VHL(von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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3p25.3
基因染色体位置图

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  希佩尔 - 林道综合征(VHL)是一种显性遗传的家族性癌症综合征的诱发各种恶性肿瘤和良性肿瘤。这种基因的胚系突变是VHL综合征的家族继承的基础。由该基因编码的蛋白质是蛋白质复合体,其包括elongin B,elongin C和滞-2的一个组成部分,并具有泛素连接酶E3活性。该蛋白质参与的缺氧诱导因子的泛素化和降解(HIF),这是在基因表达的氧调节中心作用的转录因子。 RNA聚合酶II亚基POLR2G / RPB7也报道是该蛋白质的一个目标。编码不同同种型的可变剪接转录物变体已观察到。 [由RefSeq的,2008年7月提供]

VHL基因的碱基序列:[NCBI]
VHL基因的碱基突变:           显示全部snp
rs166484       rs187873       rs187874       rs192374       rs271989       rs271990       rs271991       rs271992       rs374645       rs391818       rs409141       rs417164       rs458106       rs524411       rs779803       rs779804       rs779805       rs779806       rs779807       rs779808       rs779809       rs779811       rs779812       rs779813       rs801913       rs1058854       rs1136245       rs1136249       rs1136250       rs1136254       rs1642729       rs1642739       rs1642741       rs1642742       rs1642743       rs1678593       rs1678595      
rs1678607       rs1681660       rs1681668       rs1681669       rs1703153       rs1798965       rs2543458       rs2600005       rs2600006       rs3087462       rs5030649       rs5030651       rs5030802       rs5030803       rs5030804       rs5030805       rs5030807       rs5030808       rs5030809       rs5030810       rs5030811       rs5030813       rs5030818       rs5030819       rs5030820       rs5030821       rs5030822       rs5030823       rs5030824       rs5030825       rs5030826       rs5030827       rs5030828       rs5030829       rs5030830       rs5030832       rs5030833       rs5030834       rs5030835       rs7629500       rs7645730       rs9819196       rs9822696       rs9829048       rs9829290       rs10433558       rs11128507       rs11920834       rs12634531       rs13090098       rs13090104       rs17032456       rs17610448       rs17855706       rs28412899       rs28940298       rs28940300       rs34146044       rs34232505       rs34271731       rs34362094       rs34512214       rs34661876       rs34726585       rs34876351       rs35001715       rs35240911       rs35286098       rs35334687       rs35460768       rs35500766       rs35588036       rs35732631       rs35793832       rs35862660       rs36068404       rs59722349       rs61420345       rs61751580       rs61758376       rs62238313       rs62238314       rs63650860       rs66597916       rs67382825       rs67891117       rs71052297       rs71052298       rs71052299       rs71307726       rs72563743       rs72563744       rs72563745       rs73024525       rs73024533       rs73024535       rs73024567       rs74417383       rs74697987       rs74749021       rs75494358       rs75833577       rs76436057       rs78320262       rs78476662       rs78562649       rs78894208       rs79108474       rs79147506       rs79512469       rs80288865       rs104893829       rs104893831       rs111246617       rs111630365       rs111836423       rs111860145       rs112130915       rs112248386       rs112376325       rs112494627       rs112585154       rs112774138       rs112782301       rs112857191       rs112883893       rs112997247       rs113026623       rs113155786       rs113225030       rs113362379       rs113435866       rs113667913       rs113678809       rs114669076       rs114732761       rs114841592       rs115303528       rs115415687       rs115744107       rs115817656       rs116127341       rs116128787       rs116182840       rs116344240       rs116625682       rs116710496       rs116715791       rs121913347       rs137893497       rs138178021       rs138237298       rs138629647       rs138780791       rs138933035       rs139193686       rs139557214       rs139622356       rs139722587       rs139890789       rs140044688       rs140064807       rs140172229       rs140259776       rs140284986       