WT1(Wilms tumor 1) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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11p13
基因染色体位置图

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

[中文简述(自动翻译):]  这个基因编码包含在C-末端和在N-末端的脯氨酸/富含谷氨酰胺的DNA结合结构域4锌指基序的转录因子。它在泌尿生殖系统的正常发育中起重要作用,并且它是在患者的肾母细胞瘤的一小部分的突变。该基因具有在不同组织中的母系和父系等位基因复杂的组织特异性和多形压印图案,具有双等位基因和单等位基因表达。多个转录变体已有描述。在几个变体,有证据为使用非AUG(CUG)翻译起始密码子的上游,并在帧与第一组AUG。 PMID的作者:7926762还提??供证据表明,WT1基因发生RNA编辑在人类和老鼠,而这个过程是组织限制性和发育调控。 [由RefSeq的,2015年3月提供]

WT1基因的碱基序列:[NCBI]
WT1基因的碱基突变:           显示全部snp
rs1799925       rs2234579       rs2234580       rs2234581       rs2234582       rs2234583       rs2301250       rs2301251       rs2301252       rs2301253       rs2301254       rs3087461       rs3809060       rs3809061       rs3809062       rs3886325       rs3930513       rs5030116       rs5030118       rs5030120       rs5030121       rs5030122       rs5030123       rs5030125       rs5030129       rs5030133       rs5030135       rs5030138       rs5030139       rs5030140       rs5030141       rs5030142       rs5030143       rs5030145       rs7938333       rs9332973       rs72893528      
rs78712811       rs113395511       rs113759602       rs113948627       rs114243407       rs115248984       rs115558526       rs141135091       rs150104193       rs151311874       rs181803989       rs182381703       rs183740439       rs185255088       rs186565190       rs186594583       rs187467242       rs189447930       rs189678675       rs191071456       rs369131961       rs369870529       rs374404615       rs375855031       rs377072761       rs528076586       rs529063718       rs529637299       rs530506605       rs530992018       rs531076591       rs532824193       rs532911061       rs533543279       rs534255699       rs534295737       rs534425010       rs534679095       rs534711031       rs536728682       rs536847233       rs537150542       rs538139246       rs538228917       rs539236677       rs539323571       rs539870593       rs540863186       rs541850548       rs542877793       rs542898204       rs543803630       rs543849715       rs544477985       rs546306405       rs546343393       rs547333427       rs547827011       rs548295189       rs549280743       rs550198542       rs551192531       rs552791632       rs552828543       rs554708046       rs555140661       rs555779913       rs556528975       rs556835183       rs557166021       rs558229564       rs560061165       rs560670129       rs560756253       rs561484960       rs562550916       rs563419231       rs563744323       rs563831623       rs564636465       rs564706633       rs565689607       rs566428967       rs567200038       rs568055576       rs570243889       rs570325451       rs571591181       rs572169634       rs572688446       rs572838503       rs572926487       rs574508247       rs574567853       rs575604419       rs576466235       rs576677344       rs576708268       rs745435848       rs745506215       rs745879965       rs746540375       rs746964440       rs747929692       rs747958111       rs748045691       rs748435329       rs748974419       rs749405227       rs749940580       rs750548251       rs750588084       rs751641518       rs752686863       rs753112302       rs753238865       rs753690997       rs754173303       rs755007049       rs755336626       rs756055892       rs756414084       rs756501972       rs757349907       rs757863992       rs758361767       rs758512604       rs758900425       rs761166030       rs761252308       rs761444010       rs761530541       rs762044578       rs762288656       rs762418497       rs762660918       rs763147828       rs763920620       rs764111950       rs764552529       rs765879407       rs766441234       rs766527734       rs766817203       rs767850217       rs768165877       rs768644520       rs769467940       rs769642496       rs770403127       rs770519620       rs770618081       rs771024882       rs771681406       rs771769393       rs772890986       rs773550149       rs773831663       rs773922379       rs775333473       rs776155094       rs776209354       rs776215255       rs776426005       rs776954184       rs777059515       rs777527675       rs777617460       rs778069787       rs778194188       rs778937284       rs16754       rs1042347       rs1569776       rs1799933       rs1799934       rs1799937       rs2234584       rs2234585       rs2234586       rs2234587       rs2234588       rs2234589       rs2234590       rs2234591       