更多...
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 此基因是谷胱甘肽S-转移酶(GSTs)的超家族,其与谷胱甘肽编码多功能酶在电分子,包括致癌,诱变,和几种治疗药物的解毒重要,通过缀合的一员。这种酶也起着苯丙氨酸和酪氨酸的分解代谢一个显著的作用。因此,在这种酶的缺陷有可能导致严重的代谢紊乱,包括尿黑酸尿,苯丙酮尿症和tyrosinaemia。该基因编码多种蛋白亚型的几个转录变异体。 [由RefSeq的,2008年7月提供]
GSTZ1基因(以及对应的蛋白质)的细胞分布位置:
GSTZ1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Vestibular Diseases | 0.122367032 | 1 | 1 | CTD_human_GAD |
Bladder Neoplasm | 0.12 | 1 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Parkinson Disease | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of lung | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of urinary bladder | 0.002909916 | 3 | 2 | BeFree_GAD |
Acidosis, Lactic | 0.00272435 | 1 | 0 | LHGDN |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Actinic keratosis | 0.002367032 | 1 | 0 | GAD |
Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Sensation Disorders | 0.002367032 | 1 | 1 | GAD |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 2 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
Borderline Personality Disorder | 0.000271442 | 1 | 0 | BeFree |
Bronchopulmonary Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Fatigue | 0.000271442 | 1 | 2 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Liver Failure | 0.000271442 | 1 | 0 | BeFree |
Endometrial Stromal Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Tyrosinemia, Type I | 0.000271442 | 1 | 0 | BeFree |
Plasmodium ovale infection | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。