GZMB(granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1))

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

14q11.2
基因染色体位置图

基因简述

基因简述

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  细胞毒性T淋巴细胞（CTL）和自然杀伤（NK）细胞共同认识到，bind和裂解特定靶细胞的非凡能力。他们被认为通过裂解细胞轴承在其表面上“非己”抗原，通常肽或细胞内病原体感染导致的蛋白质来保护他们的主人。由该基因编码的蛋白质是用于快速诱导靶细胞凋亡的由CTL在细胞介导的??免疫应答是至关重要的。 [由RefSeq的，2008年7月提供]

OMIM数据库中对GZMB基因的介绍     Wikipedia数据库中对GZMB基因的介绍

基因序列

基因序列

GZMB基因的碱基序列：[NCBI]

基因突变

基因突变

GZMB基因的碱基突变：           显示全部snp
rs985931       rs1126639       rs2236337       rs2236338       rs2273843       rs2273844       rs6573910       rs6573911       rs7144366       rs8012846       rs8192916       rs8192917       rs8192918       rs8192919       rs8192920       rs8192921       rs8192922       rs9671454       rs10873219       rs10909625       rs11539752       rs45442494       rs45562442       rs45628336       rs59268439       rs61747598       rs71397792       rs71405867       rs72681027       rs74345106       rs77651310       rs79991830       rs111296281       rs111392648       rs112016093       rs112273185       rs112450811      
rs113098284       rs113203204       rs113809286       rs113822535       rs115296144       rs115748541       rs116312731       rs116546803       rs117058812       rs117236105       rs117556181       rs138110636       rs138211424       rs138221069       rs138802681       rs139103546       rs139517796       rs139769176       rs140343509       rs140998431       rs141196685       rs141592632       rs141950099       rs142224147       rs142360083       rs142875748       rs143143607       rs143247799       rs143581021       rs144452134       rs144990710       rs145697421       rs146407494       rs147007836       rs148263778       rs148812799       rs149659869       rs150026222       rs150419134       rs150525492       rs150732480       rs150753135       rs180947760       rs181331444       rs181612943       rs182838579       rs183294404       rs184348224       rs184676636       rs184795337       rs185470970       rs185593777       rs185979723       rs186189435       rs187232444       rs187532520       rs187626657       rs188074348       rs189698253       rs189780458       rs190499023       rs190593445       rs190803917       rs192166820       rs192382172       rs192649073       rs192706654       rs199546734       rs199605460       rs199941584       rs200381701       rs200934935       rs201057518       rs201073774       rs201230370       rs201406143       rs201822821       rs201850675       rs201869226       rs201881477       rs368051015       rs368181836       rs368193808       rs368453859       rs368712815       rs368884303       rs369112816       rs369766185       rs369959551       rs370648279       rs371428669       rs371505153       rs372092724       rs373774586       rs373909399       rs374673076       rs374757875       rs375750638       rs376069210       rs376239913       rs376295619       rs376441115       rs376486286       rs376948971       rs377050414       rs377126925       rs377183919       rs377255382       rs377448459       rs377752511       rs527241137       rs529182114       rs530137956       rs530707125       rs530843238       rs531899814       rs532663711       rs532800714       rs534753473       rs534811713       rs534941263       rs536568187       rs537225705       rs537691705       rs538820000       rs539219496       rs540283346       rs540925855       rs541876230       rs541920190       rs542058235       rs542322753       rs543660502       rs544112120       rs544247269       rs545182439       rs545711074       rs546200590       rs546844382       rs547334344       rs547860120       rs548836434       rs549118311       rs550878739       rs552793281       rs553009627       rs553616771       rs553670630       rs554279411       rs555421192       rs555546217       rs555803368       rs556744675       rs557284263       rs557682968       rs558049878       rs558113009       rs558724093       rs559994010       rs560946137       rs561097149       rs561541610       rs562288373       rs562327651       rs562955413       rs563098712       rs563316665       