HEY2(hes-related family bHLH transcription factor with YRPW motif 2)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

6q
基因染色体位置图

基因简述

基因简述

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基因编码的碱性螺旋 - 环 - 螺旋（bHLH结构）型转录因子分裂相关（HESR）家族的毛状和增强的成员。所编码的蛋白质的形式均聚物或该定位于核和相互作用与组蛋白脱乙酰复杂杂二聚体抑制转录。这个基因的表达是由所述Notch信号传导途径诱导。在小鼠两个类似的和冗余的基因所需的胚胎心血管发育，并且也牵连在神经发生和体节形成。可变剪接转录物变体已被发现，但它们的生物有效性尚未确定。 [由RefSeq的，2008年7月提供]

OMIM数据库中对HEY2基因的介绍     Wikipedia数据库中对HEY2基因的介绍

基因序列

基因序列

HEY2基因的碱基序列：[NCBI]

基因突变

基因突变

HEY2基因的碱基突变：           显示全部snp
rs1268078       rs1343115       rs1343116       rs1739369       rs1811852       rs1935978       rs1935983       rs2875881       rs3734637       rs3734638       rs3734640       rs3757214       rs3757217       rs3799708       rs3799709       rs3799710       rs3799711       rs3799712       rs3799714       rs3839542       rs3839543       rs6902519       rs6916590       rs6940469       rs7748729       rs7753038       rs7764016       rs9321054       rs9388450       rs9398786       rs9401844       rs10617027       rs11280366       rs11960977       rs11969768       rs13193692       rs34745209      
rs59354019       rs61737181       rs73771172       rs74858146       rs75759893       rs76017888       rs76091250       rs76523275       rs76735267       rs77339196       rs77635556       rs77759637       rs77854832       rs78213010       rs78508125       rs78944091       rs78973595       rs79960200       rs80355834       rs111785179       rs111893376       rs112132135       rs112235907       rs112265123       rs112509205       rs112677723       rs112780587       rs113023735       rs113552852       rs113682501       rs113703537       rs113880966       rs114328833       rs114390110       rs114424334       rs114582717       rs116819566       rs117713004       rs138136678       rs138413872       rs138472261       rs138966278       rs138974083       rs139453446       rs139750401       rs139759475       rs139845453       rs140010344       rs140309029       rs140485061       rs140658164       rs141082567       rs141450342       rs141795395       rs142572788       rs142760566       rs143278416       rs143945370       rs144128149       rs144406333       rs144449604       rs144879330       rs145736300       rs145752173       rs145842373       rs145842756       rs146611065       rs146612144       rs146642153       rs146693390       rs146876940       rs146975275       rs147376532       rs147406225       rs147415979       rs147479263       rs148049643       rs148304301       rs149038012       rs149344840       rs149358203       rs149518544       rs149642297       rs149827365       rs149866534       rs149958857       rs150184162       rs150274862       rs151283443       rs180839076       rs181415440       rs181601319       rs181670076       rs181882875       rs182028428       rs182600117       rs182644657       rs182657504       rs182882363       rs183434024       rs183610877       rs183750517       rs183975846       rs184344022       rs184383192       rs184960623       rs185432140       rs185938073       rs186208030       rs186280075       rs186391404       rs186978394       rs187077769       rs187308545       rs188231347       rs188375420       rs189067445       rs189553881       rs189615052       rs189710328       rs189909373       rs190385446       rs190451777       rs190699147       rs190754094       rs191015972       rs191249768       rs191390063       rs191563878       rs191791847       rs192123302       rs192359849       rs192978190       rs193035394       rs193223153       rs200354112       rs200628721       rs200676653       rs201046027       rs201084537       rs201400342       rs367742925       rs368774390       rs368902048       rs369600144       rs370035330       rs370633812       rs370671117       rs370885610       rs371231318       rs371681530       rs372109982       rs372121891       rs372295806       rs372807209       rs372907445       rs373871800       rs373889651       rs374259810       rs374277236       rs374306977       rs374312366       rs374723563       rs374782040       rs374907190       rs376521140       rs376763707       rs377149107       rs377349227       rs377597491       rs377701205       rs527238432       rs527239404       rs527363398       rs528379150       rs528505096       rs529011370       rs529103545       rs529264242       rs529565903       rs529616190       rs529677206       rs529712818       rs530112277       rs530271656       rs530618702       rs530778128       rs530834763       rs531330887       rs531343724       rs531469905       rs531777928       rs531786418       rs531897269       rs531916278       rs531918479       rs532004900       rs532500639       rs532500814       rs532565997       rs532910552       rs532913010       rs533167925       rs533629589       rs533925457       rs533926964       rs534203842       rs534264012       rs534353368       rs534847445       rs535162589       rs535718662       rs535983395       rs536471883       rs536800891       rs536859935       rs537006946       rs537192271       rs537996188       rs538061525       rs538186016       rs538271533       rs538394353       rs539211593       rs539242632       rs539259014       rs539409474       rs540209640       rs540519632       rs540634506       rs540896493       rs541020763       rs541123269       rs541230350       rs541487154       rs541607456       rs541700315       rs541878524       rs541948433       rs542174585       rs542293472       rs542560842       rs543240124       rs543493401       rs543525530       rs543548244       rs543622220       rs544102568       rs544589306       rs544686236       rs544724411       rs544749851       rs545701475       rs545734424       rs545762813       rs545959653       rs545968318       rs546650706       rs546858828       rs547068504       rs547165898       rs547257071       rs547302322       rs547542137       