rs140328612       rs140614750       rs140647963       rs141865218       rs141916278       rs141937841       rs141992155       rs142728549       rs143057620       rs143062510       rs143594259       rs143594610       rs143659897       rs143920798       rs144177371       rs144375448       rs144377135       rs144442398       rs144725336       rs144782223       rs145007067       rs145137834       rs145361181       rs145423919       rs145495041       rs145608408       rs145666034       rs145952922       rs146298896       rs146448812       rs146851054       rs147014327       rs147256417       rs147492685       rs147654121       rs148248237       rs148266912       rs148335149       rs148833516       rs148883518       rs149056499       rs149218065       rs149248243       rs149326330       rs149416955       rs149698596       rs149751890       rs149915954       rs150086748       rs150227618       rs150613310       rs151092063       rs151143926       rs180681342       rs180694494       rs181254564       rs181268910       rs181381146       rs181554676       rs181857799       rs181985090       rs182113800       rs182682353       rs182781943       rs182931000       rs183067022       rs183378634       rs184144719       rs184276409       rs184371735       rs184566286       rs185031676       rs185046143       rs185101705       rs185103997       rs185182054       rs185317373       rs185858030       rs185958607       rs186038065       rs186084634       rs186099278       rs186702263       rs187567729       rs187630323       rs187695605       rs187719061       rs188098482       rs188364490       rs188880599       rs188892594       rs189039866       rs189440558       rs189573032       rs189742164       rs190102073       rs190372469       rs190763306       rs190906863       rs191112313       rs191190884       rs191201783       rs191582744       rs191905273       rs191994474       rs192456354       rs192574225       rs192581857       rs192959094       rs193057641       rs193124102       rs193192081       rs193922608       rs193922614       rs199563741       rs199583685       rs199926195       rs199959170       rs200019083       rs200133589       rs200343185       rs200885420       rs200928782       rs201360575       rs201482330       rs201632485       rs201663073       rs201934530       rs367545984       rs367594943       rs367874037       rs368371140       rs368380625       rs368691872       rs369018004       rs369383955       rs369826473       rs370050374       rs370539457       rs370769257       rs370863212       rs371049191       rs371330108       rs371626972       rs371767834       rs371771267       rs372340900       rs372680126       rs372757722       rs373068386       rs373235921       rs373711048       rs373808892       rs374577617       rs374927292       rs375401722       rs376485698       rs376685231       rs377617872       rs377715747       rs397516444       rs397792336       rs398038465       rs527463048       rs527524417       rs527534541       rs527601820       rs528058333       rs529184907       rs529240686       rs529493376       rs529534578       rs529691220       rs529867920       rs529928317       rs529962858       rs530154637       rs530473083       rs530717420       rs531165437       rs531248279       rs531383130       rs531635002       rs531980778       rs532018719       rs532249689       rs533473223       rs533617729       rs533914115       rs534033584       rs534034008       rs534116895       rs534121774       rs534301494       rs534302950       rs534436636       rs534502397       rs534660169       rs534757144       rs535008866       rs535184650       rs535951305       rs535976168       rs536091464       rs536167237       rs536176038       rs536235802       rs536294356       rs536429573       rs536626854       rs536631685       rs536772897       rs537035541       rs537700421       rs537752431       rs538042681       