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This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Sep 2009]
[中文简述(自动翻译):]  该基因编码含有蛋白质家族的gasdermin域的成员。其他gasdermin家族基因牵涉凋亡的上皮细胞的调节,并与癌症。已发现该基因编码不同亚型的多个抄本变形。另外的变体已被描述,但它们是无义介导的mRNA降解(NMD)候选人和不太可能编码蛋白质的。 [由RefSeq的,2009年09月提供]
GSDMB基因(以及对应的蛋白质)的细胞分布位置:
GSDMB基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Asthma | 0.263279326 | 21 | 7 | BeFree_CTD_human_GAD_GWASCAT |
| Ulcerative Colitis | 0.125005506 | 3 | 2 | BeFree_GAD_GWASCAT |
| Diabetes Mellitus, Insulin-Dependent | 0.125005506 | 3 | 1 | BeFree_GAD_GWASCAT |
| Crohn Disease | 0.007372538 | 4 | 1 | BeFree_GAD |
| Immediate hypersensitivity | 0.004734064 | 2 | 0 | GAD |
| Autoimmune Diseases | 0.002909916 | 2 | 2 | BeFree_GAD |
| Liver neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
| Inflammatory Bowel Diseases | 0.002367032 | 1 | 0 | GAD |
| Obesity | 0.002367032 | 1 | 0 | GAD |
| Occupational Diseases | 0.002367032 | 1 | 0 | GAD |
| Childhood asthma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 1 | BeFree |
| Wheezing | 0.000542884 | 2 | 3 | BeFree |
| Bronchial Hyperreactivity | 0.000542884 | 2 | 2 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| asthma adult onset | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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