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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族,其成员的特征是不同的细胞周期蛋白丰度变化较大。细胞周期蛋白可以调控CDK激酶。不同细胞周期蛋白表现出不同的表达和降解模式这有助于每个有丝分裂事件的时间协调。这个周期蛋白形成具有复杂和功能与CDK4或CDK6的调节亚基,其活性所需的细胞周期G1 / S期转换。这种蛋白已经显示出与肿瘤抑制Rb蛋白相互作用和该基因的表达由铷正调控。突变,扩增和该基因,从而改变细胞周期进程的过度表达,在多种肿瘤中经常观察到,并可能有助于肿瘤的发生。 [由RefSeq的,2008年7月提供]
CCND1基因(以及对应的蛋白质)的细胞分布位置:
CCND1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Multiple Myeloma | 0.396704242 | 76 | 1 | BeFree_CTD_human_GWASCAT_LHGDN_ORPHANET |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.342985716 | 272 | 0 | BeFree_CTD_human_LHGDN_ORPHANET |
Chronic Lymphocytic Leukemia | 0.256210567 | 52 | 0 | BeFree_CTD_human_GAD_ORPHANET |
Prostatic Neoplasms | 0.216531667 | 9 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
Carcinoma, Transitional Cell | 0.20408156 | 7 | 0 | BeFree_CTD_human_LHGDN_RGD |
Mammary Neoplasms, Experimental | 0.2 | 5 | 0 | CTD_human_RGD |
Mammary Neoplasms | 0.193441786 | 59 | 0 | BeFree_CTD_human_GAD_LHGDN |
Colorectal Neoplasms | 0.150067542 | 12 | 0 | BeFree_CTD_human_GAD_LHGDN |
Liver carcinoma | 0.147012161 | 68 | 0 | BeFree_CTD_human_GAD_LHGDN |
Esophageal Neoplasms | 0.145522924 | 24 | 3 | BeFree_CTD_human_GAD_LHGDN |
Stomach Neoplasms | 0.140994289 | 8 | 0 | BeFree_CTD_human_GAD_LHGDN |
Lung Neoplasms | 0.136803109 | 11 | 0 | BeFree_CTD_human_GAD_LHGDN |
Thyroid Neoplasm | 0.134978961 | 11 | 0 | BeFree_CTD_human_LHGDN |
Precancerous Conditions | 0.129815515 | 13 | 0 | BeFree_CTD_human_GAD |
Squamous cell carcinoma of esophagus | 0.128414698 | 32 | 0 | BeFree_CTD_human |
leukemia | 0.128262808 | 16 | 0 | BeFree_CTD_human_GAD |
Hyperplasia | 0.1254487 | 4 | 0 | CTD_human_LHGDN |
Nasopharyngeal carcinoma | 0.125157396 | 20 | 0 | BeFree_CTD_human |
Hyperparathyroidism | 0.123810118 | 5 | 0 | BeFree_CTD_human_LHGDN |
Brain Neoplasms | 0.123452799 | 6 | 0 | BeFree_CTD_human_GAD |
Adenoid Cystic Carcinoma | 0.123267234 | 4 | 0 | BeFree_CTD_human_LHGDN |
Von Hippel-Lindau Syndrome | 0.123267234 | 2 | 0 | BeFree_CTD_human_LHGDN |
Colonic Neoplasms | 0.121628651 | 10 | 0 | BeFree_CTD_human |
Kidney Neoplasm | 0.120542884 | 2 | 0 | BeFree_CTD_human |
Intestinal Polyps | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Papilloma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Cecal Neoplasms | 0.12 | 1 | 0 | CTD_human |
Neoplastic Cell Transformation | 0.12 | 2 | 0 | CTD_human |
Hemangiosarcoma | 0.12 | 1 | 0 | CTD_human |
Animal Mammary Neoplasms | 0.12 | 4 | 0 | CTD_human |
Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Salivary Gland Neoplasms | 0.12 | 1 | 0 | CTD_human |
Urologic Neoplasms | 0.12 | 1 | 0 | CTD_human |
Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of breast | 0.105537483 | 265 | 3 | BeFree_GAD |
ovarian neoplasm | 0.091158911 | 15 | 0 | BeFree_LHGDN_RGD |
Squamous cell carcinoma | 0.084069457 | 100 | 0 | BeFree_GAD_LHGDN |
Liver Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Seizures | 0.08 | 1 | 0 | RGD |
Erectile dysfunction | 0.08 | 1 | 0 | RGD |
Breast Carcinoma | 0.067589026 | 249 | 3 | BeFree |
Colorectal Cancer | 0.06754689 | 66 | 1 | BeFree_GAD |
Carcinogenesis | 0.04641656 | 171 | 1 | BeFree |
Lymphoma | 0.031235678 | 96 | 0 | BeFree_LHGDN |
Malignant neoplasm of urinary bladder | 0.027079512 | 32 | 0 | BeFree_GAD |
Malignant neoplasm of esophagus | 0.026732125 | 29 | 3 | BeFree_GAD |
Neoplasm Metastasis | 0.026283711 | 62 | 0 | BeFree_GAD_LHGDN |
Malignant neoplasm of lung | 0.024050044 | 46 | 2 | BeFree_GAD |
Adenocarcinoma | 0.023784653 | 25 | 0 | BeFree_GAD_LHGDN |
melanoma | 0.021202261 | 49 | 1 | BeFree_LHGDN |
B-Cell Lymphomas | 0.020302059 | 47 | 0 | BeFree_GAD_LHGDN |
Retinoblastoma | 0.02009663 | 65 | 0 | BeFree_LHGDN |