rs564414889       rs564481037       rs564950259       rs565690652       rs565751344       rs566076515       rs566624358       rs567442112       rs567607726       rs567803789       rs567979952       rs568718229       rs569435306       rs569728872       rs572197791       rs572625254       rs575251966       rs576313863       rs576597572       rs576664797       rs577283580       rs577786603       rs577852442       rs745344569       rs745539169       rs745542995       rs745798602       rs745909320       rs746099982       rs746178542       rs746562449       rs746648398       rs746679637       rs747068918       rs747247716       rs747341505       rs747395753       rs747427440       rs748008199       rs748190755       rs748280757       rs748428522       rs748605454       rs748753120       rs749058700       rs749153595       rs749185062       rs749909360       rs750117680       rs750441382       rs750499704       rs750589801       rs750853782       rs750909705       rs751052963       rs751086776       rs751176734       rs751420415       rs751514525       rs751669946       rs751757520       rs751849448       rs752072598       rs752317415       rs752321085       rs752473990       rs753057742       rs753456826       rs753724472       rs753764959       rs754206957       rs754267669       rs754450066       rs754659432       rs754891851       rs755147051       rs755234301       rs755239181       rs755396874       rs755725451       rs755997644       rs756068868       rs756531107       rs756619054       rs756689392       rs757031846       rs757119450       rs757747585       rs757837641       rs757861505       rs758309888       rs758355849       rs758583485       rs758673556       rs758761496       rs759056620       rs759144782       rs759202086       rs759277987       rs759363757       rs759571695       rs759793850       rs759993958       rs760715673       rs760947317       rs761260391       rs761426944       rs761809164       rs761842669       rs762019149       rs762109620       rs762197253       rs762415250       rs762586737       rs762984801       rs763072582       rs763271069       rs763418748       rs763703713       rs763963542       rs763988992       rs764279869       rs764357735       rs764759773       rs764989748       rs765237461       rs765361762       rs765525690       rs765591783       rs765804309       rs765915810       rs766076703       rs766169767       rs766572030       rs766574069       rs766664881       rs766871985       rs767137056       rs767220668       rs767308603       rs767316322       rs767644740       rs767677921       rs767736704       rs767805535       rs768192491       rs768264909       rs768335959       rs768588540       rs768676395       rs769013244       rs769076829       rs769346767       rs769362168       rs769700874       rs769831969       rs769914418       rs769976739       rs770176278       rs770274334       rs770357626       rs770401311       rs770449395       rs770449645       rs770535603       rs770840459       rs770877994       rs771032663       rs771247702       rs771298498       rs771594253       rs771688554       rs771725823       rs771730129       rs772056705       rs772114618       rs772585496       rs772676872       rs772692927       rs773310354       rs773431178       rs773456898       rs773548599       rs773697237       rs773843209       rs774022502       rs774106269       rs774464415       rs774562605       rs774852201       rs774948900       rs775016785       rs775333412       rs775713251       rs775981864       rs776080399       rs776170300       rs776646060       rs776679294       rs776733343       rs776949681       rs777135288       rs777315248       rs777707861       rs777851725       rs777912001       rs778204017       rs778477049       rs778523594       rs778941783       rs778951600       rs779443659       rs779606646       rs779612215       rs779700655       rs779920467       rs780010365       rs780379082       rs780554976       rs780749959       rs780846355       rs781027493       rs781125360       rs781235383       rs781326646       rs781498758       rs781616019       rs781618659      

