HAMP(hepcidin antimicrobial peptide) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19q13.1
基因染色体位置图

基因简述

基因简述

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

[中文简述(自动翻译):]  由该基因编码的产物是参与维持铁稳态的，并且有必要对铁存储在巨噬细胞的调节，以及用于肠道铁的吸收。的前原被翻译后切割成的20,22和25个氨基酸的成熟肽，和这些活性肽是富含半胱氨酸，其中形成稳定的β-折叠片结构分子内键。这些肽表现出对细菌和真菌的抗微生物活性。在该基因引起血色病2B型，突变也被称为青少年血色素沉着症，引起严重的铁过载导致在心肌病，肝硬化和内分泌衰竭的疾病。 [由RefSeq的，2014年10月提供]

OMIM数据库中对HAMP基因的介绍     Wikipedia数据库中对HAMP基因的介绍

基因序列

基因序列

HAMP基因的碱基序列：[NCBI]

基因突变

基因突变

HAMP基因的碱基突变：           显示全部snp
rs1882694       rs1882695       rs2293689       rs3817623       rs7251432       rs7256866       rs8101606       rs10409503       rs10414846       rs10416533       rs10416795       rs10421768       rs11322802       rs11670019       rs12608868       rs55863037       rs66868858       rs74887182       rs75448148       rs75714555       rs104894696       rs111302306       rs111426994       rs111602984       rs111623180       rs112320853       rs112674139       rs113120314       rs113130816       rs116020457       rs116178041       rs116802601       rs117023744       rs117345431       rs117479093       rs117742311       rs117933989      
rs138454959       rs140022984       rs140722547       rs140906994       rs141311990       rs142015183       rs142126068       rs145230977       rs145465742       rs145846674       rs145850917       rs146776859       rs147479679       rs147615585       rs147639216       rs147816832       rs148840682       rs149146279       rs149358257       rs150075322       rs150121265       rs181305656       rs182353585       rs183395025       rs184521806       rs185009104       rs186111708       rs186957299       rs188297061       rs189798859       rs190403593       rs192021123       rs192738509       rs199840627       rs200488037       rs200699506       rs201107062       rs201371612       rs201587159       rs202098787       rs367555049       rs367646034       rs367957111       rs368503520       rs370397195       rs370717576       rs371421756       rs372237628       rs372330392       rs373178250       rs373214016       rs374126439       rs374220530       rs375386964       rs375495615       rs527734167       rs528180651       rs528725320       rs529544039       rs530196720       rs530589051       rs531175456       rs531617400       rs532616197       rs533022280       rs533059182       rs533699898       rs534709064       rs534769279       rs534927435       rs535634994       rs535688819       rs536171199       rs537129233       rs537771495       rs539072396       rs539878376       rs539954613       rs540075622       rs541140778       rs541993529       rs542308592       rs542554786       rs542942749       rs543370945       rs543723836       rs544326408       rs544888874       rs545116287       rs545339761       rs546535967       rs547142305       rs548215857       rs548857235       rs549053497       rs550281876       rs550453020       rs550562554       rs550903999       rs551685939       rs552575526       rs553409669       rs553493139       rs553554683       rs554327899       rs554570008       rs555001923       rs555198869       rs555931887       rs557063658       rs557795610       rs557874192       rs558767289       rs559183644       rs559262711       rs559516318       rs559701733       rs559737483       rs560645655       rs560688630       rs560773501       rs561076565       rs562094889       rs563098905       rs563474639       rs564159790       rs564579852       rs565099642       rs565136183       rs565532942       rs565666705       rs565929844       rs566867060       rs566908162       rs567268036       rs567543922       rs567708437       rs569086643       rs570185819       rs570375409       rs570714594       rs571299483       rs571522131       rs571977218       rs573149012       rs573187458       rs573824032       rs574446193       rs574457398       rs574579877       rs575517109       rs576477642       rs576979244       rs577503873       rs577605550       rs577640845       rs745845982       rs746974122       rs747202846       rs747626500       rs747735026       rs748923035       rs748923691       rs749023682       rs750479210       rs751003644       rs751203794       rs751603444       rs751730554       rs752428391       rs752949264       rs752958660       rs753984369       rs754172113       rs754591572       rs755419724       rs756823291       rs758054130       rs759446782       rs759793237       rs759921570       rs760104316       rs760522853       rs760576032       rs760903988       rs761276428       rs761678599       rs761907472       rs762007166       rs763369315       rs763805707       rs764107355       rs764314011       rs764425153       rs765473469       rs765599115       rs766347661       rs767080313       rs767431880       rs767679046       rs768089157       rs768305190       rs768566070       rs769458797       rs769666853       rs770745939       rs770800959       rs771075802       rs771612441       rs773184259       rs773428762       rs773869217       rs774680472       rs775336391       rs776021649       rs776298902       rs776364235       rs776526247       rs777227364       rs777235310       rs777280735       rs778686147       rs779021719       rs779117196       rs779910992       rs780532638       rs780533179       rs780585862      

