TDP2(tyrosyl-DNA phosphodiesterase 2) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

6p22.3-p22.1
基因染色体位置图

基因简述

基因简述

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  这个基因编码的二价阳离子依赖磷酸二酯酶的一个超家族的成员。所编码的蛋白质同伙与CD40，肿瘤坏死因子（TNF）受体-75和TNF受体相关因子（TRAFs），并抑制核因子-B的活化。这种蛋白质具有APE1核酸内切酶，它参与了DNA修复和转录因子的激活序列和结构相似。 [由RefSeq的，2008年7月提供]

OMIM数据库中对TDP2基因的介绍     Wikipedia数据库中对TDP2基因的介绍

基因序列

基因序列

TDP2基因的碱基序列：[NCBI]

基因突变

基因突变

TDP2基因的碱基突变：           显示全部snp
rs1061925       rs2073013       rs3181227       rs3181228       rs3756815       rs3756816       rs3756817       rs3756819       rs6456628       rs11456603       rs17243129       rs17243136       rs17243143       rs17243150       rs17243157       rs17243164       rs17243465       rs17243472       rs17243479       rs17243486       rs17249498       rs17249505       rs17249841       rs17249855       rs17249862       rs28364821       rs35306604       rs35744230       rs61760186       rs62400775       rs76659610       rs78311464       rs78727527       rs112047292       rs114696086       rs114945810       rs137917584      
rs139018301       rs139273737       rs140060283       rs140404711       rs140846415       rs141254628       rs141964303       rs142041222       rs142424556       rs142698674       rs143844222       rs144383979       rs145857752       rs146127613       rs146918851       rs147789526       rs147825101       rs148468777       rs148695509       rs149428824       rs150980857       rs151213624       rs181264159       rs182741759       rs183187487       rs183456015       rs184773170       rs184953045       rs185298008       rs186047677       rs186234968       rs187604432       rs187759047       rs187795586       rs189768834       rs190332937       rs190559226       rs190857586       rs191316319       rs191327595       rs192467972       rs199497770       rs199594700       rs199980848       rs200293826       rs200448649       rs200485971       rs200802722       rs200897993       rs201101786       rs201104912       rs201132552       rs201203124       rs201933219       rs202232519       rs202243869       rs368460491       rs368976266       rs369324156       rs369863568       rs370904533       rs371665728       rs371861850       rs372138767       rs372169731       rs372428477       rs373305535       rs374503440       rs374632872       rs374879671       rs376289525       rs376618846       rs376884101       rs397696496       rs528274877       rs528337107       rs529052113       rs531247493       rs531985039       rs532498205       rs532520718       rs533081059       rs533699262       rs533782966       rs533990165       rs534169765       rs534705697       rs535128881       rs536252126       rs537277930       rs538555212       rs539254772       rs540652605       rs541138061       rs542343971       rs542925854       rs543601775       rs543992456       rs545056826       rs545908975       rs546574066       rs547769169       rs547930220       rs548787108       rs548965708       rs549318266       rs549978239       rs550027190       rs552394171       rs553075689       rs553384035       rs553824268       rs554204280       rs555136655       rs555261473       rs555930577       rs556619847       rs558272241       rs561660494       rs564015453       rs564234186       rs564945120       rs564994163       rs565828513       rs566068393       rs567098223       rs567329218       rs568140793       rs568522581       rs568801141       rs569406071       rs569837757       rs569948062       rs571392201       rs572045907       rs572315809       rs572757620       rs573645945       rs573863399       rs574259087       rs574368040       rs575141333       rs575367597       rs576461785       rs576550237       rs577053435       rs745712158       rs746195418       rs746736116       rs747139229       rs747466730       rs747517187       rs748213796       rs748475191       rs748758001       rs748879090       rs749085711       rs749279037       rs749520354       rs749593177       rs749614922       rs749691927       rs749881140       rs750374601       rs751092306       rs751468909       rs751845810       rs752212750       rs752415197       rs752608318       rs753218291       rs753545235       rs753625369       rs753691589       rs753826333       rs754004696       rs755450845       rs755927062       rs756169471       rs756749615       rs757539692       rs758131431       rs758161626       rs758352973       rs758697778       rs758789376       rs759859886       rs760208273       rs760554150       rs761059957       rs761256693       rs761440284       rs761457468       rs761642526       rs761730495       rs762368465       rs762658629       rs762798149       rs763659985       rs763706463       rs763890425       rs763986535       rs764184914       rs764454529       rs764469672       rs764713488       rs764930902       rs764939547       rs765185701       rs765307607       rs765688086       rs765874704       rs765978658       rs766287455       rs766343145       rs766669494       rs767005683       rs767396098       rs767799429       rs768315412       rs768684552       rs768818848       rs768913204       rs769203472       rs769270221       rs769972820       rs770061117       rs770378919       rs770777577       rs770844602       rs771536656       rs771628314       rs771672053       rs771868751       rs772190723       rs772663070       rs772678433       rs772782727       rs772868867       rs773122729       rs773676234       rs773876097       rs773899351       rs773989558       rs774266776       rs774850927       rs775433216       rs775826087       rs776300645       rs776653065       rs776938646       rs777034962       rs777205836       rs777517528       rs777794075       rs777989022       rs777996628       rs778003246       rs778549935       rs778744134       rs778950052       rs779031310       rs779136889       rs779231725       rs779433262       rs779514628       rs779796863       rs780181755       rs780551850       rs780767326       