rs538222471       rs538361664       rs538435014       rs538580892       rs538719970       rs538814912       rs539147546       rs539163717       rs539843994       rs540414165       rs540489358       rs540489486       rs540552634       rs540807667       rs540810571       rs541060328       rs541428506       rs541502263       rs541565291       rs541567217       rs541939421       rs541963428       rs542395916       rs542712042       rs542775568       rs542866871       rs542880941       rs542946144       rs543201951       rs544385452       rs544465283       rs544539203       rs544794257       rs544865777       rs544928783       rs544983652       rs545406510       rs545414053       rs545480782       rs545541816       rs545583208       rs545876867       rs545878120       rs545942078       rs546116373       rs546118793       rs546263769       rs546327119       rs546328785       rs546983775       rs547237593       rs547876727       rs547896601       rs547946216       rs548008573       rs548149039       rs548236450       rs548255250       rs548409641       rs548544777       rs549302609       rs549441039       rs549680884       rs549776734       rs549807529       rs549995743       rs550082866       rs550114475       rs550134133       rs550155859       rs550217627       rs550281007       rs550375730       rs550621538       rs550707488       rs551031295       rs551099461       rs551269536       rs551861466       rs552022737       rs552138012       rs552151127       rs552161251       rs552225058       rs552290225       rs552399136       rs552624308       rs552696341       rs552760935       rs552930903       rs552980100       rs553552844       rs553986453       rs554146916       rs554471911       rs554481602       rs554489258       rs554694937       rs554804191       rs554826167       rs554950077       rs555074259       rs555288791       rs555750768       rs555812350       rs555843960       rs556061675       rs556747524       rs556747567       rs556858579       rs557157382       rs557218864       rs557392554       rs557399752       rs557407349       rs557550041       rs557551625       rs557907346       rs558525915       rs558737890       rs558788270       rs558867157       rs558870550       rs558927590       rs559157522       rs559209488       rs559500908       rs560108076       rs560141241       rs560275979       rs560575280       rs560797655       rs561087293       rs561411998       rs561484803       rs561823965       rs561874453       rs561937322       rs561953435       rs562127323       rs562154392       rs562162481       rs562171276       rs562434684       rs563221126       rs563289423       rs563750171       rs563813895       rs564154196       rs564157575       rs564292641       rs564460805       rs564685386       rs564917049       rs565282433       rs565758605       rs566022571       rs566283432       rs566297318       rs566575573       rs566621467       rs566695546       rs566714301       rs566758180       rs566770993       rs566885734       rs567849140       rs568449345       rs568570655       rs568599966       rs568603173       rs568924380       rs569120168       rs569185143       rs569579160       rs569600253       rs570219235       rs570280319       rs570354289       rs570466274       rs570603017       rs570619659       rs570755022       rs570867481       rs570932862       rs571054905       rs571181615       rs571314757       rs571519686       rs571609047       rs571917729       rs572104942       rs572179698       rs572304598       rs572770652       rs572955590       rs573000980       rs573072656       rs573133142       rs573282957       rs573388137       rs573654700       rs573815049       rs574191130       rs574326509       rs574409638       rs574596128       rs575058514       rs575076052       rs575120965       rs575360985       rs575723363       rs576059326       rs576072485       rs576228359       rs576361514       