rs2234592       rs2234593       rs2234594       rs2295081       rs2295082       rs2418909       rs2418910       rs2418911       rs2900740       rs2900741       rs3818055       rs3847589       rs3847590       rs3858440       rs3858441       rs3858442       rs3858443       rs3858444       rs3858445       rs3858446       rs3858447       rs3858448       rs3858449       rs3901671       rs3915509       rs3932463       rs4140414       rs4258351       rs4986811       rs5030146       rs5030147       rs5030148       rs5030149       rs5030150       rs5030151       rs5030155       rs5030156       rs5030157       rs5030158       rs5030159       rs5030160       rs5030161       rs5030162       rs5030163       rs5030164       rs5030165       rs5030166       rs5030168       rs5030170       rs5030171       rs5030172       rs5030173       rs5030174       rs5030175       rs5030176       rs5030177       rs5030178       rs5030179       rs5030180       rs5030181       rs5030182       rs5030183       rs5030184       rs5030185       rs5030186       rs5030187       rs5030188       rs5030189       rs5030190       rs5030191       rs5030192       rs5030193       rs5030194       rs5030195       rs5030196       rs5030198       rs5030199       rs5030201       rs5030202       rs5030203       rs5030204       rs5030205       rs5030206       rs5030207       rs5030208       rs5030212       rs5030215       rs5030216       rs5030217       rs5030218       rs5030219       rs5030220       rs5030221       rs5030222       rs5030223       rs5030224       rs5030225       rs5030226       rs5030227       rs5030228       rs5030229       rs5030230       rs5030231       rs5030232       rs5030233       rs5030234       rs5030235       rs5030236       rs5030237       rs5030239       rs5030240       rs5030241       rs5030242       rs5030243       rs5030244       rs5030245       rs5030246       rs5030247       rs5030248       rs5030249       rs5030250       rs5030251       rs5030252       rs5030253       rs5030254       rs5030255       rs5030256       rs5030259       rs5030261       rs5030262       rs5030263       rs5030264       rs5030265       rs5030266       rs5030267       rs5030268       rs5030269       rs5030270       rs5030271       rs5030273       rs5030274       rs5030276       rs5030277       rs5030278       rs5030279       rs5030280       rs5030281       rs5030282       rs5030283       rs5030284       rs5030285       rs5030286       rs5030288       rs5030290       rs5030291       rs5030292       rs5030293       rs5030294       rs5030295       rs5030296       rs5030297       rs5030298       rs5030299       rs5030300       rs5030301       rs5030302       rs5030303       rs5030304       rs5030305       rs5030306       rs5030307       rs5030308       rs5030309       rs5030310       rs5030311       rs5030312       rs5030315       rs5030316       rs5030317       rs5030318       rs5030319       rs5030320       rs5030322       rs5030323       rs5030324       rs5030325       rs5030326       rs5030327       rs5030328       rs5030329       rs5030330       rs5030331       rs5030332       rs5030333       rs5030334       rs6484577       rs7105624       rs7105964       rs7106429       rs7107082       rs7108339       rs7110547       rs7112566       rs7114908       rs7115190       rs7116462       rs7120241       rs7125543       rs7125816       rs7936152       rs7938016       rs9332974       rs10525221       rs10690035       rs10709211       rs10742277       rs10767934       rs10767935       rs10835897       rs10835898       rs10835900       rs10835901       rs10835902       rs10835903       rs10835904       rs10835905       rs10835906       rs10835907       rs11031763       rs11031765       rs11031767       rs11031769       rs11031770       rs11031771       rs11031773       rs11031775       rs11031776       rs11031778       rs11031779       rs11031780       rs11031781       rs11309547       rs11823485       rs11824258       rs11826006       rs12288783       rs12290546       rs12293603       rs12293750       rs12575247       rs12576146       rs12795847       rs16923227       rs16923242       rs16923246       rs16923250       rs16923254       rs16923260       rs16926048       rs17673913       rs28593224       rs33936715       rs34250829       rs34712216       rs35317214       rs35515910       rs36106678       rs56011807       rs56054851       rs56142321       rs57442605       rs58043598       rs59827939       