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ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003 [PubMed 12888926]).[supplied by OMIM, Sep 2009]
[中文简述(自动翻译):]  ASXL2是果蝇ASX基因的人类同源物。果蝇ASX是trithorax增强剂(见MIM 159555)和多梳(见MIM 610231)(ETP)基因,该基因编码的染色质蛋白具有双重功能的转录激活和沉默(加藤和加藤,2003 [考研12888926])。[供应通过OMIM,2009年9月]
ASXL2基因(以及对应的蛋白质)的细胞分布位置:
ASXL2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Bladder Neoplasm | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Heart Diseases | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Therapy-related myelodysplastic syndrome | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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