GPX4(glutathione peroxidase 4) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

基因染色体位置

基因染色体位置

19p13.3

基因简述

基因简述

This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

[中文简述(自动翻译):]  该基因编码的谷胱甘肽过氧化物酶蛋白家族的一个成员。谷胱甘肽过氧化物酶催化过氧化氢，有机氢过氧化物，和过氧化脂质的通过还原型谷胱甘肽和功能在细胞中的抗氧化损伤的保护的减少。人血浆谷胱甘肽过氧化物酶已被证明是一种含有硒的酶和UGA密码子翻译成硒代半胱氨酸。所编码的蛋白质已被鉴定为是根据它来服务双重用作过氧化物酶，以及在成熟精子的结构蛋白质的能力的兼职蛋白。通过选择性剪接和转录起始，大鼠产生一个定位于细胞核，线粒体和细胞质蛋白。在人类中，替代转录起始和线粒体与核转运肽的切割位点需要被实验证实。选择性剪接结果在多个抄本变形。 [由RefSeq的，2014年1月提供]

OMIM数据库中对GPX4基因的介绍     Wikipedia数据库中对GPX4基因的介绍

基因序列

基因序列

GPX4基因的碱基序列：[NCBI]

基因突变

基因突变

GPX4基因的碱基突变：           显示全部snp
rs4851       rs14283       rs713041       rs757228       rs757229       rs757230       rs757231       rs1042863       rs1808194       rs2074450       rs2074451       rs2074452       rs2075710       rs3177111       rs3203740       rs3746165       rs3746166       rs4588110       rs4807542       rs4807543       rs5826722       rs8103169       rs8103188       rs8103283       rs8103551       rs8178957       rs8178958       rs8178959       rs8178960       rs8178961       rs8178962       rs8178963       rs8178964       rs8178965       rs8178966       rs8178967       rs8178968      
rs8178970       rs8178971       rs8178972       rs8178973       rs8178975       rs8178976       rs8178977       rs8178978       rs11309920       rs11407575       rs11555179       rs12978338       rs13343462       rs17526264       rs17554931       rs17554938       rs34044728       rs34103661       rs34865773       rs34894724       rs34998479       rs35030170       rs35406680       rs35436265       rs35456941       rs35966855       rs36207273       rs36207878       rs36207883       rs36208215       rs57563163       rs58400853       rs72550710       rs73507255       rs74421142       rs74861196       rs75708066       rs76201145       rs77421492       rs77497924       rs77533333       rs79256799       rs111613279       rs111851735       rs113282777       rs113914359       rs114074763       rs116958457       rs117098862       rs117193629       rs117398924       rs137892570       rs140757850       rs144416510       rs144677581       rs145529272       rs145660099       rs146333943       rs147680662       rs148220181       rs149602518       rs180840249       rs183015432       rs185577946       rs189044633       rs190085630       rs191644348       rs192436929       rs199512776       rs199515520       rs199743575       rs199752797       rs199787199       rs199948868       rs200071465       rs200291407       rs200506822       rs200721348       rs200847274       rs200859501       rs201044864       rs201490206       rs201575676       rs201633492       rs201688509       rs201903291       rs201951088       rs202172712       rs367564504       rs367821827       rs367960722       rs368026073       rs368126228       rs368488297       rs368496760       rs368588689       rs368702176       rs368897080       rs369712159       rs369730592       rs369731020       rs369851110       rs370119671       rs370266690       rs370284106       rs370355812       rs370419921       rs370535582       rs370996243       rs371303341       rs371481974       rs371593814       rs371892333       rs372066966       rs372370002       rs372433868       rs372454438       rs372464063       rs373261191       rs373533365       rs373571319       rs373755097       rs374338127       rs374349562       rs374681817       rs375048133       rs375349552       rs375523715       rs376007177       rs376032528       rs376068124       rs376092764       rs376112545       rs376317362       rs376345610       rs376929853       rs377091174       rs397843743       rs527468323       rs527953996       rs528080431       rs528107390       rs528737278       rs529452430       rs529684277       rs530063614       rs531002432       rs531452768       rs531600656       rs531824867       rs532171942       rs533890588       rs534311184       rs535028560       rs536042270       rs536194289       rs536200712       rs536391413       rs536594546       rs536607574       rs536633606       rs537463772       rs538689362       rs538817152       rs538850044       rs539025966       rs540807904       rs541039860       rs541161235       rs541198430       rs541229619       rs541349693       rs541555521       rs541597371       rs541778225       rs543261909       rs543299818       rs543575878       rs543809238       rs544230793       rs545200041       rs545235673       rs545537200       rs545598881       rs546182511       rs546242075       rs546619864       rs546711688       rs547098735       rs547371911       rs548039328       rs548265258       rs548528852       rs548658328       rs549410862       rs549687360       rs549843877       rs550007490       rs550044041       rs550603355       rs550729580       rs551649278       rs551922675       rs552083842       rs553057420       rs553064186       rs553318268       rs554036902       rs554840447       rs554875687       rs555303726       rs555429243       rs555583226       rs556598510       rs556962104       rs557150935       rs557453519       rs558421355       rs559148315       rs559398529       rs559437061       rs559566542       rs560004644       rs560173847       rs560512083       rs561639580       rs561850729       rs561995303       rs562020484       rs562612528       rs563588859       rs563800315       rs563823784       rs563988259       rs564521219       rs564578369       rs564919541       rs565372587       rs565506620       rs565562296       rs566006122       rs566592153       