rs60519892       rs61889210       rs61889211       rs61889223       rs66798575       rs71463351       rs71479154       rs71479155       rs71873106       rs72893503       rs72893506       rs72893517       rs72893525       rs72909430       rs72909438       rs72909441       rs72909465       rs72909468       rs72909473       rs72909474       rs72909477       rs72909479       rs72909480       rs73473736       rs73473740       rs73475519       rs73475529       rs73475541       rs73479691       rs74309158       rs74345592       rs74568338       rs74595045       rs74889578       rs74890873       rs74982779       rs75159529       rs75344992       rs75396536       rs75398068       rs75401395       rs75515369       rs75671066       rs75709553       rs75848325       rs75870920       rs75940312       rs76103435       rs76134328       rs76195329       rs76255851       rs76341541       rs76425440       rs76425751       rs76492147       rs76500597       rs76747095       rs76813620       rs76815481       rs76824409       rs76850655       rs76857714       rs76902402       rs77015753       rs77052563       rs77073221       rs77176425       rs77261511       rs77286584       rs77336767       rs77462662       rs77499195       rs77535187       rs77643749       rs77801880       rs78042269       rs78090019       rs78172436       rs78199925       rs78350046       rs78397242       rs78481194       rs78616102       rs78828738       rs78993948       rs79026725       rs79039519       rs79141954       rs79147948       rs79379073       rs79407823       rs79466583       rs79477411       rs79707796       rs79888793       rs80001167       rs80075914       rs111347836       rs111351882       rs111366475       rs111367482       rs111384963       rs111460871       rs111530376       rs111550132       rs111572606       rs111601106       rs111608150       rs111624321       rs111667510       rs111692843       rs111702717       rs111764542       rs111832087       rs111907897       rs111924858       rs111938564       rs111939433       rs112000472       rs112004628       rs112103609       rs112220067       rs112227195       rs112234558       rs112240386       rs112583586       rs112676245       rs112676751       rs112717040       rs112810645       rs113039993       rs113073018       rs113129689       rs113376818       rs113403661       rs113510018       rs113521094       rs113549930       rs113568234       rs113620092       rs113648001       rs113810570       rs113945436       rs113984094       rs114067171       rs114137942       rs114144163       rs114403013       rs114406139       rs114508199       rs114596230       rs114599415       rs114684990       rs114790553       rs114820922       rs114825644       rs115115948       rs115158972       rs115196602       rs115324375       rs115507658       rs115598015       rs115733467       rs115795705       rs115946397       rs116124721       rs116362738       rs116454200       rs116557725       rs116678406       rs116748526       rs117420166       rs117885281       rs117986562       rs137863749       rs137869903       rs137984472       rs138073760       rs138122605       rs138254183       rs138398037       rs138538148       rs138586346       rs138927288       rs139264852       rs139299919       rs139349356       rs139405894       rs139475719       rs139539028       rs139544325       rs139699227       rs139829028       rs139888846       rs139893274       rs139960084       rs140108565       rs140140507       rs140240458       rs140258765       rs140322072       rs140454115       rs140563868       rs140593184       rs140745134       rs140769477       rs140807635       rs141052585       rs141222947       rs141226736       rs141264661       rs141287522       rs141352131       rs141408735       rs141472772       rs141473309       rs141740590       rs141748949       rs141758386       rs141763039       rs141777688       rs141834493       rs141990496       rs142059681       rs142146439       rs142197249       rs142233849       rs142360028       rs142369964       rs142544508       rs142653301       rs142726499       rs142831766       rs142887065       rs142920538       rs142937387       rs142941815       rs143086246       rs143285899       rs143347883       rs143405191       rs143508794       rs143761202       rs143907314       rs144131993       rs144207747       rs144273128       rs144287330       rs144367141       rs144448749       rs144598817       