基因表达

基因表达

HAMP基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TGCAAGACGTAGAACCTACC
60
AGCAGGAATAAATAAGGAAGGG
58
ATGGCTCACACCTGTAATCC
60
GGGCTCAACTGATCTTCCT
59
CACTGAGCTCCCAGATCTG
60
CTTTGATCGATGACAGCAGC
60
GCAAGACGTAGAACCTACC
58
CAGCAGGAATAAATAAGGAAGGG
59
CACTGAGCTCCCAGATCTG
60
ACTTTGATCGATGACAGCAG
58
CACTGAGCTCCCAGATCTG
60
TTTGATCGATGACAGCAGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

HAMP基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HAMP基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000122
P81172(UniProtKB)
ISS
GO:0002092
P81172(UniProtKB)
IDA
GO:0005102
P81172(UniProtKB)
IPI
GO:0005102
P81172(UniProtKB)
IPI
GO:0005179
P81172(UniProtKB)
IEA
GO:0005179
P81172(UniProtKB)
IDA
GO:0005179
P81172(UniProtKB)
IDA
GO:0005576
P81172(UniProtKB)
NAS
GO:0005615
P81172(UniProtKB)
IDA
GO:0005623
P81172(UniProtKB)
IEA
GO:0006879
P81172(UniProtKB)
IDA
GO:0006879
P81172(UniProtKB)
IDA
GO:0006955
P81172(UniProtKB)
TAS
GO:0010039
P81172(UniProtKB)
IMP
GO:0031640
P81172(UniProtKB)
IEA
GO:0032413
P81172(UniProtKB)
IDA
GO:0042742
P81172(UniProtKB)
IBA
GO:0045179
P81172(UniProtKB)
IEA
GO:0050832
P81172(UniProtKB)
IEA
GO:0060586
P81172(UniProtKB)
IMP
GO:0097690
P81172(UniProtKB)
IDA
GO:1902916
P81172(UniProtKB)
IDA
GO:1904039
P81172(UniProtKB)
IDA
GO:1904255
P81172(UniProtKB)
IDA
GO:1904479
P81172(UniProtKB)
IMP
GO:2000646
P81172(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HAMP基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HEMOCHROMATOSIS, TYPE 2B 0.36 3 2 CLINVAR_CTD_human_UNIPROT
Juvenile hemochromatosis 0.247328931 27 0 BeFree_CTD_human_ORPHANET
Iron Overload 0.169962624 104 7 BeFree_CTD_human_GAD_LHGDN
Hemochromatosis 0.167463566 73 1 BeFree_CTD_human_GAD_LHGDN
Anemia 0.150179705 65 0 BeFree_CTD_human_LHGDN
Hereditary hemochromatosis 0.13302921 48 4 BeFree_CLINVAR
beta Thalassemia 0.125895776 14 0 BeFree_CTD_human_GAD
Kidney Failure, Chronic 0.123538676 4 0 BeFree_CTD_human_LHGDN
Biliary Atresia 0.120542884 2 0 BeFree_CTD_human
Hepatolenticular Degeneration 0.12 1 0 CTD_human
Thalassemia 0.011158911 11 0 BeFree_LHGDN
Iron deficiency 0.006243163 23 0 BeFree
Inflammation 0.0054487 2 0 LHGDN
Hepatitis C 0.004895885 9 0 BeFree_LHGDN
Anemia of chronic disease 0.004885954 18 0 BeFree
Liver carcinoma 0.004885954 18 0 BeFree
Iron Metabolism Disorders 0.003995683 7 0 BeFree_GAD
Liver neoplasms 0.003528744 13 0 BeFree
Rheumatoid Arthritis 0.003267234 3 0 BeFree_LHGDN
Malaria 0.003267234 3 0 BeFree_LHGDN
Malaria, Falciparum 0.003267234 2 0 BeFree_LHGDN
Siderosis 0.003267234 2 0 BeFree_LHGDN
Adenoma 0.002995792 1 0 BeFree_LHGDN
Porphyria Cutanea Tarda 0.002995792 1 0 BeFree_LHGDN
Iron-Refractory Iron Deficiency Anemia 0.002985861 11 0 BeFree
Colorectal Neoplasms 0.00272435 1 0 LHGDN
Lupus Erythematosus, Systemic 0.00272435 1 0 LHGDN
Disorders of Porphyrin Metabolism 0.00272435 1 0 LHGDN
Amyloidosis, Familial 0.00272435 1 0 LHGDN
Infection 0.00272435 1 0 LHGDN
Iron deficiency anemia 0.002714419 10 5 BeFree
Spontaneous abortion 0.002367032 1 0 GAD
Pregnancy Complications 0.002367032 1 0 GAD
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.002367032 1 0 GAD
Cooley's anemia 0.002171535 8 0 BeFree
Obesity 0.002171535 8 0 BeFree
