GSKIP(GSK3B interacting protein) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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14q32.2
基因染色体位置图

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

[中文简述(自动翻译):]  这个基因编码所涉及作为GSK3-β的中Wnt信号通路的负调控的蛋白质。该编码的蛋白可能通过调节GSK3-β,β-连环蛋白和细胞周期蛋白D1之间的互动功能发挥维甲酸信号通路的作用,并调节β-连环蛋白/ N-cadherin的游泳池。所编码的蛋白质包含在它的C-末端,它类似于Axin蛋白的GID一个GSK3-β相互作用结构域(GID)。该蛋白质还包含一个进化上保守的RII结合结构域,这有利于与蛋白激酶A和GSK3-β结合,使得其作为A激酶锚定蛋白的作用。可变剪接转录物变体已经观察到这种基因。 [由RefSeq的,2012年12月提供]

GSKIP基因的碱基序列:[NCBI]
GSKIP基因的碱基突变:           显示全部snp
rs12434329       rs17094993       rs35941406       rs35946663       rs57280159       rs61985192       rs72706803       rs72706804       rs74419204       rs75761263       rs76541753       rs78655524       rs80144962       rs80275837       rs112552976       rs113521970       rs115399780       rs115993287       rs116712101       rs117189923       rs117285826       rs117332671       rs117671436       rs138183650       rs138420596       rs142045987       rs142226224       rs143221339       rs144036509       rs145259940       rs146375833       rs147064824       rs147614415       rs148386142       rs148611910       rs149144904       rs151226110      
rs181114178       rs182575363       rs185358001       rs186022990       rs188609904       rs190737042       rs191963808       rs200866249       rs201912169       rs369758312       rs371403080       rs371897786       rs373437785       rs374135427       rs375803555       rs376386329       rs376752256       rs527994929       rs528202089       rs529617824       rs529993366       rs530062005       rs530480357       rs531724699       rs532191202       rs533697782       rs534565282       rs534829633       rs535120209       rs537121917       rs537199217       rs537230043       rs538105627       rs538500041       rs539493225       rs540007376       rs541593232       rs542584977       rs543630975       rs543716114       rs543907848       rs545723776       rs545776474       rs546214801       rs546386007       rs548072971       rs548629629       rs548765648       rs550061778       rs551395954       rs553251408       rs553565366       rs553763873       rs555262014       rs555509060       rs555845812       rs557699713       rs557908416       rs560036683       rs560076247       rs560368756       rs561852773       rs562348521       rs562856915       rs563315144       rs564256279       rs564711282       rs565651095       rs565680822       rs567319058       rs567461071       rs568019979       rs568643695       rs569113670       rs569748218       rs570128898       rs572044591       rs572074173       rs574088274       rs576307371       rs576388235       rs745312901       rs747037166       rs747865041       rs749093618       rs749820066       rs749895468       rs750416870       rs751696157       rs751806903       rs752602512       rs752945698       rs752967956       rs754204140       rs756135778       rs757449419       rs758669863       rs759870268       rs760108020       rs760120763       rs761189085       rs763346192       rs764354511       rs765607935       rs765617907       rs770406826       rs770531520       rs771659640       rs772719296       rs772845988       rs773913878       rs774028462       rs777123624       rs777184207       rs777453720       rs778030787       rs778648853       rs778790744       rs779064171       rs780072176       rs4006       rs930517       rs930518       rs930519       rs962851       rs1015240       rs1015241       rs1545280       rs1838108       rs2053588       rs2120213       rs3759599       rs3759600       rs3834520       rs4145001       rs4905486       rs5810763       rs7147936       rs7149907       rs8006919       rs8007017       rs8011935       rs8021984       rs10143429       rs10143926       rs10145002       rs11627143       rs11845595       rs11850058       rs11850103       rs12385899       rs12435565       rs12588655       rs17094060       rs17094071       rs17094074       rs28701482       rs28742134       rs28751912       rs28855382       rs34108889       rs34610576       rs35652932       rs55671487       rs55731136       rs55838659       rs56142558       rs56410178       rs56781166       rs57574321       rs57931398       rs61985210       rs71415033       rs71415034       rs72706807       rs72706808       rs73349211       rs73349217       rs73365110       rs73365112       rs73365114       rs73365120       rs73365124       rs73365126       rs73365129       rs74419877       rs74543199       rs74996716       rs75046750       rs75228127       rs75489092       rs75556136       rs76177789       rs76660281       rs76984026       rs77065967       rs77376624       rs77411149       rs77635295       rs77727233       rs77806973       rs78119171       rs79309788       rs79543291       rs79824156       rs79970342       rs80230002       rs80314554       rs111503774       rs111671336       rs111792768       rs111993334       rs112329596       rs112496960       rs112583925       rs112743124       rs112833735       rs113034326       rs113764900       rs114168935       rs114610244       rs114637432       rs116367934       rs116684520       rs116920184       rs117085320       rs117309647       rs117516055       rs117726549       rs117990822       rs137983151       rs138050721       rs138102137       rs138652777       rs138680399       rs138721308       rs138744071       rs138886937       rs139307095       rs139436089       rs139603499       rs139694095       rs139814635       rs140105130       rs140342889       rs140466703       rs140530789       rs140562128       rs140642181       rs140757636       rs140983464       rs141003127       rs141201994       rs141346947       rs141404562       rs141612370       rs141695583       rs141763331       rs142110742       rs142151944       rs142171952       rs142292012       rs142556067       rs142972427       rs143436063       rs143469743       rs143500581       rs143504179       rs144217488       rs144281004       rs144631365       rs144701926       rs144786722       rs144850169       rs144978677       rs145292612       rs145530008       rs145554650       rs145566462       rs145587958       rs145655027       rs145817655       rs145874796       rs145884459       rs145895890       rs145992663       rs146011904       rs146645737       rs146802550       rs146820458       rs147079524       rs147224783       rs147329383       rs147631027       rs147719062       rs147735502       rs147978591       rs148066819       rs148212086       rs148227264       rs148472337       rs148511238       rs148729830       rs148756754       rs148844232       rs149003251       rs149232074       rs149376858       rs149393363       rs149577622       rs149675438       rs149728939       rs149764504       rs150200915       rs150257034       rs150292546       rs150541147       rs150729702       rs150767806       rs150782934       rs151067986       rs151314318       rs180721127       rs181102355       rs181319391       rs181462521       rs181600090       rs181636433       rs181808444       rs181997413       rs182057181       rs182077291       rs182256903       rs182280189       rs182304725       rs182354984       rs182800876       rs182835889       rs183110871       rs183427330       rs183481942       rs183487669       rs183765529       rs183868043       rs184322185       rs184328928       rs184384009       rs184801866       rs184984764       rs185010205       rs185262824       rs185655879       rs185976432       rs186055294       rs186101618       rs186368134       rs186704935       rs186772252       rs186906143       rs187015757       rs187035850       rs187251901       rs187547825       rs187832356       rs187844836       rs188050351       rs188092243       rs188301635       rs188370981       rs188439029       rs188569799       rs188617969       rs188829556       rs189062707       rs189604364       