rs144615463       rs144616771       rs144632229       rs144676564       rs144742586       rs144788858       rs144882289       rs144984987       rs145234090       rs145301479       rs145352027       rs145370969       rs145414435       rs145420350       rs145425799       rs145477984       rs145544465       rs145898075       rs145995838       rs146015252       rs146095723       rs146114578       rs146218468       rs146236862       rs146369074       rs146520270       rs146557559       rs146635660       rs146656430       rs146881242       rs146980549       rs147000090       rs147101720       rs147126640       rs147206676       rs147241955       rs147258285       rs147345949       rs147453277       rs147467689       rs147696325       rs147801140       rs147920357       rs147939483       rs148093720       rs148147885       rs148234826       rs148478722       rs148547281       rs148635596       rs148688984       rs148704360       rs148759208       rs148844443       rs148856160       rs149071773       rs149089487       rs149158270       rs149212570       rs149264072       rs149314307       rs149529057       rs149546370       rs149617657       rs149718206       rs149791786       rs149841186       rs149911732       rs149983242       rs150053414       rs150083701       rs150194429       rs150312605       rs150435444       rs150697338       rs150767364       rs150782706       rs150890676       rs150942340       rs151034312       rs151295133       rs180891675       rs180898029       rs180945577       rs181206185       rs181403514       rs181403797       rs181436412       rs181453538       rs181588819       rs181672413       rs181734034       rs181833742       rs181834838       rs181881769       rs181970448       rs182037041       rs182045630       rs182058724       rs182249118       rs182272007       rs182309671       rs182311369       rs182570741       rs182595119       rs182624170       rs182885438       rs182900526       rs182905704       rs183097927       rs183201967       rs183263057       rs183354761       rs183485479       rs183683233       rs183686294       rs183778892       rs183919141       rs183922450       rs183980446       rs183983795       rs184100025       rs184232454       rs184447085       rs184451433       rs184465287       rs184717977       rs184847211       rs184855955       rs184900368       rs184981342       rs184986200       rs185087186       rs185192128       rs185192213       rs185349564       rs185512922       rs185733434       rs185735485       rs185744719       rs185757165       rs185843818       rs185936244       rs186066444       rs186227776       rs186228659       rs186269989       rs186351971       rs186544564       rs186590514       rs186598490       rs186838973       rs186901506       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rs574791275       rs574829246       rs574836855       rs574949944       rs574986798       rs575035138       rs575081948       rs575096457       rs575232799       rs575284921       rs575348887       rs575386285       rs575523718       rs575563762       rs575600889       rs575612883       rs575636083       rs575843161       rs575879900       rs575882942       rs576023116       rs576232274       rs576486757       rs576506438       rs576602027       rs576602054       rs576635832       rs576822557       rs576864340       rs576895937       rs576902446       rs577025317       rs577130444       rs577143359       rs577232828       rs577234771       rs577273346       rs577384088       rs577493358       rs577525782       rs577579117       rs577612872       rs577653036       rs577670401       rs577897430       rs577973015       rs577983355       rs578145206       rs578175980       rs745596305       rs745663070       rs745678220       rs745787835       rs745906743       rs745911185       rs745937499       rs746241159       rs746353651       rs746367691       rs746687182       rs746853702       rs747197306       rs747363777       rs747377024       rs747502066       rs747613465       rs747790701       rs748087178       rs748112905       rs748347306       rs748864758       rs749089073       rs749194645       rs749213891       rs749214099       rs749266841       rs749568565       rs749758242       rs749860238       rs749964980       rs750018485       rs750842875       rs750988020       rs751095363       rs751396985       rs751432306       rs751693310       rs751725628       rs751800046       rs751932589       rs752102247       