SFTPC(surfactant protein C) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

8p21
基因染色体位置图

基因简述

基因简述

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

[中文简述(自动翻译):]  该基因编码的肺相关的表面活性蛋白C（SPC），极疏水性表面活性蛋白出生后肺功能和平衡至关重要。肺表面活性剂是90％的脂质和10％的蛋白质，其中包括血浆蛋白和载脂蛋白SPA，SPB，SPC和SPD组成的表面活性脂蛋白复合物。所述表面活性剂是由肺的肺泡细胞分泌，并通过减少流体，其外套肺的表面张力保持肺组织的稳定性。在该基因的多个突变已经确定，这引起肺表面活性代谢功能障碍，2型，也称为肺泡蛋白沉积症，由于表面活性蛋白C缺乏症，并且与间质性肺疾病的老年婴儿，儿童和成人相关联。另外剪接转录变体编码不同的蛋白质亚型已经确定。[由RefSeq的，2010年2月提供]

OMIM数据库中对SFTPC基因的介绍     Wikipedia数据库中对SFTPC基因的介绍

基因序列

基因序列

SFTPC基因的碱基序列：[NCBI]

基因突变

基因突变

SFTPC基因的碱基突变：           显示全部snp
rs1124       rs4715       rs7592       rs12229       rs1126931       rs1139547       rs2070685       rs2070686       rs2070687       rs3203602       rs3216166       rs8192330       rs8192331       rs8192332       rs8192342       rs12542659       rs34957318       rs35457216       rs62494025       rs74515418       rs74657125       rs75518353       rs75609798       rs78029713       rs79253830       rs79866047       rs113776961       rs149606090       rs150470549       rs181314084       rs181622448       rs183972687       rs187232702       rs189992977       rs200023904       rs200469074       rs200839715      
rs201933678       rs202145169       rs202194863       rs368155404       rs368554301       rs368604198       rs369838552       rs370068089       rs370641482       rs370825102       rs371013652       rs371385087       rs371594079       rs371893768       rs372529179       rs373519586       rs373626962       rs373783536       rs374909143       rs375538518       rs377337781       rs377655715       rs397797745       rs527723291       rs529959941       rs531634308       rs532425722       rs533510538       rs533650743       rs536149934       rs536340898       rs537383138       rs541101294       rs541769233       rs542329758       rs543423602       rs543906412       rs546294880       rs546357906       rs547997358       rs549176450       rs549473609       rs550706851       rs552366898       rs552555186       rs552621627       rs554271808       rs554530717       rs558003013       rs558150674       rs558352051       rs561604619       rs562115512       rs565381858       rs566202129       rs566370122       rs568101030       rs568615387       rs569011144       rs574963884       rs575093849       rs576411182       rs576811364       rs745419854       rs745893171       rs746180618       rs746401661       rs746541966       rs746932615       rs747047170       rs747175730       rs747417768       rs747430307       rs747785707       rs747937184       rs747946112       rs748654127       rs748954723       rs749126105       rs749681094       rs749791590       rs749972069       rs750111469       rs750273486       rs751034722       rs751323841       rs752071541       rs752095125       rs752289567       rs752593536       rs752694682       rs752977645       rs753056063       rs753589128       rs753786425       rs753810106       rs754322616       rs754434830       rs754481467       rs755369109       rs755608045       rs756373126       rs756466010       rs756912017       rs757050514       rs757387068       rs758529805       rs758875625       rs758961469       rs759031390       rs759538016       rs759555760       rs760053190       rs760478729       rs760567018       rs761040696       rs761708440       rs761742367       rs762957181       rs763045334       rs763580777       rs763934776       rs764179769       rs764914328       rs765269411       rs765421401       rs766093799       rs766180273       rs766184622       rs766430833       rs766834199       rs767403089       rs768511860       rs768543107       rs769238316       rs769328550       rs769416910       rs769483476       rs770013219       rs771089238       rs772086074       rs772176099       rs772431756       rs772568845       rs773045595       rs773456769       rs773687273       rs773787143       rs774347862       rs774388522       rs775401772       rs775696772       rs776190058       rs776348865       rs777114058       rs777132226       rs777230179       rs777312443       rs777510956       rs777707126       rs777995190       rs778451328       rs778729773       rs779136923       rs779309006       rs780083047       rs780345754       rs780397126       rs781120153       