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This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因产物属于14-3-3家族,通过结合含有磷酸丝氨酸蛋白介导的信号转导的蛋白质。此高度保守的蛋白家族在植物和哺乳动物中发现,而该蛋白质是100%相同的大鼠直向同源物。它是由生长因子的人血管平滑肌细胞诱导,并且也高度在骨骼肌和心脏肌肉中表达,这表明对肌肉组织中该蛋白具有重要作用。它已被证明与RAF1和蛋白激酶相互作用C,参与多种信号转导通路蛋白。 [由RefSeq的,2008年7月提供]
YWHAG基因(以及对应的蛋白质)的细胞分布位置:
YWHAG基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Fibroid Tumor | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Down Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Schizophrenia | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.002638474 | 2 | 0 | BeFree_GAD |
Multiple Sclerosis | 0.002367032 | 1 | 2 | GAD |
Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Williams Syndrome | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
neurobehavioral problems | 0.000271442 | 1 | 0 | BeFree |
Cerebral Ischemia | 0.000271442 | 1 | 0 | BeFree |
Intellectual Disability | 0.000271442 | 1 | 0 | BeFree |
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