基因表达

基因表达

GZMB基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TGATACGAGACGACTTCGTG
60
GTTGCTAGGTAGCCTGAGG
60
TGATACGAGACGACTTCGTG
60
GTTGCTAGGTAGCCTGAGG
60
AAGTCTCTGAAGAGGTGCG
59
GTGACATTTATGGAGCTTCCC
59
GATACGAGACGACTTCGTG
58
GTTGCTAGGTAGCCTGAGG
60
GATACGAGACGACTTCGTG
58
TGTTGCTAGGTAGCCTGAG
59
GATACGAGACGACTTCGTG
58
GTTGCTAGGTAGCCTGAGG
60
AAGTCTCTGAAGAGGTGCG
59
GGTGACATTTATGGAGCTTCC
59
GATACGAGACGACTTCGTG
58
GTTGCTAGGTAGCCTGAGG
60
AACCAATCCTGCTTCTGCT
60
TGTTGCTAGGTAGCCTGAG
59
GATACGAGACGACTTCGTG
58
TGTTGCTAGGTAGCCTGAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GZMB基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GZMB基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004252
E9PRD7(UniProtKB)
IEA
GO:0006508
E9PRD7(UniProtKB)
IEA
GO:0004252
J3KPK2(UniProtKB)
IEA
GO:0005737
J3KPK2(UniProtKB)
IDA
GO:0006508
J3KPK2(UniProtKB)
IEA
GO:0043231
J3KPK2(UniProtKB)
IDA
GO:0004252
J3KQ52(UniProtKB)
IEA
GO:0005737
J3KQ52(UniProtKB)
IDA
GO:0006508
J3KQ52(UniProtKB)
IEA
GO:0043231
J3KQ52(UniProtKB)
IDA
GO:0001772
P10144(UniProtKB)
TAS
GO:0004252
P10144(UniProtKB)
IDA
GO:0004252
P10144(UniProtKB)
TAS
GO:0004252
P10144(UniProtKB)
TAS
GO:0005515
P10144(UniProtKB)
IPI
GO:0005515
P10144(UniProtKB)
IPI
GO:0005515
P10144(UniProtKB)
IPI
GO:0005515
P10144(UniProtKB)
IPI
GO:0005634
P10144(UniProtKB)
TAS
GO:0005737
P10144(UniProtKB)
IDA
GO:0005739
P10144(UniProtKB)
IEA
GO:0005829
P10144(UniProtKB)
TAS
GO:0006915
P10144(UniProtKB)
TAS
GO:0008236
P10144(UniProtKB)
TAS
GO:0016020
P10144(UniProtKB)
IDA
GO:0016485
P10144(UniProtKB)
IBA
GO:0019835
P10144(UniProtKB)
IEA
GO:0042267
P10144(UniProtKB)
IMP
GO:0043231
P10144(UniProtKB)
IDA
GO:1900740
P10144(UniProtKB)
TAS
GO:0004252
Q6XGZ2(UniProtKB)
IEA
GO:0005737
Q6XGZ2(UniProtKB)
IDA
GO:0006508
Q6XGZ2(UniProtKB)
IEA
GO:0043231
Q6XGZ2(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GZMB基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Vitiligo 0.122367032 1 1 GAD_GWASCAT
Hepatitis 0.120271442 2 0 BeFree_CTD_human
Mammary Neoplasms 0.120271442 2 0 BeFree_CTD_human
Autistic Disorder 0.12 1 0 CTD_human
Drug Allergy 0.12 1 0 CTD_human
Infection 0.010897401 4 0 LHGDN
Lymphohistiocytosis, Hemophagocytic 0.008087174 2 0 BeFree_GAD_LHGDN
Rheumatoid Arthritis 0.005991584 3 0 BeFree_LHGDN
Leukemia, Myelocytic, Acute 0.005720142 2 0 BeFree_LHGDN
Autoimmune Diseases 0.005634266 4 0 BeFree_GAD_LHGDN
melanoma 0.005362824 2 0 BeFree_GAD_LHGDN
Myeloid Leukemia, Chronic 0.005005506 3 0 BeFree_GAD
HIV Infections 0.004895885 9 0 BeFree_LHGDN
Alzheimer's Disease 0.003452799 5 1 BeFree_GAD
Hodgkin Disease 0.003267234 3 0 BeFree_LHGDN
Malignant neoplasm of breast 0.003181358 3 0 BeFree_GAD
Aneurysm 0.002995792 2 0 BeFree_LHGDN
leukemia 0.002995792 2 0 BeFree_LHGDN
Myasthenia Gravis 0.002995792 1 0 BeFree_LHGDN
Peptic Ulcer 0.002995792 1 0 BeFree_LHGDN
Ki-1+ Anaplastic Large Cell Lymphoma 0.002995792 2 0 BeFree_LHGDN
Hepatitis B, Chronic 0.002995792 1 0 BeFree_LHGDN
Asthma 0.002909916 3 0 BeFree_GAD
Juvenile arthritis 0.002909916 2 0 BeFree_GAD
Hypersensitivity 0.00272435 1 0 LHGDN
Inflammatory Bowel Diseases 0.00272435 1 0 LHGDN
Mucocutaneous Lymph Node Syndrome 0.00272435 1 0 LHGDN
Sclerosis 0.00272435 1 0 LHGDN
Bronchiolitis, Viral 0.002367032 1 0 GAD
Pathologic Neovascularization 0.002367032 1 0 GAD
Respiratory Syncytial Virus Infections 0.002367032 1 0 GAD
Lymphoma 0.001628651 6 0 BeFree
Hyperlipoproteinemia Type III 0.001357209 5 0 BeFree
Acute GVH disease 0.001085767 4 0 BeFree
Arteriosclerosis 0.000814326 3 0 BeFree
Atherosclerosis 0.000814326 3 0 BeFree
Hepatitis B 0.000814326 3 0 BeFree
Chronic Lymphocytic Leukemia 0.000814326 3 0 BeFree
Neoplasm Metastasis 0.000814326 3 0 BeFree
Tumor Progression 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Aortic Aneurysm 0.000542884 2 0 BeFree