Mouth Neoplasms | 0.017555302 | 7 | 0 | BeFree_GAD_LHGDN |
Malignant neoplasm of prostate | 0.017415887 | 38 | 0 | BeFree_GAD |
Colorectal Carcinoma | 0.016829396 | 62 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.015939126 | 50 | 1 | BeFree_GAD |
Malignant neoplasm of mouth | 0.014354082 | 20 | 0 | BeFree_GAD |
Endometrial Neoplasms | 0.013264433 | 4 | 0 | GAD_LHGDN |
Malignant neoplasm of stomach | 0.011791553 | 27 | 0 | BeFree_GAD |
Malignant neoplasm of ovary | 0.011715608 | 20 | 0 | BeFree_GAD |
Carcinoma of lung | 0.011672 | 43 | 2 | BeFree |
Adenoma | 0.011420422 | 24 | 0 | BeFree_LHGDN |
Non-Small Cell Lung Carcinoma | 0.011324614 | 34 | 0 | BeFree_GAD |
Cervix carcinoma | 0.011248669 | 24 | 1 | BeFree_GAD |
Stomach Carcinoma | 0.011053172 | 33 | 0 | BeFree_GAD |
Glioma | 0.010791662 | 22 | 1 | BeFree_GAD_LHGDN |
Meningioma | 0.010725648 | 5 | 0 | BeFree_GAD_LHGDN |
Prostate carcinoma | 0.010586233 | 39 | 0 | BeFree |
Carcinoma of bladder | 0.010510288 | 30 | 0 | BeFree_GAD |
Colon Carcinoma | 0.010314791 | 38 | 1 | BeFree |
Bladder Neoplasm | 0.009987267 | 11 | 0 | BeFree_GAD_LHGDN |
Lymphoma, Non-Hodgkin | 0.009629949 | 9 | 0 | BeFree_GAD_LHGDN |
Secondary malignant neoplasm of lymph node | 0.009500466 | 35 | 0 | BeFree |
Malignant tumor of colon | 0.009229024 | 34 | 1 | BeFree |
Adenomatous Polyposis Coli | 0.008434561 | 13 | 0 | BeFree_LHGDN |
Tumor Progression | 0.008414698 | 31 | 0 | BeFree |
Glioblastoma | 0.008163119 | 10 | 0 | BeFree_LHGDN |
Head and Neck Neoplasms | 0.008087174 | 4 | 0 | BeFree_GAD_LHGDN |
Fibroid Tumor | 0.008087174 | 3 | 0 | BeFree_GAD_LHGDN |
Parathyroid Neoplasms | 0.007338862 | 18 | 0 | BeFree_LHGDN |
Esophageal carcinoma | 0.007057489 | 26 | 3 | BeFree |
Pancreatic carcinoma | 0.007057489 | 26 | 0 | BeFree |
Malignant neoplasm of larynx | 0.006905599 | 9 | 0 | BeFree_GAD |
Parathyroid Adenoma | 0.006786047 | 25 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.006634157 | 8 | 0 | BeFree_GAD |
Cholangiocarcinoma | 0.006534468 | 6 | 0 | BeFree_LHGDN |
Hairy Cell Leukemia | 0.006524536 | 15 | 0 | BeFree_LHGDN |
Malignant neoplasm of pancreas | 0.006514605 | 24 | 0 | BeFree |
Pituitary Neoplasms | 0.006448592 | 7 | 0 | BeFree_GAD_LHGDN |
Ovarian Carcinoma | 0.006243163 | 23 | 0 | BeFree |
Liver neoplasms | 0.006167218 | 15 | 0 | BeFree_GAD |
Lymphoma, Follicular | 0.006167218 | 15 | 0 | BeFree_GAD |
Cancer of Head and Neck | 0.006167218 | 15 | 0 | BeFree_GAD |
Malignant tumor of cervix | 0.005971721 | 22 | 1 | BeFree |
Neuroblastoma | 0.005710211 | 11 | 0 | BeFree_LHGDN |
Inflammatory Bowel Diseases | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Diffuse Large B-Cell Lymphoma | 0.005624334 | 13 | 0 | BeFree_GAD |
Laryngeal neoplasm | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Laryngeal Squamous Cell Carcinoma | 0.005352893 | 11 | 0 | BeFree_GAD |
Endometrial Carcinoma | 0.005352893 | 11 | 0 | BeFree_GAD |
Sarcoma | 0.005167327 | 10 | 0 | BeFree_LHGDN |
Lip and Oral Cavity Carcinoma | 0.005157396 | 19 | 0 | BeFree |
Uterine Cervical Neoplasm | 0.005005506 | 3 | 0 | BeFree_GAD |
Epithelial ovarian cancer | 0.004538567 | 9 | 0 | BeFree_GAD |
Lymphoproliferative Disorders | 0.00434307 | 16 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Leukemia, B-Cell | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Noninfiltrating Intraductal Carcinoma | 0.003800186 | 14 | 0 | BeFree |
Renal Cell Carcinoma | 0.003800186 | 14 | 0 | BeFree |
Malignant neoplasm of kidney | 0.003724241 | 6 | 0 | BeFree_GAD |
Myeloid Leukemia | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Pancreatic Neoplasm | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Fibromatosis, Aggressive | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Hemophilia A | 0.003452799 | 5 | 0 | BeFree_GAD |