rs547928654       rs548311799       rs548616658       rs548791613       rs548825663       rs548853947       rs549151246       rs549251787       rs549794643       rs550030443       rs550064594       rs550966073       rs551103342       rs551128913       rs551149073       rs551226420       rs551257348       rs551271079       rs551663652       rs552176692       rs552298764       rs552309330       rs552460625       rs552583070       rs553191024       rs553443719       rs553512999       rs553649524       rs554174531       rs554264265       rs554381894       rs554592352       rs554646746       rs554785398       rs555316524       rs555454267       rs555531505       rs555844036       rs556448688       rs556514325       rs556566947       rs556655883       rs557483386       rs557644350       rs557786037       rs557972777       rs558599230       rs558751274       rs558910462       rs558983626       rs559198957       rs559329623       rs559928733       rs560237661       rs560345959       rs560960423       rs561173383       rs561196868       rs561590547       rs561701556       rs561790547       rs561982108       rs562208058       rs562391472       rs562475224       rs562847699       rs562908363       rs562998950       rs563087465       rs563313651       rs563352486       rs563786003       rs563988394       rs564050036       rs564111344       rs564196173       rs564321643       rs564340258       rs564963386       rs565176202       rs565324188       rs565716695       rs565849794       rs565912061       rs565963394       rs566328885       rs566998395       rs567204370       rs567371869       rs567624058       rs567636784       rs568146342       rs568238414       rs568295363       rs568379057       rs568472749       rs568479024       rs568746911       rs569476049       rs569703468       rs570526419       rs570662067       rs570914828       rs571442497       rs571594591       rs571873705       rs572237981       rs572321531       rs572944599       rs572960766       rs572984974       rs573619783       rs573679844       rs574148924       rs574186073       rs574285243       rs574649752       rs574736722       rs574909724       rs575108857       rs575358539       rs575393770       rs575453858       rs575892677       rs576119532       rs576155800       rs576229362       rs576232252       rs577238600       rs577712992       rs578105051       rs578211409       rs578257358       rs745502281       rs745815111       rs745987325       rs746189266       rs746381020       rs746469199       rs746531685       rs747126977       rs747221103       rs747349024       rs747415627       rs747615665       rs748007219       rs748098295       rs748394657       rs748548829       rs748854346       rs748890411       rs748942098       rs749036945       rs749125871       rs749412359       rs749707731       rs749750107       rs749863283       rs749983444       rs750069876       rs750154365       rs750183240       rs750560163       rs750612594       rs750649221       rs750775754       rs750867284       rs751124003       rs751222034       rs751356539       rs751416936       rs751444142       rs751639135       rs751747164       rs752114714       rs752210748       rs752507444       rs752594984       rs752739244       rs752773448       rs752951358       rs753434608       rs753438523       rs753923633       rs753977042       rs754109328       rs754368234       rs754599347       rs754915674       rs754930506       rs755020431       rs755096617       rs755340292       rs755499957       rs756190973       rs756332618       rs756510705       rs756533636       rs756829238       rs757286685       rs757671162       rs757765112       rs758103227       rs758282127       rs758599594       rs758689226       rs759080037       rs759303884       rs759340122       rs759429944       rs759494126       rs759661730       rs760063236       rs760362065       rs760487306       rs760509987       rs760743136       rs760983884       rs761158643       rs761230362       rs761635639       rs761700891       rs761812670       rs761814943       rs761904411       rs762233099       rs762387313       rs762559147       rs762977247       rs763035505       rs763061054       rs763300749       rs763500780       rs763694079       rs763890741       rs763984618       rs764074174       rs764155692       rs764634389       rs764711233       rs765038217       rs765298987       rs765386902       rs765475262       rs766048408       rs766552559       rs766577853       rs766659659       rs766842850       rs766932885       rs767030135       rs767207956       rs767236034       rs767509095       rs767898232       rs768023160       rs768284413       rs768305223       rs768906935       rs768962310       rs769050248       rs769202043       rs769438770       rs769535036       rs769615126       rs769632168       rs769757991       rs769963246       rs770161316       rs770378982       rs770544276       rs770585455       rs770817741       rs770907626       rs770916099       rs771523537       rs771815981       rs771962430       rs772330587       rs772377585       rs772929382       rs772942465       rs773247712       rs773396810       rs773734737       rs773905567       rs774296494       rs774553825       rs774732571       rs774750328       rs774910626       rs774930568       rs775034247       rs775395778       rs775781440       rs775787936       rs775836548       rs775899596       rs776547365       rs777025715       rs777316111       rs777406714       rs777421462       rs777647930       rs778006042       rs778078848       rs778094501       rs778190656       rs778569906       rs778756969       rs779115875       rs779229847       rs779503874       rs779972686       rs780259458       rs780260550       rs780736921       rs781027590       rs781201919       rs781313488       rs781314177       rs781501897       rs781510767       rs781516744       rs781602440       rs3757217      

