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This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  此基因编码C-型凝集素/ C-型凝集素样超家族结构域(CTL / CTLD)的成员。这家人共享一个共同的蛋白折叠,并有不同的功能,例如细胞粘附,细胞 - 细胞信号传导,糖蛋白周转和角色在炎症和免疫反应的成员。所编码的II型跨膜蛋白DNAX活化蛋白12相互作用并可能在细胞活化的作用。备选剪接变体已被描述,但是它们的全长序列尚未确定。 [由RefSeq的,2008年7月提供]
CLEC5A基因(以及对应的蛋白质)的细胞分布位置:
CLEC5A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Severe Dengue | 0.120542884 | 3 | 1 | BeFree_CTD_human |
Dengue Fever | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Japanese Encephalitis | 0.000271442 | 1 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000271442 | 1 | 0 | BeFree |
Systemic Inflammatory Response Syndrome | 0.000271442 | 1 | 0 | BeFree |
Superficial ulcer | 0.000271442 | 1 | 0 | BeFree |
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