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The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  的骨形态发生蛋白(BMPs)是可诱导异位骨生长分泌的信号分子家族。许多BMP是转化生长因子-β(TGFB)超家族的一部分。骨形态发生蛋白最初是由脱钙骨提取物诱导成骨软骨在体内在骨骼外部位的能力鉴定。基于其在胚胎发育早期的表达,该基因编码的BMP在早期发展和可能的骨感性活动提出的作用。 [由RefSeq的,2008年7月提供]
BMP7基因(以及对应的蛋白质)的细胞分布位置:
BMP7基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Prostatic Neoplasms | 0.123267234 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Bone Resorption | 0.12 | 1 | 0 | CTD_human |
| Endometriosis | 0.12 | 1 | 0 | CTD_human |
| Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
| Pulmonary Fibrosis | 0.12 | 1 | 0 | CTD_human |
| Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Diabetic Nephropathy | 0.086720033 | 7 | 0 | BeFree_GAD_LHGDN_RGD |
| Kidney Diseases | 0.083267234 | 3 | 0 | BeFree_LHGDN_RGD |
| Gliosis | 0.08 | 1 | 0 | RGD |
| Acute Kidney Tubular Necrosis | 0.08 | 1 | 0 | RGD |
| Nephroblastoma | 0.08 | 1 | 0 | RGD |
| Pyelonephritis | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms | 0.011168843 | 5 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.007077352 | 8 | 0 | BeFree_LHGDN |
| melanoma | 0.006263026 | 4 | 0 | BeFree_LHGDN |
| Hypospadias | 0.00554839 | 4 | 0 | BeFree_GAD |
| Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Primary Myelofibrosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Colorectal Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Pulmonary Hypertension | 0.00272435 | 1 | 0 | LHGDN |
| Arthropathy | 0.00272435 | 1 | 0 | LHGDN |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002638474 | 1 | 0 | BeFree_GAD |
| Kidney Failure, Chronic | 0.002638474 | 2 | 0 | BeFree_GAD |
| Major Depressive Disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
| Secondary malignant neoplasm of bone | 0.002442977 | 9 | 0 | BeFree |
| Prostate carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
| Calcinosis | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus, Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
| Hyperparathyroidism, Secondary | 0.002367032 | 1 | 0 | GAD |
| Narcolepsy | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001900093 | 7 | 0 | BeFree |
| Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Osteosarcoma | 0.001628651 | 6 | 0 | BeFree |
| Osteosarcoma of bone | 0.001628651 | 6 | 0 | BeFree |
| Renal fibrosis | 0.001085767 | 4 | 0 | BeFree |
| Liver Cirrhosis | 0.000814326 | 3 | 0 | BeFree |
| Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
| Fibrosis, Liver | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Cirrhosis | 0.000814326 | 3 | 0 | BeFree |
| Colitis | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Ischemia | 0.000542884 | 2 | 0 | BeFree |
| Kidney Failure, Acute | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| Cerebrovascular accident | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Chronic Kidney Insufficiency | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Chronic Kidney Diseases | 0.000542884 | 2 | 0 | BeFree |
| Penile hypospadias | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Bone Diseases | 0.000271442 | 1 | 0 | BeFree |
| Bronchiolitis Obliterans | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Infarction | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Uterine Cervical Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Congenital ocular coloboma (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Mixed Salivary Gland Tumor | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Oral Submucous Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Peripheral Neuropathy | 0.000271442 | 1 | 0 | BeFree |
| Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
| Silicosis | 0.000271442 | 1 | 0 | BeFree |
| Sirenomelia | 0.000271442 | 1 | 0 | BeFree |
| Spinal Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Spondylolysis | 0.000271442 | 1 | 0 | BeFree |
| Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Lobular | 0.000271442 | 1 | 0 | BeFree |
| Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
| Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Degenerative spondylolisthesis | 0.000271442 | 1 | 0 | BeFree |
| Secondary pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
| Holt-Oram syndrome | 0.000271442 | 1 | 0 | BeFree |
| Prostate cancer recurrent | 0.000271442 | 1 | 0 | BeFree |
| Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Fibrous Histiocytoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
| Chronic liver disease | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Corneal fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Renal artery occlusion | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Dissecting aneurysm of the thoracic aorta | 0.000271442 | 1 | 1 | BeFree |
| Middle Cerebral Artery Occlusion | 0.000271442 | 1 | 0 | BeFree |
| Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Testicular dysgenesis syndrome | 0.000271442 | 1 | 0 | BeFree |
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