更多...
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 该基??因编码的Ikaros基因家族锌指蛋白中的一员。该蛋白质家族的三个成员(Ikaros基因,艾俄罗斯和的Helios)是参与淋巴细胞发育的调节造血特异性转录因子。该蛋白质形式均聚物或杂二聚物和其他的Ikaros家庭成员,并且被认为在早期造血发展主要的作用。已发现此基因编码不同同种型的多个转录物的变体,但是有些变体的生物有效性尚未确定。 [由RefSeq的,2008年7月提供]
IKZF2基因(以及对应的蛋白质)的细胞分布位置:
IKZF2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
Adult T-Cell Lymphoma/Leukemia | 0.12 | 1 | 0 | CTD_human |
Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Body Weight Changes | 0.002367032 | 1 | 1 | GAD |
Insulin Resistance | 0.002367032 | 1 | 2 | GAD |
Nasal Polyps | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 1 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 1 | GAD |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。