rs781612407       rs2070684       rs2236739       rs6557857       rs8192314       rs8192315       rs8192316       rs8192317       rs8192318       rs8192319       rs8192320       rs8192321       rs8192322       rs8192323       rs8192324       rs8192325       rs8192326       rs8192327       rs8192328       rs8192329       rs8192336       rs8192337       rs8192338       rs8192339       rs8192340       rs10283091       rs13248346       rs28438700       rs74639360       rs74868576       rs75413490       rs75902455       rs76324979       rs77253713       rs77654184       rs78177348       rs78196704       rs78201008       rs78333736       rs78808334       rs78910836       rs79440568       rs79642027       rs79647630       rs79784847       rs80139123       rs121917834       rs137946464       rs138547826       rs139003518       rs140610971       rs142308804       rs142313774       rs143558389       rs144603526       rs144622012       rs144781155       rs145625779       rs147884807       rs148868554       rs149756879       rs150310467       rs150819812       rs181615830       rs182134990       rs183533911       rs185568136       rs185981871       rs187195336       rs187249892       rs187659188       rs188074517       rs188420910       rs190806001       rs191784131       rs192391655       rs193152861       rs199854076       rs199905878       rs200039720       rs200665803       rs201454136       rs201567623       rs201896861       rs367559125       rs369210212       rs369239281       rs369413166       rs371321234       rs371755328       rs371998882       rs372956221       rs373338880       rs373454108       rs375113623       rs375581850       rs375665663       rs375940265       rs376399274       rs377222742       rs377267823       rs527545050       rs528780508       rs529003509       rs529300779       rs530557040       rs531432287       rs531647576       rs532360636       rs532709739       rs533083304       rs534792003       rs536140888       rs537753681       rs538796102       rs540140111       rs540501623       rs540938171       rs541039978       rs541104547       rs541138857       rs543221202       rs543709575       rs543878977       rs545131719       rs545529507       rs547252810       rs548450924       rs548523225       rs549398477       rs549699699       rs550944537       rs552943217       rs554688089       rs555949925       rs557343687       rs558341748       rs558877043       rs559328204       rs559981805       rs560553416       rs561437067       rs562103082       rs562950234       rs564071933       rs564691235       rs565272058       rs565516076       rs565675339       rs565689497       rs566914013       rs567738879       rs567867391       rs568026942       rs571514118       rs572659129       rs572746112       rs573825268       rs574004610       rs575251338       rs575634399       rs745324972       rs745700017       rs746074620       rs746473012       rs746560865       rs747210099       rs749041331       rs749232449       rs749741633       rs750070143       rs750172249       rs750366145       rs750690497       rs751292601       rs751441472       rs751703149       rs752201591       rs753248473       rs754211081       rs754258407       rs754831645       rs755128027       rs755444690       rs755609275       rs756372282       rs756529000       rs757152791       rs757721748       rs758095773       rs758154087       rs759541738       rs760679225       rs760698424       rs760718844       rs761236918       rs761336558       rs761720968       rs762202388       rs762396958       rs762876533       rs763844839       rs764196825       rs764551500       rs764616546       rs764818190       rs765120009       rs766093752       rs766383484       rs766625842       rs767156369       rs767594462       rs767971320       rs768313265       rs768626980       rs768981838       rs769996149       rs770468297       rs770491816       rs770717292       rs772183067       rs772344538       rs772841457       rs773026639       rs773257848       rs773682315       rs774494261       rs776539836       rs777039901       rs777139008       rs777698296       rs778358826       rs778363720       rs778672867       rs779705163       rs779710215       rs780385907       rs781209749       rs781417860       rs781531188      