Acoustic Neuroma | 0.003452799 | 4 | 0 | BeFree_GAD |
Endometriosis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Mixed Salivary Gland Tumor | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Hepatoblastoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Rhabdoid Tumor | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Ulcerative Colitis | 0.003181358 | 3 | 0 | BeFree_GAD |
Gastroesophageal reflux disease | 0.003181358 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of liver | 0.003181358 | 4 | 0 | BeFree_GAD |
Lymphoma, T-Cell, Cutaneous | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Squamous Cell Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Idiopathic Pulmonary Fibrosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Congenital chromosomal disease | 0.002985861 | 11 | 0 | BeFree |
Osteosarcoma | 0.002985861 | 11 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.002985861 | 11 | 0 | BeFree |
Solid tumour | 0.002985861 | 11 | 0 | BeFree |
Osteosarcoma of bone | 0.002985861 | 11 | 0 | BeFree |
Small Lymphocytic Lymphoma | 0.002985861 | 11 | 0 | BeFree |
Barrett Esophagus | 0.002909916 | 3 | 0 | BeFree_GAD |
Chronic Obstructive Airway Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Cancer of Nasopharynx | 0.002909916 | 2 | 0 | BeFree_GAD |
Cardiac Carcinoma | 0.002909916 | 3 | 0 | BeFree_GAD |
Anoxia | 0.00272435 | 1 | 0 | LHGDN |
Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Giant Cell Granuloma | 0.00272435 | 1 | 0 | LHGDN |
Heart Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
keratoacanthoma | 0.00272435 | 1 | 0 | LHGDN |
Keratosis | 0.00272435 | 1 | 0 | LHGDN |
Leukemia, T-Cell | 0.00272435 | 1 | 0 | LHGDN |
Thrombocythemia, Essential | 0.00272435 | 1 | 0 | LHGDN |
Verrucous carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Solitary fibrous tumor | 0.00272435 | 1 | 0 | LHGDN |
MYELODYSPLASTIC SYNDROME | 0.00272435 | 1 | 0 | LHGDN |
Acute lymphocytic leukemia | 0.002714419 | 10 | 0 | BeFree |
Central neuroblastoma | 0.002714419 | 10 | 0 | BeFree |
Gastritis | 0.002638474 | 2 | 0 | BeFree_GAD |
Leukoplakia, Oral | 0.002638474 | 1 | 0 | BeFree_GAD |
Peptic Ulcer | 0.002638474 | 1 | 0 | BeFree_GAD |
Pituitary carcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Skin carcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Papillary thyroid carcinoma | 0.002442977 | 9 | 1 | BeFree |
Thyroid carcinoma | 0.002442977 | 9 | 0 | BeFree |
Leukemogenesis | 0.002442977 | 9 | 0 | BeFree |
Chromosome Aberrations | 0.002367032 | 1 | 0 | GAD |
Crohn Disease | 0.002367032 | 1 | 0 | GAD |
DNA Damage | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Kidney Failure, Chronic | 0.002367032 | 1 | 0 | GAD |
Laryngeal Diseases | 0.002367032 | 1 | 0 | GAD |
Lymphatic Metastasis | 0.002367032 | 1 | 0 | GAD |
Nasopharyngeal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Chromosomal translocation | 0.002367032 | 1 | 0 | GAD |
Uterine Neoplasms | 0.002367032 | 1 | 0 | GAD |
Gastrooesophageal cancer | 0.002367032 | 1 | 0 | GAD |
Chronic ulcerative colitis | 0.002367032 | 1 | 0 | GAD |
Prostatic Hyperplasia | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of endometrium | 0.002171535 | 8 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.002171535 | 8 | 0 | BeFree |
Uterine Corpus Cancer | 0.002171535 | 8 | 0 | BeFree |
Hematopoietic Neoplasms | 0.001900093 | 7 | 0 | BeFree |
Carcinoma of larynx | 0.001900093 | 7 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001628651 | 6 | 0 | BeFree |
synovial sarcoma | 0.001628651 | 6 | 0 | BeFree |
Splenic Marginal Zone B-Cell Lymphoma | 0.001628651 | 6 | 0 | BeFree |
Parathyroid Gland Adenocarcinoma | 0.001628651 | 6 | 0 | BeFree |
Malignant Squamous Cell Neoplasm | 0.001628651 | 6 | 0 | BeFree |
