更多...
收起
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
[中文简述(自动翻译):]  抗精子抗体与不明原因不孕的情况下,相关牵连在阻止受精这些抗体的作用。改进的诊断和治疗免疫不孕,以及用于靶向避孕蛋白的鉴定,是依赖于相关精子抗原的鉴定和表征。该基因表达的蛋白质是由抗精子抗体从贫瘠的人认可。此蛋白质定位于透人类精子的尾部,并且包含8个连续的犰狳重复序列,已知介导蛋白质 - 蛋白质相互作用的基序。在小鼠中的研究表明,该蛋白质是参与精子鞭毛运动和成熟精子的结构完整性的维护。已发现该基因编码不同亚型的几个抄本变形。 [由RefSeq的,2011年12月提供]
SPAG6基因(以及对应的蛋白质)的细胞分布位置:
SPAG6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
Neoplasm, Residual | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Myeloid neoplasm | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。