基因表达

基因表达

SFTPC基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TATGACTACCAGCAGCTGC
59
CTAGTGAGAGCCTCAAGACTG
59
GGTATCAGCAGGGATTTCC
57
TCTTGGGTTCCTCAGAGAC
58
AACAAAGCAGAACGACTCAC
59
AGGTCTTGGGTTCCAACAG
59
AGGTATCAGCAGGGATTTCC
59
TCTTGGGTTCCTCAGAGAC
58
CAGTACTCACCCTGGTCAC
59
TCCATCAGGACCTCTTTGC
59
CAGTACTCACCCTGGTCAC
59
CCATCAGGACCTCTTTGCT
59
AACGCCTTCTTATCGTGGT
59
CTCCAGAACCATCTCCGTG
59
TATGACTACCAGCAGCTGC
59
AGTGAGAGCCTCAAGACTG
58
ACTCATGGGAACATTCATGTG
58
TGAAGGTCTTGGGTTCCTG
59
TATGACTACCAGCAGCTGC
59
GTGAGAGCCTCAAGACTGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

SFTPC基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

SFTPC基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005576
A0A0A0MTC9(UniProtKB)
IEA
GO:0007585
A0A0A0MTC9(UniProtKB)
IEA
GO:0016021
A0A0A0MTC9(UniProtKB)
IEA
GO:0005576
C9JYF6(UniProtKB)
IEA
GO:0007585
C9JYF6(UniProtKB)
IEA
GO:0016021
C9JYF6(UniProtKB)
IEA
GO:0005576
E5RG20(UniProtKB)
IEA
GO:0007585
E5RG20(UniProtKB)
IEA
GO:0005576
E5RHW5(UniProtKB)
IEA
GO:0007585
E5RHW5(UniProtKB)
IEA
GO:0005576
E5RI64(UniProtKB)
IEA
GO:0007585
E5RI64(UniProtKB)
IEA
GO:0005576
E5RI92(UniProtKB)
IEA
GO:0007585
E5RI92(UniProtKB)
IEA
GO:0016021
E5RI92(UniProtKB)
IEA
GO:0005515
P11686(UniProtKB)
IPI
GO:0005515
P11686(UniProtKB)
IPI
GO:0005515
P11686(UniProtKB)
IPI
GO:0005515
P11686(UniProtKB)
IPI
GO:0005515
P11686(UniProtKB)
IPI
GO:0005515
P11686(UniProtKB)
IPI
GO:0005576
P11686(UniProtKB)
TAS
GO:0005576
P11686(UniProtKB)
TAS
GO:0005576
P11686(UniProtKB)
TAS
GO:0005576
P11686(UniProtKB)
TAS
GO:0005576
P11686(UniProtKB)
TAS
GO:0005615
P11686(UniProtKB)
IEA
GO:0005789
P11686(UniProtKB)
TAS
GO:0005789
P11686(UniProtKB)
TAS
GO:0005789
P11686(UniProtKB)
TAS
GO:0007585
P11686(UniProtKB)
IEA
GO:0042599
P11686(UniProtKB)
TAS
GO:0042599
P11686(UniProtKB)
TAS
GO:0042599
P11686(UniProtKB)
TAS
GO:0044267
P11686(UniProtKB)
TAS
GO:0045334
P11686(UniProtKB)
TAS
GO:0097486
P11686(UniProtKB)
TAS
GO:0097486
P11686(UniProtKB)
TAS
GO:0097486
P11686(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控SFTPC基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 (disorder) 0.48 5 6 CLINVAR_CTD_human_ORPHANET_UNIPROT
Idiopathic Pulmonary Fibrosis 0.243257302 12 1 BeFree_CTD_human_ORPHANET
Desquamative interstitial pneumonia 0.2 0 0 MGD_ORPHANET
Diaphragmatic Hernia 0.12 1 0 CTD_human
Polycystic Ovary Syndrome 0.12 1 0 CTD_human
Respiratory Distress Syndrome In Premature Infants 0.12 0 0 ORPHANET
Surfactant Metabolism Dysfunction, Pulmonary, 1 0.12 0 0 CTD_human
Respiratory Distress Syndrome, Newborn 0.087991366 13 1 BeFree_GAD_RGD
Pneumonia, Bacterial 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Hyperoxia 0.08 1 0 RGD
Lung Diseases, Interstitial 0.027942157 36 2 BeFree_GAD_LHGDN
Lung diseases 0.01261581 19 0 BeFree_GAD_LHGDN
Bronchopulmonary Dysplasia 0.007915422 5 1 BeFree_GAD