Invasive breast carcinoma | 0.001628651 | 6 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Invasive Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Renal carcinoma | 0.001628651 | 6 | 0 | BeFree |
Medulloblastoma | 0.001357209 | 5 | 0 | BeFree |
Pituitary Diseases | 0.001357209 | 5 | 0 | BeFree |
Skin Neoplasms | 0.001357209 | 5 | 0 | BeFree |
Cutaneous Melanoma | 0.001357209 | 5 | 0 | BeFree |
Endometrial Stromal Sarcoma | 0.001357209 | 5 | 0 | BeFree |
Neoplasm, Residual | 0.001357209 | 5 | 0 | BeFree |
Trisomy 12 | 0.001357209 | 5 | 0 | BeFree |
Ductal Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.001357209 | 5 | 0 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.001357209 | 5 | 0 | BeFree |
Hepatocarcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Mammary Tumorigenesis | 0.001357209 | 5 | 0 | BeFree |
Astrocytoma | 0.001085767 | 4 | 0 | BeFree |
Fibrosarcoma | 0.001085767 | 4 | 0 | BeFree |
Hodgkin Disease | 0.001085767 | 4 | 0 | BeFree |
Multiple Endocrine Neoplasia Type 1 | 0.001085767 | 4 | 0 | BeFree |
Melanocytic nevus | 0.001085767 | 4 | 0 | BeFree |
Obesity | 0.001085767 | 4 | 1 | BeFree |
Hyperparathyroidism, Primary | 0.001085767 | 4 | 0 | BeFree |
Invasive Lobular Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Cervical Squamous Cell Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant lymphoma - lymphoplasmacytic | 0.001085767 | 4 | 0 | BeFree |
Malignant Glioma | 0.001085767 | 4 | 0 | BeFree |
Hurthle Cell Tumor | 0.001085767 | 4 | 0 | BeFree |
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Hereditary Nonpolyposis Colorectal Cancer | 0.001085767 | 4 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.001085767 | 4 | 0 | BeFree |
Skin Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Anaplasia | 0.000814326 | 3 | 0 | BeFree |
Asthma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000814326 | 3 | 0 | BeFree |
Carcinoma, Papillary | 0.000814326 | 3 | 0 | BeFree |
Drug abuse | 0.000814326 | 3 | 0 | BeFree |
Breast Fibrocystic Disease | 0.000814326 | 3 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000814326 | 3 | 0 | BeFree |
Intestinal Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Plasma Cell | 0.000814326 | 3 | 0 | BeFree |
Lymphocytosis | 0.000814326 | 3 | 0 | BeFree |
Small Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Waldenstrom Macroglobulinemia | 0.000814326 | 3 | 0 | BeFree |
Plasmacytoma | 0.000814326 | 3 | 0 | BeFree |
Benign Neoplasm | 0.000814326 | 3 | 0 | BeFree |
Oral Cavity Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000814326 | 3 | 0 | BeFree |
Agenesis of corpus callosum | 0.000814326 | 3 | 0 | BeFree |
Dysplastic Nevus | 0.000814326 | 3 | 0 | BeFree |
Medullary carcinoma | 0.000814326 | 3 | 0 | BeFree |
Neuroendocrine Tumors | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of female breast | 0.000814326 | 3 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenoid cystic carcinoma of salivary gland | 0.000814326 | 3 | 0 | BeFree |
Human papilloma virus infection | 0.000814326 | 3 | 0 | BeFree |
Breast Cancer, Familial | 0.000814326 | 3 | 0 | BeFree |
Cervical intraepithelial neoplasia grade 1 | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of tongue | 0.000814326 | 3 | 0 | BeFree |
Trisomy 11 | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Prolymphocytic, B-Cell | 0.000814326 | 3 | 0 | BeFree |
Ewings sarcoma | 0.000814326 | 3 | 0 | BeFree |
Oropharyngeal disorders | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of skin | 0.000814326 | 3 | 0 | BeFree |
Malignant lymphoma - lymphocytic, intermediate differentiation | 0.000814326 | 3 | 0 | BeFree |
Tumor Initiation | 0.000814326 | 3 | 0 | BeFree |
CARCINOMA OF VULVA | 0.000814326 | 3 | 0 | BeFree |
