H2AFX(H2A histone family, member X)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

11q23.3
基因染色体位置图

基因简述

基因简述

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  组蛋白是负责在真核生物染色体纤维的核小体结构基本核蛋白质。每四个核心组蛋白中的两个分子（H2A，H2B，H3和H4）形成八聚体，其周围约146的DNA的碱基被包裹在重复单元，称为核小体。接头组蛋白，H1与染色质成高阶结构的压实核小体和功能之间的接头DNA相互作用。这个基因编码组蛋白H2A家族的成员，并且通过使用保守的茎 - 环终止基序产生两个转录和聚腺苷酸加成序。 [由RefSeq的，2008年7月提供]

OMIM数据库中对H2AFX基因的介绍     Wikipedia数据库中对H2AFX基因的介绍

基因序列

基因序列

H2AFX基因的碱基序列：[NCBI]

基因突变

基因突变

H2AFX基因的碱基突变：           显示全部snp
rs7759       rs8551       rs643788       rs2509851       rs28990974       rs28990975       rs28990976       rs74657539       rs74992671       rs111305630       rs114472372       rs139295058       rs140366642       rs141750515       rs141849365       rs147104217       rs150240212       rs150532554       rs183334836       rs187919120       rs190772614       rs192293085       rs199716581       rs200588529       rs200747570       rs201301096       rs202124952       rs369392880       rs369980705       rs370742896       rs372629319       rs373714803       rs376363226       rs376996734       rs529508262       rs535237603       rs541589857      
rs549862935       rs552195488       rs552234070       rs555841797       rs556113084       rs557014624       rs568022844       rs571554243       rs571963833       rs574176195       rs745447691       rs746343450       rs746759603       rs747073447       rs747825322       rs748295799       rs750564616       rs751482631       rs752484662       rs752607400       rs752952347       rs753712106       rs753954658       rs754754001       rs755817347       rs756851791       rs758885855       rs759197736       rs759542218       rs759835378       rs760501264       rs760740358       rs760852075       rs761082821       rs761911331       rs763140128       rs763778104       rs764252256       rs764364040       rs765254519       rs766864469       rs767497123       rs767714392       rs768805817       rs770121489       rs771413554       rs771926606       rs772133269       rs772452302       rs773152872       rs774728221       rs775255525       rs775602137       rs775825050       rs775878331       rs776720609       rs776863215       rs777418871       rs777530944       rs777584035       rs778250734       rs779430466       rs779911586       rs780550367       rs781103118       rs7350       rs15301       rs640603       rs1064180       rs1064193       rs1134734       rs2509049       rs2509850       rs3824944       rs7103570       rs28990977       rs28990978       rs28990979       rs28990980       rs28990981       rs28990982       rs28990983       rs58232506       rs61729447       rs61902108       rs77502412       rs111497932       rs112970707       rs113101904       rs138824010       rs141007591       rs141798641       rs143606442       rs146519649       rs148034083       rs181068631       rs181345927       rs184830332       rs186004456       rs186103605       rs189422596       rs201147206       rs201924752       rs367558273       rs368063516       rs368497818       rs371487025       rs372876045       rs374184122       rs375251697       rs375920693       rs527807638       rs528415317       rs529590324       rs530049284       rs531829532       rs532484590       rs535874260       rs537689421       rs538132125       rs540482556       rs541012833       rs542084839       rs542576337       rs545752218       rs546223465       rs546244044       rs546778405       rs548245541       rs550302575       rs550995668       rs552274055       rs554546531       rs556817682       rs556944354       rs558723550       rs558818083       rs559985951       rs562640219       rs562765455       rs564208294       rs565181447       rs566456517       rs569144556       rs570689148       rs570850268       rs571230227       rs573018764       rs574677589       rs577135125       rs577466099       rs745599769       rs746112746       rs746844187       rs747002062       rs747178969       rs748295236       rs749203621       rs750802212       rs750855185       rs751244870       rs751911129       rs752137831       rs752719147       rs755203949       rs755690160       rs756194765       rs757697119       rs758687854       rs758847246       rs759159397       rs760249696       rs761465311       rs761629954       rs762376208       rs762861943       rs763678389       rs764445366       rs765259350       rs765780373       rs765910778       rs765950306       rs766183804       rs766991832       rs767226826       rs767692455       rs768230455       rs768785602       rs770639536       rs770845888       rs771936621       rs772307091       rs772469517       rs772898384       rs773214518       rs773859979       rs774060290       rs774182094       rs774730815       rs774953080       rs775216238       rs776197795       rs776657992       rs778406396       rs778785602       rs778838502       rs779396078       rs779864413       rs780380122       rs781303514      

