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Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]
[中文简述(自动翻译):]  目前主要在末梢组织的线粒体隔室,由该基因编码的蛋白质与一些苯并二氮杂卓相互作用并且具有比其内源对应物不同的亲和力。该蛋白质是在胆固醇的流入线粒体允许类固醇激素合成的起始的一个关键因素。可变剪接转录物变体已有报道;所述变体之一缺乏内部外显子和被视为非编码,和其他的变体编码相同的蛋白质。 [由RefSeq的,2012年2月提供]
TSPO基因(以及对应的蛋白质)的细胞分布位置:
TSPO基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hepatic Encephalopathy | 0.12 | 2 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
End Stage Liver Disease | 0.12 | 1 | 0 | CTD_human |
Panic Disorder | 0.005905708 | 3 | 0 | BeFree_GAD_LHGDN |
Mammary Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Glioblastoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
melanoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Schizophrenia | 0.002909916 | 3 | 0 | BeFree_GAD |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Parathyroid Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Autistic Disorder | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Neoplasm Metastasis | 0.001900093 | 7 | 0 | BeFree |
Lymphoma, Follicular | 0.001628651 | 6 | 0 | BeFree |
Myocardial Infarction | 0.001357209 | 5 | 0 | BeFree |
Anxiety Disorders | 0.001085767 | 4 | 0 | BeFree |
Mental Depression | 0.000814326 | 3 | 0 | BeFree |
Depressive disorder | 0.000814326 | 3 | 0 | BeFree |
HIV Infections | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
PANIC DISORDER 1 | 0.000814326 | 3 | 0 | BeFree |
Alzheimer's Disease | 0.000542884 | 2 | 0 | BeFree |
Separation Anxiety Disorder | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000542884 | 2 | 0 | BeFree |
Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Multiple Sclerosis | 0.000542884 | 2 | 1 | BeFree |
nervous system disorder | 0.000542884 | 2 | 0 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Neurodegenerative Disorders | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Middle Cerebral Artery Occlusion | 0.000542884 | 2 | 0 | BeFree |
Post MI | 0.000542884 | 2 | 0 | BeFree |
Separation anxiety disorder of childhood | 0.000542884 | 2 | 0 | BeFree |
Plaque, Amyloid | 0.000542884 | 2 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 1 | BeFree |
Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Allergic Conjunctivitis | 0.000271442 | 1 | 0 | BeFree |
Constipation | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 0 | BeFree |
Encephalitis | 0.000271442 | 1 | 0 | BeFree |
Fatigue | 0.000271442 | 1 | 0 | BeFree |
Fibromyalgia | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Graves Disease | 0.000271442 | 1 | 0 | BeFree |
Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Myocarditis | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Obsessive-Compulsive Disorder | 0.000271442 | 1 | 0 | BeFree |
Osteochondritis Dissecans | 0.000271442 | 1 | 0 | BeFree |
Pain | 0.000271442 | 1 | 0 | BeFree |
Paratuberculosis | 0.000271442 | 1 | 0 | BeFree |
Parkinson Disease | 0.000271442 | 1 | 0 | BeFree |
Peyronie Disease | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Psychotic Disorders | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Retinal Diseases | 0.000271442 | 1 | 0 | BeFree |
Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm, Thoracic | 0.000271442 | 1 | 0 | BeFree |
Follicular adenoma | 0.000271442 | 1 | 0 | BeFree |
brain cyst | 0.000271442 | 1 | 0 | BeFree |
Myalgia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Transitional cell carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Prostatic Intraepithelial Neoplasias | 0.000271442 | 1 | 0 | BeFree |
Senile Plaques | 0.000271442 | 1 | 0 | BeFree |
Chronic low back pain | 0.000271442 | 1 | 0 | BeFree |
Dementia | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Factor V Leiden mutation | 0.000271442 | 1 | 0 | BeFree |
Intraocular pressure disorder | 0.000271442 | 1 | 0 | BeFree |
Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis, Autoimmune, Experimental | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Stromal keratitis | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Non-Malignant Ascites Adverse Event | 0.000271442 | 1 | 0 | BeFree |
Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Painful Bladder Syndrome | 0.000271442 | 1 | 0 | BeFree |
Parvovirus B19 (disease) | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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