Hepatitis C, Chronic 0.001628651 6 0 BeFree
Alcoholic Liver Diseases 0.001357209 5 0 BeFree
Bacterial Infections 0.001085767 4 0 BeFree
Liver diseases 0.001085767 4 0 BeFree
Beta thalassemia intermedia 0.001085767 4 0 BeFree
Metabolic Syndrome X 0.001085767 4 0 BeFree
Ceruloplasmin deficiency 0.001085767 4 0 BeFree
Anemia, Sickle Cell 0.000814326 3 2 BeFree
Diabetes 0.000814326 3 0 BeFree
Diabetes Mellitus 0.000814326 3 0 BeFree
Liver Cirrhosis 0.000814326 3 0 BeFree
Adrenoleukodystrophy 0.000814326 3 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Arteriosclerosis 0.000542884 2 0 BeFree
Atherosclerosis 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Colitis 0.000542884 2 0 BeFree
Endocrine System Diseases 0.000542884 2 0 BeFree
HIV Infections 0.000542884 2 1 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Ovarian Diseases 0.000542884 2 0 BeFree
Kidney Failure 0.000542884 2 0 BeFree
Virus Diseases 0.000542884 2 0 BeFree
Fibrosis, Liver 0.000542884 2 0 BeFree
Microcytic hypochromic anemia (disorder) 0.000542884 2 0 BeFree
Chronic liver disease 0.000542884 2 0 BeFree
Non-alcoholic Fatty Liver Disease 0.000542884 2 1 BeFree
Chronic Kidney Insufficiency 0.000542884 2 0 BeFree
Overweight 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Beta thalassemia trait 0.000542884 2 0 BeFree
Chronic Kidney Diseases 0.000542884 2 0 BeFree
Cirrhosis 0.000542884 2 0 BeFree
HEMOCHROMATOSIS, TYPE 3 0.000542884 2 0 BeFree
Chronic kidney disease stage 5 0.000542884 2 0 BeFree
Nonalcoholic Steatohepatitis 0.000542884 2 0 BeFree
Refractory anemias 0.000271442 1 0 BeFree
Astrocytoma 0.000271442 1 0 BeFree
Cholangitis, Sclerosing 0.000271442 1 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Gastritis 0.000271442 1 0 BeFree
Hepatitis B 0.000271442 1 0 BeFree
Inflammatory Bowel Diseases 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree
Obesity, Morbid 0.000271442 1 0 BeFree
Peritonitis 0.000271442 1 0 BeFree
Polycystic Ovary Syndrome 0.000271442 1 0 BeFree
Polycythemia 0.000271442 1 0 BeFree
Preleukemia 0.000271442 1 0 BeFree
Salmonella infections 0.000271442 1 0 BeFree
Tuberculosis 0.000271442 1 0 BeFree
Acute Cholecystitis 0.000271442 1 0 BeFree
Anemia, severe 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Parasitemia 0.000271442 1 0 BeFree
Hypocupremia 0.000271442 1 0 BeFree
Thalassemia Intermedia 0.000271442 1 0 BeFree
Bacterial cholangitis 0.000271442 1 0 BeFree
Malonic aciduria 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Hemoglobin E/beta thalassemia disease 0.000271442 1 0 BeFree
Hepatitis B, Chronic 0.000271442 1 0 BeFree
Primary sclerosing cholangitis 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Carcinoma of lung 0.000271442 1 0 BeFree
Chronic lung disease 0.000271442 1 0 BeFree
Renal anemia 0.000271442 1 0 BeFree
Inflammatory disorder 0.000271442 1 0 BeFree
Multi-centric Castleman's Disease 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree
Renal Insufficiency 0.000271442 1 0 BeFree
Macular dystrophy, corneal type 1 0.000271442 1 0 BeFree
Refractory anemia, without ringed sideroblasts, without excess blasts 0.000271442 1 0 BeFree
MYELODYSPLASTIC SYNDROME 0.000271442 1 0 BeFree

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