rs189813182       rs190255432       rs190374649       rs190441923       rs190750088       rs190864078       rs190923744       rs191088021       rs191166132       rs191224704       rs191288779       rs191452867       rs191753811       rs191948284       rs192001434       rs192285777       rs192470152       rs192514926       rs192665794       rs193048451       rs193236290       rs199553285       rs199588276       rs200051168       rs200254306       rs200593442       rs200995016       rs201146555       rs201347348       rs201972731       rs202106867       rs202163260       rs367934585       rs368595715       rs369904820       rs370318470       rs371179479       rs371287458       rs371988437       rs373201723       rs373317656       rs373336837       rs375553697       rs375753425       rs375957695       rs376054240       rs376593860       rs377326230       rs398026272       rs398026274       rs527255978       rs527805717       rs527898593       rs527929939       rs528013393       rs528020077       rs528324275       rs528427574       rs528508552       rs528545656       rs528629082       rs528653486       rs528878997       rs528949557       rs529063691       rs529252872       rs529961602       rs530100349       rs530300010       rs530301993       rs530565400       rs530606930       rs530686084       rs530690208       rs530721598       rs530798509       rs530908579       rs530995578       rs531033998       rs531124959       rs531320672       rs532076613       rs532345027       rs532686149       rs532759296       rs532960673       rs532974640       rs532994563       rs533190800       rs533406434       rs533438122       rs533523023       rs533524845       rs533887844       rs534177000       rs534638871       rs535071068       rs535161178       rs535327309       rs535433255       rs535437656       rs535524520       rs535715958       rs535753349       rs535823468       rs535911266       rs536349738       rs536430451       rs536902632       rs536920861       rs536953744       rs537513996       rs537958295       rs538246972       rs538283790       rs538840677       rs539047051       rs539182452       rs539330597       rs539517841       rs539622501       rs539728960       rs539776158       rs539894088       rs539908605       rs539944355       rs539950969       rs540044295       rs540544754       rs540745277       rs540782822       rs541026013       rs541049601       rs541055317       rs541634837       rs541713275       rs541926609       rs542008244       rs542072084       rs542109539       rs542146256       rs542312861       rs542358226       rs542444816       rs542448077       rs542670937       rs542858983       rs542860623       rs543037385       rs543070176       rs543434595       rs543471337       rs543784373       rs543982668       rs543992412       rs544002159       rs544064556       rs544075516       rs544316404       rs544343668       rs544358651       rs544392518       rs544431567       rs544723085       rs545982172       rs546090836       rs546526327       rs546599971       rs547012354       rs547048751       rs547173024       rs547445371       rs547506864       rs547560514       rs547575126       rs547587253       rs547730595       rs547817517       rs547929016       rs548142825       rs548403300       rs548796427       rs549036292       rs549351905       rs549500180       rs549716206       rs549920707       rs550204846       rs550337197       rs550451624       rs550797822       rs550885444       rs550989121       rs551126962       rs551181970       rs551246211       rs551332993       rs551711460       rs551850580       rs551888534       rs551930021       rs552386198       rs552474943       rs552664035       rs552859435       rs553373388       rs553524311       rs553708158       rs553836944       rs554054841       rs554079305       rs554091112       rs554097973       rs554190393       rs554317270       rs554440954       rs554507712       rs554758998       rs554979808       rs555311940       rs555348243       rs555652711       rs555951243       rs555998694       rs556089124       rs556148966       rs556177059       rs556177123       rs556239763       rs556473149       rs556495089       rs556618951       rs556705063       rs557384875       rs557521818       rs557839230       rs558016506       rs558031302       rs558070025       rs558179223       rs558438679       rs558467982       rs558689183       rs558724843       rs558882146       rs559177627       rs559395564       rs559413780       rs559432742       rs559702231       rs560195638       rs560283144       rs560433458       rs560720259       rs560758731       rs560834775       rs560910081       rs561236359       rs561274001       rs561346775       rs561640406       rs562389397       rs562585764       rs562707261       rs562709086       rs562745853       rs562820644       rs562832999       rs563143812       rs563218158       rs563667097       rs563762343       rs564076392       rs564361737       rs564437928       rs564475864       rs564622725       rs564747419       rs564748236       rs565064627       rs565211140       rs565319962       rs565320025       rs565772431       rs565777330       rs565944241       rs565955650       rs566032396       rs566821850       rs567130990       rs567217923       rs567222273       rs567563982       rs567762741       rs567792378       rs567820541       rs567867357       rs567879697       rs567935150       rs568055837       rs568056831       rs568133515       rs568159924       rs568173317       rs568194459       rs568286015       rs568536768       rs569080076       rs569243977       rs569360056       rs569437059       rs569446189       rs569639843       rs569921914       rs569955428       rs570106968       rs570126769       rs570154117       rs570190761       rs570190821       rs570278389       rs570433770       rs570447109       rs570478022       rs570527007       rs570686090       rs571185954       rs571638551       rs571745162       rs571817474       rs572272200       rs572360831       rs572396611       rs572527619       rs572552917       rs572570833       rs572717341       rs572939489       rs573541579       rs573651570       rs573690346       rs574298133       rs574307292       rs574342102       rs574432207       rs574549875       rs574565886       rs574627838       rs574635926       rs574703857       rs574802188       rs574830336       rs575045911       rs575045993       rs575081607       rs575152307       rs575483423       rs575890539       rs575926326       rs576285370       rs576314668       rs576434675       rs576879867       rs576900663       rs576981771       rs577016139       rs577445426       rs577704585       rs577792184       rs578187520       rs578219746       rs578257611       rs746062504       rs747228747       rs748569748       rs748745985       rs749319245       rs749841395       rs750181117       rs751307827       rs751365117       rs751417884       rs752154045       rs752203816       rs753518568       rs754520900       rs755542637       rs755565686       rs755731284       rs757002877       rs757608565       rs757661633       rs758844241       rs758899607       rs759155039       rs760436445       rs760665565       rs760855629       rs761676591       rs761719148       rs762145140       rs762200712       rs762521727       rs762900253       rs763397586       rs763471381       rs763962704       rs766354584       rs767244629       rs767262215       rs767573605       rs769176643       rs769952250       rs770816862       rs771137320       rs771146622       rs772300147       rs772883610       rs773187816       rs773292152       rs773521710       rs774261627       rs774314871       rs774812631       rs774865563       rs776067398       rs776838902       rs777576688       rs778275720       rs779088290       rs779253935       rs779558584       rs779611607       rs779730734       rs780009662       rs781445114      

