rs528878097       rs529065996       rs529236999       rs529350207       rs529772373       rs530339758       rs530409801       rs530670772       rs530678122       rs530921993       rs531377891       rs531617978       rs531633905       rs531797749       rs531959605       rs531993121       rs532078954       rs532154367       rs532200832       rs532766786       rs532827750       rs532882806       rs533066542       rs533258518       rs533276740       rs533290524       rs533456002       rs533864331       rs534111971       rs534349349       rs534393086       rs534751699       rs535174136       rs535222256       rs535230569       rs535453168       rs535661019       rs536006833       rs536042414       rs536536174       rs536651774       rs536856364       rs536872970       rs537663101       rs537673884       rs537849354       rs537946742       rs537947162       rs538136738       rs538449347       rs538458490       rs538736297       rs538792060       rs539035597       rs539327182       rs539366984       rs539535325       rs539735790       rs540036185       rs540183122       rs540202598       rs540239776       rs540362707       rs540510492       rs540781801       rs541191163       rs541259054       rs541302761       rs541863422       rs541990085       rs541999221       rs542088994       rs542098155       rs542257030       rs542375811       rs542381389       rs542807852       rs543122727       rs543222874       rs543421626       rs543464442       rs543573538       rs543610574       rs543810807       rs543917986       rs544096165       rs544203760       rs544614483       rs544690559       rs544755079       rs544898345       rs544963242       rs545165852       rs546052102       rs546093253       rs546353068       rs546503848       rs547044690       rs547210960       rs547339990       rs547418621       rs547427925       rs547622892       rs547882614       rs548291456       rs548334544       rs548358907       rs548519709       rs548522123       rs548569456       rs548579586       rs549330419       rs549437798       rs549557658       rs549793726       rs550031845       rs550117746       rs550231828       rs551879535       rs552312237       rs552586100       rs552778865       rs552795900       rs553017329       rs553248659       rs553362917       rs553430540       rs553526616       rs553764561       rs553834864       rs553932220       rs554222728       rs554408128       rs554593657       rs555058398       rs555531078       rs555565952       rs555709133       rs556332308       rs556508802       rs556729585       rs557651961       rs557966881       rs557978928       rs558289427       rs558483342       rs558637756       rs558662163       rs558678087       rs558922177       rs559114936       rs559240526       rs559246936       rs559909731       rs560151686       rs560187847       rs560314828       rs560631144       rs560663976       rs560698918       rs560699021       rs560965426       rs561225261       rs561443248       rs561782087       rs561900025       rs562025830       rs562266160       rs562297410       rs562569216       rs562648961       rs562848173       rs562918125       rs563006169       rs563046614       rs563126653       rs563326387       rs563594804       rs563600402       rs563693959       rs563808796       rs564203375       rs564270049       rs564393531       rs564414213       rs564458414       rs564500097       rs564539873       rs564541036       rs564567356       rs564834417       rs564929222       rs565335812       rs566641690       rs566695838       rs566736792       rs567064967       rs567125181       rs567179085       rs567356749       rs567736704       rs567764798       rs567932638       rs568048208       rs568191028       rs568225282       rs568275548       rs569095425       rs569134187       rs569215400       rs569287379       rs569291751       rs569377469       rs569500818       rs569540626       rs569665751       rs569815483       rs569824042       rs570097192       rs570404970       rs570405906       rs570508893       rs570621252       rs570622749       rs571730046       rs571950145       rs572608077       rs572755023       rs572769406       rs573048637       rs573332745       rs573421490       rs573557087       rs573647138       rs573964028       rs574067298       rs574225231       rs574235997       rs574333022       rs574356041       rs574466795       rs574544158       rs574566950       rs574628388       rs574644941       rs574807669       rs575146237       rs575690040       rs575731658       rs575829963       rs576059974       rs576290430       rs576429946       rs576564762       rs576828146       rs576906201       rs577055027       rs577384907       rs577497215       rs577774795       rs577866950       rs577981583       rs578068766       rs745733445       rs745891102       rs745985845       rs747576020       rs747711488       rs748297643       rs748910192       rs749073370       rs749908410       rs750298101       rs750800626       rs750893671       rs750925495       rs751252387       rs751662705       rs751959904       rs752425270       rs753591809       rs754155330       rs754210414       rs754693010       rs754758735       rs755244709       rs755986906       rs756458171       rs756511737       rs757263704       rs757504082       rs757812744       rs757972170       rs758375986       rs759408126       rs760177794       rs760684347       rs761195411       rs761740296       rs762021397       rs763771366       rs765035453       rs765556652       rs766288534       rs766834413       rs766889243       rs766937535       rs767374454       rs767465407       rs768103464       rs769111681       rs769226460       rs769472802       rs770816722       rs770962641       rs771089341       rs771474179       rs772055067       rs772234225       rs772289123       rs774154472       rs774424437       rs774674645       rs775900491       rs776598709       rs776994947       rs777254078       rs778366890       rs778571657       rs779737918       rs779750732       rs779978441       rs780376749       rs781345981       rs781428487       rs781484512       rs869246976      