rs576802259       rs576813644       rs577201500       rs577447476       rs577660855       rs578047912       rs578053681       rs578091032       rs578147586       rs587780730       rs587780731       rs587780732       rs587780993       rs745338799       rs745439844       rs745901803       rs746101911       rs746582207       rs746646171       rs747805018       rs747861291       rs748288951       rs749091984       rs749627152       rs749704215       rs749774529       rs750103719       rs750211277       rs750301189       rs750711842       rs750952266       rs751042065       rs751232153       rs752024930       rs752940316       rs752980085       rs754016774       rs754517578       rs755014728       rs755146587       rs755333116       rs755794553       rs756068442       rs756593539       rs757151154       rs757781272       rs758034030       rs758049121       rs758157229       rs758765633       rs758853661       rs759418244       rs759737367       rs760184234       rs760414295       rs760690217       rs760899424       rs761240835       rs761828544       rs761938397       rs762113539       rs762748790       rs762790375       rs763525739       rs764053615       rs764358108       rs764755691       rs765224880       rs765555744       rs765610126       rs765978945       rs766088261       rs766571541       rs766576246       rs767062290       rs767136348       rs767780451       rs768104793       rs768390987       rs768453720       rs768637170       rs768650092       rs769102979       rs769658318       rs770268755       rs770746627       rs771222897       rs771727849       rs771880989       rs772300829       rs772489344       rs773246608       rs773519476       rs773556807       rs774380450       rs774557051       rs774753107       rs775038762       rs775446934       rs775624944       rs776399733       rs776768994       rs777033554       rs777130107       rs777622214       rs778005138       rs778205243       rs778294945       rs778674343       rs778846471       rs779157605       rs779228671       rs779514074       rs779747717       rs779910104       rs780167833       rs780178275       rs780557277       rs781063331       rs781141216       rs781248221       rs781618785      

VHL基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAGCTACCGAGTGTATACTCTG
60
AGTCTCCTGTAATTCTCAGGC
59
TCACACTGCCAGTGTATACTC
60
AGTCTCCTGTAATTCTCAGGC
59
ACAGCTACCGAGTGTATACTC
59
GTCTCCTGTAATTCTCAGGCT
59
GTTTCAGTTAAGGAGCACTTCC
60
GAGCCAAAGGTGACCTAGG
60
CACTGCCAGTGTATACTCTG
58
CCAGTCTCCTGTAATTCTCAG
58
GTATGGCTCAACTTCGACG
59
AAGAGCCAAAGGTGACCTC
60
GTGTGGTTTCAGTTAAGGAGC
60
AAAGGTGACCTAGGGTTGG
59
TGTGGTTTCAGTTAAGGAGC
58
AAAGGTGACCTAGGGTTGG
59
GCTACCGAGTGTATACTCTG
57
CCAGTCTCCTGTAATTCTCAG
58
TCACACTGCCAGTGTATACTC
60
GTCTCCTGTAATTCTCAGGCT
59
转录因子
影响类型
PubMed链接
ANGPT2
Repression
AR
Activation
CA12
Unknown
CA9
Unknown
CCND1
Unknown
CDKN1B
Activation
CDKN1C
Activation
COL4A2
Unknown
CXCR4
Repression
DAB2
Activation

VHL基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

VHL基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0000122
P40337(UniProtKB)
TAS
GO:0000902
P40337(UniProtKB)
NAS
GO:0004842
P40337(UniProtKB)
TAS
GO:0004842
P40337(UniProtKB)
TAS
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005515
P40337(UniProtKB)
IPI
GO:0005634
P40337(UniProtKB)
TAS
GO:0005654
P40337(UniProtKB)
IDA
GO:0005654
P40337(UniProtKB)
TAS
GO:0005654
P40337(UniProtKB)
TAS
GO:0005654
P40337(UniProtKB)
TAS
GO:0005739
P40337(UniProtKB)
NAS
GO:0005783
P40337(UniProtKB)
NAS
GO:0005829
P40337(UniProtKB)
TAS
GO:0005829
P40337(UniProtKB)
TAS
GO:0005829
P40337(UniProtKB)
TAS
GO:0005829
P40337(UniProtKB)
TAS
GO:0006355
P40337(UniProtKB)
IMP
GO:0006508
P40337(UniProtKB)
TAS
GO:0008134
P40337(UniProtKB)
IPI
GO:0008285
P40337(UniProtKB)
TAS
GO:0016020
P40337(UniProtKB)
IEA
GO:0016567
P40337(UniProtKB)
IEA
GO:0016567
P40337(UniProtKB)
IMP
GO:0016567
P40337(UniProtKB)
IDA