Pulmonary Fibrosis 0.005895776 14 0 BeFree_GAD
Asthma 0.005362824 2 0 BeFree_GAD_LHGDN
Fibrosis 0.00272435 1 0 LHGDN
Infection 0.00272435 1 0 LHGDN
Respiratory Distress Syndrome, Adult 0.002714419 10 0 BeFree
Chronic Obstructive Airway Disease 0.002638474 2 0 BeFree_GAD
Respiratory Syncytial Virus Infections 0.002638474 2 0 BeFree_GAD
Bronchiolitis, Viral 0.002367032 1 0 GAD
Pulmonary Emphysema 0.002367032 1 0 GAD
Pneumonia, Interstitial 0.001900093 7 0 BeFree
Hamman-Rich syndrome 0.001357209 5 1 BeFree
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 0.001357209 5 0 BeFree
Lung Neoplasms 0.001085767 4 0 BeFree
Respiratory Failure 0.001085767 4 0 BeFree
Adenocarcinoma 0.000814326 3 0 BeFree
Pneumonia 0.000814326 3 0 BeFree
Adenocarcinoma of lung (disorder) 0.000814326 3 0 BeFree
Chronic lung disease 0.000814326 3 0 BeFree
Borderline Personality Disorder 0.000542884 2 0 BeFree
Chondrosarcoma 0.000542884 2 0 BeFree
Pulmonary Hypertension 0.000542884 2 0 BeFree
Pulmonary Alveolar Proteinosis 0.000542884 2 0 BeFree
Respiratory distress 0.000542884 2 0 BeFree
Neonatal respiratory failure 0.000542884 2 0 BeFree
Chronic interstitial lung disease 0.000542884 2 0 BeFree
Nonspecific interstitial pneumonia 0.000542884 2 0 BeFree
Idiopathic Interstitial Pneumonias 0.000542884 2 0 BeFree
RDS - infants 0.000542884 2 0 BeFree
Surfactant Dysfunction 0.000542884 2 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Cystadenoma 0.000271442 1 0 BeFree
Hyperinsulinism 0.000271442 1 0 BeFree
Lipoid Proteinosis of Urbach and Wiethe 0.000271442 1 1 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Pulmonary Edema 0.000271442 1 0 BeFree
Respiration Disorders 0.000271442 1 0 BeFree
Respiratory Tract Diseases 0.000271442 1 0 BeFree
Virus Diseases 0.000271442 1 0 BeFree
Lower respiratory tract infection 0.000271442 1 0 BeFree
Small cell carcinoma of lung 0.000271442 1 0 BeFree
Idiopathic pulmonary hypertension 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lung 0.000271442 1 0 BeFree
Centriacinar Emphysema 0.000271442 1 0 BeFree
Congenital diaphragmatic hernia 0.000271442 1 0 BeFree
Non-small cell lung cancer stage I 0.000271442 1 0 BeFree
Dysequilibrium syndrome 0.000271442 1 0 BeFree
Multiple lung cysts 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Lung Diseases, Obstructive 0.000271442 1 0 BeFree
Familial Dementia 0.000271442 1 0 BeFree
Infectious disease of lung 0.000271442 1 0 BeFree
Persistent pulmonary hypertension 0.000271442 1 0 BeFree
Respiratory morbidity 0.000271442 1 0 BeFree
Preterm Premature Rupture of Fetal Membranes 0.000271442 1 0 BeFree
Pulmonary arterial hypertension 0.000271442 1 0 BeFree
Pneumonitis 0.000271442 1 0 BeFree
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia 0.000271442 1 0 BeFree

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