Mature B-Cell Non-Hodgkin Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000814326 | 3 | 0 | BeFree |
MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.000814326 | 3 | 0 | BeFree |
Ameloblastoma | 0.000542884 | 2 | 0 | BeFree |
Rheumatoid Arthritis | 0.000542884 | 2 | 3 | BeFree |
Burkitt Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Female Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of skin | 0.000542884 | 2 | 0 | BeFree |
Carcinosarcoma | 0.000542884 | 2 | 0 | BeFree |
Chondrosarcoma | 0.000542884 | 2 | 0 | BeFree |
Mental Depression | 0.000542884 | 2 | 0 | BeFree |
Depressive disorder | 0.000542884 | 2 | 0 | BeFree |
Giant Cell Tumors | 0.000542884 | 2 | 0 | BeFree |
Goiter | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Hyperglycemia | 0.000542884 | 2 | 0 | BeFree |
Lymphoid leukemia | 0.000542884 | 2 | 0 | BeFree |
Prolymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Monoclonal Gammopathy of Undetermined Significance | 0.000542884 | 2 | 0 | BeFree |
Neck Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Neurilemmoma | 0.000542884 | 2 | 0 | BeFree |
Peyronie Disease | 0.000542884 | 2 | 0 | BeFree |
Pheochromocytoma | 0.000542884 | 2 | 0 | BeFree |
Pituitary Adenoma | 0.000542884 | 2 | 0 | BeFree |
Prolactinoma | 0.000542884 | 2 | 0 | BeFree |
Psoriasis | 0.000542884 | 2 | 0 | BeFree |
Trisomy | 0.000542884 | 2 | 0 | BeFree |
Tuberous Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Uterine Fibroids | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000542884 | 2 | 0 | BeFree |
T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Peripheral T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Small cell carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of tongue | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of nasopharynx | 0.000542884 | 2 | 0 | BeFree |
Uterine Cancer | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Sarcoma, Epithelioid | 0.000542884 | 2 | 0 | BeFree |
Lichen Planus, Oral | 0.000542884 | 2 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Giant Cell Tumor of Bone | 0.000542884 | 2 | 0 | BeFree |
Neuroectodermal Tumor, Primitive | 0.000542884 | 2 | 0 | BeFree |
Pilomatrixoma | 0.000542884 | 2 | 0 | BeFree |
Epithelioid and spindle cell nevus | 0.000542884 | 2 | 0 | BeFree |
Nevi and Melanomas | 0.000542884 | 2 | 0 | BeFree |
Comedone | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of Male Breast | 0.000542884 | 2 | 0 | BeFree |
Medullary carcinoma of thyroid | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of male breast | 0.000542884 | 2 | 0 | BeFree |
Carcinoma, Small Cell | 0.000542884 | 2 | 0 | BeFree |
Carcinoma breast stage IV | 0.000542884 | 2 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Transitional cell carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Conventional (Clear Cell) Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000542884 | 2 | 0 | BeFree |
Prostatic Intraepithelial Neoplasias | 0.000542884 | 2 | 0 | BeFree |
High-Grade Squamous Intraepithelial Lesions | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Myofibroblastic Tumor | 0.000542884 | 2 | 0 | BeFree |
Clear cell sarcoma of kidney | 0.000542884 | 2 | 0 | BeFree |
Intrahepatic Cholangiocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Hematologic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Hemimegalencephaly | 0.000542884 | 2 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
Tongue Carcinoma | 0.000542884 | 2 | 0 | BeFree |
invasive cancer | 0.000542884 | 2 | 0 | BeFree |
extranodal lymphoma | 0.000542884 | 2 | 0 | BeFree |
Premenopausal breast cancer | 0.000542884 | 2 | 0 | BeFree |
Pharyngeal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.000542884 | 2 | 0 | BeFree |
Intraepithelial Neoplasia | 0.000542884 | 2 | 0 | BeFree |