GO:0019899
P40337(UniProtKB)
IPI
GO:0030891
P40337(UniProtKB)
IBA
GO:0043066
P40337(UniProtKB)
NAS
GO:0045597
P40337(UniProtKB)
NAS
GO:0045893
P40337(UniProtKB)
IMP
GO:0050821
P40337(UniProtKB)
NAS
GO:0061418
P40337(UniProtKB)
TAS
GO:0061428
P40337(UniProtKB)
IDA
GO:0061630
P40337(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控VHL基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Von Hippel-Lindau Syndrome 0.658392406 202 50 BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT
ERYTHROCYTOSIS, FAMILIAL, 2 0.56 3 6 CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT
Pheochromocytoma 0.415849807 86 11 BeFree_CLINVAR_CTD_human_GAD_LHGDN_UNIPROT
Renal Cell Carcinoma 0.239057833 222 0 BeFree_CTD_human_GAD_LHGDN
Kidney Neoplasm 0.219888658 24 0 BeFree_CTD_human_GAD_LHGDN_RGD
Nephroblastoma 0.2 1 0 CTD_human_RGD
Conventional (Clear Cell) Renal Cell Carcinoma 0.142529675 84 3 BeFree_UNIPROT
Neoplastic Syndromes, Hereditary 0.124895885 9 26 BeFree_CLINVAR_LHGDN
Adenoma 0.121085767 5 0 BeFree_CTD_human
Lung Neoplasms 0.120271442 2 0 BeFree_CTD_human
Bladder Neoplasm 0.08 1 0 RGD
Sudden infant death syndrome 0.08 0 0 MGD
Parkinsonian Disorders 0.08 1 0 RGD
Paraganglioma 0.037272208 32 0 BeFree_GAD_LHGDN
Adrenal Gland Neoplasms 0.02367032 10 0 GAD
Malignant neoplasm of kidney 0.021878509 42 0 BeFree_GAD
Hemangioblastoma 0.021397758 43 0 BeFree_GAD_LHGDN
Carcinogenesis 0.017643722 65 2 BeFree
Polycythemia 0.01534016 22 2 BeFree_GAD_LHGDN
Renal carcinoma 0.013300652 49 0 BeFree
Multiple Endocrine Neoplasia Type 2a 0.010086957 14 0 BeFree_GAD
Head and Neck Neoplasms 0.009468128 4 0 GAD
Anoxia 0.008173051 3 0 LHGDN
Clear-cell metastatic renal cell carcinoma 0.007871814 29 0 BeFree
Pancreatic Neoplasm 0.005634266 4 0 BeFree_GAD_LHGDN
Mammary Neoplasms 0.0054487 2 0 LHGDN
MYELODYSPLASTIC SYNDROME 0.005091382 2 0 GAD_LHGDN
Adenocarcinoma 0.003810118 5 0 BeFree_LHGDN
Adenomatous Polyposis Coli 0.003538676 3 0 BeFree_LHGDN
Squamous cell carcinoma 0.003267234 3 0 BeFree_LHGDN
Malignant neoplasm of breast 0.003181358 4 0 BeFree_GAD
Colorectal Carcinoma 0.003181358 3 0 BeFree_GAD
Meningioma 0.002995792 1 0 BeFree_LHGDN
Thyroid Neoplasm 0.002995792 2 0 BeFree_LHGDN
Disorder of eye 0.00272435 1 0 LHGDN
Lymphoma 0.00272435 1 0 LHGDN
Mouth Neoplasms 0.00272435 1 0 LHGDN
Thrombosis 0.00272435 1 0 LHGDN
Tongue Neoplasms 0.00272435 1 0 LHGDN
Cerebellar Neoplasms 0.002367032 1 0 GAD
Lymphoproliferative Disorders 0.002367032 1 0 GAD
Neoplasms, Multiple Primary 0.002367032 1 0 GAD
Malignant neoplasm of brain 0.002367032 1 0 GAD
Tumor Progression 0.002171535 8 0 BeFree
Non-Hereditary Clear Cell Renal Cell Carcinoma 0.002171535 8 0 BeFree
Hemangioma 0.001900093 7 0 BeFree
Neoplasm Metastasis 0.001628651 6 0 BeFree
Neurofibromatosis 1 0.001628651 6 0 BeFree
Neuroendocrine Tumors 0.001357209 5 0 BeFree
Breast Carcinoma 0.001357209 5 0 BeFree
Central Nervous System Hemangioblastoma 0.001357209 5 0 BeFree
Angioma 0.001357209 5 0 BeFree
Glioma 0.001085767 4 0 BeFree
Hemangioma of retina 0.001085767 4 0 BeFree
Adenocarcinoma, Clear Cell 0.001085767 4 0 BeFree
Vascular Neoplasms 0.001085767 4 0 BeFree
Cerebellar hemangioblastoma 0.001085767 4 0 BeFree
Hereditary Malignant Neoplasm 0.001085767 4 0 BeFree
Endolymphatic sac tumor 0.001085767 4 0 BeFree
Bilateral pheochromocytoma and islet cell adenoma of the pancreas 0.001085767 4 0 BeFree
Neuroblastoma 0.000814326 3 0 BeFree
Malignant neoplasm of lung 0.000814326 3 0 BeFree
Carcinoma of lung 0.000814326 3 0 BeFree
Hurthle Cell Tumor 0.000814326 3 0 BeFree
Papillary Renal Cell Carcinoma 0.000814326 3 0 BeFree
Erythrocytosis 0.000814326 3 0 BeFree
Aneurysm 0.000542884 2 0 BeFree
Astrocytoma 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000542884 2 0 BeFree
Congenital chromosomal disease 0.000542884 2 0 BeFree
Cyst 0.000542884 2 0 BeFree
Glomerulonephritis 0.000542884 2 0 BeFree