GSKIP基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TGTGGCCTATATCAATGTGGA
59
ATAGCCTACCACCTTGAGC
59
TGTGGCCTATATCAATGTGGA
59
ATAGCCTACCACCTTGAGC
59
GGAGGAAGGAAGAAGAGGA
58
CCAAACAGTTGTGATAATCAGC
58
GCTCGGTGCTGATTATCAC
58
GGAAGGAATCCTCACAGGT
58
ATGTGGCCTATATCAATGTGGA
60
ATAGCCTACCACCTTGAGC
59
TGTGGCCTATATCAATGTGGA
59
ATAGCCTACCACCTTGAGC
59
ATGTGGCCTATATCAATGTGGA
60
ATAGCCTACCACCTTGAGC
59
ATGTGGCCTATATCAATGTGGA
60
ATAGCCTACCACCTTGAGC
59
CGGAGGAAGGAAGAAGAGG
59
CCAAACAGTTGTGATAATCAGC
58
GTGGCCTATATCAATGTGGA
57
CATAGCCTACCACCTTGAG
57
      尚未收录相关数据

GSKIP基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GSKIP基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0005737
Q9P0R6(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控GSKIP基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Myeloproliferative disease 0.120271442 1 0 BeFree_CTD_human
Myeloid Leukemia 0.12 1 0 CTD_human
Chronic myeloproliferative disorder 0.000271442 1 0 BeFree
Myeloid neoplasm 0.000271442 1 0 BeFree
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