rs566928862       rs566974741       rs567296975       rs567349608       rs568830391       rs568951115       rs569137841       rs569196053       rs569335216       rs569667691       rs569964280       rs570136765       rs570421363       rs571333957       rs571504513       rs571770278       rs573381087       rs573390223       rs573695884       rs573806985       rs574013336       rs574375652       rs575039682       rs575612246       rs575697870       rs577573367       rs577836354       rs577906600       rs577949105       rs577966752       rs745314165       rs745337363       rs745425210       rs745507433       rs745707351       rs745797291       rs745799475       rs745885476       rs746007422       rs746262144       rs746349582       rs746579938       rs746824565       rs746840072       rs747013916       rs747058722       rs747356988       rs747381755       rs747423599       rs747601013       rs747887804       rs748362432       rs748434370       rs748450322       rs748578422       rs748668129       rs748758139       rs748868849       rs748876191       rs749154135       rs749243663       rs749330569       rs749509892       rs749653718       rs749766545       rs750297144       rs750347551       rs750348731       rs750572438       rs750675271       rs750709533       rs750853594       rs750939686       rs751121983       rs751317795       rs751333238       rs751368206       rs751425206       rs751452053       rs751723961       rs751742835       rs751845338       rs751928727       rs751931035       rs752016643       rs752167709       rs752207175       rs752733635       rs752797013       rs752965720       rs752983685       rs753179152       rs753350196       rs753545286       rs753639294       rs753790400       rs754002873       rs754121801       rs754215826       rs754258940       rs754288488       rs754417099       rs754502718       rs754504650       rs754920720       rs755024081       rs755235087       rs755415132       rs755509750       rs755894874       rs756060142       rs756296662       rs756485267       rs756502326       rs756549849       rs756571473       rs756803895       rs756916315       rs756929751       rs757133049       rs757261297       rs757354426       rs757354500       rs757440433       rs757559152       rs757673527       rs757831633       rs758436183       rs758523802       rs758625205       rs758755482       rs758851198       rs758936260       rs759011380       rs759105125       rs759367637       rs759634320       rs759722982       rs759817182       rs760039914       rs760126037       rs760464236       rs760519520       rs760584379       rs760877738       rs760885288       rs760967203       rs761124387       rs761261587       rs761352256       rs761444591       rs761538444       rs761611683       rs761637110       rs761646022       rs761699782       rs761888816       rs762088801       rs762193339       rs762558423       rs762588266       rs762675618       rs762678264       rs762792092       rs763031415       rs763243332       rs763436287       rs763745871       rs763783774       rs763882969       rs763975118       rs764047352       rs764134016       rs764426541       rs764451341       rs764518643       rs764846862       rs765117498       rs765230184       rs765267261       rs765324004       rs765530985       rs765611709       rs765681822       rs765996806       rs766168909       rs766180510       rs766270762       rs766374099       rs766444073       rs766655878       rs766661274       rs766745635       rs766828184       rs766834737       rs766841959       rs766916114       rs767048072       rs767130132       rs767392421       rs767480305       rs767854085       rs768267697       rs768355562       rs768357556       rs768722652       rs768812644       rs768879858       rs768925022       rs769173951       rs769250904       rs769340944       rs769428770       rs769589678       rs769640321       rs769967246       rs770059063       rs770192113       rs770360197       rs770399907       rs770487829       rs770665061       rs770740384       rs770775625       rs770953842       rs771277721       rs771500646       rs771535901       rs771717955       rs772104779       rs772198561       rs772251077       rs772284404       rs772394824       rs772592100       rs772748802       rs772757452       rs772822658       rs772921346       rs773132188       rs773134735       rs773450719       rs773718263       rs773984936       rs773985714       rs774076212       rs774736103       rs774824204       rs775144873       rs775146234       rs775322412       rs775503308       rs775795035       rs775885362       rs776175491       rs776252514       rs776385017       rs776390793       rs776479091       rs776536583       rs776936631       rs777216470       rs777236046       rs777503568       rs777518288       rs777609968       rs777613964       rs777819499       rs777912075       rs778000261       rs778266724       rs778354676       rs778370256       rs778377555       rs778458157       rs778651341       rs778748373       rs778842247       rs778959445       rs779018164       rs779141388       rs779400936       rs779416718       rs779516356       rs779529317       rs779619280       rs779793952       rs779891202       rs780068753       rs780173011       rs780178425       rs780265532       rs780273947       rs780546024       rs780636974       rs780647717       rs780675386       rs780732940       rs780763270       rs780851132       rs781318061       rs781320737       rs781683954       rs781740869       rs796239820      