rs752438619       rs752617875       rs752756426       rs752801263       rs752801406       rs752854428       rs753180506       rs753193344       rs753563999       rs753971493       rs754336808       rs754700684       rs754938612       rs755113185       rs755198850       rs755936509       rs756078681       rs756618631       rs756695525       rs756837300       rs757237600       rs757242370       rs757572403       rs757807247       rs757962229       rs758280375       rs758331851       rs758410591       rs758624956       rs758798048       rs758920371       rs758986691       rs759192423       rs759275928       rs759464627       rs759850491       rs759955361       rs760219458       rs760272651       rs760370132       rs760438749       rs760447794       rs760601723       rs760654956       rs760776653       rs760854185       rs760865601       rs761360324       rs761414130       rs761525624       rs761627098       rs761813691       rs761913397       rs761936559       rs762325377       rs762380113       rs762563522       rs762688982       rs763082845       rs763242177       rs763551837       rs763645824       rs764075020       rs764206826       rs764644655       rs764701739       rs764718170       rs764802290       rs765218093       rs765230888       rs765570602       rs765743928       rs765923808       rs766344955       rs766425764       rs766642594       rs766697865       rs766755764       rs767103760       rs767419243       rs767472597       rs767584364       rs767727682       rs767729335       rs767850636       rs768268023       rs768271212       rs768375130       rs768505896       rs768589097       rs768792358       rs768828897       rs769034786       rs769131510       rs769371345       rs769499906       rs769618028       rs769934402       rs769958048       rs770062804       rs770366595       rs770658294       rs770782823       rs771117558       rs771170643       rs771455202       rs771494968       rs771527206       rs771785407       rs771827898       rs771938327       rs772132710       rs772409488       rs772590420       rs772822466       rs772866120       rs772916500       rs773040516       rs773146794       rs773408487       rs773527284       rs773532792       rs773989805       rs774094201       rs774104210       rs774228907       rs774547006       rs774626752       rs774650640       rs774716776       rs774936527       rs774976881       rs775063171       rs775085343       rs775175632       rs775453593       rs775629219       rs775630812       rs776256676       rs776258782       rs776384327       rs776489080       rs776565536       rs776651253       rs776846827       rs776971636       rs777119782       rs777166391       rs777343048       rs777650194       rs777703414       rs777825688       rs778157653       rs778247582       rs778578204       rs778673400       rs778743616       rs778830651       rs778873654       rs779291668       rs779321799       rs779451877       rs779805518       rs779813097       rs779844084       rs780092599       rs780259089       rs780497248       rs780543841       rs780554363       rs780953688       rs781006585       rs781301946       rs781316935       rs781613684       rs796105444       rs869199268       rs869252469      

WT1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TCAGAGGCATTCAGGATGTG
60
CTCTTATTGCAGCCTGGGT
60
CAGAGGCATTCAGGATGTG
58
CGTTTCTCACTGGTCTCAG
58
CCTACAGCAGTGACAATTTATACC
60
ATTTCACTGAGCTGGAGCT
59
TCAGAGGCATTCAGGATGTG
60
TCTCTTATTGCAGCCTGGG
60
CCTACAGCAGTGACAATTTATACC
60
TTTCACTGAGCTGGAGCTC
60
CCTACAGCAGTGACAATTTATACC
60
CATTTCACTGAGCTGGAGC
59
转录因子
影响类型
PubMed链接
ABCB1
Unknown
10392899     10860921    
AMH
Activation
AR
Repression
BCL2
Unknown
CAMP
Repression
CCNE1
Repression
CD14
Activation
ADGRE5
Activation
CDC73
Repression
CDH1
Repression
23298185     23945386    

WT1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

WT1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0003676
A0A0A0MT54(UniProtKB)
IEA
GO:0005634
A0A0A0MT54(UniProtKB)
IEA
GO:0006355
A0A0A0MT54(UniProtKB)
IEA
GO:0046872
A0A0A0MT54(UniProtKB)
IEA
GO:0005634
E9PKS2(UniProtKB)
IEA
GO:0006355
E9PKS2(UniProtKB)
IEA
GO:0003676
E9PPW3(UniProtKB)
IEA
GO:0046872
E9PPW3(UniProtKB)
IEA
GO:0005634
H0Y3F0(UniProtKB)
IEA
GO:0006355
H0Y3F0(UniProtKB)
IEA
GO:0003676
H0Y7K5(UniProtKB)
IEA
GO:0005634
H0Y7K5(UniProtKB)
IEA
GO:0006355
H0Y7K5(UniProtKB)
IEA
GO:0046872
H0Y7K5(UniProtKB)
IEA
GO:0003676
H0YED9(UniProtKB)
IEA
GO:0005634
