ACTC1(actin, alpha, cardiac muscle 1)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

15q14
基因染色体位置图

基因简述

基因简述

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  肌动蛋白是高度保守的那些涉及各类细胞运动的蛋白质。球状??肌动蛋白（G-肌动蛋白）的聚合导致在两股螺旋形式的结构长丝（F-肌动蛋白）。每个肌动蛋白可以绑定到其他四个。由该基因编码的蛋白质属于肌动蛋白家族，其是由肌动蛋白同种型，α，β，和γ的三组主要的。阿尔法肌动蛋白在肌肉组织中发现，并且是收缩装置的主要成分。该基因缺陷已与原发性扩张型心肌病（IDC）和家族性肥厚型心肌病（FHC）有关。 [由RefSeq的，2008年7月提供]

OMIM数据库中对ACTC1基因的介绍     Wikipedia数据库中对ACTC1基因的介绍

基因序列

基因序列

ACTC1基因的碱基序列：[NCBI]

基因突变

基因突变

ACTC1基因的碱基突变：           显示全部snp
rs496394       rs503639       rs525720       rs533021       rs533115       rs589759       rs604689       rs670957       rs746216       rs1370154       rs1370155       rs2033707       rs2070664       rs2307493       rs2307494       rs3059225       rs3729755       rs3729756       rs3729757       rs3729758       rs3759834       rs7165006       rs7166290       rs7166484       rs7178464       rs8027352       rs8037241       rs11629614       rs11635130       rs12904588       rs16959824       rs28595759       rs28730667       rs34323254       rs35166832       rs62006139       rs63346461      
rs73387693       rs73387694       rs73387696       rs74009718       rs74009719       rs74009720       rs74563378       rs75876276       rs76013827       rs76187079       rs76816522       rs76891510       rs77247635       rs77350268       rs78308231       rs78596978       rs78639435       rs78697034       rs78727649       rs78848103       rs79104010       rs79209261       rs79792346       rs79813694       rs79823729       rs79955486       rs80085137       rs80139141       rs111611449       rs112062652       rs112420026       rs112660730       rs112920084       rs113062201       rs113063427       rs113178069       rs113513162       rs113835687       rs115016806       rs115295911       rs115415793       rs115586078       rs116034611       rs116184851       rs116410626       rs116419104       rs117033977       rs117348243       rs121912676       rs138347995       rs138374537       rs138752414       rs138812333       rs139028283       rs139480222       rs139559367       rs139651417       rs139691739       rs140004011       rs140261885       rs141322728       rs141349170       rs141368726       rs141451626       rs142089717       rs142735669       rs142839840       rs143407466       rs144181590       rs144559389       rs144819872       rs145023222       rs145050508       rs145070828       rs145085048       rs145178906       rs145445499       rs145818722       rs145857148       rs146060905       rs146619035       rs146629760       rs147406641       rs147572632       rs147582430       rs147668573       rs147815755       rs148321492       rs148643629       rs148695567       rs149007948       rs149031785       rs149345326       rs149432225       rs149670574       rs149715837       rs151321743       rs181013324       rs181479041       rs181638011       rs181924243       rs182044003       rs182840803       rs183288639       rs183632308       rs183854208       rs183972120       rs184599823       rs184602686       rs184744276       rs185151197       rs185293070       rs185420671       rs186732149       rs186863977       rs187039112       rs187923382       rs188299421       rs188312846       rs189725849       rs189851454       rs189953579       rs190990403       rs191101101       rs191155306       rs191468971       rs193056424       rs193922680       rs199947846       rs200369344       rs200532721       rs201258118       rs201921957       rs368171271       rs368741225       rs369019849       rs370082904       rs370129723       rs370322510       rs370499568       rs371495641       rs371590770       rs371877455       rs371940910       rs372238368       rs373261583       rs373997876       rs374029107       rs374099539       rs374252209       rs374649080       rs375435815       rs375944676       rs376417852       rs376566924       rs376724957       rs377217263       rs377546862       rs377610013       rs397517056       rs397517057       rs397517058       rs397517062       rs397517066       rs527277176       rs527292617       rs527397732       rs527856007       rs528359840       rs528475765       rs529572133       rs529603008       rs529650679       rs529727545       rs529758887       rs530841804       rs530906320       rs531043932       rs531195437       rs531880202       rs531912878       rs532433161       rs532941484       rs533344087       rs533668609       rs534109822       rs534755873       rs535341692       rs535622574       rs535623090       rs535827143       rs536122084       rs536432438       rs537031515       