Malignant neoplasm of larynx 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Cytomegalovirus Infections 0.000542884 2 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000542884 2 0 BeFree
Toxic Epidermal Necrolysis 0.000542884 2 0 BeFree
Chronic Obstructive Airway Disease 0.000542884 2 0 BeFree
Lymphocytic Choriomeningitis 0.000542884 2 0 BeFree
Nephrotic Syndrome 0.000542884 2 0 BeFree
Pneumonia 0.000542884 2 0 BeFree
Septicemia 0.000542884 2 0 BeFree
Stevens-Johnson Syndrome 0.000542884 2 0 BeFree
Virus Diseases 0.000542884 2 0 BeFree
T-Cell Lymphoma 0.000542884 2 0 BeFree
Non-arthropod borne lymphocytic choriomeningitis 0.000542884 2 0 BeFree
Sepsis 0.000542884 2 0 BeFree
Miller Dieker syndrome 0.000542884 2 0 BeFree
Metastatic melanoma 0.000542884 2 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Carcinoma of larynx 0.000542884 2 0 BeFree
Classical Hodgkin's Lymphoma 0.000542884 2 0 BeFree
Colorectal Cancer 0.000542884 2 0 BeFree
LIPOPROTEIN GLOMERULOPATHY 0.000542884 2 0 BeFree
Juvenile rheumatoid arthritis 0.000542884 2 0 BeFree
Alopecia Areata 0.000271442 1 0 BeFree
Bacterial Infections 0.000271442 1 0 BeFree
Malignant neoplasm of urinary bladder 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Ulcerative Colitis 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Dengue Fever 0.000271442 1 0 BeFree
Ectromelia 0.000271442 1 0 BeFree
Eczema 0.000271442 1 0 BeFree
Graft-vs-Host Disease 0.000271442 1 0 BeFree
Atrial Septal Defects 0.000271442 1 0 BeFree
Hepatitis A 0.000271442 1 0 BeFree
Herpes Simplex Infections 0.000271442 1 0 BeFree
Immune System Diseases 0.000271442 1 0 BeFree
Influenza 0.000271442 1 0 BeFree
Intestinal Diseases 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Acute lymphocytic leukemia 0.000271442 1 0 BeFree
Lichen Sclerosus et Atrophicus 0.000271442 1 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Myocarditis 0.000271442 1 0 BeFree
Myositis 0.000271442 1 0 BeFree
Nephritis, Interstitial 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Papillon-Lefevre Disease 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Pulmonary Emphysema 0.000271442 1 0 BeFree
Respiratory Distress Syndrome, Adult 0.000271442 1 0 BeFree
Subacute Sclerosing Panencephalitis 0.000271442 1 0 BeFree
Urinary tract infection 0.000271442 1 0 BeFree
Urticaria 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Peripheral T-Cell Lymphoma 0.000271442 1 0 BeFree
Epstein-Barr Virus Infections 0.000271442 1 0 BeFree
Idiopathic pulmonary hypertension 0.000271442 1 0 BeFree
Dermatitis, Allergic Contact 0.000271442 1 0 BeFree
Aortic Aneurysm, Abdominal 0.000271442 1 0 BeFree
Welts 0.000271442 1 0 BeFree
Pancreatic carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Neoplasm, Residual 0.000271442 1 0 BeFree
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Hematologic Neoplasms 0.000271442 1 0 BeFree
Chronic rejection of renal transplant 0.000271442 1 0 BeFree
Transplant glomerulopathy 0.000271442 1 0 BeFree
Hepatitis C, Chronic 0.000271442 1 0 BeFree
Squamous cell carcinoma of mouth 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Carcinoma of bladder 0.000271442 1 0 BeFree
Histiocytosis haematophagic 0.000271442 1 0 BeFree
Vascular inflammations 0.000271442 1 0 BeFree
Epidermal necrosis 0.000271442 1 0 BeFree
Aggressive natural killer-cell leukemia 0.000271442 1 0 BeFree
Pericytic Neoplasm 0.000271442 1 0 BeFree
Systemic onset juvenile chronic arthritis 0.000271442 1 0 BeFree
Renal tubular necrosis 0.000271442 1 0 BeFree
Severe Aplastic Anemia 0.000271442 1 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000271442 1 0 BeFree
Pulmonary arterial hypertension 0.000271442 1 0 BeFree
Triple Negative Breast Neoplasms 0.000271442 1 0 BeFree
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia 0.000271442 1 0 BeFree

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