基因表达

基因表达

GPX4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTAACCTGGACAAGTACCGG
60
TTCGTTACTCCCTGCTTCC
59
TCCACAGTTCCTCATCGAC
59
GTCCTTCTCTATCACCAGGG
59
TAACCTGGACAAGTACCGG
59
CTCTTCGTTACTCCCTGCT
59
TAACCTGGACAAGTACCGG
59
TTCGTTACTCCCTGCTTCC
59
ATGTTCAGCAAGATCTGCG
59
CGATGAGGAATTTCCCAGG
58
TAACCTGGACAAGTACCGG
59
TTTACTTCGGTCTTGCCTC
58
GTTCAGCAAGATCTGCGTG
60
CGATGAGGAATTTCCCAGGA
60
GTTAACCTGGACAAGGGCT
60
GAGCTGAGTGTAGTTTACTTCG
59
TTAACCTGGACAAGTACCGG
60
TACTTCGGTCTTGCCTCAC
59
AGTGGATGAAGATCCAACCC
60
TGTCGATGAGGAACTTGGT
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

GPX4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

GPX4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004602
A0A087WT12(UniProtKB)
IEA
GO:0006979
A0A087WT12(UniProtKB)
IEA
GO:0055114
A0A087WT12(UniProtKB)
IEA
GO:0098869
A0A087WT12(UniProtKB)
IEA
GO:0098869
A0A087WT12(UniProtKB)
IEA
GO:0004602
A0A087X247(UniProtKB)
IEA
GO:0006979
A0A087X247(UniProtKB)
IEA
GO:0055114
A0A087X247(UniProtKB)
IEA
GO:0098869
A0A087X247(UniProtKB)
IEA
GO:0098869
A0A087X247(UniProtKB)
IEA
GO:0004602
A0A087X2I2(UniProtKB)
IEA
GO:0006979
A0A087X2I2(UniProtKB)
IEA
GO:0055114
A0A087X2I2(UniProtKB)
IEA
GO:0098869
A0A087X2I2(UniProtKB)
IEA
GO:0098869
A0A087X2I2(UniProtKB)
IEA
GO:0004602
A0A0A0MTT1(UniProtKB)
IEA
GO:0006979
A0A0A0MTT1(UniProtKB)
IEA
GO:0055114
A0A0A0MTT1(UniProtKB)
IEA
GO:0098869
A0A0A0MTT1(UniProtKB)
IEA
GO:0098869
A0A0A0MTT1(UniProtKB)
IEA
GO:0004602
K7EJ20(UniProtKB)
IEA
GO:0006979
K7EJ20(UniProtKB)
IEA
GO:0055114
K7EJ20(UniProtKB)
IEA
GO:0098869
K7EJ20(UniProtKB)
IEA
GO:0098869
K7EJ20(UniProtKB)
IEA
GO:0004602
K7EKX7(UniProtKB)
IEA
GO:0006979
K7EKX7(UniProtKB)
IEA
GO:0055114
K7EKX7(UniProtKB)
IEA
GO:0098869
K7EKX7(UniProtKB)
IEA
GO:0098869
K7EKX7(UniProtKB)
IEA
GO:0004602
K7ENB4(UniProtKB)
IEA
GO:0006979
K7ENB4(UniProtKB)
IEA
GO:0055114
K7ENB4(UniProtKB)
IEA
GO:0098869
K7ENB4(UniProtKB)
IEA
GO:0098869
K7ENB4(UniProtKB)
IEA
GO:0004602
K7ERP4(UniProtKB)
IEA
GO:0006979
K7ERP4(UniProtKB)
IEA
GO:0055114
K7ERP4(UniProtKB)
IEA
GO:0098869
K7ERP4(UniProtKB)
IEA
GO:0098869
K7ERP4(UniProtKB)
IEA
GO:0004602
P36969(UniProtKB)
TAS
GO:0004602
P36969(UniProtKB)
TAS
GO:0004602
P36969(UniProtKB)
TAS
GO:0005634
P36969(UniProtKB)
IDA
GO:0005739
P36969(UniProtKB)
TAS
GO:0005829
P36969(UniProtKB)
TAS
GO:0005829
P36969(UniProtKB)
TAS
GO:0006644
P36969(UniProtKB)
TAS
GO:0006979
P36969(UniProtKB)
IEA
GO:0007275
P36969(UniProtKB)
IEA
