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Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
[中文简述(自动翻译):]  组氨酸氨 - 裂合酶是一种胞质酶催化组氨酸代谢,L-组氨酸的非氧化性脱氨反式尿刊酸的第一反应。组氨酸氨 - 裂合酶缺陷引起his??tidinemia其特点是增加组氨酸和组胺和体液降低尿刊酸。已发现该基因编码不同亚型的几个抄本变形。 [由RefSeq的,2012年4月提供]
HAL基因(以及对应的蛋白质)的细胞分布位置:
HAL基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Histidinemia | 0.480814326 | 3 | 4 | BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT |
Squamous cell carcinoma | 0.002638474 | 1 | 0 | BeFree_GAD |
Schizophrenia | 0.002638474 | 1 | 0 | BeFree_GAD |
Basal cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Radiation-Induced | 0.002367032 | 1 | 0 | GAD |
Skin Neoplasms | 0.002367032 | 1 | 0 | GAD |
Sunburn | 0.002367032 | 1 | 0 | GAD |
Solar Erythema | 0.002367032 | 1 | 0 | GAD |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Ehrlich Tumor | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Malignant hyperpyrexia due to anesthesia | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
Effects of heat | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Skin carcinoma | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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