Mesothelioma 0.000542884 2 0 BeFree
Multiple Endocrine Neoplasia 0.000542884 2 0 BeFree
Adenocarcinoma of lung (disorder) 0.000542884 2 0 BeFree
Neurofibromatoses 0.000542884 2 0 BeFree
Gastrointestinal Stromal Tumors 0.000542884 2 0 BeFree
Hemangioma of liver 0.000542884 2 0 BeFree
Medullary carcinoma of thyroid 0.000542884 2 0 BeFree
Simple renal cyst 0.000542884 2 0 BeFree
Tumor Initiation 0.000542884 2 0 BeFree
Epithelial ovarian cancer 0.000542884 2 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree
Central neuroblastoma 0.000542884 2 0 BeFree
Dissecting aneurysm of the thoracic aorta 0.000542884 2 0 BeFree
Pheochromocytoma, Extra-Adrenal 0.000542884 2 0 BeFree
Paragangliomas, head and neck 0.000542884 2 0 BeFree
Hereditary Paraganglioma 0.000542884 2 0 BeFree
Tumor Angiogenesis 0.000542884 2 0 BeFree
Ataxia Telangiectasia 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Carcinoma, Papillary 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Cystadenoma 0.000271442 1 0 BeFree
Endocrine Gland Neoplasms 0.000271442 1 0 BeFree
Fenestration (morphologic abnormality) 0.000271442 1 0 BeFree
Hemangiosarcoma 0.000271442 1 0 BeFree
Hepatitis B 0.000271442 1 0 BeFree
Hydrocephalus 0.000271442 1 0 BeFree
Intestinal Neoplasms 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Kidney Failure, Chronic 0.000271442 1 0 BeFree
Cystic kidney 0.000271442 1 0 BeFree
Chronic Lymphocytic Leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia, Chronic 0.000271442 1 0 BeFree
Acute Promyelocytic Leukemia 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Muscle Cramp 0.000271442 1 0 BeFree
Nervous System Neoplasms 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pancreatic Cyst 0.000271442 1 0 BeFree
Extra-Adrenal Paraganglioma 0.000271442 1 0 BeFree
Kidney Failure 0.000271442 1 0 BeFree
Retinal Diseases 0.000271442 1 0 BeFree
Retinoblastoma 0.000271442 1 0 BeFree
Spermatocele 0.000271442 1 0 BeFree
Trisomy 0.000271442 1 0 BeFree
Tuberous Sclerosis 0.000271442 1 0 BeFree
Varicosity 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Severe Combined Immunodeficiency 0.000271442 1 0 BeFree
Small cell carcinoma of lung 0.000271442 1 0 BeFree
Familial erythrocytosis 0.000271442 1 0 BeFree
Malignant neoplasm of tongue 0.000271442 1 0 BeFree
Adenoma, Microcystic 0.000271442 1 0 BeFree
Leiomyomatosis 0.000271442 1 0 BeFree
Follicular thyroid carcinoma 0.000271442 1 0 BeFree
Acinar Cell Carcinoma 0.000271442 1 0 BeFree
Cystadenoma, Serous 0.000271442 1 0 BeFree
Rapidly progressive glomerulonephritis 0.000271442 1 0 BeFree
Papillary thyroid carcinoma 0.000271442 1 0 BeFree
Chronic colitis 0.000271442 1 0 BeFree
Renal glomerular disease 0.000271442 1 0 BeFree
Metastatic Renal Cell Cancer 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Venous retinal branch occlusion 0.000271442 1 0 BeFree
Oncocytoma, renal 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
ovarian neoplasm 0.000271442 1 0 BeFree
Renal ischaemia 0.000271442 1 0 BeFree
Clear cell tumor 0.000271442 1 0 BeFree
Nodular Neoplasm 0.000271442 1 0 BeFree
Well Differentiated Pancreatic Endocrine Tumor 0.000271442 1 0 BeFree
Differentiated Thyroid Gland Carcinoma 0.000271442 1 0 BeFree
Epithelioma 0.000271442 1 0 BeFree
Angiogenic Switch 0.000271442 1 0 BeFree
Desmoplastic 0.000271442 1 0 BeFree
Malignant Conversion 0.000271442 1 0 BeFree
Alport Syndrome 0.000271442 1 0 BeFree
Meningioma, benign, no ICD-O subtype 0.000271442 1 0 BeFree
HEREDITARY RENAL CANCER ASSOCIATED 1 0.000271442 1 0 BeFree
Multiple endocrine neoplasia (MEN) Syndrome 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps 0.000271442 1 0 BeFree
Pancreatic islet cell tumors 0.000271442 1 0 BeFree
Familial renal cell carcinoma 0.000271442 1 0 BeFree
Nasopharyngeal carcinoma 0.000271442 1 0 BeFree
Unspecified visual loss 0.000271442 1 0 BeFree
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