更多...
收起
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
[中文简述(自动翻译):]  这个基因编码包含在C-末端和在N-末端的脯氨酸/富含谷氨酰胺的DNA结合结构域4锌指基序的转录因子。它在泌尿生殖系统的正常发育中起重要作用,并且它是在患者的肾母细胞瘤的一小部分的突变。该基因具有在不同组织中的母系和父系等位基因复杂的组织特异性和多形压印图案,具有双等位基因和单等位基因表达。多个转录变体已有描述。在几个变体,有证据为使用非AUG(CUG)翻译起始密码子的上游,并在帧与第一组AUG。 PMID的作者:7926762还提??供证据表明,WT1基因发生RNA编辑在人类和老鼠,而这个过程是组织限制性和发育调控。 [由RefSeq的,2015年3月提供]
WT1基因(以及对应的蛋白质)的细胞分布位置:
WT1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Denys-Drash Syndrome | 0.572691755 | 43 | 11 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT |
| Frasier Syndrome | 0.487610304 | 19 | 5 | BeFree_CLINVAR_CTD_human_LHGDN_ORPHANET_UNIPROT |
| Nephroblastoma | 0.444098287 | 220 | 2 | BeFree_CTD_human_GAD_LHGDN_ORPHANET_UNIPROT |
| MEACHAM SYNDROME (disorder) | 0.36 | 2 | 2 | CLINVAR_ORPHANET_UNIPROT |
| WAGR Syndrome | 0.246167218 | 14 | 0 | BeFree_CTD_human_GAD_ORPHANET |
| NEPHROTIC SYNDROME, TYPE 4 | 0.24 | 4 | 0 | CTD_human_UNIPROT |
| Leukemia, Myelocytic, Acute | 0.174303151 | 62 | 1 | BeFree_CTD_human_GAD_LHGDN |
| leukemia | 0.142840843 | 49 | 1 | BeFree_CTD_human_LHGDN |
| Mammary Neoplasms | 0.142337686 | 10 | 0 | BeFree_CTD_human_LHGDN |
| Desmoplastic Small Round Cell Tumor | 0.130314791 | 38 | 0 | BeFree_ORPHANET |
| Myeloid Leukemia, Chronic | 0.127991366 | 15 | 0 | BeFree_CTD_human_GAD |
| Mesothelioma | 0.12408156 | 6 | 1 | BeFree_CLINVAR_LHGDN |
| Glioblastoma | 0.123810118 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Glomerulonephritis | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Diffuse mesangial sclerosis (disorder) | 0.122638474 | 2 | 5 | BeFree_CLINVAR_GAD |
| Pancreatic Neoplasm | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Diaphragmatic Hernia | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Congenital diaphragmatic hernia | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Colonic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Lung Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Neurilemmoma | 0.12 | 1 | 0 | CTD_human |
| Ovarian Failure, Premature | 0.12 | 1 | 0 | CTD_human |
| Meacham Winn Culler syndrome | 0.12 | 0 | 0 | CTD_human |
| Deletion 11p13 | 0.12 | 0 | 0 | ORPHANET |
| Nephrotic Syndrome | 0.026456802 | 12 | 0 | BeFree_GAD_LHGDN |
| Sarcoma | 0.010073144 | 9 | 0 | BeFree_LHGDN |
| Myeloid Leukemia | 0.008458305 | 8 | 0 | BeFree_GAD |
| Squamous cell carcinoma | 0.008444493 | 4 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.008173051 | 3 | 0 | LHGDN |
| Focal glomerulosclerosis | 0.008001298 | 5 | 0 | BeFree_GAD_LHGDN |
| Carcinogenesis | 0.006786047 | 25 | 0 | BeFree |
| Kidney Neoplasm | 0.006634157 | 9 | 0 | BeFree_GAD |
| Lymphoma | 0.005991584 | 4 | 0 | BeFree_LHGDN |
| Mental Retardation | 0.005971721 | 22 | 0 | BeFree |
| Endometrial Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Smooth Muscle Tumor | 0.0054487 | 2 | 0 | LHGDN |
| Neoplasm, Residual | 0.005157396 | 19 | 0 | BeFree |
| Alzheimer's Disease | 0.005091382 | 1 | 0 | GAD_LHGDN |
| Acute leukemia | 0.004885954 | 18 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.004353001 | 7 | 0 | BeFree_LHGDN |
| Glioma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Osteosarcoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Adenocarcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| melanoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| ovarian neoplasm | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.003257302 | 12 | 0 | BeFree |
| Breast Carcinoma | 0.003257302 | 12 | 0 | BeFree |
| Hyperparathyroidism | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Fibromatosis, Aggressive | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Hypereosinophilic syndrome | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Kidney Failure, Chronic | 0.002909916 | 3 | 0 | BeFree_GAD |
| Hypospadias | 0.002909916 | 3 | 0 | BeFree_GAD |
| Carcinoid Tumor | 0.00272435 | 1 | 0 | LHGDN |
| Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
| Medulloblastoma | 0.00272435 | 1 | 0 | LHGDN |
| Sclerosis | 0.00272435 | 1 | 0 | LHGDN |
| Sertoli Cell Tumor | 0.00272435 | 1 | 0 | LHGDN |
| Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Gastrointestinal Stromal Tumors | 0.00272435 | 1 | 0 | LHGDN |
| Endometrial Stromal Tumors | 0.00272435 | 1 | 0 | LHGDN |
| Hepatic Insufficiency | 0.00272435 | 1 | 0 | LHGDN |
| Solid tumour | 0.002714419 | 10 | 0 | BeFree |
| Desmoplastic | 0.002714419 | 10 | 0 | BeFree |
| Preleukemia | 0.002638474 | 2 | 0 | BeFree_GAD |
| Acute lymphocytic leukemia | 0.002442977 | 9 | 0 | BeFree |
| Cytogenetically normal acute myeloid leukemia | 0.002442977 | 9 | 1 | BeFree |
| Disorder of eye | 0.002367032 | 1 | 0 | GAD |
| Leukemia, Myelomonocytic, Chronic | 0.002367032 | 1 | 0 | GAD |
| Pathologic Neovascularization | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| MYELODYSPLASTIC SYNDROME | 0.002367032 | 1 | 0 | GAD |
| Aniridia | 0.002171535 | 8 | 0 | BeFree |
| Congenital Abnormality | 0.001900093 | 7 | 0 | BeFree |
| pediatric acute myeloblastic leukemia | 0.001900093 | 7 | 1 | BeFree |
| Steroid-resistant nephrotic syndrome | 0.001900093 | 7 | 0 | BeFree |
| Gonadal Dysgenesis | 0.001628651 | 6 | 0 | BeFree |
| Turner Syndrome | 0.001628651 | 6 | 0 | BeFree |
