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This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]
[中文简述(自动翻译):] 该基因编码的SP / XKLF转录因子的SP亚科的成员。属家族蛋白是序列特异性DNA结合蛋白特征为氨基末端反式激活结构域和三个羧基末端锌指基序。这种蛋白是骨特异性转录因子和所需的成骨细胞分化和骨形成。[通过的RefSeq,2010年7月提供]
SP7基因(以及对应的蛋白质)的细胞分布位置:
SP7基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Osteogenesis imperfecta type IV (disorder) | 0.12 | 0 | 0 | ORPHANET |
OSTEOGENESIS IMPERFECTA, TYPE XI | 0.12 | 0 | 0 | CLINVAR |
Bone Diseases | 0.00272435 | 1 | 0 | LHGDN |
Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Tumor of Bone | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
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