基因表达

基因表达

H2AFX基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAGTGCTGGAGTACCTCAC
59
TTCGCGTCTTCTTGTTGTC
58
CAGTGCTGGAGTACCTCAC
59
ATTCGCGTCTTCTTGTTGTC
59
CTTCTGGAAGACTTGGCCT
59
TGTTACCAAGTGCTTCGTC
58
CTTCTGGAAGACTTGGCCT
59
CTGTTACCAAGTGCTTCGTC
59
CTTCTGGAAGACTTGGCCT
59
GTTACCAAGTGCTTCGTCC
58
AAGAAGACGCGAATCATCC
58
CTTAGTACTCCTGGGAGGC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

H2AFX基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

H2AFX基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000077
P16104(UniProtKB)
IDA
GO:0000724
P16104(UniProtKB)
IEA
GO:0000786
P16104(UniProtKB)
IEA
GO:0000790
P16104(UniProtKB)
IBA
GO:0000794
P16104(UniProtKB)
IEA
GO:0001673
P16104(UniProtKB)
IEA
GO:0001741
P16104(UniProtKB)
IEA
GO:0003677
P16104(UniProtKB)
IBA
GO:0003677
P16104(UniProtKB)
NAS
GO:0003684
P16104(UniProtKB)
IEA
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005515
P16104(UniProtKB)
IPI
GO:0005634
P16104(UniProtKB)
IDA
GO:0005634
P16104(UniProtKB)
IDA
GO:0005634
P16104(UniProtKB)
IDA
GO:0005634
P16104(UniProtKB)
IDA
GO:0005634
P16104(UniProtKB)
IDA
GO:0005634
P16104(UniProtKB)
IDA
GO:0005654
P16104(UniProtKB)
IDA
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005654
P16104(UniProtKB)
TAS
GO:0005657
P16104(UniProtKB)
IEA
GO:0006302
P16104(UniProtKB)
NAS
GO:0006303
P16104(UniProtKB)
TAS
GO:0006334
P16104(UniProtKB)
NAS
GO:0006342
P16104(UniProtKB)
IBA
GO:0006974
P16104(UniProtKB)
IDA
GO:0007283
P16104(UniProtKB)
IEA
GO:0007283
P16104(UniProtKB)
IEA
GO:0010212
P16104(UniProtKB)
NAS
GO:0016032
P16104(UniProtKB)
IEA
GO:0019899
P16104(UniProtKB)
IPI
GO:0021987
P16104(UniProtKB)
IEA
GO:0035861
P16104(UniProtKB)
IDA
GO:0042393
P16104(UniProtKB)
IPI
GO:0045739
P16104(UniProtKB)
NAS
GO:0046982
P16104(UniProtKB)
IEA
GO:0051321
P16104(UniProtKB)
IEA
GO:0070062
P16104(UniProtKB)
IDA
GO:0071480
P16104(UniProtKB)
IEA
GO:0090398
P16104(UniProtKB)
IEA
GO:0000781
P16104(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控H2AFX基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Mammary Neoplasms 0.122995792 4 0 BeFree_CTD_human_LHGDN
Neoplasm Recurrence, Local 0.12 1 0 CTD_human
Polyploidy 0.12 1 0 CTD_human
Chromosome Breakage 0.12 1 0 CTD_human
Liver neoplasms 0.080271442 2 0 BeFree_RGD
Transient Ischemic Attack 0.08 1 0 RGD
Hypertensive disease 0.08 1 0 RGD
Myocardial Reperfusion Injury 0.08 1 0 RGD
Status Epilepticus 0.08 1 0 RGD
Drug-Induced Liver Injury 0.08 1 0 RGD
Malignant neoplasm of breast 0.008262808 14 0 BeFree_GAD
Ataxia Telangiectasia 0.00706742 17 0 BeFree_LHGDN
Lymphoma, Non-Hodgkin 0.005905708 3 0 BeFree_GAD_LHGDN
Glioma 0.00408156 5 0 BeFree_LHGDN
melanoma 0.003810118 5 0 BeFree_LHGDN
Breast Carcinoma 0.003528744 13 0 BeFree
Huntington Disease 0.002995792 2 0 BeFree_LHGDN
Werner Syndrome 0.002995792 2 0 BeFree_LHGDN
Bloom Syndrome 0.00272435 1 0 LHGDN
Ataxia, Spinocerebellar 0.00272435 1 0 LHGDN
Azoospermia 0.002367032 1 0 GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Oligospermia 0.002367032 1 0 GAD
Prostatic Neoplasms 0.002367032 1 0 GAD
Lymphoma 0.001628651 6 0 BeFree
Congenital chromosomal disease 0.001357209 5 0 BeFree
Colorectal Carcinoma 0.001085767 4 0 BeFree