rs780955346       rs781147591       rs781417764       rs781582506       rs781614136       rs781683053       rs12393       rs707887       rs1047782       rs1129644       rs2056998       rs2056999       rs2143339       rs2143340       rs2294688       rs2294689       rs2294690       rs2294691       rs3087943       rs3181230       rs3181233       rs3181234       rs3181235       rs3181236       rs3181237       rs3181238       rs3181239       rs3181244       rs3181245       rs3212228       rs3212229       rs3212230       rs3212231       rs3212232       rs3212233       rs3212234       rs3212235       rs3756815       rs3830786       rs3841676       rs5874998       rs6907640       rs6920675       rs6937327       rs6937517       rs6937533       rs7745192       rs7759417       rs7768291       rs9295628       rs9295629       rs9358786       rs9358787       rs9379679       rs9379681       rs9379682       rs9393574       rs9393575       rs9467250       rs9467251       rs10085192       rs10597437       rs10644291       rs10701529       rs11559067       rs11754730       rs13212011       rs16889567       rs16889581       rs16889592       rs16889597       rs16889601       rs16901739       rs17243206       rs17243213       rs17243220       rs17243234       rs17243241       rs17243269       rs17243276       rs17243339       rs17243353       rs17243367       rs17243374       rs17243388       rs17243395       rs17243409       rs17243416       rs17243493       rs17243499       rs17243506       rs17243513       rs17243527       rs17243534       rs17243541       rs17243548       rs17243562       rs17243569       rs17243578       rs17243585       rs17243599       rs17249554       rs17249561       rs17249568       rs17249575       rs17249582       rs17249603       rs17249631       rs17249673       rs17249687       rs17249729       rs17249771       rs17249785       rs17249848       rs17249869       rs17249876       rs17249883       rs17249890       rs17249904       rs17249911       rs17249924       rs17249931       rs17249945       rs17249952       rs17249966       rs17249973       rs17249980       rs35977478       rs55997270       rs56410060       rs61757564       rs67414927       rs70974926       rs71555156       rs71555157       rs71694858       rs74356997       rs75107302       rs75461385       rs77153369       rs77273535       rs77294163       rs77317004       rs77370926       rs78080315       rs78424960       rs78674511       rs111415264       rs111627244       rs111845966       rs112192292       rs112560835       rs112564645       rs112996957       rs113134059       rs114754446       rs115054353       rs115247596       rs115268436       rs116596225       rs138035586       rs138664603       rs139013425       rs139085454       rs139153310       rs139320518       rs140355661       rs140419173       rs140909215       rs141073084       rs141264084       rs141577737       rs141692562       rs142381612       rs142438588       rs142718615       rs143104802       rs143459965       rs143489460       rs143559471       rs143596142       rs143879282       rs144064433       rs144094433       rs144798461       rs144922001       rs145663114       rs145708673       rs146544499       rs146645304       rs146793080       rs147333894       rs147357100       rs147724380       rs147997768       rs148051522       rs148937075       rs149587517       rs149606674       rs149976199       rs150341875       rs150496746       rs150757671       rs150867443       rs180737963       rs180748175       rs180872600       rs181137517       rs181867225       rs182045789       rs182132193       rs182749466       rs182758509       rs183535626       rs183606831       rs183741083       rs183784826       rs184042958       rs184675480       rs184861504       rs185071658       rs185096500       rs185626389       rs185826912       rs185969550       rs186352862       rs186383121       rs186947688       rs187053671       rs187181295       rs187187410       rs188061340       rs188533601       rs188709598       rs188941835       rs188963156       rs188993226       rs189267365       rs189628159       rs189681790       rs189921201       rs189922192       rs190365522       rs190476358       rs191019881       rs191316319       rs191409162       rs191674833       rs191764489       rs192184290       rs192375081       rs192926685       rs192966075       rs193059242       rs193127117       rs193245509       rs199499565       rs199528335       rs199602263       rs200729372       rs200729725       rs201010815       rs201471047       rs202040495       rs367700182       rs367970445       rs368197541       rs368291396       rs368561786       rs368572259       rs368633310       rs369086085       rs369149075       rs369194484       rs369498680       rs370316626       rs370485187       rs370543848       rs370814588       rs370842213       rs370974576       rs371457221       rs372058337       rs372245668       rs372373164       rs372592899       rs372857753       rs373596614       rs373958621       rs374024270       rs374270370       rs374315615       rs374732253       rs374818883       rs374956181       rs375353513       rs375654749       rs375948102       rs376083649       rs376223201       rs376542386       rs376811160       rs377119756       rs377136376       rs377222266       rs527326700       rs527545938       rs528064022       rs528235895       rs528341850       rs528737573       rs528848868       rs528963454       rs529142686       rs529456186       rs529804099       rs529904089       rs530773386       rs530777279       rs531691981       rs531735368       rs531943468       rs532261526       rs533066188       rs533256194       rs533452028       rs533590468       rs533612063       rs533666668       rs534520394       rs534939468       rs534940377       rs535177405       rs535588081       rs535596585       rs535763682       rs536360643       rs536361103       rs536524163       rs537091335       rs537263499       