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Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
[中文简述(自动翻译):]  松弛素是已知的内分泌和自分泌/旁分泌激素,属于胰岛素基因超家族。在人类有三种非等位基因的松弛素基因,RLN1,RLN2和RLN3,其中RLN1和RLN2分享高序列同源性。由该基因编码的蛋白质被合成为一种单链多肽,但活性形式由一个A链和由二硫键连接的B链。松弛素是由卵巢产生,并且针对哺乳动物生殖系统成熟宫颈,拉长耻骨联合,抑制子宫收缩。它可能有增强精子活力,调节血压,控制心脏率和释放催产素和血管加压素其他角色。 [由RefSeq的,2013年1月提供]
RLN1基因(以及对应的蛋白质)的细胞分布位置:
RLN1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Premature Birth | 0.005091382 | 2 | 0 | GAD_LHGDN |
Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
Hypertensive disease | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Testicular malignant germ cell tumor | 0.000271442 | 1 | 0 | BeFree |
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