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This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
[中文简述(自动翻译):]  该基因编码在POU域转录因子家族的成员。 POU结构域转录因子绑定到特定的DNA八聚体和主题调节细胞类型特异性的分化途径。所编码的蛋白质是在表皮主要表达,并起着角化细胞增殖和分化的关键作用。所编码的蛋白质也候选肿瘤抑制蛋白,而这个基因的异常启动子甲基化可能在宫颈癌的作用。编码多种亚型选择性剪接的转录物变体已经观察到这种基因。 [由RefSeq的,2011年9月提供]
POU2F3基因(以及对应的蛋白质)的细胞分布位置:
POU2F3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Myocardial Infarction | 0.002171535 | 8 | 0 | BeFree |
Coronary Artery Disease | 0.001628651 | 6 | 0 | BeFree |
Coronary Arteriosclerosis | 0.001085767 | 4 | 0 | BeFree |
Coronary heart disease | 0.001085767 | 4 | 0 | BeFree |
Alloimmune thrombocytopenia | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
Diabetic Retinopathy | 0.000542884 | 2 | 0 | BeFree |
Arterial thrombosis | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Alloimmunisation | 0.000542884 | 2 | 0 | BeFree |
Neonatal alloimmune thrombocytopenia (NAIT) | 0.000542884 | 2 | 0 | BeFree |
Behcet Syndrome | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Myelitis | 0.000271442 | 1 | 0 | BeFree |
Optic Neuritis | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Arteritis | 0.000271442 | 1 | 0 | BeFree |
Thrombasthenia | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Deep Vein Thrombosis | 0.000271442 | 1 | 0 | BeFree |
Deep thrombophlebitis | 0.000271442 | 1 | 0 | BeFree |
Restenosis | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
aspirin sensitivity | 0.000271442 | 1 | 0 | BeFree |
Acute Coronary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Stroke, Lacunar | 0.000271442 | 1 | 0 | BeFree |
Unspecified visual loss | 0.000271442 | 1 | 0 | BeFree |
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