GO:0019372
P36969(UniProtKB)
TAS
GO:0047066
P36969(UniProtKB)
IEA
GO:0055114
P36969(UniProtKB)
TAS
GO:0070062
P36969(UniProtKB)
IDA
GO:0070062
P36969(UniProtKB)
IDA
GO:0098869
P36969(UniProtKB)
IEA
GO:0098869
P36969(UniProtKB)
IEA
GO:0004602
R4GNE4(UniProtKB)
IEA
GO:0006979
R4GNE4(UniProtKB)
IEA
GO:0055114
R4GNE4(UniProtKB)
IEA
GO:0098869
R4GNE4(UniProtKB)
IEA
GO:0098869
R4GNE4(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控GPX4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Spondylometaphyseal dysplasia, Sedaghatian type 0.24 0 2 CLINVAR_ORPHANET
Mammary Neoplasms 0.122995792 2 0 BeFree_CTD_human_LHGDN
Colorectal Neoplasms 0.122367032 2 0 CTD_human_GAD
Male infertility 0.120271442 3 0 BeFree_CTD_human
Cadmium poisoning 0.12 1 0 CTD_human
Cryptorchidism 0.12 1 0 CTD_human
Heart failure 0.12 1 0 CTD_human
Embryo Loss 0.12 1 0 CTD_human
Malignant neoplasm of breast 0.010553895 7 1 BeFree_GAD
Malignant neoplasm of prostate 0.005276948 3 0 BeFree_GAD
Lymphoma, Non-Hodgkin 0.004734064 2 0 GAD
Squamous cell carcinoma 0.002995792 2 0 BeFree_LHGDN
Malignant neoplasm of lung 0.002909916 3 0 BeFree_GAD
Colorectal Cancer 0.002909916 2 0 BeFree_GAD
Cerebral Palsy 0.00272435 1 0 LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN
Ductal Carcinoma 0.00272435 1 0 LHGDN
Atherosclerosis 0.002638474 2 0 BeFree_GAD
Adenoma 0.002367032 1 0 GAD
Asthma 0.002367032 1 0 GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Diabetes Mellitus, Non-Insulin-Dependent 0.002367032 1 0 GAD
Liver diseases 0.002367032 1 0 GAD
Chronic Obstructive Airway Disease 0.002367032 1 0 GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Malignant neoplasm of ovary 0.002367032 1 0 GAD
Breast Carcinoma 0.001085767 4 0 BeFree
melanoma 0.000814326 3 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Carcinoma of lung 0.000542884 2 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Renal Cell Carcinoma 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Hypercholesterolemia, Familial 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Kidney Failure, Acute 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree
B-Cell Lymphomas 0.000271442 1 0 BeFree
Essential Hypertension 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Scleroatonic muscular dystrophy 0.000271442 1 0 BeFree
Breast adenocarcinoma 0.000271442 1 0 BeFree
Kashin-Beck Disease 0.000271442 1 0 BeFree

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