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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  
GRIA1基因(以及对应的蛋白质)的细胞分布位置:
GRIA1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Substance Withdrawal Syndrome | 0.120271442 | 3 | 0 | BeFree_CTD_human |
| Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
| Hypotension | 0.12 | 1 | 0 | CTD_human |
| Learning Disorders | 0.12 | 1 | 0 | CTD_human |
| Morphine Dependence | 0.12 | 1 | 0 | CTD_human |
| Psychosexual Disorders | 0.12 | 1 | 0 | CTD_human |
| Cocaine-Related Disorders | 0.12 | 5 | 0 | CTD_human |
| Hyperactive behavior | 0.12 | 2 | 0 | CTD_human |
| Sudden Cardiac Arrest | 0.12 | 1 | 1 | GWASCAT |
| Epilepsy | 0.080814326 | 4 | 0 | BeFree_RGD |
| Seizures | 0.080542884 | 3 | 0 | BeFree_RGD |
| Fetal Growth Retardation | 0.08 | 1 | 0 | RGD |
| Hepatic Encephalopathy | 0.08 | 1 | 0 | RGD |
| Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Status Epilepticus | 0.08 | 1 | 0 | RGD |
| Central Nervous System Viral Diseases | 0.08 | 1 | 0 | RGD |
| Schizophrenia | 0.007262917 | 8 | 0 | BeFree_GAD_LHGDN |
| Bipolar Disorder | 0.00554839 | 4 | 0 | BeFree_GAD |
| Amyotrophic Lateral Sclerosis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Glioma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Migraine Disorders | 0.002909916 | 2 | 0 | BeFree_GAD |
| Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
| Epilepsy, Temporal Lobe | 0.00272435 | 1 | 0 | LHGDN |
| Mental disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
| Body Weight Changes | 0.002367032 | 1 | 1 | GAD |
| Drug Allergy | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Weight Gain | 0.002367032 | 1 | 0 | GAD |
| Sudden Cardiac Death | 0.002367032 | 1 | 1 | GAD |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.002367032 | 1 | 0 | GAD |
| Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
| Drug habituation | 0.000814326 | 3 | 0 | BeFree |
| Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
| Mental Depression | 0.000542884 | 2 | 0 | BeFree |
| Depressive disorder | 0.000542884 | 2 | 0 | BeFree |
| Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
| Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
| Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
| Decreased Libido | 0.000271442 | 1 | 0 | BeFree |
| Globus Hystericus | 0.000271442 | 1 | 0 | BeFree |
| HIV Infections | 0.000271442 | 1 | 0 | BeFree |
| Muscle Spasticity | 0.000271442 | 1 | 0 | BeFree |
| Psychotic Disorders | 0.000271442 | 1 | 0 | BeFree |
| organic sexual dysfunction | 0.000271442 | 1 | 0 | BeFree |
| Drug withdrawal syndrome | 0.000271442 | 1 | 0 | BeFree |
| Convulsions in the newborn | 0.000271442 | 1 | 0 | BeFree |
| Subependymal Glioma | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Spastic | 0.000271442 | 1 | 0 | BeFree |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| Sexual Dysfunction | 0.000271442 | 1 | 0 | BeFree |
| mass lesion | 0.000271442 | 1 | 0 | BeFree |
| Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
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