Colorectal cancer metastatic | 0.000542884 | 2 | 1 | BeFree |
Plasma cell dyscrasia | 0.000542884 | 2 | 0 | BeFree |
Endometrial adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Chromophobe Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Atypical teratoid/rhabdoid tumor | 0.000542884 | 2 | 0 | BeFree |
Adenoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Primary Lesion | 0.000542884 | 2 | 0 | BeFree |
Breast Cancer Model | 0.000542884 | 2 | 0 | BeFree |
Ductal Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 | 0.000542884 | 2 | 0 | BeFree |
TUBEROUS SCLEROSIS 2 (disorder) | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, Follicular, Grade 1 | 0.000542884 | 2 | 0 | BeFree |
Coronary Artery Disease | 0.000542884 | 2 | 0 | BeFree |
Plasma Cell Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Urothelial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Oropharyngeal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adrenal incidentaloma | 0.000542884 | 2 | 0 | BeFree |
Clear-cell metastatic renal cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Endometrial sarcoma | 0.000542884 | 2 | 0 | BeFree |
Esophageal Spindle Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Apert syndrome | 0.000271442 | 1 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Anus Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
Basal Cell Nevus Syndrome | 0.000271442 | 1 | 0 | BeFree |
Benign Ovarian Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Bronchioloalveolar Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Cerebral Palsy | 0.000271442 | 1 | 0 | BeFree |
Coxsackievirus Infections | 0.000271442 | 1 | 0 | BeFree |
Craniosynostosis | 0.000271442 | 1 | 0 | BeFree |
Phyllodes Tumor | 0.000271442 | 1 | 0 | BeFree |
Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
Dwarfism | 0.000271442 | 1 | 0 | BeFree |
Epithelial hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Fatigue | 0.000271442 | 1 | 0 | BeFree |
Fatty Liver | 0.000271442 | 1 | 0 | BeFree |
Ganglioneuroma | 0.000271442 | 1 | 0 | BeFree |
Nodular Goiter | 0.000271442 | 1 | 0 | BeFree |
Hamartoma | 0.000271442 | 1 | 0 | BeFree |
Hemangioma | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Huntington Disease | 0.000271442 | 1 | 0 | BeFree |
leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
Acute Erythroblastic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myeloid, Accelerated Phase | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukoencephalopathy, Progressive Multifocal | 0.000271442 | 1 | 0 | BeFree |
Lichen Sclerosus et Atrophicus | 0.000271442 | 1 | 0 | BeFree |
Hyperlipoproteinemia Type I | 0.000271442 | 1 | 0 | BeFree |
liposarcoma | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Monosomy | 0.000271442 | 1 | 0 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Mycosis Fungoides | 0.000271442 | 1 | 0 | BeFree |
Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
Multiple Endocrine Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Nephrotic Syndrome | 0.000271442 | 1 | 2 | BeFree |
Nevus | 0.000271442 | 1 | 0 | BeFree |
Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
Parathyroid Diseases | 0.000271442 | 1 | 0 | BeFree |
Plague | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Retroviridae Infections | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Sertoli Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
Sezary Syndrome | 0.000271442 | 1 | 0 | BeFree |
Soft Tissue Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Gastric ulcer | 0.000271442 | 1 | 0 | BeFree |
Thymoma | 0.000271442 | 1 | 0 | BeFree |
Thymus Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
High Grade Lymphoma (neoplasm) | 0.000271442 | 1 | 0 | BeFree |