基因表达

基因表达

CSTA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GTTGATAAGGTTAAACCACAGC
58
GTTCCAGCAACAACTTGAG
57
GTTGATAAGGTTAAACCACAGC
58
TCCAGTAAGTACCAAGTCCT
57
GTTGATAAGGTTAAACCACAGC
58
CCAGTAAGTACCAAGTCCTC
57

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CSTA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

CSTA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004869
C9J0E4(UniProtKB)
IEA
GO:0005622
C9J0E4(UniProtKB)
IEA
GO:0010951
C9J0E4(UniProtKB)
IEA
GO:0010951
C9J0E4(UniProtKB)
IEA
GO:0001533
P01040(UniProtKB)
IDA
GO:0002020
P01040(UniProtKB)
IPI
GO:0004869
P01040(UniProtKB)
IDA
GO:0004869
P01040(UniProtKB)
IDA
GO:0005198
P01040(UniProtKB)
IDA
GO:0005615
P01040(UniProtKB)
IDA
GO:0005634
P01040(UniProtKB)
IDA
GO:0005737
P01040(UniProtKB)
IDA
GO:0005737
P01040(UniProtKB)
IDA
GO:0010466
P01040(UniProtKB)
IDA
GO:0010951
P01040(UniProtKB)
IEA
GO:0010951
P01040(UniProtKB)
IEA
GO:0016337
P01040(UniProtKB)
IMP
GO:0018149
P01040(UniProtKB)
IDA
GO:0030216
P01040(UniProtKB)
IDA
GO:0030674
P01040(UniProtKB)
IDA
GO:0045861
P01040(UniProtKB)
IDA
GO:0070062
P01040(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控CSTA基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Exfoliative Ichthyosis, Autosomal Recessive, Ichthyosis Bullosa of Siemens-like 0.24 0 4 CLINVAR_ORPHANET
Neoplasm Metastasis 0.123267234 3 0 BeFree_CTD_human_LHGDN
Nasopharyngeal carcinoma 0.120271442 1 0 BeFree_CTD_human
Glioblastoma 0.12 1 0 CTD_human
Disease Progression 0.12 2 0 CTD_human
Psoriasis 0.005905708 3 0 BeFree_GAD_LHGDN
Dermatitis, Atopic 0.002995792 1 0 BeFree_LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Malignant neoplasm of prostate 0.001085767 4 1 BeFree
Prostate carcinoma 0.001085767 4 1 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Diabetes Mellitus 0.000542884 2 0 BeFree
Ichthyoses 0.000542884 2 0 BeFree
Congenital ichthyosis 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Asthma 0.000271442 1 0 BeFree
Brain Neoplasms 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Eczema 0.000271442 1 0 BeFree
Glaucoma 0.000271442 1 0 BeFree
Chronic Obstructive Airway Disease 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Varicose Ulcer 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Secondary malignant neoplasm of bone 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Squamous cell carcinoma of esophagus 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Invasive breast carcinoma 0.000271442 1 0 BeFree
Invasive Ductal Breast Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
High Grade Intraepithelial Neoplasia 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

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