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This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. The protein encoded by this locus contains a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
[中文简述(自动翻译):]  此基因是谷胱甘肽过氧化物酶家族的成员,并且编码硒依赖性谷胱甘肽过氧化物酶,它负责在胃肠道的上皮大多数谷胱甘肽依赖性过氧化氢 - 还原活性的两种同工酶之一。通过该位点编码的蛋白质包含由UGA密码子,通常信号翻译终止编码的硒代半胱氨酸(秒)残留物。可变剪接转录物变体已有描述。 [由RefSeq的,2012年2月提供]
GPX2基因(以及对应的蛋白质)的细胞分布位置:
GPX2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Neoplasm Metastasis | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Malignant neoplasm of lung | 0.005276948 | 4 | 0 | BeFree_GAD |
Adenoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Colitis | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Intestinal Cancer | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Adenoma of large intestine | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Residual Cancer | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mammary Carcinoma, Human | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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