rs537551929       rs538029965       rs539060452       rs539391317       rs539981464       rs540240407       rs540451830       rs540721330       rs541476797       rs541587344       rs541805662       rs542059917       rs542478705       rs543030688       rs543105230       rs544013796       rs544452045       rs545484464       rs545523213       rs545662026       rs545762703       rs546234337       rs546907646       rs547153356       rs547800928       rs547964711       rs548256827       rs548996341       rs549286823       rs549446281       rs549951154       rs549986676       rs550695315       rs551182742       rs551820554       rs551847673       rs551903189       rs551939950       rs552355887       rs553391201       rs553612327       rs553628367       rs553652706       rs553885411       rs554012838       rs554104818       rs554219325       rs554945478       rs555107579       rs556051745       rs556148550       rs556400562       rs557782296       rs558792304       rs558820668       rs559011430       rs559235996       rs559661985       rs559691079       rs559788933       rs559798665       rs559901215       rs559979638       rs560065427       rs560074407       rs560362537       rs561081869       rs562187785       rs562381720       rs562506296       rs562747106       rs563537092       rs563713150       rs563713498       rs563821469       rs564151494       rs565047760       rs565085900       rs565164105       rs565588533       rs566025687       rs566201991       rs567109682       rs567765343       rs568152383       rs568272940       rs568392345       rs568596720       rs568877892       rs569463018       rs570150463       rs570583275       rs570663792       rs570825701       rs571704149       rs571817347       rs572031368       rs572654192       rs573030321       rs573700119       rs574151093       rs574484555       rs574521280       rs574698645       rs575737144       rs576017800       rs576088444       rs576816681       rs576925720       rs577101643       rs577134148       rs577209836       rs578233638       rs730880407       rs745838366       rs745939876       rs746308321       rs746508669       rs746748461       rs747281221       rs748053539       rs748062476       rs748380799       rs748506621       rs748575010       rs748718899       rs748909803       rs749154513       rs749354463       rs749931177       rs750091318       rs750131288       rs750389888       rs750536667       rs750951965       rs750991515       rs751044644       rs751535500       rs751661762       rs751751696       rs751851323       rs752322493       rs752499457       rs752512209       rs753155881       rs753552901       rs753599089       rs754736799       rs755214735       rs755521922       rs755858258       rs756060664       rs756249146       rs756470577       rs756594449       rs757146524       rs758021855       rs758173419       rs758606996       rs758865091       rs758955371       rs759078213       rs759156523       rs759495229       rs759988070       rs760269526       rs761399043       rs761554405       rs761593696       rs761756548       rs762048029       rs762354030       rs762550009       rs762753367       rs763073776       rs763198919       rs763452221       rs763616452       rs763713642       rs763817712       rs763905846       rs764168686       rs764208251       rs764630691       rs764640888       rs764683976       rs764875992       rs765049172       rs766013863       rs766861052       rs766868624       rs766934253       rs767180775       rs767644255       rs767734253       rs768169477       rs768363857       rs768526036       rs769158928       rs769303249       rs769654627       rs769737060       rs769780832       rs769795473       rs769881551       rs770397773       rs770486092       rs770650598       rs771011464       rs771047512       rs771206086       rs771310484       rs771314720       rs771382882       rs771632205       rs771926957       rs772110994       rs772344965       rs773112383       rs773231264       rs773272217       rs773788749       rs774244503       rs774527581       rs774559521       rs774767260       rs774821992       rs774956583       rs775769592       rs775883084       rs776430979       rs776468970       rs777284383       rs777285554       rs777680760       rs777875134       rs777933415       rs778572289       rs778914066       rs779004124       rs779663711       rs779813808       rs779942233       rs780088008       rs780321005       rs780634156       rs780724030       rs780884645       rs781220417       rs781651067       rs3729758       rs139480222       rs145818722       rs541476797      