基因表达

基因表达

HEY2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GGGTAAAGGCTACTTTGACG
59
GCAACTTCTGTTAGGCACTC
59
GGGTAAAGGCTACTTTGACG
59
CGCAACTTCTGTTAGGCAC
60
AGAAGACTTGTGCCAACTG
58
CGTCAAAGTAGCCTTTACCC
59

转录因子

转录因子

转录因子
影响类型
PubMed链接
ACTA2
Repression
18239137
GATA4
Repression
16199874
GATA6
Repression
16199874

基因本体信息

HEY2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

HEY2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003677
Q5TF93(UniProtKB)
IEA
GO:0005634
Q5TF93(UniProtKB)
IEA
GO:0006351
Q5TF93(UniProtKB)
IEA
GO:0006355
Q5TF93(UniProtKB)
IEA
GO:0046983
Q5TF93(UniProtKB)
IEA
GO:0000122
Q9UBP5(UniProtKB)
IDA
GO:0000122
Q9UBP5(UniProtKB)
IMP
GO:0000122
Q9UBP5(UniProtKB)
IDA
GO:0000122
Q9UBP5(UniProtKB)
IDA
GO:0000122
Q9UBP5(UniProtKB)
IDA
GO:0000122
Q9UBP5(UniProtKB)
IDA
GO:0000983
Q9UBP5(UniProtKB)
ISS
GO:0000988
Q9UBP5(UniProtKB)
IDA
GO:0001102
Q9UBP5(UniProtKB)
IPI
GO:0001570
Q9UBP5(UniProtKB)
ISS
GO:0003150
Q9UBP5(UniProtKB)
ISS
GO:0003151
Q9UBP5(UniProtKB)
ISS
GO:0003184
Q9UBP5(UniProtKB)
ISS
GO:0003186
Q9UBP5(UniProtKB)
ISS
GO:0003195
Q9UBP5(UniProtKB)
IEA
GO:0003199
Q9UBP5(UniProtKB)
IEA
GO:0003208
Q9UBP5(UniProtKB)
ISS
GO:0003214
Q9UBP5(UniProtKB)
ISS
GO:0003215
Q9UBP5(UniProtKB)
ISS
GO:0003222
Q9UBP5(UniProtKB)
IEA
GO:0003700
Q9UBP5(UniProtKB)
IDA
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005515
Q9UBP5(UniProtKB)
IPI
GO:0005634
Q9UBP5(UniProtKB)
ISS
GO:0005654
Q9UBP5(UniProtKB)
TAS
GO:0005737
Q9UBP5(UniProtKB)
ISS
GO:0006351
Q9UBP5(UniProtKB)
IEA
GO:0007219
Q9UBP5(UniProtKB)
ISS
GO:0008134
Q9UBP5(UniProtKB)
NAS
GO:0009948
Q9UBP5(UniProtKB)
IEA
GO:0010460
Q9UBP5(UniProtKB)
IEA
GO:0010621
Q9UBP5(UniProtKB)
ISS
GO:0010629
Q9UBP5(UniProtKB)
ISS
GO:0010667
Q9UBP5(UniProtKB)
IEA
GO:0014031
Q9UBP5(UniProtKB)
ISS
GO:0014898
Q9UBP5(UniProtKB)
IEA
GO:0017053
Q9UBP5(UniProtKB)
IDA
GO:0035910
Q9UBP5(UniProtKB)
ISS
GO:0035912
Q9UBP5(UniProtKB)
ISS
GO:0035939
Q9UBP5(UniProtKB)
IDA
GO:0036304
Q9UBP5(UniProtKB)
ISS
GO:0042803
Q9UBP5(UniProtKB)
IEA
GO:0042826
Q9UBP5(UniProtKB)
IPI
GO:0043565
Q9UBP5(UniProtKB)
IDA
GO:0045165
Q9UBP5(UniProtKB)
IEA
GO:0045607
Q9UBP5(UniProtKB)
IEA
GO:0045746
Q9UBP5(UniProtKB)
IEA
GO:0045892
Q9UBP5(UniProtKB)
IDA
GO:0045892
Q9UBP5(UniProtKB)
IDA
GO:0045944
Q9UBP5(UniProtKB)
ISS
GO:0046982
Q9UBP5(UniProtKB)
IEA
GO:0051145
Q9UBP5(UniProtKB)
NAS
GO:0055015
Q9UBP5(UniProtKB)
ISS
GO:0060045
Q9UBP5(UniProtKB)
IEA
GO:0060317
Q9UBP5(UniProtKB)
ISS
GO:0060347
Q9UBP5(UniProtKB)
IEA
GO:0060411
Q9UBP5(UniProtKB)
ISS
GO:0060412
Q9UBP5(UniProtKB)
ISS
GO:0060413