rs537321845       rs537570075       rs537802966       rs538007936       rs538476254       rs538609817       rs539092585       rs539280948       rs539962817       rs540037026       rs540074702       rs540945448       rs541432330       rs541508359       rs541545166       rs542236757       rs542681832       rs542769503       rs542879617       rs542925578       rs543684016       rs543879734       rs543988011       rs544356367       rs544423286       rs544522450       rs544672401       rs544907762       rs545018063       rs545117739       rs545191357       rs545547677       rs545708889       rs546210181       rs546548679       rs546879508       rs547221461       rs547768787       rs547991845       rs548444605       rs548673779       rs548963021       rs549072756       rs549111384       rs549184949       rs549344211       rs549355124       rs549575981       rs549626170       rs549848969       rs551243721       rs551593330       rs551629041       rs551630525       rs551658886       rs552644381       rs552717705       rs552985122       rs553008711       rs553008777       rs553170105       rs553172635       rs553236370       rs554204556       rs554292283       rs554463185       rs554697839       rs554738801       rs555419303       rs555659155       rs555820039       rs556298784       rs556897889       rs557081121       rs557168684       rs557193070       rs557221136       rs557309043       rs557975714       rs558011766       rs558062517       rs558088817       rs558110703       rs558164210       rs558630922       rs558656047       rs558749678       rs558938823       rs559241922       rs559444246       rs559541626       rs559604260       rs559652793       rs559757211       rs559896508       rs559970006       rs560058757       rs560768993       rs561270038       rs562195438       rs562601875       rs562766608       rs562840465       rs563318918       rs563368280       rs563657983       rs563761439       rs563931041       rs564608157       rs564778747       rs564925944       rs565012883       rs565103897       rs565276220       rs565280390       rs565679865       rs565724041       rs565900253       rs566008555       rs566009990       rs566650556       rs567057962       rs567291660       rs567483118       rs567980015       rs568574185       rs568678852       rs568767686       rs568801026       rs568933062       rs569371407       rs569568949       rs569763525       rs569874887       rs570127921       rs570239840       rs570248666       rs570326950       rs570363013       rs571189678       rs571189789       rs571450166       rs571489469       rs571516928       rs571560143       rs571604043       rs572166443       rs572358998       rs572437839       rs572472127       rs572840333       rs572988907       rs573588550       rs573779224       rs573865108       rs573902272       rs574107603       rs574187012       rs574253630       rs574297277       rs574441144       rs574994820       rs575148669       rs575202215       rs575204310       rs575233998       rs575723128       rs575832809       rs576157712       rs576163427       rs576240381       rs576267666       rs576638312       rs577601258       rs577612860       rs577790528       rs577931607       rs577996889       rs578031643       rs578037012       rs578077205       rs745612304       rs745911675       rs746102191       rs746303603       rs746383136       rs746591763       rs746943158       rs747049195       rs747139051       rs747265150       rs747342160       rs747429858       rs747623866       rs747711301       rs747910516       rs747947979       rs748509364       rs748967921       rs749041076       rs749121954       rs749388275       rs749917446       rs750067912       rs750223762       rs750724107       rs750960362       rs751004223       rs751106145       rs751347138       rs751482713       rs751705106       rs752083509       rs752649752       rs752837935       rs753098097       rs753784871       rs753925982       rs754236525       rs754324675       rs754525926       rs754566959       rs754787459       rs754973689       rs755048353       rs755523298       rs755957636       rs756022937       rs756393458       rs756535178       rs756665707       rs756704457       rs756824510       rs757486840       rs757575420       rs757593327       rs757911418       rs758067744       rs758114038       rs758350133       rs758512360       rs758629003       rs758885890       rs758993809       rs759190297       rs759422172       rs759933045       rs760021221       rs760501353       rs760589504       rs760887221       rs761188759       rs761522826       rs761748044       rs761991069       rs762418465       rs762485056       rs762971437       rs763266803       rs763802104       rs763995072       rs764059759       rs764172023       rs764543965       rs765115330       rs765344588       rs765549838       rs765624333       rs765648402       rs765989075       rs766104701       rs766253411       rs766587845       rs766838630       rs767038221       rs767059984       rs767202133       rs767868725       rs768064857       rs768834156       rs769412827       rs769500692       rs769512669       rs769599954       rs770016841       rs770754690       rs770848492       rs770963867       rs771160250       rs771536448       rs771928592       rs772204099       rs772244923       rs772352587       rs772444109       rs772870880       rs773229997       rs773809373       rs774278694       rs774390589       rs774662352       rs774768351       rs775044884       rs775050456       rs775719133       rs775886529       rs775911404       rs776204631       rs776274216       rs776842541       rs777079370       rs777222372       rs777421271       rs778102996       rs778299111       rs778662539       rs778665520       rs778750350       rs778875394       rs778941478       rs779332301       rs779430620       rs779622434       rs779810274       rs779834703       rs780006118       rs780190952       rs780279136       rs781406884       rs781613923      