基因表达

基因表达

ACTC1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTTGAAAGTGTCCTCGGGA
59
AGTCCAGAACAATGCACAC
58
CATCATGCGTCTGGATCTG
58
ATTTCACGTTCAGCAGTGG
58
ATCATGCGTCTGGATCTGG
59
AATTTCACGTTCAGCAGTGG
59
TTGAGACCTTCAATGTCCCT
59
GAACAATGCCTGTGGTACG
59
ATCATGCGTCTGGATCTGG
60
AATTTCACGTTCAGCAGTGG
60
ATTTGAAAGTGTCCTCGGGA
59
AGTCCAGAACAATGCACAC
58
ATTTGAAAGTGTCCTCGGG
58
AGTCCAGAACAATGCACAC
58
ATCATGCGTCTGGATCTGG
59
ATTTCACGTTCAGCAGTGG
58
TGAGACCTTCAATGTCCCTG
60
GAACAATGCCTGTGGTACG
59
CATCATGCGTCTGGATCTG
59
ATTTCACGTTCAGCAGTGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

ACTC1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

ACTC1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005524
P68032(UniProtKB)
IDA
GO:0005615
P68032(UniProtKB)
IDA
GO:0005615
P68032(UniProtKB)
IDA
GO:0005737
P68032(UniProtKB)
IDA
GO:0005829
P68032(UniProtKB)
TAS
GO:0005829
P68032(UniProtKB)
TAS
GO:0005829
P68032(UniProtKB)
TAS
GO:0005829
P68032(UniProtKB)
TAS
GO:0005884
P68032(UniProtKB)
IDA
GO:0005884
P68032(UniProtKB)
IDA
GO:0005925
P68032(UniProtKB)
IDA
GO:0006915
P68032(UniProtKB)
ISS
GO:0010628
P68032(UniProtKB)
ISS
GO:0016020
P68032(UniProtKB)
IDA
GO:0016887
P68032(UniProtKB)
IDA
GO:0016887
P68032(UniProtKB)
IDA
GO:0017022
P68032(UniProtKB)
IPI
GO:0017022
P68032(UniProtKB)
IDA
GO:0030017
P68032(UniProtKB)
IDA
GO:0030027
P68032(UniProtKB)
ISS
GO:0030048
P68032(UniProtKB)
IDA
GO:0030049
P68032(UniProtKB)
TAS
GO:0030175
P68032(UniProtKB)
ISS
GO:0030240
P68032(UniProtKB)
ISS
GO:0031032
P68032(UniProtKB)
ISS
GO:0031674
P68032(UniProtKB)
ISS
GO:0033275
P68032(UniProtKB)
IMP
GO:0042493
P68032(UniProtKB)
IEA
GO:0042643
P68032(UniProtKB)
IDA
GO:0043066
P68032(UniProtKB)
IEA
GO:0044297
P68032(UniProtKB)
ISS
GO:0045471
P68032(UniProtKB)
IEA
GO:0055003
P68032(UniProtKB)
ISS
GO:0055008
P68032(UniProtKB)
ISS
GO:0060047
P68032(UniProtKB)
IMP
GO:0060047
P68032(UniProtKB)
IMP
GO:0060047
P68032(UniProtKB)
IMP
GO:0060048
P68032(UniProtKB)
IEA
GO:0070062
P68032(UniProtKB)
IDA
GO:0070062
P68032(UniProtKB)
IDA
GO:0072562
P68032(UniProtKB)
IDA
GO:0090131
P68032(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控ACTC1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Cardiomyopathy, Familial Hypertrophic, 11 0.24 4 0 CTD_human_UNIPROT
Atrial Septal Defect 5 0.24 1 0 CTD_human_UNIPROT
CARDIOMYOPATHY, DILATED, 1R 0.2 1 0 MGD_UNIPROT
Cardiomyopathy, Dilated 0.131368221 11 11 BeFree_CTD_human_GAD
Left ventricular noncompaction 0.120271442 1 0 BeFree_ORPHANET
Precancerous Conditions 0.12 1 0 CTD_human
Refractive Errors 0.12 1 0 CTD_human
Stomach Neoplasms 0.12 1 0 CTD_human
Ostium secundum atrial septal defect 0.12 0 0 ORPHANET
Cardiomyopathy, Familial Hypertrophic, 1 (disorder) 0.12 0 0 CTD_human
Hypertensive disease 0.08 1 0 RGD
Endotoxemia 0.08 1 0 RGD
Hypertrophic Cardiomyopathy 0.015916719 10 0 BeFree_GAD_LHGDN
Cardiomyopathies 0.009087065 8 1 BeFree_GAD_LHGDN
Atrial Septal Defects 0.003810118 4 0 BeFree_LHGDN
Myopathies, Nemaline 0.002995792 2 0 BeFree_LHGDN
Cardiomyopathy, Familial Idiopathic 0.002638474 2 0 BeFree_GAD
Cardiomegaly 0.002367032 1 0 GAD
Myopia 0.002367032 1 0 GAD
Blood pressure finding 0.002367032 1 1 GAD
Systemic arterial pressure 0.002367032 1 1 GAD
Cardiomyopathy, Hypertrophic, Familial 0.000542884 2 0 BeFree
Coronary heart disease 0.000271442 1 0 BeFree
Patent ductus arteriosus 0.000271442 1 0 BeFree
Congenital Heart Defects 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Heart Septal Defects 0.000271442 1 0 BeFree
Congenital heart disease 0.000271442 1 0 BeFree
Myopia, Degenerative 0.000271442 1 0 BeFree
Hyperlipoproteinemia Type IIa 0.000271442 1 0 BeFree
CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder) 0.000271442 1 0 BeFree

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