H2AFZ(H2A histone family, member Z)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

4q23
基因染色体位置图

基因简述

基因简述

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  组蛋白是负责在真核生物染色体纤维的核小体结构基本核蛋白质。核小体是由约146 bp的DNA围绕组蛋白包裹着的八聚体由多对四个核心组蛋白（H2A，H2B，H3和H4）的组成。染色质纤维是通过接头组蛋白，H1的相互作用进一步压实，用D核小体之间的NA，形成高阶染色质结构。这个基因编码组蛋白H2A家族，它是从家庭的其他成员不同的有复制独立成员。已经在小鼠中的研究表明，这种特定的组蛋白所需的胚胎发育和表明缺少功能性组蛋白H2A的导致胚胎致死。 [由RefSeq的，2008年7月提供]

OMIM数据库中对H2AFZ基因的介绍     Wikipedia数据库中对H2AFZ基因的介绍

基因序列

基因序列

H2AFZ基因的碱基序列：[NCBI]

基因突变

基因突变

H2AFZ基因的碱基突变：           显示全部snp
rs11554391       rs76263771       rs76968446       rs78656098       rs114507825       rs114559492       rs142139638       rs143581503       rs145706763       rs147645289       rs148929471       rs180748109       rs181236803       rs184293207       rs190024711       rs201726975       rs202011503       rs371942491       rs377429947       rs529026864       rs529141527       rs530951864       rs533452282       rs535289126       rs535333977       rs539216506       rs541608124       rs545237681       rs545489251       rs547173613       rs547192018       rs547235182       rs549079846       rs550060076       rs551468495       rs555055708       rs556044144      
rs561675868       rs563699791       rs565152103       rs565541399       rs569620023       rs575996459       rs578179487       rs578224427       rs747804114       rs747924199       rs750579215       rs754878863       rs759268414       rs762198930       rs763465722       rs764376041       rs765776033       rs767222939       rs767838789       rs771708608       rs771765670       rs772770726       rs774139841       rs775895608       rs780135101       rs2276939       rs3756087       rs11554386       rs11554389       rs13111286       rs17029673       rs28635099       rs61203457       rs73832925       rs78032150       rs79002079       rs111727157       rs111775986       rs112283204       rs112383138       rs112445319       rs113550334       rs114299525       rs137864981       rs138869217       rs140487187       rs143698630       rs146386102       rs147202119       rs149462356       rs181987228       rs185949232       rs186120127       rs186322510       rs191910830       rs199573896       rs199997351       rs200598187       rs200739517       rs201831158       rs202074505       rs369008608       rs369350507       rs369466140       rs370063450       rs370608688       rs372912583       rs373152482       rs373436350       rs374372807       rs374654880       rs375051093       rs375529001       rs376055860       rs376782735       rs376884397       rs377144974       rs377735103       rs527904627       rs527972104       rs528116075       rs528420701       rs529593816       rs530316492       rs531822332       rs532032167       rs532091895       rs533058409       rs533778821       rs534023465       rs534089022       rs535813166       rs536413402       rs536473560       rs537881661       rs538206637       rs539136134       rs539248769       rs540339981       rs540936185       rs541400276       rs542129174       rs542816803       rs542878135       rs543909505       rs544980949       rs545225901       rs545426612       rs546597390       rs548357401       rs548417622       rs549954533       rs552408293       rs553719493       rs554863965       rs554924604       rs555801450       rs556507093       rs556996844       rs557584980       rs557596719       rs558395907       rs558517179       rs558704591       rs558965865       rs559185347       rs559249020       rs560382215       rs560443436       rs560995494       rs561055370       rs562139562       rs563071065       rs564728683       rs564957094       rs565394949       rs566661390       rs566729063       rs568473973       rs569504818       rs569763623       rs570892606       rs571943657       rs572916303       rs572977819       rs573027160       rs574112493       rs575323711       rs575366571       rs575589765       rs575739939       rs576854181       rs576910264       rs577179857       rs577918139       rs745408684       rs745774401       rs746104506       rs746676079       rs747075872       rs747437251       rs747567084       rs747930398       rs748156598       rs748362188       rs748672088       rs748794878       rs748898430       rs749471021       rs749524048       rs750109970       rs750181796       rs750703840       rs750928017       rs750949848       rs751347012       rs751578214       rs752141827       rs752531577       rs752769937       rs753571708       rs753948840       rs754569862       rs755278613       rs755330454       rs755657593       rs755889881       rs756501416       rs756554681       rs756913300       rs757306566       rs757838909       rs758223843       rs758271040       rs758433867       rs758584043       rs759022301       rs759209196       rs759331894       rs759631334       rs760515871       rs760644452       rs760924394       rs761236197       rs761283253       rs761605091       rs761878557       rs762616085       rs762942753       rs762994263       rs763370339       rs763525436       rs763616838       rs764001955       rs764058769       rs764780259       rs765193638       rs765588625       rs765712066       rs766240073       rs766374566       rs766610489       rs766850582       rs767356590       rs767522659       rs768348413       rs768799382       rs769127353       rs769376411       rs769495557       rs769521750       rs770047246       rs770368210       rs770546883       rs770867852       rs771102298       rs771352023       rs771892969       rs772087635       rs772703986       rs772823667       rs773054742       rs773108429       rs773645563       rs773908326       rs774234792       rs774376664       rs774636266       rs774965949       rs775032760       rs775600508       rs776146590       rs776623315       rs776806155       rs777545759       rs777855543       rs778521428       rs778892566       rs778972041       rs779109291       rs779778011       rs780110263       rs780215555       rs780348061       rs780399393       rs780631013       rs780875045       rs781242350       rs781525376       rs781666157      