| Leukemogenesis | 0.001628651 | 6 | 0 | BeFree |
| Blast Phase | 0.001357209 | 5 | 0 | BeFree |
| Urogenital Abnormalities | 0.001357209 | 5 | 0 | BeFree |
| Kidney Diseases | 0.001085767 | 4 | 0 | BeFree |
| Gonadoblastoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
| MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.001085767 | 4 | 0 | BeFree |
| Bilateral Wilms Tumor | 0.001085767 | 4 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Obesity | 0.000814326 | 3 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Glomerulosclerosis (disorder) | 0.000814326 | 3 | 0 | BeFree |
| Renal glomerular disease | 0.000814326 | 3 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Segmental glomerulosclerosis | 0.000814326 | 3 | 0 | BeFree |
| Malignant Glioma | 0.000814326 | 3 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Congenital chromosomal disease | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Cryptorchidism | 0.000542884 | 2 | 0 | BeFree |
| Hemangioma | 0.000542884 | 2 | 0 | BeFree |
| Lymphoid leukemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
| Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| Kidney Failure | 0.000542884 | 2 | 0 | BeFree |
| Retinoblastoma | 0.000542884 | 2 | 0 | BeFree |
| Congenital malformation of genital organs | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Alveolar rhabdomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
| Adult Acute Myeloblastic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Malignant mesothelioma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Hematologic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Bilateral Cryptorchidism | 0.000542884 | 2 | 0 | BeFree |
| Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000542884 | 2 | 0 | BeFree |
| Adult Acute Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Nephrogenic rest | 0.000542884 | 2 | 0 | BeFree |
| Renal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000542884 | 2 | 0 | BeFree |
| Penile hypospadias | 0.000542884 | 2 | 0 | BeFree |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Beckwith-Wiedemann Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
| Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Hemangiosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
| Male infertility | 0.000271442 | 1 | 0 | BeFree |
| leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Eosinophilic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Liver diseases | 0.000271442 | 1 | 0 | BeFree |
| Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Myelodysplasia | 0.000271442 | 1 | 0 | BeFree |
| Pseudohermaphroditism | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Vascular anomaly | 0.000271442 | 1 | 0 | BeFree |
| Follicular adenoma | 0.000271442 | 1 | 0 | BeFree |
| Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Hypereosinophilic Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Neuroectodermal Tumor, Primitive | 0.000271442 | 1 | 0 | BeFree |
| Sex Cord-Stromal Tumor | 0.000271442 | 1 | 0 | BeFree |
| Congenital defects | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Defect of diaphragm | 0.000271442 | 1 | 0 | BeFree |
| Myofibroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Disseminated eosinophilic collagen disease | 0.000271442 | 1 | 0 | BeFree |
| Dermatomyositis, Childhood Type | 0.000271442 | 1 | 0 | BeFree |
| Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 0.000271442 | 1 | 0 | BeFree |
| Laryngeal Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Myofibroblastic Tumor | 0.000271442 | 1 | 0 | BeFree |
| Malignant Fibrous Histiocytoma | 0.000271442 | 1 | 0 | BeFree |
| Sarcomatoid Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Malignant Mesothelioma of Peritoneum | 0.000271442 | 1 | 0 | BeFree |
| Chronic eosinophilic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Chromosome 8, trisomy | 0.000271442 | 1 | 0 | BeFree |
| Sleep Apnea, Obstructive | 0.000271442 | 1 | 0 | BeFree |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Inflammatory Myopathies | 0.000271442 | 1 | 0 | BeFree |
| Testicular malignant germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
| Post MI | 0.000271442 | 1 | 0 | BeFree |
| Epithelioid mesothelioma, malignant | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Extraskeletal Myxoid Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
| Childhood Renal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Malignant Vascular Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Mesenchymal Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Skull Base Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Spindle Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
| Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
| Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| MYELOPROLIFERATIVE SYNDROME, TRANSIENT | 0.000271442 | 1 | 0 | BeFree |
| Chronic kidney disease stage 5 | 0.000271442 | 1 | 0 | BeFree |
| 46, XY Disorders of Sex Development | 0.000271442 | 1 | 0 | BeFree |
| Mixed phenotype acute leukemia | 0.000271442 | 1 | 0 | BeFree |
| Juvenile dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
| Myeloid neoplasm | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。