Q9UBP5(UniProtKB)
ISS
GO:0060633
Q9UBP5(UniProtKB)
IDA
GO:0060716
Q9UBP5(UniProtKB)
ISS
GO:0060842
Q9UBP5(UniProtKB)
ISS
GO:0060948
Q9UBP5(UniProtKB)
IEA
GO:0060977
Q9UBP5(UniProtKB)
IEA
GO:0061156
Q9UBP5(UniProtKB)
ISS
GO:0061314
Q9UBP5(UniProtKB)
IC
GO:0065004
Q9UBP5(UniProtKB)
IEA
GO:0090102
Q9UBP5(UniProtKB)
IEA
GO:0097084
Q9UBP5(UniProtKB)
IEP
GO:2000678
Q9UBP5(UniProtKB)
IDA
GO:2000723
Q9UBP5(UniProtKB)
ISS
GO:2000820
Q9UBP5(UniProtKB)
ISS
GO:2001212
Q9UBP5(UniProtKB)
ISS
GO:0016580
Q9UBP5(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控HEY2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Brugada Syndrome (disorder) 0.120542884 2 3 BeFree_CTD_human
Astrocytoma 0.12 1 0 CTD_human
Hypertrophic Cardiomyopathy 0.12 1 0 CTD_human
Carcinoma, Pancreatic Ductal 0.12 1 0 CTD_human
Mammary Neoplasms 0.12 1 0 CTD_human
Tetralogy of Fallot 0.080271442 1 0 BeFree_MGD
Coronary heart disease 0.000814326 3 0 BeFree
Congenital Abnormality 0.000542884 2 0 BeFree
Congenital Heart Defects 0.000542884 2 0 BeFree
Ventricular Septal Defects 0.000542884 2 0 BeFree
Alcoholic Intoxication, Chronic 0.000271442 1 0 BeFree
Anaplasia 0.000271442 1 0 BeFree
Aortic Aneurysm 0.000271442 1 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Cholestasis 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Ependymoma 0.000271442 1 0 BeFree
Heart Septal Defects 0.000271442 1 0 BeFree
Atrial Septal Defects 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Alagille Syndrome 0.000271442 1 0 BeFree
Pancreatitis, Chronic 0.000271442 1 0 BeFree
Congenital heart disease 0.000271442 1 0 BeFree
Hyperandrogenism 0.000271442 1 0 BeFree
Reactive systemic amyloidosis 0.000271442 1 0 BeFree
Common atrioventricular canal 0.000271442 1 0 BeFree
Atresia 0.000271442 1 0 BeFree
Congenital anomaly of face 0.000271442 1 0 BeFree
Pilocytic Astrocytoma 0.000271442 1 0 BeFree
Atrioventricular septal defect and common atrioventricular junction 0.000271442 1 0 BeFree
Complete atrioventricular septal defect 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Overweight 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Cardiac defects 0.000271442 1 0 BeFree
Sporadic Breast Carcinoma 0.000271442 1 0 BeFree
ATRIOVENTRICULAR CANAL DEFECT 0.000271442 1 0 BeFree
Atrioventricular Septal Defect 0.000271442 1 0 BeFree
Vascular lesions 0.000271442 1 0 BeFree
Benign Prostatic Hyperplasia 0.000271442 1 0 BeFree
Non-Neoplastic Disorder 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree

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