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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  
GRIA1基因(以及对应的蛋白质)的细胞分布位置:
GRIA1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Substance Withdrawal Syndrome | 0.120271442 | 3 | 0 | BeFree_CTD_human |
Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
Hypotension | 0.12 | 1 | 0 | CTD_human |
Learning Disorders | 0.12 | 1 | 0 | CTD_human |
Morphine Dependence | 0.12 | 1 | 0 | CTD_human |
Psychosexual Disorders | 0.12 | 1 | 0 | CTD_human |
Cocaine-Related Disorders | 0.12 | 5 | 0 | CTD_human |
Hyperactive behavior | 0.12 | 2 | 0 | CTD_human |
Sudden Cardiac Arrest | 0.12 | 1 | 1 | GWASCAT |
Epilepsy | 0.080814326 | 4 | 0 | BeFree_RGD |
Seizures | 0.080542884 | 3 | 0 | BeFree_RGD |
Fetal Growth Retardation | 0.08 | 1 | 0 | RGD |
Hepatic Encephalopathy | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Status Epilepticus | 0.08 | 1 | 0 | RGD |
Central Nervous System Viral Diseases | 0.08 | 1 | 0 | RGD |
Schizophrenia | 0.007262917 | 8 | 0 | BeFree_GAD_LHGDN |
Bipolar Disorder | 0.00554839 | 4 | 0 | BeFree_GAD |
Amyotrophic Lateral Sclerosis | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Glioma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Migraine Disorders | 0.002909916 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
Epilepsy, Temporal Lobe | 0.00272435 | 1 | 0 | LHGDN |
Mental disorders | 0.002638474 | 2 | 0 | BeFree_GAD |
Body Weight Changes | 0.002367032 | 1 | 1 | GAD |
Drug Allergy | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Weight Gain | 0.002367032 | 1 | 0 | GAD |
Sudden Cardiac Death | 0.002367032 | 1 | 1 | GAD |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.002367032 | 1 | 0 | GAD |
Weight Gain Adverse Event | 0.002367032 | 1 | 0 | GAD |
Drug habituation | 0.000814326 | 3 | 0 | BeFree |
Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
Mental Depression | 0.000542884 | 2 | 0 | BeFree |
Depressive disorder | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Decreased Libido | 0.000271442 | 1 | 0 | BeFree |
Globus Hystericus | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Muscle Spasticity | 0.000271442 | 1 | 0 | BeFree |
Psychotic Disorders | 0.000271442 | 1 | 0 | BeFree |
organic sexual dysfunction | 0.000271442 | 1 | 0 | BeFree |
Drug withdrawal syndrome | 0.000271442 | 1 | 0 | BeFree |
Convulsions in the newborn | 0.000271442 | 1 | 0 | BeFree |
Subependymal Glioma | 0.000271442 | 1 | 0 | BeFree |
Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Spastic | 0.000271442 | 1 | 0 | BeFree |
Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
Sexual Dysfunction | 0.000271442 | 1 | 0 | BeFree |
mass lesion | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
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