H0YED9(UniProtKB)
IEA
GO:0006355
H0YED9(UniProtKB)
IEA
GO:0046872
H0YED9(UniProtKB)
IEA
GO:0005634
J3KNN9(UniProtKB)
IEA
GO:0043565
J3KNN9(UniProtKB)
IEA
GO:0045944
J3KNN9(UniProtKB)
IEA
GO:0046872
J3KNN9(UniProtKB)
IEA
GO:0000122
P19544(UniProtKB)
IDA
GO:0001077
P19544(UniProtKB)
ISS
GO:0001570
P19544(UniProtKB)
ISS
GO:0001657
P19544(UniProtKB)
ISS
GO:0001658
P19544(UniProtKB)
IGI
GO:0001822
P19544(UniProtKB)
IGI
GO:0003156
P19544(UniProtKB)
ISS
GO:0003700
P19544(UniProtKB)
ISS
GO:0003700
P19544(UniProtKB)
NAS
GO:0003700
P19544(UniProtKB)
NAS
GO:0003723
P19544(UniProtKB)
IEA
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005515
P19544(UniProtKB)
IPI
GO:0005634
P19544(UniProtKB)
IDA
GO:0005634
P19544(UniProtKB)
IDA
GO:0005634
P19544(UniProtKB)
IDA
GO:0005634
P19544(UniProtKB)
IDA
GO:0005634
P19544(UniProtKB)
IDA
GO:0005634
P19544(UniProtKB)
IDA
GO:0005654
P19544(UniProtKB)
IDA
GO:0005730
P19544(UniProtKB)
IEA
GO:0005737
P19544(UniProtKB)
ISS
GO:0006355
P19544(UniProtKB)
ISS
GO:0006355
P19544(UniProtKB)
NAS
GO:0006355
P19544(UniProtKB)
NAS
GO:0006357
P19544(UniProtKB)
ISS
GO:0006366
P19544(UniProtKB)
IEA
GO:0007281
P19544(UniProtKB)
ISS
GO:0007356
P19544(UniProtKB)
ISS
GO:0007507
P19544(UniProtKB)
IGI
GO:0007530
P19544(UniProtKB)
IDA
GO:0008270
P19544(UniProtKB)
IDA
GO:0008285
P19544(UniProtKB)
IDA
GO:0008285
P19544(UniProtKB)
IDA
GO:0008380
P19544(UniProtKB)
ISS
GO:0008406
P19544(UniProtKB)
ISS
GO:0008584
P19544(UniProtKB)
IEP
GO:0009888
P19544(UniProtKB)
ISS
GO:0016607
P19544(UniProtKB)
IDA
GO:0016607
P19544(UniProtKB)
IDA
GO:0016607
P19544(UniProtKB)
IDA
GO:0017148
P19544(UniProtKB)
IDA
GO:0030308
P19544(UniProtKB)
IDA
GO:0030308
P19544(UniProtKB)
IDA
GO:0030308
P19544(UniProtKB)
IDA
GO:0030325
P19544(UniProtKB)
IGI
GO:0030539
P19544(UniProtKB)
ISS
GO:0030855
P19544(UniProtKB)
ISS
GO:0032835
P19544(UniProtKB)
IGI
GO:0032836
P19544(UniProtKB)
IMP
GO:0035802
P19544(UniProtKB)
ISS
GO:0043010
P19544(UniProtKB)
ISS
GO:0043065
P19544(UniProtKB)
IDA
GO:0043066
P19544(UniProtKB)
IGI
GO:0043565
P19544(UniProtKB)
IDA
GO:0043565
P19544(UniProtKB)
IDA
GO:0043565
P19544(UniProtKB)
IDA
GO:0044212
P19544(UniProtKB)
IDA
GO:0044212
P19544(UniProtKB)
IDA
GO:0044212
P19544(UniProtKB)
IDA
GO:0044212
P19544(UniProtKB)
IDA
GO:0044212
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045892
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IGI
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
GO:0045944
P19544(UniProtKB)
IEA
GO:0060231
P19544(UniProtKB)
ISS
GO:0060421
P19544(UniProtKB)
ISS
GO:0060539
P19544(UniProtKB)
ISS
GO:0060923
P19544(UniProtKB)
ISS
GO:0061032
P19544(UniProtKB)
IGI
GO:0070742
P19544(UniProtKB)
IPI
GO:0071320
P19544(UniProtKB)
IEP
GO:0071371
P19544(UniProtKB)
IDA
GO:0072075
P19544(UniProtKB)
ISS
GO:0072112
P19544(UniProtKB)
ISS
GO:0072166
P19544(UniProtKB)
ISS
GO:0072207
P19544(UniProtKB)
IEP
GO:0072284
P19544(UniProtKB)
IGI
GO:0072302
P19544(UniProtKB)
ISS
GO:2000020
P19544(UniProtKB)
ISS
GO:2000195
P19544(UniProtKB)
ISS
GO:2001076
P19544(UniProtKB)
ISS
GO:0045893
P19544(UniProtKB)
IDA
GO:0045893
P19544(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控WT1基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Denys-Drash Syndrome 0.572691755 43 11 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
Frasier Syndrome 0.487610304 19 5 BeFree_CLINVAR_CTD_human_LHGDN_ORPHANET_UNIPROT
Nephroblastoma 0.444098287 220 2 BeFree_CTD_human_GAD_LHGDN_ORPHANET_UNIPROT
MEACHAM SYNDROME (disorder) 0.36 2 2 CLINVAR_ORPHANET_UNIPROT
WAGR Syndrome 0.246167218 14 0 BeFree_CTD_human_GAD_ORPHANET
NEPHROTIC SYNDROME, TYPE 4 0.24 4 0 CTD_human_UNIPROT
Leukemia, Myelocytic, Acute 0.174303151 62 1 BeFree_CTD_human_GAD_LHGDN
leukemia 0.142840843 49 1 BeFree_CTD_human_LHGDN
Mammary Neoplasms 0.142337686 10 0 BeFree_CTD_human_LHGDN
Desmoplastic Small Round Cell Tumor 0.130314791 38 0 BeFree_ORPHANET
Myeloid Leukemia, Chronic 0.127991366 15 0 BeFree_CTD_human_GAD
Mesothelioma 0.12408156 6 1 BeFree_CLINVAR_LHGDN
Glioblastoma 0.123810118 5 0 BeFree_CTD_human_LHGDN
Glomerulonephritis 0.12272435 2 0 CTD_human_LHGDN
Diffuse mesangial sclerosis (disorder) 0.122638474 2 5 BeFree_CLINVAR_GAD
Pancreatic Neoplasm 0.122367032 2 0 CTD_human_GAD
Diaphragmatic Hernia 0.120271442 2 0 BeFree_CTD_human
Congenital diaphragmatic hernia 0.120271442 2 0 BeFree_CTD_human
Colonic Neoplasms 0.12 1 0 CTD_human
Lung Neoplasms 0.12 1 0 CTD_human
Neurilemmoma 0.12 1 0 CTD_human