Precursor cell lymphoblastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
Diffuse Mixed-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Peripheral Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Cerebral Amyloid Angiopathy | 0.000271442 | 1 | 0 | BeFree |
Alcohol abuse | 0.000271442 | 1 | 0 | BeFree |
Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of parathyroid gland | 0.000271442 | 1 | 0 | BeFree |
Acute myocardial infarction | 0.000271442 | 1 | 0 | BeFree |
Adrenoleukodystrophy | 0.000271442 | 1 | 0 | BeFree |
Cicatrix, Hypertrophic | 0.000271442 | 1 | 0 | BeFree |
Follicular adenoma | 0.000271442 | 1 | 0 | BeFree |
Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
Liposarcoma, Dedifferentiated | 0.000271442 | 1 | 0 | BeFree |
Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Thymic Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenomyoma | 0.000271442 | 1 | 0 | BeFree |
Mesoblastic Nephroma | 0.000271442 | 1 | 0 | BeFree |
Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mucoepidermoid Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hemangioblastoma | 0.000271442 | 1 | 0 | BeFree |
Nevus, Blue | 0.000271442 | 1 | 0 | BeFree |
Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
Chondromyxoid fibroma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of extrahepatic bile duct | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
Anaplastic thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Dyslipidemias | 0.000271442 | 1 | 0 | BeFree |
Proliferative vitreoretinopathy | 0.000271442 | 1 | 0 | BeFree |
Isovaleryl-CoA dehydrogenase deficiency | 0.000271442 | 1 | 0 | BeFree |
Parathyroid hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Erythroblastosis | 0.000271442 | 1 | 0 | BeFree |
Virchow's node (disorder) | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of colon stage IV | 0.000271442 | 1 | 0 | BeFree |
Non-small cell lung cancer stage III | 0.000271442 | 1 | 0 | BeFree |
Disseminated neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Gallbladder adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Bladder Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
stage, Kaposi's sarcoma | 0.000271442 | 1 | 0 | BeFree |
stage, non-small cell lung cancer | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of vulva | 0.000271442 | 1 | 0 | BeFree |
Bone Marrow Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Fibrolamellar hepatocellular carcinoma | 0.000271442 | 1 | 0 | BeFree |
Superficial spreading malignant melanoma of skin | 0.000271442 | 1 | 0 | BeFree |
Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphomatous polyposis | 0.000271442 | 1 | 0 | BeFree |
Endometrial Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of colon | 0.000271442 | 1 | 0 | BeFree |
Proliferative retinopathy | 0.000271442 | 1 | 0 | BeFree |
Jaw Keratocyst | 0.000271442 | 1 | 0 | BeFree |
Cerebellar decompression injury | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Stage 0 Skin Melanoma | 0.000271442 | 1 | 0 | BeFree |
Vulval intraepithelial neoplasia | 0.000271442 | 1 | 0 | BeFree |
Oncocytoma, renal | 0.000271442 | 1 | 0 | BeFree |
Malignant melanoma of ciliary body | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of large intestine | 0.000271442 | 1 | 0 | BeFree |
Richter's syndrome | 0.000271442 | 1 | 0 | BeFree |
Pre B-cell acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Chromosome 8, trisomy | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma of spleen | 0.000271442 | 1 | 0 | BeFree |
Low grade B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
Plasma cell tumor, malignant | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 1 | BeFree |
mantle lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoid neoplasm | 0.000271442 | 1 | 0 | BeFree |