基因表达

基因表达

H2AFZ基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CGGAATTCGAAATGGCTGG
59
CAACTACTGACCTGCAAGC
58
TAGGACGACCAGTCATGGA
59
GTTCAAGTACCTCTGCGGT
59
CTAGGACGACCAGTCATGG
59
TTCAAGTACCTCTGCGGTG
59
CGGAATTCGAAATGGCTGG
59
CTGCACGAACAACTACTGAC
59
TAGGACGACCAGTCATGGA
59
TTCAAGTACCTCTGCGGTG
59
CGGAATTCGAAATGGCTGG
59
GCACGAACAACTACTGACC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

H2AFZ基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

H2AFZ基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000786
P0C0S5(UniProtKB)
IEA
GO:0000978
P0C0S5(UniProtKB)
IDA
GO:0000979
P0C0S5(UniProtKB)
IDA
GO:0000979
P0C0S5(UniProtKB)
IDA
GO:0000980
P0C0S5(UniProtKB)
IDA
GO:0000980
P0C0S5(UniProtKB)
IDA
GO:0005515
P0C0S5(UniProtKB)
IPI
GO:0005515
P0C0S5(UniProtKB)
IPI
GO:0005634
P0C0S5(UniProtKB)
IDA
GO:0005634
P0C0S5(UniProtKB)
IDA
GO:0005634
P0C0S5(UniProtKB)
IDA
GO:0005634
P0C0S5(UniProtKB)
IDA
GO:0005634
P0C0S5(UniProtKB)
IDA
GO:0005719
P0C0S5(UniProtKB)
IDA
GO:0005719
P0C0S5(UniProtKB)
IDA
GO:0005720
P0C0S5(UniProtKB)
IDA
GO:0006342
P0C0S5(UniProtKB)
IBA
GO:0031490
P0C0S5(UniProtKB)
IDA
GO:0031490
P0C0S5(UniProtKB)
IDA
GO:0031492
P0C0S5(UniProtKB)
IDA
GO:0045944
P0C0S5(UniProtKB)
IMP
GO:0045944
P0C0S5(UniProtKB)
IMP
GO:0046982
P0C0S5(UniProtKB)
IEA
GO:0070062
P0C0S5(UniProtKB)
IDA
GO:0071392
P0C0S5(UniProtKB)
IMP
GO:0001740
P0C0S5(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控H2AFZ基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
IGA Glomerulonephritis 0.12 1 0 CTD_human
Mammary Neoplasms 0.00272435 1 0 LHGDN
Malignant neoplasm of breast 0.001085767 4 0 BeFree
Malignant neoplasm of prostate 0.001085767 4 0 BeFree
Prostate carcinoma 0.001085767 4 0 BeFree
Breast Carcinoma 0.001085767 4 0 BeFree
Carcinogenesis 0.000814326 3 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree
Acute lymphocytic leukemia 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Fibrosis, Liver 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Toxic Shock Syndrome 0.000271442 1 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000271442 1 0 BeFree

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基因相关服务

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