Ovarian Failure, Premature 0.12 1 0 CTD_human
Meacham Winn Culler syndrome 0.12 0 0 CTD_human
Deletion 11p13 0.12 0 0 ORPHANET
Nephrotic Syndrome 0.026456802 12 0 BeFree_GAD_LHGDN
Sarcoma 0.010073144 9 0 BeFree_LHGDN
Myeloid Leukemia 0.008458305 8 0 BeFree_GAD
Squamous cell carcinoma 0.008444493 4 0 BeFree_LHGDN
Neoplasm Metastasis 0.008173051 3 0 LHGDN
Focal glomerulosclerosis 0.008001298 5 0 BeFree_GAD_LHGDN
Carcinogenesis 0.006786047 25 0 BeFree
Kidney Neoplasm 0.006634157 9 0 BeFree_GAD
Lymphoma 0.005991584 4 0 BeFree_LHGDN
Mental Retardation 0.005971721 22 0 BeFree
Endometrial Neoplasms 0.0054487 2 0 LHGDN
Smooth Muscle Tumor 0.0054487 2 0 LHGDN
Neoplasm, Residual 0.005157396 19 0 BeFree
Alzheimer's Disease 0.005091382 1 0 GAD_LHGDN
Acute leukemia 0.004885954 18 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.004353001 7 0 BeFree_LHGDN
Glioma 0.00408156 5 0 BeFree_LHGDN
Liver carcinoma 0.00408156 5 0 BeFree_LHGDN
Osteosarcoma 0.003538676 4 0 BeFree_LHGDN
Adenocarcinoma 0.003267234 2 0 BeFree_LHGDN
melanoma 0.003267234 3 0 BeFree_LHGDN
ovarian neoplasm 0.003267234 3 0 BeFree_LHGDN
Malignant neoplasm of breast 0.003257302 12 0 BeFree
Breast Carcinoma 0.003257302 12 0 BeFree
Hyperparathyroidism 0.002995792 2 0 BeFree_LHGDN
Fibromatosis, Aggressive 0.002995792 1 0 BeFree_LHGDN
Hypereosinophilic syndrome 0.002995792 2 0 BeFree_LHGDN
Kidney Failure, Chronic 0.002909916 3 0 BeFree_GAD
Hypospadias 0.002909916 3 0 BeFree_GAD
Carcinoid Tumor 0.00272435 1 0 LHGDN
Fibrosis 0.00272435 1 0 LHGDN
Medulloblastoma 0.00272435 1 0 LHGDN
Sclerosis 0.00272435 1 0 LHGDN
Sertoli Cell Tumor 0.00272435 1 0 LHGDN
Thyroid Neoplasm 0.00272435 1 0 LHGDN
Gastrointestinal Stromal Tumors 0.00272435 1 0 LHGDN
Endometrial Stromal Tumors 0.00272435 1 0 LHGDN
Hepatic Insufficiency 0.00272435 1 0 LHGDN
Solid tumour 0.002714419 10 0 BeFree
Desmoplastic 0.002714419 10 0 BeFree
Preleukemia 0.002638474 2 0 BeFree_GAD
Acute lymphocytic leukemia 0.002442977 9 0 BeFree
Cytogenetically normal acute myeloid leukemia 0.002442977 9 1 BeFree
Disorder of eye 0.002367032 1 0 GAD
Leukemia, Myelomonocytic, Chronic 0.002367032 1 0 GAD
Pathologic Neovascularization 0.002367032 1 0 GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Neoplasms, Second Primary 0.002367032 1 0 GAD
MYELODYSPLASTIC SYNDROME 0.002367032 1 0 GAD
Aniridia 0.002171535 8 0 BeFree
Congenital Abnormality 0.001900093 7 0 BeFree
pediatric acute myeloblastic leukemia 0.001900093 7 1 BeFree
Steroid-resistant nephrotic syndrome 0.001900093 7 0 BeFree
Gonadal Dysgenesis 0.001628651 6 0 BeFree
Turner Syndrome 0.001628651 6 0 BeFree
Leukemogenesis 0.001628651 6 0 BeFree
Blast Phase 0.001357209 5 0 BeFree
Urogenital Abnormalities 0.001357209 5 0 BeFree
Kidney Diseases 0.001085767 4 0 BeFree
Gonadoblastoma 0.001085767 4 0 BeFree
Malignant neoplasm of lung 0.001085767 4 0 BeFree
MULTICYSTIC RENAL DYSPLASIA, BILATERAL 0.001085767 4 0 BeFree
Bilateral Wilms Tumor 0.001085767 4 0 BeFree
Non-Small Cell Lung Carcinoma 0.000814326 3 0 BeFree
Obesity 0.000814326 3 0 BeFree
Ovarian Carcinoma 0.000814326 3 0 BeFree
Glomerulosclerosis (disorder) 0.000814326 3 0 BeFree
Renal glomerular disease 0.000814326 3 0 BeFree
Conventional (Clear Cell) Renal Cell Carcinoma 0.000814326 3 0 BeFree
Segmental glomerulosclerosis 0.000814326 3 0 BeFree
Malignant Glioma 0.000814326 3 0 BeFree
Epithelial ovarian cancer 0.000814326 3 0 BeFree
Carcinoma of lung 0.000814326 3 0 BeFree
Congenital chromosomal disease 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Cryptorchidism 0.000542884 2 0 BeFree
Hemangioma 0.000542884 2 0 BeFree
Lymphoid leukemia 0.000542884 2 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000542884 2 0 BeFree
Liver neoplasms 0.000542884 2 0 BeFree
Malignant neoplasm of stomach 0.000542884 2 0 BeFree
Kidney Failure 0.000542884 2 0 BeFree
Retinoblastoma 0.000542884 2 0 BeFree
Congenital malformation of genital organs 0.000542884 2 0 BeFree
Tumor Progression 0.000542884 2 0 BeFree
Alveolar rhabdomyosarcoma 0.000542884 2 0 BeFree
Adult Acute Myeloblastic Leukemia 0.000542884 2 0 BeFree
Malignant mesothelioma 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Hematologic Neoplasms 0.000542884 2 0 BeFree
Bilateral Cryptorchidism 0.000542884 2 0 BeFree
Osteosarcoma of bone 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of kidney 0.000542884 2 0 BeFree
Adult Acute Lymphocytic Leukemia 0.000542884 2 0 BeFree
Malignant neoplasm of ovary 0.000542884 2 0 BeFree