psychosocial stressor | 0.000271442 | 1 | 0 | BeFree |
Adult Acute Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lymphangioleiomyomatosis | 0.000271442 | 1 | 0 | BeFree |
AICARDI-GOUTIERES SYNDROME 1 | 0.000271442 | 1 | 0 | BeFree |
Adenomatous polyp of colon | 0.000271442 | 1 | 0 | BeFree |
Bile duct cancer resectable | 0.000271442 | 1 | 0 | BeFree |
Synovial sarcoma metastatic | 0.000271442 | 1 | 0 | BeFree |
Mantle cell lymphoma refractory | 0.000271442 | 1 | 0 | BeFree |
Advanced cancer | 0.000271442 | 1 | 0 | BeFree |
Gastric hyperplastic polyp | 0.000271442 | 1 | 0 | BeFree |
cancer recurrence | 0.000271442 | 1 | 0 | BeFree |
Stage 4S neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Skin toxicity | 0.000271442 | 1 | 0 | BeFree |
Lymphocytic infiltration | 0.000271442 | 1 | 0 | BeFree |
Large cell neuroendocrine carcinoma | 0.000271442 | 1 | 0 | BeFree |
Collecting Duct Carcinoma of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Metanephric adenoma | 0.000271442 | 1 | 0 | BeFree |
Cutaneous lymphoma | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Atypical polypoid adenomyoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Primary Cutaneous Anaplastic Large Cell | 0.000271442 | 1 | 0 | BeFree |
ACTH-Secreting Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Liver regeneration disorder | 0.000271442 | 1 | 0 | BeFree |
Anterior Tongue Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Atypical Ductal Breast Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Congenital Mesoblastic Nephroma | 0.000271442 | 1 | 0 | BeFree |
Childhood Renal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Gastric Precancerous Condition | 0.000271442 | 1 | 0 | BeFree |
Low Grade Ductal Breast Carcinoma In Situ | 0.000271442 | 1 | 0 | BeFree |
Primary Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Solid pseudopapillary tumour of the pancreas | 0.000271442 | 1 | 0 | BeFree |
Testicular Germ Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
Burkitt-like lymphoma | 0.000271442 | 1 | 0 | BeFree |
Benign melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Smoldering myeloma | 0.000271442 | 1 | 0 | BeFree |
Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
androgen independent prostate cancer | 0.000271442 | 1 | 0 | BeFree |
Peripheral Arterial Diseases | 0.000271442 | 1 | 0 | BeFree |
Keratocystic Odontogenic Tumor | 0.000271442 | 1 | 0 | BeFree |
Papillary Thyroid Microcarcinoma | 0.000271442 | 1 | 0 | BeFree |
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type | 0.000271442 | 1 | 0 | BeFree |
Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
MYELOPROLIFERATIVE SYNDROME, TRANSIENT | 0.000271442 | 1 | 0 | BeFree |
HYPERPARATHYROIDISM 1 | 0.000271442 | 1 | 0 | BeFree |
HYPERTRICHOSIS, CONGENITAL GENERALIZED | 0.000271442 | 1 | 0 | BeFree |
HYPERPARATHYROIDISM 3 | 0.000271442 | 1 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
malignant neoplasm of breast staging | 0.000271442 | 1 | 0 | BeFree |
Endometrial stromal sarcoma, high grade | 0.000271442 | 1 | 0 | BeFree |
Bulimia Nervosa | 0.000271442 | 1 | 0 | BeFree |
Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Lentigo maligna melanoma | 0.000271442 | 1 | 0 | BeFree |
Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C | 0.000271442 | 1 | 0 | BeFree |
Bisphosphonate-associated osteonecrosis | 0.000271442 | 1 | 0 | BeFree |
Early-Stage Breast Carcinoma | 0.000271442 | 1 | 2 | BeFree |
Palisaded myofibroblastoma | 0.000271442 | 1 | 0 | BeFree |
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus of skin | 0.000271442 | 1 | 0 | BeFree |
Mammary adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Fibromyxosarcoma | 0.000271442 | 1 | 0 | BeFree |
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