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X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]
[中文简述(自动翻译):]  X染色体失活是在哺乳动物雌性早期发育过程,转录沉默的一对X染色体中的一个,从而提供男性和女性之间的剂量等价。这个过程是由几个因素,包括染色体的一个区域X称为X染色体失活中心(XIC)调节。的XIC包括若干非编码和编码蛋白的基因,并且该基因是XIC内确定的第一非编码基因。该基因是从失活的X染色体的XIC完全表达,并??且是X染色体失活的启动和传播至关重要。该成绩单是剪接的RNA。可变剪接转录物变体已经确定,但其全长序列尚未确定。在XIST启动子家族事业倾斜的突变X染色体失活。 [由RefSeq的,2012年4月提供]
XIST基因(以及对应的蛋白质)的细胞分布位置:
XIST基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Influenza | 0.12 | 1 | 0 | CTD_human |
| X INACTIVATION, FAMILIAL SKEWED, 1 (disorder) | 0.12 | 0 | 0 | CLINVAR |
| Mental Retardation | 0.001357209 | 5 | 0 | BeFree |
| Fibroid Tumor | 0.000542884 | 2 | 0 | BeFree |
| Preleukemia | 0.000542884 | 2 | 0 | BeFree |
| Seminoma | 0.000542884 | 2 | 0 | BeFree |
| Uterine Fibroids | 0.000542884 | 2 | 0 | BeFree |
| Kabuki make-up syndrome | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
| Dwarfism | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Myelodysplasia | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Oligospermia | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Parkinson Disease | 0.000271442 | 1 | 0 | BeFree |
| Severe mental retardation (I.Q. 20-34) | 0.000271442 | 1 | 0 | BeFree |
| Testicular Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Embryonal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Superficial ulcer | 0.000271442 | 1 | 0 | BeFree |
| Triploidy syndrome | 0.000271442 | 1 | 0 | BeFree |
| Developmental delay (disorder) | 0.000271442 | 1 | 0 | BeFree |
| XX males | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Single tumor | 0.000271442 | 1 | 0 | BeFree |
| Congenital malformation syndrome | 0.000271442 | 1 | 0 | BeFree |
| Testicular Germ Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
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