Nephrogenic rest 0.000542884 2 0 BeFree
Renal carcinoma 0.000542884 2 0 BeFree
Colorectal Cancer 0.000542884 2 0 BeFree
Glioblastoma Multiforme 0.000542884 2 0 BeFree
Penile hypospadias 0.000542884 2 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000542884 2 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Anaplasia 0.000271442 1 0 BeFree
Autistic Disorder 0.000271442 1 0 BeFree
Beckwith-Wiedemann Syndrome 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Malignant neoplasm of thyroid 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Endometriosis 0.000271442 1 0 BeFree
Eosinophilia 0.000271442 1 0 BeFree
Fanconi Anemia 0.000271442 1 0 BeFree
Hemangiosarcoma 0.000271442 1 0 BeFree
Hematological Disease 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Hypertensive disease 0.000271442 1 0 BeFree
Male infertility 0.000271442 1 0 BeFree
leiomyosarcoma 0.000271442 1 0 BeFree
Leukemia, Eosinophilic, Acute 0.000271442 1 0 BeFree
Liver diseases 0.000271442 1 0 BeFree
Meningioma 0.000271442 1 0 BeFree
Myelodysplasia 0.000271442 1 0 BeFree
Pseudohermaphroditism 0.000271442 1 0 BeFree
Pulmonary Fibrosis 0.000271442 1 0 BeFree
Rhabdomyosarcoma 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Malignant neoplasm of testis 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Vascular anomaly 0.000271442 1 0 BeFree
Follicular adenoma 0.000271442 1 0 BeFree
Germ cell tumor 0.000271442 1 0 BeFree
Idiopathic Hypereosinophilic Syndrome 0.000271442 1 0 BeFree
Neuroectodermal Tumor, Primitive 0.000271442 1 0 BeFree
Sex Cord-Stromal Tumor 0.000271442 1 0 BeFree
Congenital defects 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Defect of diaphragm 0.000271442 1 0 BeFree
Myofibroblastoma 0.000271442 1 0 BeFree
Disseminated eosinophilic collagen disease 0.000271442 1 0 BeFree
Dermatomyositis, Childhood Type 0.000271442 1 0 BeFree
Metastatic melanoma 0.000271442 1 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000271442 1 0 BeFree
Extraosseous Ewings sarcoma-primitive neuroepithelial tumor 0.000271442 1 0 BeFree
Laryngeal Squamous Cell Carcinoma 0.000271442 1 0 BeFree
Inflammatory Myofibroblastic Tumor 0.000271442 1 0 BeFree
Malignant Fibrous Histiocytoma 0.000271442 1 0 BeFree
Sarcomatoid Mesothelioma 0.000271442 1 0 BeFree
Malignant neoplasm of liver 0.000271442 1 0 BeFree
Malignant Mesothelioma of Peritoneum 0.000271442 1 0 BeFree
Chronic eosinophilic leukemia 0.000271442 1 0 BeFree
Malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Secondary malignant neoplasm of pancreas 0.000271442 1 0 BeFree
Hematopoietic Neoplasms 0.000271442 1 0 BeFree
Chromosome 8, trisomy 0.000271442 1 0 BeFree
Sleep Apnea, Obstructive 0.000271442 1 0 BeFree
Thyroid carcinoma 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Ewings sarcoma-primitive neuroectodermal tumor (PNET) 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Idiopathic Inflammatory Myopathies 0.000271442 1 0 BeFree
Testicular malignant germ cell tumor 0.000271442 1 0 BeFree
Post MI 0.000271442 1 0 BeFree
Epithelioid mesothelioma, malignant 0.000271442 1 0 BeFree
Squamous cell carcinoma of the head and neck 0.000271442 1 0 BeFree
Extraskeletal Myxoid Chondrosarcoma 0.000271442 1 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000271442 1 0 BeFree
Eosinophilic disorder 0.000271442 1 0 BeFree
Adenocarcinoma of large intestine 0.000271442 1 0 BeFree
Childhood Renal Neoplasm 0.000271442 1 0 BeFree
Malignant Vascular Neoplasm 0.000271442 1 0 BeFree
Mesenchymal Cell Neoplasm 0.000271442 1 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000271442 1 0 BeFree
Skull Base Meningioma 0.000271442 1 0 BeFree
Spindle Cell Neoplasm 0.000271442 1 0 BeFree
Autism Spectrum Disorders 0.000271442 1 0 BeFree
Non-Malignant Ascites Adverse Event 0.000271442 1 0 BeFree
Disorder characterized by eosinophilia 0.000271442 1 0 BeFree
Meningioma, benign, no ICD-O subtype 0.000271442 1 0 BeFree
MYELOPROLIFERATIVE SYNDROME, TRANSIENT 0.000271442 1 0 BeFree
Chronic kidney disease stage 5 0.000271442 1 0 BeFree
46, XY Disorders of Sex Development 0.000271442 1 0 BeFree
Mixed phenotype acute leukemia 0.000271442 1 0 BeFree
Juvenile dermatomyositis 0.000271442 1 0 BeFree
Myeloid neoplasm 0.000271442 1 0 BeFree
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) 0.000271442 1 0 BeFree
Triple Negative Breast Neoplasms 0.000271442 1 0 BeFree
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