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This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
[中文简述(自动翻译):]  这个基因编码所涉及作为GSK3-β的中Wnt信号通路的负调控的蛋白质。该编码的蛋白可能通过调节GSK3-β,β-连环蛋白和细胞周期蛋白D1之间的互动功能发挥维甲酸信号通路的作用,并调节β-连环蛋白/ N-cadherin的游泳池。所编码的蛋白质包含在它的C-末端,它类似于Axin蛋白的GID一个GSK3-β相互作用结构域(GID)。该蛋白质还包含一个进化上保守的RII结合结构域,这有利于与蛋白激酶A和GSK3-β结合,使得其作为A激酶锚定蛋白的作用。可变剪接转录物变体已经观察到这种基因。 [由RefSeq的,2012年12月提供]
GSKIP基因(以及对应的蛋白质)的细胞分布位置:
GSKIP基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Myeloproliferative disease | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Myeloid Leukemia | 0.12 | 1 | 0 | CTD_human |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Myeloid neoplasm | 0.000271442 | 1 | 0 | BeFree |
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