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This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的通用转录因子IIB,由RNA聚合酶II转录起始所需的无所不在的因素之一。该蛋白质定位于在那里形成一个复合物(民建联络合物)的核转录因子IID及IIA。转录因子IIB用作最初识别启动子序列的因子RNA聚合酶II的IID之间的桥梁,和。 [由RefSeq的,2008年7月提供]
GTF2B基因(以及对应的蛋白质)的细胞分布位置:
GTF2B基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
Tumor Angiogenesis | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
stage, non-small cell lung cancer | 0.000271442 | 1 | 0 | BeFree |
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