基因表达

基因表达

TDP2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AATGCAAGAGGCTCCAGAG
60
ACCACATCTGGTAACCTCTC
59
CCCAGATGTGATATTTCTACAGGA
60
GTGAAATATCCTTCTTCATGACCTG
60
GGAGATGGAAAGGGCTCTG
60
AGAGATGGTTTCAGGTCGG
59
CTCTCATTACCTGGAATATTGATGG
59
CATCTGGGCTGTACAAAGC
59
ATCGAGAGGTTACCAGATGTG
59
TGGCAATGTTTAGGTTTGCC
60
CTCTCATTACCTGGAATATTGATGG
59
ATCTGGGCTGTACAAAGCT
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TDP2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TDP2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000287
O95551(UniProtKB)
TAS
GO:0000287
O95551(UniProtKB)
IDA
GO:0000287
O95551(UniProtKB)
IDA
GO:0003697
O95551(UniProtKB)
IDA
GO:0003714
O95551(UniProtKB)
TAS
GO:0004518
O95551(UniProtKB)
IEA
GO:0005515
O95551(UniProtKB)
IPI
GO:0005515
O95551(UniProtKB)
IPI
GO:0005634
O95551(UniProtKB)
IDA
GO:0005634
O95551(UniProtKB)
IDA
GO:0005730
O95551(UniProtKB)
IEA
GO:0005737
O95551(UniProtKB)
IDA
GO:0006302
O95551(UniProtKB)
IDA
GO:0006302
O95551(UniProtKB)
IMP
GO:0007166
O95551(UniProtKB)
TAS
GO:0016605
O95551(UniProtKB)
IDA
GO:0030145
O95551(UniProtKB)
IDA
GO:0036317
O95551(UniProtKB)
IDA
GO:0045171
O95551(UniProtKB)
IDA
GO:0070260
O95551(UniProtKB)
IDA
GO:0070260
O95551(UniProtKB)
IMP
GO:0070260
O95551(UniProtKB)
IDA
GO:0070260
O95551(UniProtKB)
IDA
GO:0090305
O95551(UniProtKB)
IEA
GO:1903507
O95551(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TDP2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Narcolepsy 0.002367032 1 0 GAD
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating 0.002367032 1 0 GAD
Atrioventricular Block 0.000542884 2 0 BeFree
Malignant neoplasm of lung 0.000542884 2 0 BeFree
Dyslexia 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Reading Disabilities 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Long QT Syndrome 0.000271442 1 0 BeFree
Multiple malignancy 0.000271442 1 0 BeFree

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