Colorectal Cancer 0.001085767 4 0 BeFree
Liver carcinoma 0.001085767 4 0 BeFree
Non-Small Cell Lung Carcinoma 0.000814326 3 0 BeFree
Fanconi Anemia 0.000814326 3 0 BeFree
Ovarian Carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of lung 0.000814326 3 0 BeFree
Carcinoma of lung 0.000814326 3 0 BeFree
Malignant neoplasm of ovary 0.000814326 3 0 BeFree
Sarcoma 0.000814326 3 0 BeFree
Invasive Carcinoma 0.000814326 3 0 BeFree
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) 0.000814326 3 0 BeFree
Malignant neoplasm of endometrium 0.000542884 2 0 BeFree
Glioblastoma 0.000542884 2 0 BeFree
Myeloid Leukemia, Chronic 0.000542884 2 0 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Retinoblastoma 0.000542884 2 0 BeFree
Diffuse Large B-Cell Lymphoma 0.000542884 2 0 BeFree
Lymphoma, Large-Cell, Follicular 0.000542884 2 1 BeFree
Li-Fraumeni Syndrome 0.000542884 2 0 BeFree
Small cell carcinoma of lung 0.000542884 2 0 BeFree
Gastrointestinal Stromal Tumors 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Endometrial Carcinoma 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Sporadic Breast Carcinoma 0.000542884 2 0 BeFree
Uterine Corpus Cancer 0.000542884 2 0 BeFree
Triple Negative Breast Neoplasms 0.000542884 2 0 BeFree
Anorexia 0.000271442 1 0 BeFree
Astrocytoma 0.000271442 1 0 BeFree
Blast Phase 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Cerebral Infarction 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Exanthema 0.000271442 1 0 BeFree
Keratosis 0.000271442 1 0 BeFree
Actinic keratosis 0.000271442 1 0 BeFree
Seborrheic keratosis 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
Mitral Valve Stenosis 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Spinal Muscular Atrophy 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Polycythemia Vera 0.000271442 1 0 BeFree
Pulmonary Emphysema 0.000271442 1 0 BeFree
Schizophrenia 0.000271442 1 0 BeFree
Stomatitis 0.000271442 1 0 BeFree
Thrombocythemia, Essential 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Acute leukemia 0.000271442 1 0 BeFree
Thyroid Gland Follicular Adenoma 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Follicular adenoma 0.000271442 1 0 BeFree
Teratocarcinoma 0.000271442 1 0 BeFree
Follicular thyroid carcinoma 0.000271442 1 0 BeFree
Testicular embryonal carcinoma 0.000271442 1 0 BeFree
Cancer of Head and Neck 0.000271442 1 0 BeFree
Adenocarcinoma Of Esophagus 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Diffuse Astrocytoma 0.000271442 1 0 BeFree
Superficial ulcer 0.000271442 1 0 BeFree
Nijmegen Breakage Syndrome 0.000271442 1 0 BeFree
Overweight 0.000271442 1 0 BeFree
Varicella zoster 0.000271442 1 0 BeFree
polyp benign 0.000271442 1 0 BeFree
Frontotemporal Lobar Degeneration 0.000271442 1 0 BeFree
Spots on skin 0.000271442 1 0 BeFree
latent infection 0.000271442 1 0 BeFree
Cerebral Ischemia 0.000271442 1 0 BeFree
Differentiated Thyroid Gland Carcinoma 0.000271442 1 0 BeFree
Neoplasms, Intracranial 0.000271442 1 0 BeFree
Oral Mucositis 0.000271442 1 0 BeFree
Glioblastoma Multiforme 0.000271442 1 0 BeFree
ATAXIA-TELANGIECTASIA-LIKE DISORDER 0.000271442 1 0 BeFree

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